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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LEP HGNC:6553 (HGNC)
3952 (Entrez Gene)
164160 (OMIM)
Leptin (MyGene.info)
HGNC homology
Chr7 q32.1 Chr7:128241201-128257629 (+)
P41159 (UniProt | EBI)
NM_000230 (RefSeq)
mouse Lep MGI:104663 (MGI)
16846 (Entrez Gene)
Gene Tree
HGNC homology
Chr6 12.3 cM Chr6:29060220-29073877 (+)
abdominal obesity-metabolic syndrome
fatty liver disease
metabolic syndrome X
type 2 diabetes mellitus
OTTMUSG00000035815 (VEGA)
OTTMUSP00000050551 (VEGA)
OTTMUST00000091731 (VEGA)
rat Lep 25608 (Entrez Gene)
Chr4 q22 P50596 (UniProt | EBI)
NM_013076 (RefSeq)
chimpanzee LEP 449638 (Entrez Gene)
Chr7 O02750 (UniProt | EBI)
NM_001193672 (RefSeq)
cattle LEP 280836 (Entrez Gene)
Chr4 q32 P50595 (UniProt | EBI)
NM_173928 (RefSeq)
dog LEP 403616 (Entrez Gene)
Chr14 O02720 (UniProt | EBI)
NM_001003070 (RefSeq)
frog, western clawed lep 100486715 (Entrez Gene)
Chr3 XP_002931881 (RefSeq)
macaque, rhesus LEP 698728 (Entrez Gene)
Chr3 Q28504 (UniProt | EBI)
NM_001042755 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory