| Age | E5 | E6 | E7 | E8 | E9 | E10 | E11 | E11.5 | E12 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E17 | E18 | E18.5 | P |
| Western blot | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 4 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 4 |
| Nf2 neurofibromin 2 (Synonyms: merlin, moesin-ezrin-radixin-like protein, schwannomin) | |
| Results | Reference |
| 1 | J:166833 Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI, The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010 Nov 16;19(5):727-39 |
| 15* | J:96960 Gronholm M, Teesalu T, Tyynela J, Piltti K, Bohling T, Wartiovaara K, Vaheri A, Carpen O, Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system. Mol Cell Neurosci. 2005 Apr;28(4):683-93 |
| 9* | J:37192 Huynh DP, Tran TM, Nechiporuk T, Pulst SM, Expression of neurofibromatosis 2 transcript and gene product during mouse fetal development. Cell Growth Differ. 1996 Nov;7(11):1551-61 |
| 1 | J:238700 Kwan J, Sczaniecka A, Arash EH, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V, DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016 Dec 15;30(24):2696-2709 |
| 1* | J:199301 Lavado A, He Y, Pare J, Neale G, Olson EN, Giovannini M, Cao X, Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34 |
| 2 | J:217604 Lavado A, Ware M, Pare J, Cao X, The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development. 2014 Nov;141(21):4182-93 |
| 2 | J:363692 Liao J, Huang Y, Sun F, Zheng C, Yao Y, Zhang C, Zhou C, Zhang X, Wu M, Chen G, Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration. Nat Commun. 2025 Mar 12;16(1):2478 |
| 1 | J:125901 McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, Jacks T, The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3261-6 |
| 1 | J:241275 Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H, A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016 Aug 02;7:12309 |
| 1 | J:218609 Serinagaoglu Y, Pare J, Giovannini M, Cao X, Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol. 2015 Feb 1;398(1):97-109 |
| 1 | J:369936 Wu S, Bian Y, Zhang C, Liu K, Sun F, Chen E, Zhou C, Yu L, Chen G, Wu M, Merlin controls limb development and thumb formation by regulating primary cilium-hedgehog signaling. Cell Rep. 2025 Jun 24;44(6):115849 |
| 1 | J:162628 Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J, Giovannini M, Liu P, Anders RA, Pan D, The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell. 2010 Jul 20;19(1):27-38 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/19/2026 MGI 6.24 |
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