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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human GCLC HGNC:4311 (HGNC)
2729 (Entrez Gene)
606857 (OMIM)
HGNC homology
Chr6 p12 Chr6:53497341-53545129 (-)
Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due to
Myocardial Infarction, Susceptibility to
P48506 (UniProt | EBI)
NM_001197115 (RefSeq)
mouse Gclc MGI:104990 (MGI)
14629 (Entrez Gene)
Gene Tree
HGNC homology
Chr9 43.36 cM Chr9:77754535-77794485 (+)
Cataract, Age-Related Nuclear
OTTMUSG00000021059 (VEGA)
OTTMUSP00000023141 (VEGA)
OTTMUST00000049815 (VEGA)
rat Gclc 25283 (Entrez Gene)
Chr8 q31 P19468 (UniProt | EBI)
NM_012815 (RefSeq)
chimpanzee GCLC 742732 (Entrez Gene)
Chr6 XP_001155930 (RefSeq)
rhesus macaque GCLC 710508 (Entrez Gene)
Chr4 NP_001248036 (RefSeq)
NM_001261107 (RefSeq)
cattle GCLC 512468 (Entrez Gene)
Chr23 NP_001077143 (RefSeq)
NM_001083674 (RefSeq)
dog GCLC 609822 (Entrez Gene)
Chr12 XP_852845 (RefSeq)
chicken GCLC 421894 (Entrez Gene)
Chr3 XP_419910 (RefSeq)
western clawed frog gclc 780264 (Entrez Gene)
ChrUN NP_001072803 (RefSeq)
NM_001079335 (RefSeq)
zebrafish gclc 326857 (Entrez Gene)
Chr13 NP_954971 (RefSeq)
NM_199277 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory