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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human MMACHC HGNC:24525 (HGNC)
25974 (Entrez Gene)
609831 (OMIM)
HGNC homology
Chr1 p34.1 Chr1:45500184-45511067 (+)
Methylmalonic Aciduria and Homocystinuria, CblC Type
Q9Y4U1 (UniProt | EBI)
NM_015506 (RefSeq)
mouse Mmachc MGI:1914346 (MGI)
67096 (Entrez Gene)
Gene Tree
HGNC homology
Chr4 53.29 cM Chr4:116702279-116708406 (-)
OTTMUSG00000009547 (VEGA)
OTTMUSP00000009973 (VEGA)
OTTMUST00000021860 (VEGA)
rat Mmachc 313520 (Entrez Gene)
Chr5 q36 NP_001101432 (RefSeq)
NM_001107962 (RefSeq)
chimpanzee MMACHC 469180 (Entrez Gene)
Chr1 XP_524565 (RefSeq)
rhesus macaque MMACHC 706247 (Entrez Gene)
Chr1 NP_001253269 (RefSeq)
NM_001266340 (RefSeq)
cattle MMACHC 513433 (Entrez Gene)
Chr3 Q5E9C8 (UniProt | EBI)
NM_001015588 (RefSeq)
dog MMACHC 482514 (Entrez Gene)
Chr15 XP_539631 (RefSeq)
chicken MMACHC 424597 (Entrez Gene)
Chr8 Q5ZL21 (UniProt | EBI)
NM_001031281 (RefSeq)
western clawed frog mmachc 549685 (Entrez Gene)
ChrUN NP_001016931 (RefSeq)
NM_001016931 (RefSeq)
zebrafish mmachc 555267 (Entrez Gene)
Chr20 Q5RFU5 (UniProt | EBI)
NM_001114889 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.0
The Jackson Laboratory