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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LRRK2 HGNC:18618 (HGNC)
120892 (Entrez Gene)
609007 (OMIM)
LRRK2 (MyGene.info)
HGNC homology
Chr12 q12 Chr12:40224895-40369285 (+)
autosomal dominant Parkinson disease 8
Q5S007 (UniProt | EBI)
NM_198578 (RefSeq)
mouse Lrrk2 MGI:1913975 (MGI)
66725 (Entrez Gene)
Gene Tree
HGNC homology
Chr15 46.07 cM Chr15:91673175-91816120 (+)
autosomal dominant Parkinson disease 8
OTTMUSG00000020864 (VEGA)
OTTMUSP00000022827 (VEGA)
OTTMUST00000049323 (VEGA)
rat Lrrk2 300160 (Entrez Gene)
Chr7 q35 NP_001178718 (RefSeq)
NM_001191789 (RefSeq)
chimpanzee LRRK2 745893 (Entrez Gene)
Chr12 XP_016779129 (RefSeq)
cattle LRRK2 535652 (Entrez Gene)
Chr5 NP_001193015 (RefSeq)
NM_001206086 (RefSeq)
dog LRRK2 486608 (Entrez Gene)
Chr27 XP_013964022 (RefSeq)
chicken LRRK2 427844 (Entrez Gene)
Chr1 NP_001274122 (RefSeq)
NM_001287193 (RefSeq)
zebrafish lrrk2 559366 (Entrez Gene)
Chr25 NP_001188385 (RefSeq)
NM_001201456 (RefSeq)
frog, western clawed lrrk2 100145062 (Entrez Gene)
Chr3 XP_012815442 (RefSeq)
macaque, rhesus LRRK2 697930 (Entrez Gene)
Chr11 XP_015006935 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.10
The Jackson Laboratory