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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LRP5 HGNC:6697 (HGNC)
4041 (Entrez Gene)
603506 (OMIM)
LRP5 (MyGene.info)
HGNC homology
Chr11 q13.2 Chr11:68298866-68449275 (+)
autosomal dominant endosteal hyperostosis
autosomal dominant osteopetrosis 1
exudative vitreoretinopathy 1
exudative vitreoretinopathy 4
osteoporosis-pseudoglioma syndrome
Worth's syndrome
O75197 (UniProt | EBI)
NM_001291902 (RefSeq)
mouse Lrp5 MGI:1278315 (MGI)
16973 (Entrez Gene)
Gene Tree
HGNC homology
Chr19 3.33 cM Chr19:3584828-3686564 (-)
exudative vitreoretinopathy
osteoporosis-pseudoglioma syndrome
ENSMUSG00000024913 (Ensembl Gene Model)
ENSMUSP00000025856 (Ensembl)
ENSMUST00000025856 (Ensembl)
rat Lrp5 293649 (Entrez Gene)
Chr1 q42-q43 NP_001099791 (RefSeq)
NM_001106321 (RefSeq)
chimpanzee LRP5 451380 (Entrez Gene)
Chr11 XP_024203051 (RefSeq)
cattle LRP5 534450 (Entrez Gene)
Chr29 XP_024843356 (RefSeq)
dog LRP5 100306933 (Entrez Gene)
Chr18 XP_022260833 (RefSeq)
chicken LRP5 423114 (Entrez Gene)
Chr5 NP_001012915 (RefSeq)
NM_001012897 (RefSeq)
zebrafish lrp5 568518 (Entrez Gene)
Chr25 NP_001170929 (RefSeq)
NM_001177458 (RefSeq)
frog, western clawed lrp5 100491803 (Entrez Gene)
Chr4 XP_017948939 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory