Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Epas1  endothelial PAS domain protein 1   (Synonyms: bHLHe73, HIF2A, HIF-2alpha, Hif like protein, HLF, HRF, hypoxia inducible transcription factor 2alpha, MOP2)
Results	Reference
1*	J:180152 Bridges JP, Lin S, Ikegami M, Shannon JM, Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 1;362(1):24-41
1	J:77480 Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P, Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002 Jul;8(7):702-10
1*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:162597 Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J, Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem. 2010 Apr 30;285(18):13646-57
1	J:321522 Kirschner KM, Kelterborn S, Stehr H, Penzlin JLT, Jacobi CLJ, Endesfelder S, Sieg M, Kruppa J, Dame C, Sciesielski LK, Adaptation of the Oxygen Sensing System during Lung Development. Oxid Med Cell Longev. 2022;2022:9714669
1	J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
1	J:185536 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW, Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development. 2012 Jul;139(13):2340-50
1*	J:265444 Matsumoto L, Hirota Y, Saito-Fujita T, Takeda N, Tanaka T, Hiraoka T, Akaeda S, Fujita H, Shimizu-Hirota R, Igaue S, Matsuo M, Haraguchi H, Saito-Kanatani M, Fujii T, Osuga Y, HIF2alpha in the uterine stroma permits embryo invasion and luminal epithelium detachment. J Clin Invest. 2018 Jul 2;128(7):3186-3197
1*	J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
1	J:82257 Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K, Yamamoto M, Fujii-Kuriyama Y, HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003 Mar 3;22(5):1134-46
1	J:201437 Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM, BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun 3;123(6):2539-50
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
1	J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
1	J:342401 Zhao H, Wong RJ, Stevenson DK, The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185
1	J:228857 Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li J, Han W, Li J, Liu G, Gao S, Yang Z, A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589