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Gene Expression Literature Summary
Symbol
Name
ID
Tgfb2
transforming growth factor, beta 2
MGI:98726

153 matching records from 153 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 2 4 2 3 1 5 1 9 3 12 5 7 3 2 2 4 2 1 3 3 6
In situ RNA (section) 1 2 1 1 2 3 3 10 4 9 3 10 1 9 1 8 1 14 12 10 2 5 4 9
In situ protein (whole mount) 1 2 1 1 1 1 1 1 1 1 1
In situ RNA (whole mount) 1 1 2 2 11 4 6 1 1 2 1 1 1 1 3
In situ reporter (knock in) 1 1
Northern blot 1 1 2 3 1 2 3 3 2 3 2 3 2 7 1 1 1 3 1 1 5
Western blot 1 2
RT-PCR 1 1 1 1 8 2 12 3 10 3 8 3 8 4 7 1 3 3 5 1 1 3 5 14
cDNA clones 1 1 1
RNase protection 1 1 1 2 2 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tgfb2  transforming growth factor, beta 2   (Synonyms: Tgfb-2, Tgf-beta2)
Results  Reference
1J:143626 Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF, Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9319-24
3J:136394 Anthwal N, Chai Y, Tucker AS, The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun;237(6):1604-13
2J:150973 Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP, Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009 Jun;136(7):2325-33
6J:128363 Arai KY, Nishiyama T, Developmental Changes in Extracellular Matrix Messenger RNAs in the Mouse Placenta During the Second Half of Pregnancy: Possible Factors Involved in the Regulation of Placental Extracellular Matrix Expression. Biol Reprod. 2007 Dec;77(6):923-33
1J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
2J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
9J:99404 Behnan S, Guo C, Gong TW, Shum L, Gong SG, Gene and protein expression of Transforming growth factorbeta2 gene during murine primary palatogenesis. Differentiation. 2005 Jun;73(5):233-9
1J:157112 Bjork BC, Turbe-Doan A, Prysak M, Herron BJ, Beier DR, Prdm16 is required for normal palatogenesis in mice. Hum Mol Genet. 2010 Mar 1;19(5):774-89
1J:189446 Bonod-Bidaud C, Roulet M, Hansen U, Elsheikh A, Malbouyres M, Ricard-Blum S, Faye C, Vaganay E, Rousselle P, Ruggiero F, In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol. 2012 Jul;132(7):1841-9
1J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
1J:72639 Bragg AD, Moses HL, Serra R, Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development. Mech Dev. 2001 Nov;109(1):13-26
2J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
7*J:18919 Buchman VL, Sporn M, Davies AM, Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development. Development. 1994 Jun;120(6):1621-9
6*J:17727 Burns TM, Clough JA, Klein RM, Wood GW, Berman NE, Developmental regulation of cytokine expression in the mouse brain. Growth Factors. 1993;9(4):253-8
2J:178530 Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL, Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2. Dev Biol. 2011 Dec 15;360(2):381-90
2J:198628 Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL, Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
2J:214093 Cambier L, Plate M, Sucov HM, Pashmforoush M, Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
5J:78405 Camenisch TD, Molin DG, Person A, Runyan RB, Gittenberger-de Groot AC, McDonald JA, Klewer SE, Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev Biol. 2002 Aug 1;248(1):170-81
2J:17122 Chai Y, Mah A, Crohin C, Groff S, Bringas P Jr, Le T, Santos V, Slavkin HC, Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Dev Biol. 1994 Mar;162(1):85-103
3*J:57068 Chai Y, Zhao J, Mogharei A, Xu B, Bringas P Jr, Shuler C, Warburton D, Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants. Mech Dev. 1999 Aug;86(1-2):63-74
1J:67398 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ, The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb;158(2):469-79
2J:124144 Chen F, Desai TJ, Qian J, Niederreither K, Lu J, Cardoso WV, Inhibition of Tgf{beta} signaling by endogenous retinoic acid is essential for primary lung bud induction. Development. 2007 Aug;134(16):2969-79
2J:16945 Cheng HL, Schneider SL, Kane CM, Gollnick SO, Grande C, Thompson D, Pietrzak E, Tomasi TB, TGF-beta 2 gene and protein expression in maternal and fetal tissues at various stages of murine development. J Reprod Immunol. 1993 Nov;25(2):133-48
1J:169692 Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL, Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011;11:12
1J:40384 Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH, Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
2J:169302 da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F, Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-{beta} signaling. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3395-400
4J:51265 Degitz SJ, Morris D, Foley GL, Francis BM, Role of TGF-beta in RA-induced cleft palate in CD-1 mice. Teratology. 1998 Nov;58(5):197-204
3J:131874 Di-Poi N, Zakany J, Duboule D, Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development. PLoS Genet. 2007 Dec 21;3(12):e232
7*J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74
16*J:4372 Dickson MC, Slager HG, Duffie E, Mummery CL, Akhurst RJ, RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development. Development. 1993 Feb;117(2):625-39
3J:105113 Dunker N, Krieglstein K, Reduced programmed cell death in the retina and defects in lens and cornea of Tgfbeta2(-/-) Tgfbeta3(-/-) double-deficient mice. Cell Tissue Res. 2003 Jul;313(1):1-10
2J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
5J:198451 El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G, Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013 Jun 15;378(2):83-93
4J:3784 Ferguson MW, Sharpe PM, Thomas BL, Beck F, Differential expression of insulin-like growth factors I and II (IGF I and II), mRNA, peptide and binding protein 1 during mouse palate development: comparison with TGF beta peptide distribution. J Anat. 1992 Oct;181(Pt 2):219-38
8*J:92176 Ficker M, Powles N, Warr N, Pirvola U, Maconochie M, Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
1J:133699 Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M, Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63
6*J:32953 Fitzpatrick DR, Denhez F, Kondaiah P, Akhurst RJ, Differential expression of TGF beta isoforms in murine palatogenesis. Development. 1990 Jul;109(3):585-95
10J:31836 Flanders KC, Ludecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K, Localization and actions of transforming growth factor-beta s in the embryonic nervous system. Development. 1991 Sep;113(1):183-91
1J:198516 Fujita K, Taya Y, Shimazu Y, Aoba T, Soeno Y, Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family. Int J Dev Biol. 2013;57(5):399-406
1J:167570 Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H, Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52
4J:75084 Gaussin V, Van de Putte T, Mishina Y, Hanks MC, Zwijsen A, Huylebroeck D, Behringer RR, Schneider MD, Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2878-83
3*J:21746 Gehris AL, Pisano MM, Nugent P, Greene RM, Regulation of TGF beta 3 gene expression in embryonic palatal tissue. In Vitro Cell Dev Biol Anim. 1994 Oct;30A(10):671-9
4*J:30189 Ginsburg GT, Royster D, Kassabian G, Shuler CF, Dougherty WR, Sank AC, Mesenchymal commitment to digital joint formation. Ann Plast Surg. 1995 Jul;35(1):95-104
2J:96841 Gong SG, Gong TW, Shum L, Identification of markers of the midface. J Dent Res. 2005 Jan;84(1):69-72
2*J:30824 Grass S, Arnold HH, Braun T, Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development. 1996 Jan;122(1):141-50
2*J:75698 Grunder A, Ebel TT, Mallo M, Schwarzkopf G, Shimizu T, Sippel AE, Schrewe H, Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
4*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:123620 Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM, Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol. 2007 Aug;27(15):5352-64
1J:203028 Hasenpusch-Theil K, Magnani D, Amaniti EM, Han L, Armstrong D, Theil T, Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex. 2012 Dec;22(12):2878-93
1J:170963 Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22;332(6028):458-61
1*J:109593 Heanue TA, Pachnis V, Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6919-24
3J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1J:137692 Huang X, Gao X, Diaz-Trelles R, Ruiz-Lozano P, Wang Z, Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180. Dev Biol. 2008 Jul 15;319(2):258-66
2J:213572 Ishtiaq Ahmed AS, Bose GC, Huang L, Azhar M, Generation of mice carrying a knockout-first and conditional-ready allele of transforming growth factor beta2 gene. Genesis. 2014 Sep;52(9):817-26
1J:152572 Iwao K, Inatani M, Matsumoto Y, Ogata-Iwao M, Takihara Y, Irie F, Yamaguchi Y, Okinami S, Tanihara H, Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest. 2009 Jul;119(7):1997-2008
1J:97750 Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E, A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 2005 Jan;3(1):e11
6J:36479 Jaskoll T, Choy HA, Chen H, Melnick M, Developmental expression and CORT-regulation of TGF-beta and EGF receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-beta 2 mRNA expression. Teratology. 1996 Jul;54(1):34-44
1J:22585 Jaskoll T, Choy HA, Melnick M, Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J Craniofac Genet Dev Biol. 1994 Oct-Dec;14(4):217-30
1J:33469 Jaskoll T, Choy HA, Melnick M, The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo. Pediatr Res. 1996 May;39(5):749-59
1J:69420 Jaskoll T, Melnick M, Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 Nov 1;256(3):252-68
3*J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
1J:90988 Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu MM, Epstein JA, Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development. 2004 Jul;131(14):3481-90
6J:41235 Kaestner KH, Silberg DG, Traber PG, Schutz G, The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 1997 Jun 15;11(12):1583-95
2J:164076 Karamboulas K, Dranse HJ, Underhill TM, Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci. 2010 Jun 15;123(Pt 12):2068-76
1J:206644 Konkel JE, Jin W, Abbatiello B, Grainger JR, Chen W, Thymocyte apoptosis drives the intrathymic generation of regulatory T cells. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E465-73
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1J:209780 Krcmery J, Gupta R, Sadleir RW, Ahrens MJ, Misener S, Kamide C, Fitchev P, Losordo DW, Crawford SE, Simon HG, Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. PLoS One. 2013;8(11):e80809
2J:64428 Kruger O, Plum A, Kim JS, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers WH, Willecke K, Defective vascular development in connexin 45-deficient mice. Development. 2000 Oct;127(19):4179-93
4*J:74237 Kubalak SW, Hutson DR, Scott KK, Shannon RA, Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development. 2002 Feb;129(3):733-46
1J:177567 Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W, Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
1J:187713 Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS, Myocardin-like protein 2 regulates TGFbeta signaling in embryonic stem cells and the developing vasculature. Development. 2012 Oct;139(19):3531-42
1J:105272 Li J, Shiroyanagi Y, Lin G, Haqq C, Lin CS, Lue TF, Willingham E, Baskin LS, Serum response factor, its cofactors, and epithelial-mesenchymal signaling in urinary bladder smooth muscle formation. Differentiation. 2006 Feb;74(1):30-9
7J:145162 Li JY, Hu B, Wang XJ, Wang SL, Temporal and spatial expression of TGF-beta2 in tooth crown development in mouse first lower molar. Eur J Histochem. 2008 Oct-Dec;52(4):243-50
1J:193698 Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP, Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1738-43
2J:86349 Lian Q, Samuel TS, Dheen ST, Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide. Neurosci Lett. 2003 Nov 6;351(1):51-5
2J:133705 Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J, Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007 Mar 2;100(4):527-35
1J:82199 Liu Y, Hogan BL, Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002 Dec;2(3-4):229-33
2J:165329 Luna-Zurita L, Prados B, Grego-Bessa J, Luxan G, del Monte G, Benguria A, Adams RH, Perez-Pomares JM, de la Pompa JL, Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 2010 Oct 1;120(10):3493-507
1*J:15320 Lyons KM, Pelton RW, Hogan BL, Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. 1989 Nov;3(11):1657-68
2*J:32952 Lyons KM, Pelton RW, Hogan BL, Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development. 1990 Aug;109(4):833-44
1J:104417 Ma L, Lu MF, Schwartz RJ, Martin JF, Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 2005 Dec;132(24):5601-11
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4J:28117 Mahmood R, Flanders KC, Morriss-Kay GM, The effects of retinoid status on TGF beta expression during mouse embryogenesis. Anat Embryol (Berl). 1995 Jul;192(1):21-33
1J:145175 Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V, Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol. 2009 Feb 15;326(2):368-77
7*J:1989 Manova K, Paynton BV, Bachvarova RF, Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua. Mech Dev. 1992 Feb;36(3):141-52
1J:116885 Mayanil CS, Pool A, Nakazaki H, Reddy AC, Mania-Farnell B, Yun B, George D, McLone DG, Bremer EG, Regulation of murine TGFbeta2 by Pax3 during early embryonic development. J Biol Chem. 2006 Aug 25;281(34):24544-52
5J:80722 McLennan IS, Koishi K, The transforming growth factor-betas: multifaceted regulators of the development and maintenance of skeletal muscles, motoneurons and Schwann cells. Int J Dev Biol. 2002;46(4):559-67
4J:136358 Mecha M, Rabadan MA, Pena-Melian A, Valencia M, Mondejar T, Blanco MJ, Expression of TGF-betas in the embryonic nervous system: analysis of interbalance between isoforms. Dev Dyn. 2008 Jun;237(6):1709-17
1J:145458 Memon MA, Anway MD, Covert TR, Uzumcu M, Skinner MK, Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development. Mol Cell Endocrinol. 2008 Nov 6;294(1-2):70-80
1J:155154 Mesbah K, Harrelson Z, Theveniau-Ruissy M, Papaioannou VE, Kelly RG, Tbx3 is required for outflow tract development. Circ Res. 2008 Sep 26;103(7):743-50
1J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
4J:195695 Miles DC, Wakeling SI, Stringer JM, van den Bergen JA, Wilhelm D, Sinclair AH, Western PS, Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One. 2013;8(1):e54606
2J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
6*J:11119 Millan FA, Denhez F, Kondaiah P, Akhurst RJ, Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Development. 1991 Jan;111(1):131-43
6*J:24256 Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R, Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol. 1989 Jul;3(7):1108-14
7J:16024 Miller DA, Pelton RW, Derynck R, Moses HL, Transforming growth factor-beta. A family of growth regulatory peptides. Ann N Y Acad Sci. 1990;593:208-17
2*J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
7*J:84445 Molin DG, Bartram U, Van der Heiden K, Van Iperen L, Speer CP, Hierck BP, Poelmann RE, Gittenberger-de-Groot AC, Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton. Dev Dyn. 2003 Jul;227(3):431-44
3J:160474 Moreno SG, Attali M, Allemand I, Messiaen S, Fouchet P, Coffigny H, Romeo PH, Habert R, TGFbeta signaling in male germ cells regulates gonocyte quiescence and fertility in mice. Dev Biol. 2010 Jun 1;342(1):74-84
2J:141347 Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L, Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circ Res. 2007 Sep 28;101(7):682-91
1J:190629 Niimori D, Kawano R, Felemban A, Niimori-Kita K, Tanaka H, Ihn H, Ohta K, Tsukushi controls the hair cycle by regulating TGF-beta1 signaling. Dev Biol. 2012 Dec 1;372(1):81-7
1J:101311 Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ, Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005 Sep 16;280(37):32531-8
2J:176132 O'Leary J, Osborne LR, Global analysis of gene expression in the developing brain of gtf2ird1 knockout mice. PLoS One. 2011;6(8):e23868
6J:44398 Ohyama K, Kawano H, Kawamura K, Localization of extracellular matrix molecules, integrins and their regulators, TGF betas, is correlated with axon pathfinding in the spinal cord of normal and Danforth's short tail mice. Brain Res Dev Brain Res. 1997 Nov 12;103(2):143-54
5J:100384 Okano J, Takigawa T, Seki K, Suzuki S, Shiota K, Ishibashi M, Transforming growth factor beta2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol. 2005;49(1):23-31
2*J:108109 Oxburgh L, Chu GC, Michael SK, Robertson EJ, TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
6*J:52221 Paradies NE, Sanford LP, Doetschman T, Friedman RA, Developmental expression of the TGF beta s in the mouse cochlea. Mech Dev. 1998 Dec;79(1-2):165-8
6*J:32189 Paria BC, Jones KL, Flanders KC, Dey SK, Localization and binding of transforming growth factor-beta isoforms in mouse preimplantation embryos and in delayed and activated blastocysts. Dev Biol. 1992 May;151(1):91-104
1J:112269 Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K, Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development. 2006 Sep;133(17):3473-84
3J:11609 Pelton RW, Dickinson ME, Moses HL, Hogan BL, In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development. 1990 Oct;110(2):609-20
7*J:43626 Pelton RW, Saxena B, Jones M, Moses HL, Gold LI, Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol. 1991 Nov;115(4):1091-105
1J:99177 Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG, Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol. 2005 Jun;25(12):5073-83
1J:185712 Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, HarveyRP, An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 9;128(5):947-59
3J:29901 Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MW, Doetschman T, Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet. 1995 Dec;11(4):409-14
5J:147280 Pryce BA, Watson SS, Murchison ND, Staverosky JA, Dunker N, Schweitzer R, Recruitment and maintenance of tendon progenitors by TGF{beta} signaling are essential for tendon formation. Development. 2009 Apr;136(8):1351-61
1J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
1J:129349 Ribeiro I, Kawakami Y, Buscher D, Raya A, Rodriguez-Leon J, Morita M, Rodriguez Esteban C, Izpisua Belmonte JC, Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling. PLoS ONE. 2007;2(4):e398
4J:22323 Roelen BA, Lin HY, Knezevic V, Freund E, Mummery CL, Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo. Dev Biol. 1994 Dec;166(2):716-28
1J:132815 Ryckebusch L, Wang Z, Bertrand N, Lin SC, Chi X, Schwartz R, Zaffran S, Niederreither K, Retinoic acid deficiency alters second heart field formation. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2913-8
4J:194494 Sarraj MA, Escalona RM, Western P, Findlay JK, Stenvers KL, Effects of TGFbeta2 on Wild-Type and Tgfbr3 Knockout Mouse Fetal Testis. Biol Reprod. 2013;88(3):66
8J:31180 Schmid P, Cox D, Bilbe G, Maier R, McMaster GK, Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis. Development. 1991 Jan;111(1):117-30
2J:18657 Schmid P, Cox D, van der Putten H, McMaster GK, Bilbe G, Expression of TGF-beta s and TGF-beta type II receptor mRNAs in mouse folliculogenesis: stored maternal TGF-beta 2 message in oocytes. Biochem Biophys Res Commun. 1994 Jun 15;201(2):649-56
2J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1J:62831 Shipley JM, Mecham RP, Maus E, Bonadio J, Rosenbloom J, McCarthy RT, Baumann ML, Frankfater C, Segade F, Shapiro SD, Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. Mol Cell Biol. 2000 Jul;20(13):4879-87
1J:181526 Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, 't Hoen PA, Kispert A, Christoffels VM, Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2011 Dec 1;
7J:34424 Slager HG, Lawson KA, van den Eijnden-van Raaij AJ, de Laat SW, Mummery CL, Differential localization of TGF-beta 2 in mouse preimplantation and early postimplantation development. Dev Biol. 1991 Jun;145(2):205-18
5*J:91721 Smoak IW, Hyperglycemia-induced TGFbeta and fibronectin expression in embryonic mouse heart. Dev Dyn. 2004 Sep;231(1):179-89
2J:50050 St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, McMahon JA, Lewis PM, Paus R, McMahon AP, Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998 Sep 24;8(19):1058-68
2J:194131 Sugiyama D, Kulkeaw K, Mizuochi C, TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
1J:64492 Suzuki K, Yamanishi K, Mori O, Kamikawa M, Andersen B, Kato S, Toyoda T, Yamada G, Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Lett. 2000 Sep 8;481(1):53-6
2J:82356 Takahashi T, Takahashi K, St John PL, Fleming PA, Tomemori T, Watanabe T, Abrahamson DR, Drake CJ, Shirasawa T, Daniel TO, A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol. 2003 Mar;23(5):1817-31
3J:28346 Taylor LE, Bennett GD, Finnell RH, Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar;15(1):13-25
5*J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
2J:17586 Timme TL, Truong LD, Merz VW, Krebs T, Kadmon D, Flanders KC, Park SH, Thompson TC, Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis. Endocrinology. 1994 Mar;134(3):1039-45
3J:87765 Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC, de la Pompa JL, Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004 Jan 1;18(1):99-115
2J:167709 Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB, Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn. 2011 Jan;240(1):176-87
2J:128012 Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB, Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development. 2007 Oct;134(20):3723-32
3*J:151233 Trimarchi JM, Cho SH, Cepko CL, Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep;238(9):2327-9
3J:121629 Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK, TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol. 2007 May 15;305(2):508-521
1J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
5J:172391 Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL, Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One. 2011;6(4):e18723
1J:199879 Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B, Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One. 2013;8(4):e60244
1J:111284 Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M, M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
2J:35222 Whitby DJ, Ferguson MW, Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol. 1991 Sep;147(1):207-15
1*J:185683 Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B, Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res. 2011 Jul 8;109(2):183-92
1J:136063 Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC, Cited2 is required for fetal lung maturation. Dev Biol. 2008 May 1;317(1):95-105
1J:187117 Xu J, Qi X, Gong J, Yu M, Zhang F, Sha H, Gao X, Fstl1 antagonizes BMP signaling and regulates ureter development. PLoS One. 2012;7(4):e32554
1*J:145581 Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H, TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood. 2009 Feb 5;113(6):1250-6
1J:163721 Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B, E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul 1;120(7):2474-85
1J:210623 Yeh ML, Gonda Y, Mommersteeg MT, Barber M, Ypsilanti AR, Hanashima C, Parnavelas JG, Andrews WD, Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
1J:167938 Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD, TGF-beta signaling specifies axons during brain development. Cell. 2010 Jul 9;142(1):144-57
1*J:82768 Zhang Y, Mori T, Iseki K, Hagino S, Takaki H, Takeuchi M, Hikake T, Tase C, Murakawa M, Yokoya S, Wanaka A, Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice. Dev Dyn. 2003 Apr;226(4):618-26
6J:125640 Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM, Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct;39(10):1225-34

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