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Gene Expression Literature Summary
Symbol
Name
ID
Otp
orthopedia homeobox
MGI:99835

37 matching records from 37 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8.5 E9.5 E10 E10.5 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18.5 E19.5 E P
Immunohistochemistry (section) 2 3 1 3 2 3 1 1 2 1
In situ RNA (section) 1 1 1 2 4 5 12 1 6 1 5 1 9 2 1 1 4 1 1 11
In situ RNA (whole mount) 2 1 1 1 1
In situ reporter (knock in) 1 1 2 1 1 2 2 1 1 1 1
Northern blot 1 1
Western blot 1
RT-PCR 1
cDNA clones 1 1 1
RNase protection 1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Otp  orthopedia homeobox  
Results  Reference
3J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50
2J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
5J:58466 Acampora D, Postiglione MP, Avantaggiato V, Di Bonito M, Vaccarino FM, Michaud J, Simeone A, Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes Dev. 1999 Nov 1;13(21):2787-800
1*J:26895 Avantaggiato V, Pandolfi PP, Ruthardt M, Hawe N, Acampora D, Pelicci PG, Simeone A, Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. J Neurosci. 1995 Jul;15(7 Pt 1):4927-42
2*J:119269 Caqueret A, Boucher F, Michaud JL, Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
2*J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
6*J:87378 Cremona M, Colombo E, Andreazzoli M, Cossu G, Broccoli V, Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. Gene Expr Patterns. 2004 Jan;4(1):47-51
1J:231601 de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S, Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405
9J:161632 Garcia-Moreno F, Pedraza M, Di Giovannantonio LG, Di Salvio M, Lopez-Mascaraque L, Simeone A, De Carlos JA, A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat Neurosci. 2010 Jun;13(6):680-9
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1J:98802 Kriks S, Lanuza GM, Mizuguchi R, Nakafuku M, Goulding M, Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. Development. 2005 Jul;132(13):2991-3002
1J:78622 Kruger M, Schafer K, Braun T, The homeobox containing gene Lbx1 is required for correct dorsal-ventral patterning of the neural tube. J Neurochem. 2002 Aug;82(4):774-82
5J:263715 Lee B, Kim J, An T, Kim S, Patel EM, Raber J, Lee SK, Lee S, Lee JW, Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons. Nat Commun. 2018 May 23;9(1):2026
2J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
2J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
1J:152673 Mishima Y, Lindgren AG, Chizhikov VV, Johnson RL, Millen KJ, Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth. J Neurosci. 2009 Sep 9;29(36):11377-84
1J:258875 Mona B, Uruena A, Kollipara RK, Ma Z, Borromeo MD, Chang JC, Johnson JE, Repression by PRDM13 is critical for generating precision in neuronal identity. Elife. 2017 Aug 29;6
4J:171208 Morales-Delgado N, Merchan P, Bardet SM, Ferran JL, Puelles L, Diaz C, Topography of Somatostatin Gene Expression Relative to Molecular Progenitor Domains during Ontogeny of the Mouse Hypothalamus. Front Neuroanat. 2011;5:10
1J:220452 Nasif S, de Souza FS, Gonzalez LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M, Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1861-70
1J:266266 Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S, Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol. 2018 Oct 15;442(2):236-248
1J:225813 Puelles L, Morales-Delgado N, Merchan P, Castro-Robles B, Martinez-de-la-Torre M, Diaz C, Ferran JL, Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area. Brain Struct Funct. 2016 Jul;221(6):3027-65
3J:196967 Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Houart C, Meyer G, Blackshaw S, Tole S, LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. J Neurosci. 2013 Apr 17;33(16):6877-84
6J:122105 Ryu S, Mahler J, Acampora D, Holzschuh J, Erhardt S, Omodei D, Simeone A, Driever W, Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol. 2007 May 15;17(10):873-80
1*J:55154 Schwarz M, Alvarez-Bolado G, Dressler G, Urbanek P, Busslinger M, Gruss P, Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech Dev. 1999 Apr;82(1-2):29-39
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
18*J:19476 Simeone A, D'Apice MR, Nigro V, Casanova J, Graziani F, Acampora D, Avantaggiato V, Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron. 1994 Jul;13(1):83-101
1J:149516 Szabo NE, Zhao T, Cankaya M, Theil T, Zhou X, Alvarez-Bolado G, Role of neuroepithelial Sonic hedgehog in hypothalamic patterning. J Neurosci. 2009 May 27;29(21):6989-7002
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
5J:171421 Vandunk C, Hunter LA, Gray PA, Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2J:196218 Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL, Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 1;521(7):1561-84
1J:92940 Wang W, Grimmer JF, Van De Water TR, Lufkin T, Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
10J:65759 Wang W, Lufkin T, The murine otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Dev Biol. 2000 Nov 15;227(2):432-49
3J:139698 Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y, Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11796-801
4J:120909 Xu C, Fan CM, Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1. Mol Endocrinol. 2007 May;21(5):1234-45
1J:157468 Zagoraiou L, Akay T, Martin JF, Brownstone RM, Jessell TM, Miles GB, A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron. 2009 Dec 10;64(5):645-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory