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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SERPINA1 HGNC:8941 (HGNC)
5265 (Entrez Gene)
107400 (OMIM)
Alpha 1-antitrypsin (MyGene.info)
HGNC homology
Chr14 q32.13 Chr14:94376747-94390692 (-)
alpha 1-antitrypsin deficiency
P01009 (UniProt | EBI)
NM_001127702 (RefSeq)
mouse Serpina1a MGI:891971 (MGI)
20700 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 52.98 cM Chr12:103853589-103863562 (-)
ENSMUSG00000066366 (Ensembl Gene Model)
ENSMUSP00000072652 (Ensembl)
ENSMUST00000072876 (Ensembl)
Serpina1b MGI:891970 (MGI)
20701 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 52.98 cM Chr12:103728156-103738189 (-)
20701 (NCBI Gene Model)
P22599 (UniProt | EBI)
NM_009244 (RefSeq)
Serpina1c MGI:891969 (MGI)
20702 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 52.98 cM Chr12:103894926-103904887 (-)
ENSMUSG00000079015 (Ensembl Gene Model)
ENSMUSP00000073695 (Ensembl)
ENSMUST00000074051 (Ensembl)
Serpina1d MGI:891968 (MGI)
20703 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 52.98 cM Chr12:103763594-103773592 (-)
ENSMUSG00000071177 (Ensembl Gene Model)
ENSMUSP00000077909 (Ensembl)
ENSMUST00000078869 (Ensembl)
Serpina1e MGI:891967 (MGI)
20704 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 52.98 cM Chr12:103946931-103956897 (-)
20704 (NCBI Gene Model)
Q00898 (UniProt | EBI)
NM_009247 (RefSeq)
rat Serpina1 24648 (Entrez Gene)
Chr6 q32 P17475 (UniProt | EBI)
NM_022519 (RefSeq)
chimpanzee SERPINA1 467541 (Entrez Gene)
Chr14 XP_009426637 (RefSeq)
cattle SERPINA1 280699 (Entrez Gene)
Chr21 P34955 (UniProt | EBI)
NM_173882 (RefSeq)
dog SERPINA1 480422 (Entrez Gene)
Chr8 NP_001073578 (RefSeq)
NM_001080109 (RefSeq)
chicken SPIA1 423434 (Entrez Gene)
Chr5 NP_001264422 (RefSeq)
NM_001277493 (RefSeq)
SPIA4 423433 (Entrez Gene)
Chr5 NP_001264421 (RefSeq)
NM_001277492 (RefSeq)
SPIA5 423435 (Entrez Gene)
Chr5 XP_015143254 (RefSeq)
SPIA9 423436 (Entrez Gene)
Chr5 XP_025006916 (RefSeq)
zebrafish serpina1 322701 (Entrez Gene)
Chr20 NP_001071226 (RefSeq)
NM_001077758 (RefSeq)
serpina1l 321195 (Entrez Gene)
Chr20 NP_001013277 (RefSeq)
NM_001013259 (RefSeq)
frog, western clawed LOC100488834 100488834 (Entrez Gene)
Chr8 XP_002936115 (RefSeq)
serpina1 100145012 (Entrez Gene)
Chr8 XP_004917137 (RefSeq)
serpina3k 496632 (Entrez Gene)
Chr8 XP_002936116 (RefSeq)
macaque, rhesus SERPINA1 701361 (Entrez Gene)
Chr7 NP_001252946 (RefSeq)
NM_001266017 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory