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Gene Expression Literature Summary
Symbol
Name
ID
Id4
inhibitor of DNA binding 4
MGI:99414

47 matching records from 47 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E6.5 E7 E7.5 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 1 1 3
In situ RNA (section) 1 1 2 3 2 5 8 2 1 6 1 5 4 1 1 1 2
In situ RNA (whole mount) 1 2 1 1 1
In situ reporter (knock in) 1 1 1 1
Northern blot 1 1 1 1 1 2
Western blot 1 2 1 1 1 1
RT-PCR 1 1 1 1 3 2 1 1 1 3 1 3 4 1 2 4 4 1 3 1 9
cDNA clones 2 1
RNase protection 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Id4  inhibitor of DNA binding 4   (Synonyms: bHLHb27, Id4, Idb4)
Results  Reference
2J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
4J:98270 Bedford L, Walker R, Kondo T, van Cruchten I, King ER, Sablitzky F, Id4 is required for the correct timing of neural differentiation. Dev Biol. 2005 Apr 15;280(2):386-95
1J:181229 Bonilla-Claudio M, Wang J, Bai Y, Klysik E, Selever J, Martin JF, Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development. 2012 Feb;139(4):709-19
1J:202352 Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M, A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66
1J:174488 Britz O, Mattar P, Nguyen L, Langevin LM, Zimmer C, Alam S, Guillemot F, Schuurmans C, A role for proneural genes in the maturation of cortical progenitor cells. Cereb Cortex. 2006 Jul;16 Suppl 1:i138-51
3J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
1J:154602 Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, Hoang J, Escobar SS, Gow A, Arnett HA, Trapp BD, Karandikar NJ, Hsieh J, Lu QR, The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci. 2009 Nov;12(11):1398-406
1J:137156 Desmazieres A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P, Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution. J Neurosci. 2008 Jun 4;28(23):5891-900
11J:170418 Du Y, Yip HK, The expression and roles of inhibitor of DNA binding helix-loop-helix proteins in the developing and adult mouse retina. Neuroscience. 2011 Feb 23;175:367-79
1J:101181 Gokhan S, Marin-Husstege M, Yung SY, Fontanez D, Casaccia-Bonnefil P, Mehler MF, Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci. 2005 Sep 7;25(36):8311-21
2*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:203028 Hasenpusch-Theil K, Magnani D, Amaniti EM, Han L, Armstrong D, Theil T, Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex. 2012 Dec;22(12):2878-93
4J:181942 Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H, RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex. EMBO J. 2012 Mar 7;31(5):1190-202
7J:36589 Jen Y, Manova K, Benezra R, Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev Dyn. 1996 Nov;207(3):235-52
9J:37519 Jen Y, Manova K, Benezra R, Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis. Dev Dyn. 1997 Jan;208(1):92-106
4J:104323 Jones JM, Montcouquiol M, Dabdoub A, Woods C, Kelley MW, Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci. 2006 Jan 11;26(2):550-8
2J:105840 Kusunoki T, Sugai M, Katakai T, Omatsu Y, Iyoda T, Inaba K, Nakahata T, Shimizu A, Yokota Y, TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice. J Allergy Clin Immunol. 2003 Jan;111(1):136-42
1J:190509 Li Y, Hibbs MA, Gard AL, Shylo NA, Yun K, Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells. 2012 Apr;30(4):741-52
1J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
1J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
1J:125511 Loomes KM, Stevens SA, O'brien ML, Gonzalez DM, Ryan MJ, Segalov M, Dormans NJ, Mimoto MS, Gibson JD, Sewell W, Schaffer AA, Nah HD, Rappaport EF, Pratt SC, Dunwoodie SL, Kusumi K, Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects. Dev Dyn. 2007 Oct;236(10):2943-51
3*J:93141 Mattar P, Britz O, Johannes C, Nieto M, Ma L, Rebeyka A, Klenin N, Polleux F, Guillemot F, Schuurmans C, A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol. 2004 Sep 15;273(2):373-89
1J:197761 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL, Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98
2J:56699 Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein JL, Early neocortical regionalization in the absence of thalamic innervation. Science. 1999 Aug 6;285(5429):906-9
2J:122971 Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE, A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 2007 Jun 29;129(7):1365-76
6*J:149226 Mukhopadhyay P, Rezzoug F, Webb CL, Pisano MM, Greene RM, Suppression of chondrogenesis by Id helix-loop-helix proteins in murine embryonic orofacial tissue. Differentiation. 2009 Jun;77(5):462-72
1J:174493 Muzio L, Soria JM, Pannese M, Piccolo S, Mallamaci A, A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus. Cereb Cortex. 2005 Dec;15(12):2021-8
4J:112269 Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K, Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development. 2006 Sep;133(17):3473-84
1J:200551 Paschaki M, Schneider C, Rhinn M, Thibault-Carpentier C, Dembele D, Niederreither K, Dolle P, Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS One. 2013;8(4):e62274
2*J:118301 Patel S, Xi ZF, Seo EY, McGaughey D, Segre JA, Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18668-73
3J:112064 Peddada S, Yasui DH, LaSalle JM, Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet. 2006 Jun 15;15(12):2003-14
1J:162001 Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ, NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. J Neurosci. 2010 Jul 7;30(27):9127-39
3J:27790 Riechmann V, Sablitzky F, Mutually exclusive expression of two dominant-negative helix-loop-helix (dnHLH) genes, ld4 and ld3, in the developing brain of the mouse suggests distinct regulatory roles of these dnHLH proteins during cellular proliferation and differentiation of the nrvous system. Cell Growth Differ. 1995 Jul;6(7):837-43
10*J:17442 Riechmann V, van Cruchten I, Sablitzky F, The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res. 1994 Mar 11;22(5):749-55
1J:170671 Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S, MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 2011 Mar 2;31(9):3407-22
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
5*J:44393 Stewart HJ, Zoidl G, Rossner M, Brennan A, Zoidl C, Nave KA, Mirsky R, Jessen KR, Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. J Neurosci Res. 1997 Dec 1;50(5):684-701
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2J:162236 Tokuzawa Y, Yagi K, Yamashita Y, Nakachi Y, Nikaido I, Bono H, Ninomiya Y, Kanesaki-Yatsuka Y, Akita M, Motegi H, Wakana S, Noda T, Sablitzky F, Arai S, Kurokawa R, Fukuda T, Katagiri T, Schonbach C, Suda T, Mizuno Y, Okazaki Y, Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLoS Genet. 2010;6(7):e1001019
6*J:51805 van Cruchten I, Cinato E, Fox M, King ER, Newton JS, Riechmann V , Sablitzky F, Structure, chromosomal localisation and expression of the murine dominant negative helix-loop-helix Id4 gene. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):55-64
2J:194044 Walcher T, Xie Q, Sun J, Irmler M, Beckers J, Ozturk T, Niessing D, Stoykova A, Cvekl A, Ninkovic J, Gotz M, Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation. Development. 2013 Mar;140(5):1123-36
3*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1J:198588 Yumoto K, Thomas PS, Lane J, Matsuzaki K, Inagaki M, Ninomiya-Tsuji J, Scott GJ, Ray MK, Ishii M, Maxson R, Mishina Y, Kaartinen V, TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem. 2013 May 10;288(19):13467-80
2*J:93574 Yun K, Mantani A, Garel S, Rubenstein J, Israel MA, Id4 regulates neural progenitor proliferation and differentiation in vivo. Development. 2004 Nov;131(21):5441-8
1*J:119277 Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ, Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. J Neurochem. 2006 Aug;98(3):860-75
1J:109778 Zhou CJ, Pinson KI, Pleasure SJ, Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. J Neurosci. 2004 Sep 1;24(35):7632-9

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory