About   Help   FAQ
Gene Expression Literature Summary
Symbol
Name
ID
Prkci
protein kinase C, iota
MGI:99260

68 matching records from 68 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E7.5 E8 E8.5 E9 E9.5 E10.5 E11.5 E12 E12.5 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 1 1 1 1 2 8 8 1 7 5 2 8 1 5 1 7 2 3 2 8
In situ RNA (section) 1 1 1 1 1 1 3 1 1 2 1 1 2
Immunohistochemistry (whole mount) 1 2 1 2 3 1 1 1 1
Western blot 1 1 1 1 1 1 2 3 1 1 1 1 4 4 1 4 3 3 1 2 1 7
RT-PCR 1 1 1 1 3 1 1 1 1 2 1 1 2
cDNA clones 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Prkci  protein kinase C, iota   (Synonyms: 2310021H13Rik, aPKClambda, Pkci, Pkcl, PKClambda, Prkcl)
Results  Reference
1J:240005 Aldiri I, Ajioka I, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, Dyer MA, Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma. Development. 2015 Dec 01;142(23):4092-106
2J:178696 Asami M, Pilz GA, Ninkovic J, Godinho L, Schroeder T, Huttner WB, Gotz M, The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development. 2011 Dec;138(23):5067-78
4*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2J:113146 Cappello S, Attardo A, Wu X, Iwasato T, Itohara S, Wilsch-Brauninger M, Eilken HM, Rieger MA, Schroeder TT, Huttner WB, Brakebusch C, Gotz M, The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci. 2006 Sep;9(9):1099-107
5J:206193 Castelli M, Boca M, Chiaravalli M, Ramalingam H, Rowe I, Distefano G, Carroll T, Boletta A, Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun. 2013;4:2658
1J:145166 Cervantes S, Yamaguchi TP, Hebrok M, Wnt5a is essential for intestinal elongation in mice. Dev Biol. 2009 Feb 15;326(2):285-94
1J:88495 Chae TH, Kim S, Marz KE, Hanson PI, Walsh CA, The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet. 2004 Mar;36(3):264-70
2J:228786 Charrier LE, Loie E, Laprise P, Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep. 2015;5:17699
3J:116100 Chen L, Liao G, Yang L, Campbell K, Nakafuku M, Kuan CY, Zheng Y, Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
1J:175551 Chilov D, Sinjushina N, Rita H, Taketo MM, Makela TP, Partanen J, Phosphorylated beta-catenin localizes to centrosomes of neuronal progenitors and is required for cell polarity and neurogenesis in developing midbrain. Dev Biol. 2011 Sep 1;357(1):259-68
9J:87315 Cogram P, Hynes A, Dunlevy LP, Greene ND, Copp AJ, Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum Mol Genet. 2004 Jan 1;13(1):7-14
2J:130194 Costa MR, Wen G, Lepier A, Schroeder T, Gotz M, Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex. Development. 2008 Jan;135(1):11-22
5J:101323 Dehghani H, Hahnel AC, Expression profile of protein kinase C isozymes in preimplantation mouse development. Reproduction. 2005 Oct;130(4):441-51
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:201606 Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP, Le Bivic A, Nurnberg B, Sans N, Montcouquiol M, Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol. 2013 Sep;15(9):1107-15
1J:115047 Fu X, Sun H, Klein WH, Mu X, Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol. 2006 Nov 15;299(2):424-37
1J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
2J:166833 Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI, The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010 Nov 16;19(5):727-39
1J:168537 Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A, Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev Dyn. 2011 Mar;240(3):589-604
2J:230653 Grego-Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson KV, The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5
1J:220469 Grego-Bessa J, Hildebrand J, Anderson KV, Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
4J:178336 Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL, Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development. 2011 Oct;138(20):4423-32
3J:140256 Hartleben B, Schweizer H, Lubben P, Bartram MP, Moller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB, Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008 Aug 22;283(34):23033-8
1J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
3J:122204 Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S, Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development. 2006 May;133(9):1735-44
5J:157396 Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H, Cdc42-mediated tubulogenesis controls cell specification. Cell. 2009 Nov 13;139(4):791-801
1J:211342 Kielar M, Tuy FP, Bizzotto S, Lebrand C, de Juan Romero C, Poirier K, Oegema R, Mancini GM, Bahi-Buisson N, Olaso R, Le Moing AG, Boutourlinsky K, Boucher D, Carpentier W, Berquin P, Deleuze JF, Belvindrah R, Borrell V, Welker E, Chelly J, Croquelois A, Francis F, Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Nat Neurosci. 2014 Jul;17(7):923-33
1J:237224 Kim JY, Park R, Lee JH, Shin J, Nickas J, Kim S, Cho SH, Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347
1*J:220858 Kim JY, Song JY, Karnam S, Park JY, Lee JJ, Kim S, Cho SH, Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. Gene Expr Patterns. 2015 Jan;17(1):31-7
1J:160624 Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA, The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15;66(1):69-84
7J:102364 Koike C, Nishida A, Akimoto K, Nakaya MA, Noda T, Ohno S, Furukawa T, Function of atypical protein kinase Clambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci. 2005 Nov 2;25(44):10290-8
15*J:115984 Kovac J, Oster H, Leitges M, Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis. Gene Expr Patterns. 2007 Jan;7(1-2):187-196
7*J:83700 Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW, EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn. 2003 Jun;227(2):216-26
1J:168023 Lahti L, Saarimaki-Vire J, Rita H, Partanen J, FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev Biol. 2011 Jan 15;349(2):270-82
1J:220325 Lemaire LA, Goulley J, Kim YH, Carat S, Jacquemin P, Rougemont J, Constam DB, Grapin-Botton A, Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis. Development. 2015 Mar 1;142(5):858-70
2J:224948 Lin C, Yao E, Chuang PT, A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13
1J:181885 Liu C, Bakeri H, Li T, Swaroop A, Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma. Hum Mol Genet. 2012 Apr 15;21(8):1848-60
1J:127463 Ma X, Bao J, Adelstein RS, Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice. Mol Biol Cell. 2007 Jun;18(6):2305-12
1J:226036 Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV, Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol. 2015 Oct 1;406(1):74-91
1J:169135 Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57
2J:229014 Marty-Santos L, Cleaver O, Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12
1J:147041 Matsuyama M, Aizawa S, Shimono A, Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 2009 Mar;5(3):e1000427
2J:98298 Michaut MA, Williams CJ, Schultz RM, Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs. Dev Biol. 2005 Apr 1;280(1):26-37
2J:196288 Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V, Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84
1J:240000 Park JY, Hughes LJ, Moon UY, Park R, Kim SB, Tran K, Lee JS, Cho SH, Kim S, The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development. 2016 Jan 01;143(1):133-46
1J:235630 Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM, Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation. Cereb Cortex. 2015 Oct;25(10):3977-93
14*J:63657 Pauken CM, Capco DG, The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev Biol. 2000 Jul 15;223(2):411-21
1J:171698 Pramparo T, Libiger O, Jain S, Li H, Youn YH, Hirotsune S, Schork NJ, Wynshaw-Boris A, Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. PLoS Genet. 2011 Mar;7(3):e1001331
1J:29381 Quaderi NA, Gianfrancesco F, Brown SD, D'Urso M, D'Esposito M, Genetic mapping of a gene encoding an atypical protein kinase C, protein kinase C lambda, to the proximal region of mouse chromosome 3. Genomics. 1995 Oct 10;29(3):815-6
1J:238551 Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV, Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol. 2016 Dec;18(12):1281-1291
2J:215827 Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R, Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ, Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest. 2014 Sep 2;124(9):3891-900
5J:202124 Seidl S, Braun U, Roos N, Li S, Ludtke TH, Kispert A, Leitges M, Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One. 2013;8(5):e62756
4J:213479 Shibasaki T, Tokunaga A, Sakamoto R, Sagara H, Noguchi S, Sasaoka T, Yoshida N, PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus. Cereb Cortex. 2013 Aug;23(8):1824-35
1J:157301 Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ, Retinoic acid from the meninges regulates cortical neuron generation. Cell. 2009 Oct 30;139(3):597-609
2*J:92719 Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick SM, Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 1;173(5):3250-60
2J:162396 Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Shipman M, Cheung A, Gaston-Massuet C, Ferretti P, Molnar Z, Lu X, ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell. 2010 Jul 20;19(1):126-37
1J:174237 Sripathy S, Lee M, Vasioukhin V, Mammalian Llgl2 Is Necessary for Proper Branching Morphogenesis during Placental Development. Mol Cell Biol. 2011 Jul;31(14):2920-33
4J:154910 Sugiyama Y, Akimoto K, Robinson ML, Ohno S, Quinlan RA, A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol. 2009 Dec 15;336(2):246-56
1J:183948 Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa S, Ueno N, Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012 Apr 15;364(2):138-48
1J:144091 Tinkle CL, Pasolli HA, Stokes N, Fuchs E, New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15405-10
2J:166759 Villasenor A, Chong DC, Henkemeyer M, Cleaver O, Epithelial dynamics of pancreatic branching morphogenesis. Development. 2010 Dec;137(24):4295-305
1J:139368 Wang G, Krishnamurthy K, Chiang YW, Dasgupta S, Bieberich E, Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development. J Neurochem. 2008 Jul;106(2):718-33
4J:157918 Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD, CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Dev Cell. 2010 Jan 19;18(1):114-25
2J:206750 Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B, Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014 Jan;34(1):43-56
1J:231671 Xu B, Washington AM, Domeniconi RF, Ferreira Souza AC, Lu X, Sutherland A, Hinton BT, Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct. Dev Biol. 2016 Apr 15;412(2):219-33
1J:156943 Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Hatta T, Nishita M, Minami Y, Otani H, Ror2 is required for midgut elongation during mouse development. Dev Dyn. 2010 Jan 8;239(3):941-953
2J:240523 Yang Z, Zimmerman SE, Tsunezumi J, Braitsch C, Trent C, Bryant DM, Cleaver O, Gonzalez-Manchon C, Marciano DK, Role of CD34 family members in lumen formation in the developing kidney. Dev Biol. 2016 Oct 01;418(1):66-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory