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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LRRK2 HGNC:18618 (HGNC)
120892 (Entrez Gene)
609007 (OMIM)
Chr12 q12 Chr12:40225011-40369285 (+)
Parkinson Disease 8, Autosomal Dominant; PARK8
Q5S007 (UniProt | EBI)
NM_198578 (RefSeq)
mouse Lrrk2 MGI:1913975 (MGI)
66725 (Entrez Gene)
Gene Tree
Chr15 46.07 cM Chr15:91673175-91816120 (+)
Parkinson Disease 8, Autosomal Dominant; PARK8
OTTMUSG00000020864 (VEGA)
OTTMUSP00000022827 (VEGA)
OTTMUST00000049323 (VEGA)
rat Lrrk2 300160 (Entrez Gene)
Chr7 q35 NP_001178718 (RefSeq)
NM_001191789 (RefSeq)
chimpanzee LRRK2 745893 (Entrez Gene)
Chr12 XP_001168494 (RefSeq)
rhesus macaque LRRK2 697930 (Entrez Gene)
Chr11 XP_002798616 (RefSeq)
cattle LRRK2 535652 (Entrez Gene)
Chr5 NP_001193015 (RefSeq)
NM_001206086 (RefSeq)
dog LRRK2 486608 (Entrez Gene)
Chr27 XP_543734 (RefSeq)
chicken LRRK2 427844 (Entrez Gene)
Chr1 NP_001274122 (RefSeq)
NM_001287193 (RefSeq)
western clawed frog lrrk2 100145062 (Entrez Gene)
ChrUN XP_002932250 (RefSeq)
zebrafish lrrk2 559366 (Entrez Gene)
Chr25 NP_001188385 (RefSeq)
NM_001201456 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory