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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
11085

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human OPTN HGNC:17142 (HGNC)
10133 (Entrez Gene)
602432 (OMIM)
Chr10 p13 Chr10:13100075-13138291 (+)
GRCh38
Amyotrophic Lateral Sclerosis 12; ALS12
Glaucoma, Normal Tension, Susceptibility to
Glaucoma, Primary Open Angle; POAG
Q96CV9 (UniProt | EBI)
NM_001008211 (RefSeq)
mouse Optn MGI:1918898 (MGI)
71648 (Entrez Gene)
Gene Tree
VISTA-Point
Chr2 3.15 cM Chr2:5020642-5064051 (-)
GRCm38
OTTMUSG00000010864 (VEGA)
OTTMUSP00000011649 (VEGA)
OTTMUST00000025422 (VEGA)
rat Optn 246294 (Entrez Gene)
Chr17 q12.3 Q8R5M4 (UniProt | EBI)
NM_145081 (RefSeq)
chimpanzee OPTN 736417 (Entrez Gene)
Chr10 XP_001139979 (RefSeq)
rhesus macaque OPTN 574252 (Entrez Gene)
Chr9 Q861Q8 (UniProt | EBI)
NM_001032897 (RefSeq)
cattle OPTN 534150 (Entrez Gene)
Chr13 NP_001029774 (RefSeq)
NM_001034602 (RefSeq)
dog OPTN 478003 (Entrez Gene)
Chr2 XP_535187 (RefSeq)
chicken OPTN 374079 (Entrez Gene)
Chr1 Q90Z16 (UniProt | EBI)
NM_204236 (RefSeq)
western clawed frog optn 100144665 (Entrez Gene)
ChrUN XP_002935287 (RefSeq)
zebrafish optn 336159 (Entrez Gene)
Chr4 Q5RI56 (UniProt | EBI)
NM_001100066 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory