Gene Expression Literature Summary

• Symbol: Sod2
• Name: superoxide dismutase 2, mitochondrial
• ID: MGI:98352

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)									2	1		1	1	1		2	1		3
In situ RNA (section)									1	3		1	1	1		1
In situ RNA (whole mount)		1	1		1	1	1	1	1									1
Northern blot																			1
Western blot			1	1	2	1	1	2	4	1	1	2	2	1	2	1			11
RT-PCR	1	1	2	1	2	1	2	1	1	1	1	1	1	1	1	1		2	13

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sod2  superoxide dismutase 2, mitochondrial   (Synonyms: manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2)
Results	Reference
1	J:180632 Ahlemeyer B, Gottwald M, Baumgart-Vogt E, Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40
1	J:316661 Barallobre MJ, Perier C, Bove J, Laguna A, Delabar JM, Vila M, Arbones ML, DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. Cell Death Dis. 2014 Jun 12;5:e1289
1	J:274697 Celaya AM, Sanchez-Perez I, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Pintado-Berninches L, Perona R, Murillo-Cuesta S, Varela-Nieto I, Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159
4*	J:150363 Chung YW, Jeong D, Noh OJ, Park YH, Kang SI, Lee MG, Lee TH, Yim MB, Kim IY, Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death. Mol Cells. 2009 May;27(5):609-13
1	J:247084 Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC, FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014 Jul 07;115(2):238-251
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:57158 El Mouatassim S, Guerin P, Menezo Y, Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation. Mol Hum Reprod. 1999 Aug;5(8):720-5
1	J:250104 Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B, The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49
1	J:29012 Harvey MB, Arcellana-Panlilio MY, Zhang X, Schultz GA, Watson AJ, Expression of genes encoding antioxidant enzymes in preimplantation mouse and cow embryos and primary bovine oviduct cultures employed for embryo coculture. Biol Reprod. 1995 Sep;53(3):532-40
1	J:224310 Ishihara T, Ban-Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, Aoki H, Katada S, Nakada K, Nomura M, Mizushima N, Mihara K, Ishihara N, Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015 Jan;35(1):211-23
1	J:326350 Keppner A, Correia M, Santambrogio S, Koay TW, Maric D, Osterhof C, Winter DV, Clerc A, Stumpe M, Chalmel F, Dewilde S, Odermatt A, Kressler D, Hankeln T, Wenger RH, Hoogewijs D, Androglobin, a chimeric mammalian globin, is required for male fertility. Elife. 2022 Jun 14;11:e72374
2*	J:82905 Khan JY, Black SM, Developmental changes in murine brain antioxidant enzymes. Pediatr Res. 2003 Jul;54(1):77-82
2	J:152528 Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ, The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci. 2009 Aug;12(8):973-80
1	J:281366 Liu C, Tate T, Batourina E, Truschel ST, Potter S, Adam M, Xiang T, Picard M, Reiley M, Schneider K, Tamargo M, Lu C, Chen X, He J, Kim H, Mendelsohn CL, Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells. Nat Commun. 2019 Oct 9;10(1):4589
2	J:253948 Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD, Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol. 2016 Aug;97:1-14
1	J:344186 Munoz-Gallardo MDM, Garcia-Padilla C, Vicente-Garcia C, Carvajal J, Arenega A, Franco D, miR-195b is required for proper cellular homeostasis in the elderly. Sci Rep. 2024 Jan 8;14(1):810
1	J:100019 Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, van Rooij E, Richardson JA, Hill JA, De Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA, Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol. 2005 Aug;25(15):6629-38
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
2	J:316416 Perico L, Morigi M, Pezzotta A, Corna D, Brizi V, Conti S, Zanchi C, Sangalli F, Trionfini P, Butto S, Xinaris C, Tomasoni S, Zoja C, Remuzzi G, Benigni A, Imberti B, Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis. Sci Rep. 2021 Dec 8;11(1):23580
3	J:301859 Poche RA, Zhang M, Rueda EM, Tong X, McElwee ML, Wong L, Hsu CW, Dejosez M, Burns AR, Fox DA, Martin JF, Zwaka TP, Dickinson ME, RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Cell Rep. 2016 Feb 23;14(7):1684-1697
3*	J:181412 Powell KA, Davies JR, Taylor E, Wride MA, Votruba M, Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III. Invest Ophthalmol Vis Sci. 2011 Jun;52(7):4369-80
1	J:106626 Sanchez-Carbente MR, Castro-Obregon S, Covarrubias L, Narvaez V, Motoneuronal death during spinal cord development is mediated by oxidative stress. Cell Death Differ. 2005 Mar;12(3):279-91
2	J:108566 Schnabel D, Salas-Vidal E, Narvaez V, Sanchez-Carbente Mdel R, Hernandez-Garcia D, Cuervo R, Covarrubias L, Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death. Dev Biol. 2006 Mar 15;291(2):291-9
3*	J:345131 Schraps N, Tirre M, Pyschny S, Reis A, Schlierbach H, Seidl M, Kehl HG, Schanzer A, Heger J, Jux C, Drenckhahn JD, Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction. Free Radic Biol Med. 2024 Jan 22;213:248-265
1	J:141141 Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ, Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest. 2008 Oct;118(10):3378-89
1*	J:258689 Strappazzon F, Nazio F, Corrado M, Cianfanelli V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M, Cecconi F, AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ. 2015 Mar;22(3):419-32
1*	J:272586 Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4):dev168146
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:238642 Vrbacky M, Kovalcikova J, Chawengsaksophak K, Beck IM, Mracek T, Nuskova H, Sedmera D, Papousek F, Kolar F, Sobol M, Hozak P, Sedlacek R, Houstek J, Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet. 2016 Nov 01;25(21):4674-4685
1	J:125471 Wang J, Silva JP, Gustafsson CM, Rustin P, Larsson NG, Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4038-43
43*	J:174063 Yon JM, Baek IJ, Lee BJ, Yun YW, Nam SY, Dynamic expression of manganese superoxide dismutase during mouse embryonic organogenesis. Int J Dev Biol. 2011;55(3):327-34
1*	J:334015 Yoshioka H, Komura S, Kuramitsu N, Goto A, Hasegawa T, Amizuka N, Ishimoto T, Ozasa R, Nakano T, Imai Y, Akiyama H, Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures. J Bone Miner Metab. 2022 Sep;40(5):839-852
1	J:321746 Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B, LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021;143(20):2007-2022
4	J:342401 Zhao H, Wong RJ, Stevenson DK, The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185
2	J:315123 Zhong J, Xu C, Gabbay-Benziv R, Lin X, Yang P, Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy. Free Radic Biol Med. 2016 Jul;96:234-44