Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Isl1  ISL1 transcription factor, LIM/homeodomain   (Synonyms: Islet 1)
Results	Reference
1	J:288982 Assenza MR, Barbagallo F, Barrios F, Cornacchione M, Campolo F, Vivarelli E, Gianfrilli D, Auletta L, Soricelli A, Isidori AM, Lenzi A, Pellegrini M, Naro F, Critical role of phosphodiesterase 2A in mouse congenital heart defects. Cardiovasc Res. 2018 May 1;114(6):830-845
1	J:87725 Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS, Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. 2004 Feb;131(4):797-806
1	J:315974 Chen X, Wang L, Huang R, Qiu H, Wang P, Wu D, Zhu Y, Ming J, Wang Y, Wang J, Na J, Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein Cell. 2019 May;10(5):327-346
1	J:184511 Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE, Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012 Jun;139(11):1931-40
1	J:170963 Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22;332(6028):458-61
1	J:158677 Huh SH, Ornitz DM, Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development. 2010 Apr;137(7):1137-47
1	J:245319 Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA, HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science. 2015 Jun 26;348(6242):aaa6071
1	J:186421 Klaus A, Muller M, Schulz H, Saga Y, Martin JF, Birchmeier W, Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6
1	J:143832 Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM, Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9313-8
1	J:238888 Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z, Akt1 signaling coordinates BMP signaling and beta-catenin activity to regulate second heart field progenitor development. Development. 2015 Feb 15;142(4):732-42
1	J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1*	J:130227 Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI, Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan;8(2):124-39
1*	J:265627 Nie J, Jiang M, Zhang X, Tang H, Jin H, Huang X, Yuan B, Zhang C, Lai JC, Nagamine Y, Pan D, Wang W, Yang Z, Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development. Cell Rep. 2015 Oct 27;13(4):723-732
1	J:212358 Singh AP, Archer TK, Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
1	J:158582 Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE, Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell. 2010 Feb 16;18(2):275-87
1	J:147278 Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Li L, Lewandoski M, Gorivodsky M, Love PE, Porter FD, Westphal H, Yang Y, LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development. 2009 Apr;136(8):1375-85
1	J:187883 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK, Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3;150(3):590-605
1	J:169047 Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF, Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14;19(6):903-12
1	J:330768 Wang Y, Elsherbiny A, Kessler L, Cordero J, Shi H, Serke H, Lityagina O, Trogisch FA, Mohammadi MM, El-Battrawy I, Backs J, Wieland T, Heineke J, Dobreva G, Lamin A/C-dependent chromatin architecture safeguards naive pluripotency to prevent aberrant cardiovascular cell fate and function. Nat Commun. 2022 Nov 4;13(1):6663
1	J:170879 Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham ME, Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res. 2010 Feb 19;106(3):495-503
1	J:262085 Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ, Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018 Jan 25;3(2)
1	J:244345 Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T, Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017 Jun 01;127(6):2235-2248
1	J:206589 Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M, Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
1	J:310132 Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L, Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol. 2015 Aug;85:1-12