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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human GRN HGNC:4601 (HGNC)
2896 (Entrez Gene)
138945 (OMIM)
Granulin (MyGene.info)
HGNC homology
Chr17 q21.31 Chr17:44345086-44353106 (+)
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions
neuronal ceroid lipofuscinosis 11
P28799 (UniProt | EBI)
NM_002087 (RefSeq)
mouse Grn MGI:95832 (MGI)
14824 (Entrez Gene)
Gene Tree
HGNC homology
Chr11 66.29 cM Chr11:102430322-102436809 (+)
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions
nephrogenic diabetes insipidus
14824 (NCBI Gene Model)
P28798 (UniProt | EBI)
NM_008175 (RefSeq)
rat Grn 29143 (Entrez Gene)
Chr10 q32.1 P23785 (UniProt | EBI)
NM_017113 (RefSeq)
chimpanzee GRN 454728 (Entrez Gene)
Chr17 XP_016787145 (RefSeq)
NM_001280142 (RefSeq)
cattle GRN 767942 (Entrez Gene)
Chr19 XP_024836683 (RefSeq)
NM_001077014 (RefSeq)
zebrafish grna 791524 (Entrez Gene)
Chr3 NP_001348163 (RefSeq)
NM_001001949 (RefSeq)
frog, western clawed grn 594884 (Entrez Gene)
Chr10 NP_001072169 (RefSeq)
NM_001078701 (RefSeq)
macaque, rhesus GRN 714851 (Entrez Gene)
Chr16 XP_028692412 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory