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Gene Expression Literature Summary
Symbol
Name
ID
Thbs1
thrombospondin 1
MGI:98737

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7.5 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E19.5 E P
Immunohistochemistry (section) 2 1 1 1 1 1 1 4 1 1 1 1 1 1 5
In situ RNA (section) 1 2 3 1 5 3 2 1 1 2 1 1
In situ RNA (whole mount) 1 1
Northern blot 1 1 1 1 1 1 1
Western blot 1 1 1 1 1
RT-PCR 1 1 1 2 1 2 1 1 1 1 1 6
cDNA clones 1 1 1 1
RNase protection 1 1 1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Thbs1  thrombospondin 1   (Synonyms: tbsp1, Thbs-1, TSP1, TSP-1)
Results  Reference
2J:166547 Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A, Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
2J:213829 Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG, Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
1J:79427 Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL, c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002 Oct 1;16(19):2530-43
3J:143787 Blake SM, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider WJ, Nimpf J, Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J. 2008 Nov 19;27(22):3069-80
2J:43380 Bornstein P, O'Rourke K, Wikstrom K, Wolf FW, Katz R, Li P, Dixit VM, A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome. J Biol Chem. 1991 Jul 15;266(20):12821-4
3J:192829 Chandler RL, Brennan J, Schisler JC, Serber D, Patterson C, Magnuson T, ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013 Jan;33(2):265-80
1J:202949 Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J, Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
3J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1*J:79225 Flugel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER, Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn. 2002 Oct;225(2):111-25
2J:159895 Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D, The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26;285(9):6770-80
1J:235912 Ghanem LR, Kromer A, Silverman IM, Chatterji P, Traxler E, Penzo-Mendez A, Weiss MJ, Stanger BZ, Liebhaber SA, The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Mol Cell Biol. 2015 Nov 02;36(2):304-19
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1J:207517 Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, Griffin CT, The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013 Dec;9(12):e1004031
16*J:14410 Iruela-Arispe ML, Liska DJ, Sage EH, Bornstein P, Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn. 1993 May;197(1):40-56
1J:268349 Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR, Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018 Nov 2;9(1):4600
1J:205338 Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo-Garcia P, Mundlos S, Stricker S, Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93
7*J:1991 Laherty CD, O'Rourke K, Wolf FW, Katz R, Seldin MF, Dixit VM, Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development. J Biol Chem. 1992 Feb 15;267(5):3274-81
2*J:82199 Liu Y, Hogan BL, Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002 Dec;2(3-4):229-33
1J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
1J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
3J:227951 Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Muller U, Jones SM, Mustapha M, Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014 Apr;39(8):1256-67
2*J:96883 Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG, Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3708-13
1*J:130143 Redmond LC, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells. Dev Dyn. 2008 Feb;237(2):436-46
2J:269217 Regano D, Visintin A, Clapero F, Bussolino F, Valdembri D, Maione F, Serini G, Giraudo E, Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1710-1721
7*J:91885 Saika S, Miyamoto T, Ishida I, Barbour WK, Ohnishi Y, Ooshima A, Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation. Exp Eye Res. 2004 Aug;79(2):147-56
1J:281428 Schneider AJ, Gawdzik J, Vezina CM, Baker TR, Peterson RE, Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration. Gene Expr Patterns. 2019 Oct 25;34:119075
2J:44113 Scott-Drew S, ffrench-Constant C, Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system. J Neurosci Res. 1997 Oct 15;50(2):202-14
1J:181974 Seo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T, Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1J:278988 Tian C, Johnson KR, TBX1 is required for normal stria vascularis and semicircular canal development. Dev Biol. 2019 Sep 21;
7J:49028 Tooney PA, Sakai T, Sakai K, Aeschlimann D, Mosher DF, Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1. Matrix Biol. 1998 Jun;17(2):131-43
1J:81587 Volpert OV, Pili R, Sikder HA, Nelius T, Zaichuk T, Morris C, Shiflett CB, Devlin MK, Conant K, Alani RM, Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell. 2002 Dec;2(6):473-83
1J:167088 Zhao Q, Beck AJ, Vitale JM, Schneider JS, Gao S, Chang C, Elson G, Leibovich SJ, Park JY, Tian B, Nam HS, Fraidenraich D, Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. Dev Biol. 2011 Jan 1;349(1):53-64
1J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76
2J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147

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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory