About   Help   FAQ
Gene Expression Literature Summary
wingless-type MMTV integration site family, member 3A

243 matching records from 243 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 1 1 1
In situ RNA (section) 1 1 3 7 6 2 8 20 3 24 3 41 1 7 16 1 5 1 6 1 5 2 4 8
Immunohistochemistry (whole mount) 1 1
In situ RNA (whole mount) 1 3 14 16 30 8 35 6 27 17 13 4 1 6
Northern blot 1 1 1 2
Western blot 1 1 1
RT-PCR 1 2 3 2 1 2 3 2 1 2 1 1 1 4 3 1 6 2 5 9 1 7 2 7 2 4 2 3 1 1 4 1 12
cDNA clones 1
RNase protection 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Wnt3a  wingless-type MMTV integration site family, member 3A   (Synonyms: Wnt-3a)
Results  Reference
3J:169706 Abdul-Ghani M, Dufort D, Stiles R, De Repentigny Y, Kothary R, Megeney LA, Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol. 2011 Jan;31(1):163-78
2J:67399 Abu-Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M, The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40
1*J:81583 Abu-Abed S, Dolle P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M, Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1. Development. 2003 Apr;130(7):1449-59
3J:155074 Agalliu D, Takada S, Agalliu I, McMahon AP, Jessell TM, Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 2009 Mar 12;61(5):708-20
2J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74
1J:156721 Alfieri CM, Cheek J, Chakraborty S, Yutzey KE, Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol. 2010 Feb 15;338(2):127-35
2J:232560 Anderson MJ, Schimmang T, Lewandoski M, An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016 May;12(5):e1006018
1J:135132 Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP, Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development. 2007 Apr;134(8):1499-508
1J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
1J:186055 Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS, The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal. 2009;2(95):ra70
2J:84706 Assimacopoulos S, Grove EA, Ragsdale CW, Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003 Jul 23;23(16):6399-403
1J:88851 Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG, Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell. 2003 Mar;4(3):395-406
3*J:40358 Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W, A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood. 1997 May 15;89(10):3624-35
2J:84975 Bach A, Lallemand Y, Nicola MA, Ramos C, Mathis L, Maufras M, Robert B, Msx1 is required for dorsal diencephalon patterning. Development. 2003 Sep;130(17):4025-36
1J:96233 Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S, Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol. 2005 Mar 1;279(1):155-68
1J:231655 Barber M, Arai Y, Morishita Y, Vigier L, Causeret F, Borello U, Ledonne F, Coppola E, Contremoulins V, Pfrieger FW, Tissir F, Govindan S, Jabaudon D, Proux-Gillardeaux V, Galli T, Pierani A, Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Curr Biol. 2015 Oct 5;25(19):2466-78
1J:142365 Barry G, Piper M, Lindwall C, Moldrich R, Mason S, Little E, Sarkar A, Tole S, Gronostajski RM, Richards LJ, Specific glial populations regulate hippocampal morphogenesis. J Neurosci. 2008 Nov 19;28(47):12328-40
1*J:135507 Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R, Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol. 2008 Apr;128(4):871-81
5J:152099 Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009 Jun 26;108(1):295-303
1J:190539 Bialecka M, Young T, Chuva de Sousa Lopes S, ten Berge D, Sanders A, Beck F, Deschamps J, Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse. Dev Biol. 2012 Nov 15;371(2):227-34
1J:210109 Biris KK, Yamaguchi TP, Two-color in situ hybridization of whole-mount mouse embryos. Methods Mol Biol. 2014;1092:17-30
2*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2J:154363 Bluske KK, Kawakami Y, Koyano-Nakagawa N, Nakagawa Y, Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn. 2009 Nov 18;238(12):3297-3309
6J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
2J:237195 Bosch PJ, Fuller LC, Sleeth CM, Weiner JA, Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016 Nov 21;11(1):21
3*J:35540 Bouillet P, Oulad-Abdelghani M, Ward SJ, Bronner S, Chambon P, Dolle P, A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid. Mech Dev. 1996 Aug;58(1-2):141-52
2J:190545 Boulet AM, Capecchi MR, Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
1*J:67304 Bulchand S, Grove EA, Porter FD, Tole S, LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev. 2001 Feb;100(2):165-75
1J:214093 Cambier L, Plate M, Sucov HM, Pashmforoush M, Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
9J:124082 Cambray N, Wilson V, Two distinct sources for a population of maturing axial progenitors. Development. 2007 Aug;134(15):2829-40
1J:160559 Caronia G, Wilcoxon J, Feldman P, Grove EA, Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci. 2010 May 5;30(18):6291-301
1J:232481 Caronia-Brown G, Anderegg A, Awatramani R, Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development. Neural Dev. 2016;11:9
1J:205649 Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP, The Wnt3a/beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011;2:390
1J:106970 Chan BW, Chan KS, Koide T, Yeung SM, Leung MB, Copp AJ, Loeken MR, Shiroishi T, Shum AS, Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes. 2002 Sep;51(9):2811-6
1*J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
2J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
2J:110657 Cheng X, Hsu CM, Currle DS, Hu JS, Barkovich AJ, Monuki ES, Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci. 2006 Jul 19;26(29):7640-9
1J:184876 Chiara F, Badaloni A, Croci L, Yeh ML, Cariboni A, Hoerder-Suabedissen A, Consalez GG, Eickholt B, Shimogori T, Parnavelas JG, Rakic S, Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem. Dev Biol. 2012 May 1;365(1):277-89
1J:214899 Chou SJ, O'Leary DD, Role for Lhx2 in corticogenesis through regulation of progenitor differentiation. Mol Cell Neurosci. 2013 Sep;56:1-9
1J:154611 Chou SJ, Perez-Garcia CG, Kroll TT, O'Leary DD, Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci. 2009 Nov;12(11):1381-9
2J:98338 Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE, Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004 Oct;131(19):4819-29
1J:67377 Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW, Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan;21(2):663-77
1J:70485 Ciruna B, Rossant J, FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001;1(1):37-49
1J:213591 Concepcion D, Papaioannou VE, Nature and extent of left/right axis defects in T(Wis) /T(Wis) mutant mouse embryos. Dev Dyn. 2014 Aug;243(8):1046-53
6J:102820 Conway SJ, Bundy J, Chen J, Dickman E, Rogers R, Will BM, Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant. Cardiovasc Res. 2000 Aug;47(2):314-28
5J:148823 Corrigan PM, Dobbin E, Freeburn RW, Wheadon H, Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev. 2009 Jun;18(5):759-72
1J:143865 Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA, Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):641-6
1J:18916 Dickinson ME, Krumlauf R, McMahon AP, Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 1994 Jun;120(6):1453-71
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:205579 Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C, Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. J Neurosci. 2014 Jan 8;34(2):539-53
1J:188692 Dixit R, Zimmer C, Waclaw RR, Mattar P, Shaker T, Kovach C, Logan C, Campbell K, Guillemot F, Schuurmans C, Ascl1 participates in Cajal-Retzius cell development in the neocortex. Cereb Cortex. 2011 Nov;21(11):2599-611
2J:58961 Esterbauer H, Oberkofler H, Krempler F, Patsch W, Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics. 1999 Nov 15;62(1):98-102
2J:176438 Esteve P, Sandonis A, Ibanez C, Shimono A, Guerrero I, Bovolenta P, Secreted frizzled-related proteins are required for Wnt/{beta}-catenin signalling activation in the vertebrate optic cup. Development. 2011 Oct;138(19):4179-84
3J:224201 Evans AL, Faial T, Gilchrist MJ, Down T, Vallier L, Pedersen RA, Wardle FC, Smith JC, Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS One. 2012;7(3):e33346
2J:154650 Favaro R, Valotta M, Ferri AL, Latorre E, Mariani J, Giachino C, Lancini C, Tosetti V, Ottolenghi S, Taylor V, Nicolis SK, Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009 Oct;12(10):1248-56
1J:170384 Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N, Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Dev Biol. 2011 Feb 15;350(2):496-510
2J:155332 Fotaki V, Larralde O, Zeng S, McLaughlin D, Nichols J, Price DJ, Theil T, Mason JO, Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon. Dev Dyn. 2010 Jan;239(1):284-96
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2J:136720 Friedrichs M, Larralde O, Skutella T, Theil T, Lamination of the cerebral cortex is disturbed in Gli3 mutant mice. Dev Biol. 2008 Jun 1;318(1):203-14
1J:196515 Fu J, Hsu W, Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol. 2013 Apr;133(4):890-8
1J:167835 Fu J, Ivy Yu HM, Maruyama T, Mirando AJ, Hsu W, Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn. 2011 Feb;240(2):365-71
2J:154679 Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W, Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603
1J:174118 Fuccillo M, Rutlin M, Fishell G, Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice. Cereb Cortex. 2006 Jul;16 Suppl 1:i96-102
2J:54101 Galceran J, Farinas I, Depew MJ, Clevers H, Grosschedl R, Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev. 1999 Mar 15;13(6):709-17
1J:133091 Galceran J, Hsu SC, Grosschedl R, Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8668-73
1J:94049 Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R, LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 2004 Nov 15;18(22):2718-23
2J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
1J:82309 Garel S, Huffman KJ, Rubenstein JL, Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development. 2003 May;130(9):1903-14
1J:140315 Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica-Krezel L, Jeong Y, Epstein DJ, Oliver G, Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
1J:176262 Giros A, Grgur K, Gossler A, Costell M, alpha5beta1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One. 2011;6(7):e22002
1*J:44237 Goh KL, Yang JT, Hynes RO, Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
1J:228726 Golonzhka O, Nord A, Tang PL, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JL, Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207
2J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152
1*J:98371 Gotz K, Briscoe J, Ruther U, Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev Dyn. 2005 Jun;233(2):623-30
5J:31335 Greco TL, Takada S, Newhouse MM, McMahon JA, McMahon AP, Camper SA, Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev. 1996 Feb 1;10(3):313-24
3J:202907 Grigoryan T, Stein S, Qi J, Wende H, Garratt AN, Nave KA, Birchmeier C, Birchmeier W, Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
1J:165303 Griveau A, Borello U, Causeret F, Tissir F, Boggetto N, Karaz S, Pierani A, A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium. PLoS Biol. 2010;8(7):e1000440
2J:102085 Grove EA, Tole S, Patterning events and specification signals in the developing hippocampus. Cereb Cortex. 1999 Sep;9(6):551-61
5*J:48569 Grove EA, Tole S, Limon J, Yip L, Ragsdale CW, The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 1998 Jun;125(12):2315-25
4*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1*J:21617 Gunther T, Struwe M, Aguzzi A, Schughart K, Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994 Nov;120(11):3119-30
1J:135128 Guo Q, Li JY, Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development. 2007 Jun;134(12):2251-60
1J:119019 Gutin G, Fernandes M, Palazzolo L, Paek H, Yu K, Ornitz DM, McConnell SK, Hebert JM, FGF signalling generates ventral telencephalic cells independently of SHH. Development. 2006 Aug;133(15):2937-46
6J:125693 Hanashima C, Fernandes M, Hebert JM, Fishell G, The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci. 2007 Oct 10;27(41):11103-11
7*J:122362 Harwood BN, Cross SK, Radford EE, Haac BE, de Vries WN, Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Dev Dyn. 2008;237(4):1099-1111
2J:128377 Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL, Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
3J:155247 Hierholzer A, Kemler R, beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos. Dev Dyn. 2009 Aug 24;239(1):191-199
2*J:58691 Hildebrand JD, Soriano P, Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell. 1999 Nov 24;99(5):485-97
1J:142596 Hirano M, Hashimoto S, Yonemura S, Sabe H, Aizawa S, EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol. 2008 Sep 22;182(6):1217-30
1J:119561 Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M, Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006 Oct;133(20):3993-4004
1J:196059 Hodge RD, Garcia AJ 3rd, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF, Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27;33(9):4165-80
3J:173637 Horner VL, Caspary T, Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling. Dev Biol. 2011 Jul 1;355(1):43-54
2J:227000 Hsu LC, Nam S, Cui Y, Chang CP, Wang CF, Kuo HC, Touboul JD, Chou SJ, Lhx2 regulates the timing of beta-catenin-dependent cortical neurogenesis. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12199-204
1J:125109 Huang X, Litingtung Y, Chiang C, Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum Mol Genet. 2007 Jun 15;16(12):1454-68
1J:44094 Ikeya M, Lee SM, Johnson JE, McMahon AP, Takada S, Wnt signalling required for expansion of neural crest and CNS progenitors. Nature. 1997 Oct 30;389(6654):966-70
2J:139170 Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R, Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
1J:122556 Inoue T, Ota M, Mikoshiba K, Aruga J, Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol. 2007 Jun 15;306(2):669-84
1J:121744 Inoue T, Ota M, Ogawa M, Mikoshiba K, Aruga J, Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J Neurosci. 2007 May 16;27(20):5461-73
2*J:79394 Ishibashi M, McMahon AP, A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002 Oct;129(20):4807-19
1*J:142123 Ishimura A, Chida S, Osada S, Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Dev Dyn. 2008 Dec;237(12):3565-76
1J:199291 Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J, Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep;140(17):3589-94
1J:216160 Jurberg AD, Aires R, Novoa A, Rowland JE, Mallo M, Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol. 2014 Oct 15;394(2):253-63
2J:198634 Jurberg AD, Aires R, Varela-Lasheras I, Novoa A, Mallo M, Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos. Dev Cell. 2013 Jun 10;25(5):451-62
1J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
1*J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1*J:95686 Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM, Beamer WG, Hammer GD, Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Hum Mol Genet. 2005 Jan 1;14(1):113-23
6*J:98792 Kemp C, Willems E, Abdo S, Lambiv L, Leyns L, Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn. 2005 May 5;233(3):1064-1075
1J:98539 Kimura J, Suda Y, Kurokawa D, Hossain ZM, Nakamura M, Takahashi M, Hara A, Aizawa S, Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci. 2005 May 25;25(21):5097-108
4J:117138 Kimura T, Nakamura T, Murayama K, Umehara H, Yamano N, Watanabe S, Taketo MM, Nakano T, The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression. Dev Biol. 2006 Dec 15;300(2):545-53
1J:59069 Klingensmith J, Ang SL, Bachiller D, Rossant J, Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev Biol. 1999 Dec 15;216(2):535-49
1*J:67969 Koizumi Ki, Nakajima M, Yuasa S, Saga Y, Sakai T, Kuriyama T, Shirasawa T, Koseki H, The role of presenilin 1 during somite segmentation. Development. 2001 Apr;128(8):1391-402
1J:210110 Komatsu Y, Kishigami S, Mishina Y, In situ hybridization methods for mouse whole mounts and tissue sections with and without additional beta-galactosidase staining. Methods Mol Biol. 2014;1092:1-15
1*J:117234 Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y, BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev Dyn. 2007 Feb;236(2):512-7
2J:203109 Konno D, Iwashita M, Satoh Y, Momiyama A, Abe T, Kiyonari H, Matsuzaki F, The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One. 2012;7(10):e46577
2J:84901 Kuschel S, Ruther U, Theil T, A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol. 2003 Aug 15;260(2):484-95
2J:107400 Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I, p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development. 2006 Apr;133(8):1553-63
1J:199301 Lavado A, He Y, Pare J, Neale G, Olson EN, Giovannini M, Cao X, Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
2J:166777 Lavado A, Lagutin OV, Chow LM, Baker SJ, Oliver G, Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 2010;8(8)
1J:130851 Lavado A, Lagutin OV, Oliver G, Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
5J:59283 Lee SM, Tole S, Grove E, McMahon AP, A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. 2000 Feb;127(3):457-67
2J:165715 Lee YJ, McPherron A, Choe S, Sakai Y, Chandraratna RA, Lee SJ, Oh SP, Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development. Dev Biol. 2010 Nov 1;347(1):195-203
3J:222442 Li BI, Matteson PG, Ababon MF, Nato AQ Jr, Lin Y, Nanda V, Matise TC, Millonig JH, The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015 Jun 1;402(1):17-31
1J:98484 Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J, Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun;132(11):2599-609
2*J:70601 Lickert H, Kispert A, Kutsch S, Kemler R, Expression patterns of Wnt genes in mouse gut development. Mech Dev. 2001 Jul;105(1-2):181-4
1*J:119031 Lillevali K, Haugas M, Matilainen T, Pussinen C, Karis A, Salminen M, Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mech Dev. 2006 Jun;123(6):415-29
3*J:139251 Lin C, Yin Y, Long F, Ma L, Tissue-specific requirements of beta-catenin in external genitalia development. Development. 2008 Aug;135(16):2815-25
3J:84478 Liu H, Mohamed O, Dufort D, Wallace VA, Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev Dyn. 2003 Jul;227(3):323-34
1J:179217 Liu HX, Grosse AS, Iwatsuki K, Mishina Y, Gumucio DL, Mistretta CM, Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development. Dev Biol. 2012 Jan 1;361(1):39-56
1J:224422 Liu M, Zhao S, Lin Q, Wang XP, YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues. Mol Cell Biol. 2015 Apr;35(8):1449-61
1*J:84359 Lloyd S, Fleming TP, Collins JE, Expression of Wnt genes during mouse preimplantation development. Gene Expr Patterns. 2003 Jun;3(3):309-12
1J:197427 Lopez TP, Fan CM, Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2019-27
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:130167 Mangale VS, Hirokawa KE, Satyaki PR, Gokulchandran N, Chikbire S, Subramanian L, Shetty AS, Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S, Monuki ES, Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science. 2008 Jan 18;319(5861):304-9
1J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
3J:154452 Martinez-Ferre A, Martinez S, The development of the thalamic motor learning area is regulated by Fgf8 expression. J Neurosci. 2009 Oct 21;29(42):13389-400
1J:101031 Maruhashi M, Van De Putte T, Huylebroeck D, Kondoh H, Higashi Y, Involvement of SIP1 in positioning of somite boundaries in the mouse embryo. Dev Dyn. 2005 Oct;234(2):332-8
3J:971 McMahon AP, Joyner AL, Bradley A, McMahon JA, The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell. 1992 May 15;69(4):581-95
2J:177133 Mehta V, Abler LL, Keil KP, Schmitz CT, Joshi PS, Vezina CM, Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. Dev Dyn. 2011 Nov;240(11):2548-60
2J:30339 Millen KJ, Hui CC, Joyner AL, A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development. 1995 Dec;121(12):3935-45
2*J:119921 Miller SF, Summerhurst K, Runker AE, Kerjan G, Friedel RH, Chedotal A, Murphy P, Mitchell KJ, Expression of Plxdc2/TEM7R in the developing nervous system of the mouse. Gene Expr Patterns. 2007 Apr;7(5):635-44
1J:123406 Miquelajauregui A, Van de Putte T, Polyakov A, Nityanandam A, Boppana S, Seuntjens E, Karabinos A, Higashi Y, Huylebroeck D, Tarabykin V, Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12919-24
1J:162847 Miquelajauregui A, Varela-Echavarria A, Ceci ML, Garcia-Moreno F, Ricano I, Hoang K, Frade-Perez D, Portera-Cailliau C, Tamariz E, De Carlos JA, Westphal H, Zhao Y, LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells. J Neurosci. 2010 Aug 4;30(31):10551-62
1J:157031 Misra K, Matise MP, A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol. 2010 Jan 1;337(1):74-83
1J:159998 Miura S, Singh AP, Mishina Y, Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. Dev Biol. 2010 May 1;341(1):246-54
1J:148515 Miyagawa S, Satoh Y, Haraguchi R, Suzuki K, Iguchi T, Taketo MM, Nakagata N, Matsumoto T, Takeyama KI, Kato S, Yamada G, Genetic interactions of the Androgen and Wnt/{beta}-catenin Pathways for the Masculinization of External Genitalia. Mol Endocrinol. 2009 June;23(6):871-880
2J:187747 Miyoshi H, Ajima R, Luo CT, Yamaguchi TP, Stappenbeck TS, Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science. 2012 Oct 5;338(6103):108-13
2*J:91871 Mohamed OA, Dufort D, Clarke HJ, Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation. Biol Reprod. 2004 Aug;71(2):417-24
1J:81152 Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H, Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003 Feb;130(3):495-505
1J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
1J:78037 Muzio L, DiBenedetto B, Stoykova A, Boncinelli E, Gruss P, Mallamaci A, Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice. Nat Neurosci. 2002 Aug;5(8):737-45
1J:174499 Muzio L, DiBenedetto B, Stoykova A, Boncinelli E, Gruss P, Mallamaci A, Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium. Cereb Cortex. 2002 Feb;12(2):129-39
2J:98698 Muzio L, Mallamaci A, Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium. J Neurosci. 2005 Apr 27;25(17):4435-41
4J:60644 Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K, Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1618-23
1J:38554 Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K , Mikoshiba K, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol. 1997 Feb 15;182(2):299-313
2J:170831 Naiche LA, Holder N, Lewandoski M, FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4018-23
4J:104377 Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP, Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development. 2005 Dec;132(24):5425-36
1J:180300 Noda T, Oki S, Kitajima K, Harada T, Komune S, Meno C, Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo. Dev Biol. 2012 Feb 1;362(1):83-93
8J:185807 Nowotschin S, Ferrer-Vaquer A, Concepcion D, Papaioannou VE, Hadjantonakis AK, Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo. Dev Biol. 2012 Jul 1;367(1):1-14
1J:185597 Ohmura T, Shioi G, Hirano M, Aizawa S, Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012 Aug;241(8):1350-64
1J:114817 Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG, Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell. 2006 May 5;125(3):593-605
1J:150347 Paek H, Gutin G, Hebert JM, FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development. 2009 Jul;136(14):2457-65
4*J:14717 Parr BA, Shea MJ, Vassileva G, McMahon AP, Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 1993 Sep;119(1):247-61
1J:215309 Patterson ES, Waller LE, Kroll KL, Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol. 2014 Sep 1;393(1):44-56
1J:175303 Pino D, Choe Y, Pleasure SJ, Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro. 2011;3(3):e00059
2J:64989 Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC, An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 2000 Sep 28;407(6803):535-8
1J:162001 Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ, NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. J Neurosci. 2010 Jul 7;30(27):9127-39
3J:127039 Rash BG, Grove EA, Patterning the dorsal telencephalon: a role for sonic hedgehog?. J Neurosci. 2007 Oct 24;27(43):11595-603
2J:178496 Rash BG, Grove EA, Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol. 2011 Nov 15;359(2):242-50
2J:18543 Rashbass P, Wilson V, Rosen B, Beddington RS, Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos. Int J Dev Biol. 1994 Mar;38(1):35-44
6*J:71419 Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE, Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev. 2001 Sep;107(1-2):69-82
1J:210664 Restelli M, Lopardo T, Lo Iacono N, Garaffo G, Conte D, Rustighi A, Napoli M, Del Sal G, Perez-Morga D, Costanzo A, Merlo GR, Guerrini L, DLX5, FGF8 and the Pin1 isomerase control DeltaNp63alpha protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations. Hum Mol Genet. 2014 Jul 15;23(14):3830-42
4J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
6*J:11028 Roelink H, Nusse R, Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 1991 Mar;5(3):381-8
2J:220958 Rosenthal EH, Tonchev AB, Stoykova A, Chowdhury K, Regulation of archicortical arealization by the transcription factor Zbtb20. Hippocampus. 2012 Nov;22(11):2144-56
1J:57948 Rowitch DH, S.-Jacques B, Lee SM, Flax JD, Snyder EY, McMahon AP, Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci. 1999 Oct 15;19(20):8954-65
1J:27770 Sadler TW, Liu ET, Augustine KA, Antisense targeting of engrailed-1 causes abnormal axis formation in mouse embryos. Teratology. 1995 May;51(5):292-9
1J:148018 Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K, Shiroishi T, A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
2J:166617 Sakurai Y, Kurokawa D, Kiyonari H, Kajikawa E, Suda Y, Aizawa S, Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 2010 Nov 15;347(2):392-403
3J:205383 Salti A, Nat R, Neto S, Puschban Z, Wenning G, Dechant G, Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev. 2013 Feb 1;22(3):397-411
2J:106551 Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A, Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
1J:135313 Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A, Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 2008 Feb;46(2):92-103
2J:215514 Saulnier A, Keruzore M, De Clercq S, Bar I, Moers V, Magnani D, Walcher T, Filippis C, Kricha S, Parlier D, Viviani L, Matson CK, Nakagawa Y, Theil T, Gotz M, Mallamaci A, Marine JC, Zarkower D, Bellefroid EJ, The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals. Cereb Cortex. 2013 Nov;23(11):2552-67
3J:154904 Savory JG, Bouchard N, Pierre V, Rijli FM, De Repentigny Y, Kothary R, Lohnes D, Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110
2J:195133 Semba K, Araki K, Matsumoto K, Suda H, Ando T, Sei A, Mizuta H, Takagi K, Nakahara M, Muta M, Yamada G, Nakagata N, Iida A, Ikegawa S, Nakamura Y, Araki M, Abe K, Yamamura K, Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204
2J:141122 Shibata M, Kurokawa D, Nakao H, Ohmura T, Aizawa S, MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. J Neurosci. 2008 Oct 8;28(41):10415-21
1J:170671 Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S, MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 2011 Mar 2;31(9):3407-22
3*J:104602 Shimizu T, Kagawa T, Wada T, Muroyama Y, Takada S, Ikenaka K, Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol. 2005 Jun 15;282(2):397-410
3J:94394 Shimogori T, Banuchi V, Ng HY, Strauss JB, Grove EA, Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex. Development. 2004 Nov;131(22):5639-47
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1*J:90405 Shinozaki K, Yoshida M, Nakamura M, Aizawa S, Suda Y, Emx1 and Emx2 cooperate in initial phase of archipallium development. Mech Dev. 2004 May;121(5):475-89
3J:56417 Shum AS, Poon LL, Tang WW, Koide T, Chan BW, Leung YC, Shiroishi T, Copp AJ, Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech Dev. 1999 Jun;84(1-2):17-30
1J:186213 Sparrow DB, Chapman G, Smith AJ, Mattar MZ, Major JA, O'Reilly VC, Saga Y, Zackai EH, Dormans JP, Alman BA, McGregor L, Kageyama R, Kusumi K, Dunwoodie SL, A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell. 2012 Apr 13;149(2):295-306
3*J:30825 Sporle R, Gunther T, Struwe M, Schughart K, Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos. Development. 1996 Jan;122(1):79-86
1*J:154376 Stottmann RW, Tran PV, Turbe-Doan A, Beier DR, Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol. 2009 Nov 1;335(1):166-78
2*J:133947 Summerhurst K, Stark M, Sharpe J, Davidson D, Murphy P, 3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19). Gene Expr Patterns. 2008 May;8(5):331-48
2*J:155223 Suomalainen M, Thesleff I, Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. Dev Dyn. 2009 Oct 5;239(1):364-372
1J:50437 Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I , Ho A , Wakeham A , Itie A , Khoo W , Fukumoto M , Mak TW, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 1998 Oct 22;8(21):1169-78
7J:16716 Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP, Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
2J:236406 Takada Y, Fukuda A, Chiba T, Seno H, Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling. Development. 2016 Oct 1;143(19):3532-3539
1J:33667 Takahashi Y, Organization of the spina bifida neural tube in Splotch (Pax-3 defective) mouse embryos. Dev Growth Differ. 1996 FEB;38(1):23-31
2J:217059 Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H, Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
1J:199855 Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R, Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1*J:79849 Theil T, Aydin S, Koch S, Grotewold L, Ruther U, Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development. 2002 Jul;129(13):3045-54
1*J:72659 Tole S, Goudreau G, Assimacopoulos S, Grove EA, Emx2 is required for growth of the hippocampus but not for hippocampal field specification. J Neurosci. 2000 Apr 1;20(7):2618-25
1J:59923 Tole S, Ragsdale CW, Grove EA, Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15;217(2):254-65
2J:201966 Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K, Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17552-7
1*J:34768 Tremblay P, Pituello F, Gruss P, Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice. Development. 1996 Aug;122(8):2555-67
1J:160254 Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL, FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol. 2010 Apr 15;340(2):595-604
4*J:96629 Vacalla CM, Theil T, Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development. Mech Dev. 2002 Oct;118(1-2):265-8
2J:180902 van de Ven C, Bialecka M, Neijts R, Young T, Rowland JE, Stringer EJ, Van Rooijen C, Meijlink F, Novoa A, Freund JN, Mallo M, Beck F, Deschamps J, Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development. 2011 Aug;138(16):3451-62
1J:185604 van Rooijen C, Simmini S, Bialecka M, Neijts R, van de Ven C, Beck F, Deschamps J, Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence. Development. 2012 Jul;139(14):2576-83
1*J:118503 Verani R, Cappuccio I, Spinsanti P, Gradini R, Caruso A, Magnotti MC, Motolese M, Nicoletti F, Melchiorri D, Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid. J Neurochem. 2007 Jan;100(1):242-50
1*J:127119 Visel A, Carson J, Oldekamp J, Warnecke M, Jakubcakova V, Zhou X, Shaw CA, Alvarez-Bolado G, Eichele G, Regulatory pathway analysis by high-throughput in situ hybridization. PLoS Genet. 2007 Oct 19;3(10):1867-83
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:221658 Vithayathil J, Pucilowska J, Goodnough LH, Atit RP, Landreth GE, Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation. J Neurosci. 2015 Apr 29;35(17):6836-48
4J:106144 Ware SM, Harutyunyan KG, Belmont JW, Zic3 is critical for early embryonic patterning during gastrulation. Dev Dyn. 2006 Mar;235(3):776-85
3J:77089 Weidenfeld J, Shu W, Zhang L, Millar SE, Morrisey EE, The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem. 2002 Jun 7;277(23):21061-70
1*J:93603 Wine-Lee L, Ahn KJ, Richardson RD, Mishina Y, Lyons KM, Crenshaw EB 3rd, Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development. 2004 Nov;131(21):5393-403
7*J:146657 Witte F , Dokas J , Neuendorf F , Mundlos S , Stricker S, Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23
1J:103454 Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME, Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo. BMC Dev Biol. 2005 Aug 18;5:17
1J:152813 Wolf M, Lommes P, Sock E, Reiprich S, Friedrich RP, Kriesch J, Stolt CC, Bermingham JR Jr, Wegner M, Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Dev Biol. 2009 Aug 15;332(2):418-28
2J:226692 Wright KD, Mahoney Rogers AA, Zhang J, Shim K, Cooperative and independent functions of FGF and Wnt signaling during early inner ear development. BMC Dev Biol. 2015;15:33
1J:185531 Wu H, Lu Y, Barik A, Joseph A, Taketo MM, Xiong WC, Mei L, beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
2J:59271 Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP, T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev. 1999 Dec 15;13(24):3185-90
1J:98395 Yamaguchi Y, Ogura S, Ishida M, Karasawa M, Takada S, Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo. Dev Dyn. 2005 Jun;233(2):484-95
1J:70892 Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP, Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
1*J:38397 Yoshida M, Suda Y, Matsuo I, Miyamoto N, Takeda N, Kuratani S, Aizawa S, Emx1 and Emx2 functions in development of dorsal telencephalon. Development. 1997 Jan;124(1):101-11
2*J:39344 Yoshikawa Y, Fujimori T, McMahon AP, Takada S, Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol. 1997 Mar 15;183(2):234-42
8J:154781 Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009 Oct;17(4):516-26
1J:165556 Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J, Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development. 2010 Nov;137(21):3707-17
3J:145023 Yu X, Wang Y, Jiang M, Bierie B, Roy-Burman P, Shen MM, Taketo MM, Wills M, Matusik RJ, Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate. 2009 Feb 15;69(3):249-62
1*J:93574 Yun K, Mantani A, Garel S, Rubenstein J, Israel MA, Id4 regulates neural progenitor proliferation and differentiation in vivo. Development. 2004 Nov;131(21):5441-8
2J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
2J:124891 Zaghetto AA, Paina S, Mantero S, Platonova N, Peretto P, Bovetti S, Puche A, Piccolo S, Merlo GR, Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci. 2007 Sep 5;27(36):9757-68
1J:98379 Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM, Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May;132(10):2489-99
1*J:119277 Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ, Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. J Neurochem. 2006 Aug;98(3):860-75
1J:229467 Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suner D, Garcia-Pavia P, Zhang X, Wang Q, Xie L, Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51
1J:207612 Zhang L, Li H, Yu J, Cao J, Chen H, Zhao H, Zhao J, Yao Y, Cheng H, Wang L, Zhou R, Yao Z, Guo X, Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
1J:105879 Zhang TJ, Hoffman BG, Ruiz de Algara T, Helgason CD, SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Gene Expr Patterns. 2006 Mar;6(3):310-24
1*J:150714 Zhao X, Duester G, Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension. Gene Expr Patterns. 2009 Sept;9(6):430-5
2J:207050 Zhao X, Huang H, Chen Y, Liu Y, Zhang Z, Ma Q, Qiu M, Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Jul 1;248C:594-601
1J:187603 Zhu H, Zhao J, Zhou W, Li H, Zhou R, Zhang L, Zhao H, Cao J, Zhu X, Hu H, Ma G, He L, Yao Z, Yao L, Guo X, Ndrg2 regulates vertebral specification in differentiating somites. Dev Biol. 2012 Sep 15;369(2):308-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.07
The Jackson Laboratory