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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human GCH1 HGNC:4193 (HGNC)
2643 (Entrez Gene)
600225 (OMIM)
HGNC homology
Chr14 q22.1-q22.2 Chr14:54842005-54902885 (-)
Dystonia, Dopa-Responsive; DRD
Hyperphenylalaninemia, Bh4-Deficient, B; HPABH4B
P30793 (UniProt | EBI)
NM_001024024 (RefSeq)
mouse Gch1 MGI:95675 (MGI)
14528 (Entrez Gene)
Gene Tree
Chr14 24.6 cM Chr14:47153895-47189402 (-)
14528 (NCBI Gene Model)
Q05915 (UniProt | EBI)
NM_008102 (RefSeq)
rat Gch1 29244 (Entrez Gene)
Chr15 p14 P22288 (UniProt | EBI)
NM_024356 (RefSeq)
chimpanzee GCH1 743728 (Entrez Gene)
Chr14 XP_009426111 (RefSeq)
rhesus macaque GCH1 695675 (Entrez Gene)
Chr7 XP_001087365 (RefSeq)
cattle GCH1 286815 (Entrez Gene)
Chr10 XP_002690995 (RefSeq)
dog GCH1 609393 (Entrez Gene)
Chr8 XP_005623474 (RefSeq)
chicken GCH1 396146 (Entrez Gene)
Chr5 P50141 (UniProt | EBI)
NM_205223 (RefSeq)
western clawed frog gch1 448485 (Entrez Gene)
ChrUN NP_001006789 (RefSeq)
NM_001006788 (RefSeq)
zebrafish gch1 100192219 (Entrez Gene)
Chr17 NP_001129727 (RefSeq)
NM_001136255 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory