Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ucp1  uncoupling protein 1 (mitochondrial, proton carrier)   (Synonyms: Slc25a7)
Results	Reference
1	J:308105 Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco MN, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P, Defining the lineage of thermogenic perivascular adipose tissue. Nat Metab. 2021 Apr;3(4):469-484
1	J:262187 Cautivo KM, Lizama CO, Tapia PJ, Agarwal AK, Garg A, Horton JD, Cortes VA, AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue. Mol Metab. 2016 Jul;5(7):491-505
1	J:274697 Celaya AM, Sanchez-Perez I, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Pintado-Berninches L, Perona R, Murillo-Cuesta S, Varela-Nieto I, Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159
1	J:182286 Charalambous M, Ferron SR, da Rocha ST, Murray AJ, Rowland T, Ito M, Schuster-Gossler K, Hernandez A, Ferguson-Smith AC, Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21
1	J:260351 Chen Q, Huang L, Pan D, Zhu LJ, Wang YX, Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018 Mar 13;22(11):2860-2872
1	J:269807 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA, An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 6;10(1):62-74
1	J:146771 da Rocha ST, Charalambous M, Lin SP, Gutteridge I, Ito Y, Gray D, Dean W, Ferguson-Smith AC, Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. PLoS Genet. 2009 Feb;5(2):e1000392
1*	J:271356 Dai N, Zhao L, Wrighting D, Kramer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J, IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 7;21(4):609-21
1*	J:282838 Fan J, Campioli E, Sottas C, Zirkin B, Papadopoulos V, Amhr2-Cre-Mediated Global Tspo Knockout. J Endocr Soc. 2020 Feb 1;4(2):bvaa001
1	J:324530 Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC, Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 May 1;163(5)
1	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
1	J:319657 Glaser J, Iranzo J, Borensztein M, Marinucci M, Gualtieri A, Jouhanneau C, Teissandier A, Gaston-Massuet C, Bourc'his D, The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates. Elife. 2022 Jan 20;11:e65641
1	J:213153 Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P, Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
1	J:314107 Ito K, Schneeberger M, Gerber A, Jishage M, Marchildon F, Maganti AV, Cohen P, Friedman JM, Roeder RG, Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes Dev. 2021 May 1;35(9-10):729-748
1*	J:314174 Jang Y, Park YK, Lee JE, Wan D, Tran N, Gavrilova O, Ge K, MED1 is a lipogenesis coactivator required for postnatal adipose expansion. Genes Dev. 2021 May 1;35(9-10):713-728
1	J:342314 Jun S, Angueira AR, Fein EC, Tan JME, Weller AH, Cheng L, Batmanov K, Ishibashi J, Sakers AP, Stine RR, Seale P, Control of murine brown adipocyte development by GATA6. Dev Cell. 2023 Nov 6;58(21):2195-2205.e5
1	J:291969 Kang HS, Lee JH, Oh KJ, Lee EW, Han BS, Park KY, Suh JM, Min JK, Chi SW, Lee SC, Bae KH, Kim WK, IDH1-dependent alpha-KG regulates brown fat differentiation and function by modulating histone methylation. Metabolism. 2020 Apr;105:154173
1	J:263715 Lee B, Kim J, An T, Kim S, Patel EM, Raber J, Lee SK, Lee S, Lee JW, Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons. Nat Commun. 2018 May 23;9(1):2026
1	J:294283 Liang Q, Zheng Q, Zuo Y, Chen Y, Ma J, Ni P, Cheng J, SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Rep. 2019 Aug 20;28(8):2004-2011.e4
1*	J:292617 Lin YC, Lu YH, Lee YC, Hung CS, Lin JC, Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism. Biochim Biophys Acta Gene Regul Mech. 2020 Jul 3;1863(9):194601
1	J:203690 Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R, Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
1	J:320737 Nagai N, Habuchi H, Sugaya N, Nakamura M, Imamura T, Watanabe H, Kimata K, Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice. Glycobiology. 2013 Aug;23(8):980-92
1*	J:158888 Oh WJ, Westmoreland JJ, Summers R, Condie BG, Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice. PLoS One. 2010;5(3):e9758
1	J:337469 Park A, Kim KE, Park I, Lee SH, Park KY, Jung M, Li X, Sleiman MB, Lee SJ, Kim DS, Kim J, Lim DS, Woo EJ, Lee EW, Han BS, Oh KJ, Lee SC, Auwerx J, Mun JY, Rhee HW, Kim WK, Bae KH, Suh JM, Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Nat Commun. 2023 Jun 23;14(1):3746
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
1	J:204551 Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB, A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013 Aug 26;26(4):393-404
1*	J:244382 Park YK, Ge K, Glucocorticoid Receptor Accelerates, but Is Dispensable for, Adipogenesis. Mol Cell Biol. 2017 Jan 15;37(2)
1	J:244281 Park YK, Wang L, Giampietro A, Lai B, Lee JE, Ge K, Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor gamma in Adipogenesis. Mol Cell Biol. 2017 Jan 15;37(2)
1*	J:283695 Quesada-Lopez T, Gavalda-Navarro A, Moron-Ros S, Campderros L, Iglesias R, Giralt M, Villarroya F, GPR120 controls neonatal brown adipose tissue thermogenic induction. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E742-E750
1*	J:273070 Rodriguez-de la Rosa L, Sanchez-Calderon H, Contreras J, Murillo-Cuesta S, Falagan S, Avendano C, Dopazo J, Varela-Nieto I, Milo M, Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Hear Res. 2015 Dec;330(Pt A):62-77
1	J:299569 Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA, PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 2012 Sep 5;16(3):348-62
1	J:138823 Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM, PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
1	J:154380 Seo J, Fortuno ES 3rd, Suh JM, Stenesen D, Tang W, Parks EJ, Adams CM, Townes T, Graff JM, Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 2009 Nov;58(11):2565-73
1	J:247178 Singh R, Braga M, Reddy ST, Lee SJ, Parveen M, Grijalva V, Vergnes L, Pervin S, Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017 May 01;158(5):1217-1230
1	J:327433 Song Z, Xiaoli AM, Li Y, Siqin G, Wu T, Strich R, Pessin JE, Yang F, The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation. Mol Metab. 2022 Jul 19;64:101548
1*	J:88742 Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV Jr, Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19;279(12):11767-76
1	J:238410 Sun C, Berry WL, Olson LE, PDGFRalpha controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017 Jan 01;144(1):83-94
1	J:257079 Tafaj O, Hann S, Ayturk U, Warman ML, Juppner H, Mice maintain predominantly maternal Galphas expression throughout life in brown fat tissue (BAT), but not other tissues. Bone. 2017 Oct;103:177-187
1	J:232408 Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM, Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016 Mar;12(3):e1005916
1	J:269323 Vazquez P, Hernandez-Sanchez C, Escalona-Garrido C, Pereira L, Contreras C, Lopez M, Balsinde J, de Pablo F, Valverde AM, Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation. J Lipid Res. 2018 Dec;59(12):2308-2320
1	J:240993 Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G, A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009 Sep 04;138(5):976-89
1*	J:160941 Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS, The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 5;11(5):364-78
1	J:311150 Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J, FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021 Aug 3;36(5):109481
1*	J:236180 Zhou H, Black SM, Benson TW, Weintraub NL, Chen W, Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function. Mol Cell Biol. 2016 Aug 1;36(15):2027-38
1*	J:228546 Zhou H, Wan B, Grubisic I, Kaplan T, Tjian R, TAF7L modulates brown adipose tissue formation. Elife. 2014;3
1	J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988
1	J:277057 Zhu X, Xie S, Xu T, Wu X, Han M, Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders. Mol Metab. 2017 Jun;6(6):494-502
1	J:262992 Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K, Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796