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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SOST HGNC:13771 (HGNC)
50964 (Entrez Gene)
605740 (OMIM)
Sclerostin (MyGene.info)
HGNC homology
Chr17 q21.31 Chr17:43753731-43758788 (-)
craniometaphyseal dysplasia
sclerosteosis 1
SOST-related sclerosing bone dysplasia
Q9BQB4 (UniProt | EBI)
NM_025237 (RefSeq)
mouse Sost MGI:1921749 (MGI)
74499 (Entrez Gene)
Gene Tree
HGNC homology
Chr11 65.48 cM Chr11:101962458-101967015 (-)
sclerosteosis 1
SOST-related sclerosing bone dysplasia
OTTMUSG00000002135 (VEGA)
OTTMUSP00000002060 (VEGA)
OTTMUST00000004344 (VEGA)
rat Sost 80722 (Entrez Gene)
Chr10 q32.1 Q99P67 (UniProt | EBI)
NM_030584 (RefSeq)
chimpanzee SOST 740261 (Entrez Gene)
Chr17 XP_001153653 (RefSeq)
cattle SOST 282880 (Entrez Gene)
Chr19 Q9BG79 (UniProt | EBI)
NM_001166514 (RefSeq)
dog SOST 490948 (Entrez Gene)
Chr9 XP_548071 (RefSeq)
chicken SOST 429784 (Entrez Gene)
Chr27 XP_004948608 (RefSeq)
zebrafish sost 100000500 (Entrez Gene)
Chr12 XP_021336017 (RefSeq)
macaque, rhesus SOST 713617 (Entrez Gene)
Chr16 NP_001181537 (RefSeq)
NM_001194608 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory