Gene Expression Literature Summary

• Symbol: Sptan1
• Name: spectrin alpha, non-erythrocytic 1
• ID: MGI:98386

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E13.5	E14.5	E15	E16	E16.5	E17.5	E18	E18.5	E20	E	P
Immunohistochemistry (section)	1	2			2	1	1	2	4	1	2	9
In situ RNA (section)			2
Immunohistochemistry (whole mount)									2			2
Northern blot				1								2
Western blot	1		1						1		1	5
RT-PCR											2	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sptan1  spectrin alpha, non-erythrocytic 1   (Synonyms: 2610027H02Rik, alpha-fodrin, alphaII-spectrin, Spna2, Spna-2)
Results	Reference
2*	J:306185 Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S, GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons. FASEB J. 2020 Dec;34(12):16601-16621
4	J:30147 Barisoni L, Trudel M, Chretien N, Ward L, van Adelsberg J, D'Agati V, Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. Am J Pathol. 1995 Dec;147(6):1728-35
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4	J:119451 Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV, Asymmetric distribution of Prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci. 2007 Mar 21;27(12):3139-47
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:273293 Du TT, Dewey JB, Wagner EL, Cui R, Heo J, Park JJ, Francis SP, Perez-Reyes E, Guillot SJ, Sherman NE, Xu W, Oghalai JS, Kachar B, Shin JB, LMO7 deficiency reveals the significance of the cuticular plate for hearing function. Nat Commun. 2019 Mar 8;10(1):1117
1	J:260849 El-Hassan AR, Leung V, Kharfallah F, Guyot MC, Allache R, Gros P, Kibar Z, Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2. Mamm Genome. 2018 Apr;29(3-4):229-244
1	J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
1	J:107653 Garcia-Fresco GP, Sousa AD, Pillai AM, Moy SS, Crawley JN, Tessarollo L, Dupree JL, Bhat MA, Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5137-42
1	J:157099 Grimsley-Myers CM, Sipe CW, Geleoc GS, Lu X, The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci. 2009 Dec 16;29(50):15859-69
2*	J:214712 Le Bras B, Freal A, Czarnecki A, Legendre P, Bullier E, Komada M, Brophy PJ, Davenne M, Couraud F, In vivo assembly of the axon initial segment in motor neurons. Brain Struct Funct. 2014 Jul;219(4):1433-50
5	J:142574 Legendre K, Safieddine S, Kussel-Andermann P, Petit C, El-Amraoui A, alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008 Oct 15;121(Pt 20):3347-56
1	J:164479 Lozovatsky L, Abayasekara N, Piawah S, Walther Z, CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell. 2009 Nov;20(21):4489-99
3	J:304965 Miazek A, Zalas M, Skrzymowska J, Bogin BA, Grzymajlo K, Goszczynski TM, Levine ZA, Morrow JS, Stankewich MC, Age-dependent ataxia and neurodegeneration caused by an alphaII spectrin mutation with impaired regulation of its calpain sensitivity. Sci Rep. 2021 Mar 31;11(1):7312
2*	J:202995 Ren DD, Kelly M, Kim SM, Grimsley-Myers CM, Chi FL, Chen P, Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice. Dev Dyn. 2013 Dec;242(12):1454-65
2	J:325068 Rudolf MA, Andreeva A, Kim CE, DeNovio AC, Koshar AN, Baker W, Cartagena-Rivera AX, Corwin JT, Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear. Front Cell Neurosci. 2022;16:859882
1	J:148808 Sawallisch C, Berhorster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp HJ, The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem. 2009 Apr 3;284(14):9225-36
2	J:163685 Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL, Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15151-6
1	J:175534 Sipe CW, Lu X, Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development. 2011 Aug;138(16):3441-9
4	J:186305 Stankewich MC, Cianci CD, Stabach PR, Ji L, Nath A, Morrow JS, Cell organization, growth, and neural and cardiac development require alphaII-spectrin. J Cell Sci. 2011 Dec 1;124(Pt 23):3956-66
1	J:175868 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC, Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct;31(19):4097-106
1	J:335806 Yan L, Yin H, Mi Y, Wu Y, Zheng Y, Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front Cell Dev Biol. 2023;11:1084245
2*	J:3114 Zimmer WE, Ma Y, Zagon IS, Goodman SR, Developmental expression of brain beta-spectrin isoform messenger RNAs. Brain Res. 1992 Oct 23;594(1):75-83