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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LEPR HGNC:6554 (HGNC)
3953 (Entrez Gene)
601007 (OMIM)
Leptin receptor (MyGene.info)
HGNC homology
Chr1 p31.3 Chr1:65420652-65637493 (+)
P48357 (UniProt | EBI)
NM_001198689 (RefSeq)
mouse Lepr MGI:104993 (MGI)
16847 (Entrez Gene)
Gene Tree
HGNC homology
Chr4 46.96 cM Chr4:101717404-101815352 (+)
type 2 diabetes mellitus
OTTMUSG00000008454 (VEGA)
OTTMUSP00000008794 (VEGA)
OTTMUST00000019183 (VEGA)
rat Lepr 24536 (Entrez Gene)
Chr5 q33 Q62959 (UniProt | EBI)
NM_012596 (RefSeq)
chimpanzee LEPR 456919 (Entrez Gene)
Chr1 XP_016775598 (RefSeq)
cattle LEPR 497205 (Entrez Gene)
Chr3 q33 NP_001012285 (RefSeq)
NM_001012285 (RefSeq)
dog LEPR 450207 (Entrez Gene)
Chr5 NP_001019805 (RefSeq)
NM_001024634 (RefSeq)
chicken LEPR 374223 (Entrez Gene)
Chr8 NP_989654 (RefSeq)
NM_204323 (RefSeq)
zebrafish lepr 567241 (Entrez Gene)
Chr6 NP_001296332 (RefSeq)
NM_001113376 (RefSeq)
frog, western clawed lepr 724071 (Entrez Gene)
Chr4 NP_001037866 (RefSeq)
NM_001044401 (RefSeq)
macaque, rhesus LEPR 574126 (Entrez Gene)
Chr1 Q9MYL0 (UniProt | EBI)
NM_001032819 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory