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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human OPA1 HGNC:8140 (HGNC)
4976 (Entrez Gene)
605290 (OMIM)
HGNC homology
Chr3 q29 Chr3:193593144-193697811 (+)
Glaucoma, Normal Tension, Susceptibility to
Optic Atrophy 1; OPA1
Optic Atrophy with or without Deafness, Ophthalmoplegia, Myopathy, Ataxia, and Neuropathy
O60313 (UniProt | EBI)
NM_130836 (RefSeq)
mouse Opa1 MGI:1921393 (MGI)
74143 (Entrez Gene)
Gene Tree
HGNC homology
Chr16 20.65 cM Chr16:29579334-29654884 (+)
Optic Atrophy 1; OPA1
OTTMUSG00000031484 (VEGA)
OTTMUSP00000043672 (VEGA)
OTTMUST00000081593 (VEGA)
rat Opa1 171116 (Entrez Gene)
Chr11 q22 Q2TA68 (UniProt | EBI)
NM_133585 (RefSeq)
chimpanzee OPA1 471042 (Entrez Gene)
Chr3 XP_003310225 (RefSeq)
rhesus macaque OPA1 698540 (Entrez Gene)
Chr2 XP_001087037 (RefSeq)
cattle OPA1 524142 (Entrez Gene)
Chr1 NP_001179890 (RefSeq)
NM_001192961 (RefSeq)
dog OPA1 477129 (Entrez Gene)
Chr23 XP_013962054 (RefSeq)
chicken OPA1 424900 (Entrez Gene)
Chr9 Q5F499 (UniProt | EBI)
NM_001039309 (RefSeq)
western clawed frog opa1 100145638 (Entrez Gene)
ChrUN NP_001120510 (RefSeq)
NM_001127038 (RefSeq)
zebrafish LOC100307079 100307079 (Entrez Gene)
opa1 492332 (Entrez Gene)
Chr6 Q5U3A7 (UniProt | EBI)
NM_001007298 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory