Gene Expression Literature Summary
| Age | E7.5 |
| Immunohistochemistry (section) | 1 |
| In situ RNA (section) | 11 |
| Immunohistochemistry (whole mount) | 1 |
| In situ RNA (whole mount) | 7 |
| In situ reporter (knock in) | 1 |
| Northern blot | 1 |
| RT-PCR | 3 |
| Hand1 heart and neural crest derivatives expressed 1 (Synonyms: bHLHa27, eHAND, Ehand1, Hxt, Th1, Thing1) | |
| Results | Reference |
| 1 | J:368249 Abraham E, Kostina A, Volmert B, Roule T, Huang L, Yu J, Williams AE, Megill E, Douglas A, Pericak OM, Morris A, Stronati E, Larrinaga-Zamanillo A, Fueyo R, Zubillaga M, Andrake MD, Akizu N, Aguirre A, Estaras C, A retinoic acid:YAP1 signaling axis controls atrial lineage commitment. Cell Rep. 2025 May 27;44(5):115687 |
| 1 | J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47 |
| 1 | J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9 |
| 1 | J:293009 Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S, Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14280-14291 |
| 1 | J:41048 Biben C, Harvey RP, Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 1997 Jun 1;11(11):1357-69 |
| 1 | J:277240 Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW, Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221 |
| 3* | J:28009 Cross JC, Flannery ML, Blanar MA, Steingrimsson E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z, Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23 |
| 1* | J:28312 Cserjesi P, Brown D, Lyons GE, Olson EN, Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol. 1995 Aug;170(2):664-78 |
| 1 | J:46384 Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN, Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70 |
| 1 | J:371855 Harland LTG, Lohoff T, Koulena N, Pierson N, Pape C, Ameen F, Griffiths J, Theeuwes B, Wilson NK, Kreshuk A, Reik W, Nichols J, Cai L, Marioni JC, Gottgens B, Ghazanfar S, A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space. Cell Rep. 2025 Aug 26;44(8):116047 |
| 1 | J:356183 Jiang X, Wang Y, Xiao Z, Yan L, Guo S, Wang Y, Wu H, Zhao X, Lu X, Wang H, A differentiation roadmap of murine placentation at single-cell resolution. Cell Discov. 2023 Mar 17;9(1):30 |
| 1* | J:147318 Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R, Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct;149(10):5012-23 |
| 1 | J:152657 Martindill DM, Risebro CA, Smart N, Franco-Viseras Mdel M, Rosario CO, Swallow CJ, Dennis JW, Riley PR, Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol. 2007 Oct;9(10):1131-41 |
| 2 | J:367359 Menezes NA, Peterson KJ, Guo X, Castiglioni V, Kalvisa A, Filimonow K, Schachter K, Schuh CM, Pasias A, Mariani L, Brickman JM, Sedzinski J, Ferretti E, Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations. Nat Commun. 2025 May 29;16(1):5000 |
| 1* | J:55840 Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji, Inoue T, MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47 |
| 1 | J:168015 Shibata M, Garcia-Garcia MJ, The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41 |
| 2 | J:340402 Wang R, Yang X, Chen J, Zhang L, Griffiths JA, Cui G, Chen Y, Qian Y, Peng G, Li J, Wang L, Marioni JC, Tam PPL, Jing N, Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat Commun. 2023 Sep 14;14(1):5675 |
| 1* | J:377779 Wang R, Yang X, Lian C, Wang J, Chen J, Qian Y, Xu Y, Wang L, Marioni JC, Tam PPL, Jing N, Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures. iScience. 2026 Jan 16;29(1):114307 |
| 1 | J:109087 Yamada K, Kanda H, Tanaka S, Takamatsu N, Shiba T, Ito M, Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. Differentiation. 2006 Jun;74(5):212-21 |
| 1 | J:379628 Yang X, Xie B, Shen P, Chen Y, Li C, Tan F, Yang Y, Yang Y, Song R, Mi P, Liu Z, Wen M, Tam PPL, Suo S, Jing N, Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation. Nat Commun. 2026 Jan 12;17(1):1572 |
| 1 | J:362605 Zhang Q, Carlin D, Zhu F, Cattaneo P, Ideker T, Evans SM, Bloomekatz J, Chi NC, Unveiling Complexity and Multipotentiality of Early Heart Fields. Circ Res. 2021 Aug 6;129(4):474-487 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/19/2026 MGI 6.24 |
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