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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human POLG HGNC:9179 (HGNC)
5428 (Entrez Gene)
174763 (OMIM)
HGNC homology
Chr15 q25 Chr15:89316305-89334795 (-)
Mitochondrial DNA Depletion Syndrome 1 (mngie Type); MTDPS1
Mitochondrial DNA Depletion Syndrome 4a (alpers Type); MTDPS4A
Mitochondrial DNA Depletion Syndrome 4b (mngie Type); MTDPS4B
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant 1; PEOA1
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive 1; PEOB1
Sensory Ataxic Neuropathy, Dysarthria, and Ophthalmoparesis; SANDO
P54098 (UniProt | EBI)
NM_002693 (RefSeq)
mouse Polg MGI:1196389 (MGI)
18975 (Entrez Gene)
Gene Tree
HGNC homology
Chr7 45.04 cM Chr7:79446231-79466362 (-)
Myelodysplastic Syndrome; MDS
OTTMUSG00000029097 (VEGA)
OTTMUSP00000037076 (VEGA)
OTTMUST00000072160 (VEGA)
rat Polg 85472 (Entrez Gene)
Chr1 q31 Q9QYV8 (UniProt | EBI)
NM_053528 (RefSeq)
chimpanzee POLG 467754 (Entrez Gene)
Chr15 XP_009428073 (RefSeq)
rhesus macaque POLG 699750 (Entrez Gene)
Chr7 XP_014998464 (RefSeq)
cattle POLG 533090 (Entrez Gene)
Chr21 XP_010823124 (RefSeq)
dog POLG 100856383 (Entrez Gene)
Chr3 XP_013967894 (RefSeq)
chicken POLG 404292 (Entrez Gene)
Chr10 Q92076 (UniProt | EBI)
western clawed frog polg 100488393 (Entrez Gene)
ChrUN XP_012815010 (RefSeq)
zebrafish polg 100150924 (Entrez Gene)
Chr25 XP_001921130 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory