Gene Expression Literature Summary

• Symbol: Pmel
• Name: premelanosome protein
• ID: MGI:98301

20 matching records from 20 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	P
Immunohistochemistry (section)			1					2	1
In situ RNA (section)		2	2		2		2
In situ RNA (whole mount)	1	3	7	1	3	1
RT-PCR								2	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pmel  premelanosome protein   (Synonyms: D10H12S53E, D12S53Eh, gp100, gp87, Pmel17, Si)
Results	Reference
1	J:173609 Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL, The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun;138(12):2555-65
5*	J:86959 Baxter LL, Pavan WJ, Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development. Gene Expr Patterns. 2003 Dec;3(6):703-7
1*	J:152494 Behesti H, Papaioannou VE, Sowden JC, Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol. 2009 Sep 15;333(2):360-72
2	J:160209 Buac K, Xu M, Cronin J, Weeraratna AT, Hewitt SM, Pavan WJ, NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation. Pigment Cell Melanoma Res. 2009 Dec;22(6):773-84
2*	J:321576 Colombo S, Petit V, Wagner RY, Champeval D, Yajima I, Gesbert F, Aktary Z, Davidson I, Delmas V, Larue L, Stabilization of beta-catenin promotes melanocyte specification at the expense of the Schwann cell lineage. Development. 2022 Jan 15;149(2):dev194407
1	J:211299 Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, Gheldof A, De Craene B, Van Gele M, Brochez L, Udupi GM, Rafferty M, Balint B, Gallagher WM, Ghanem G, Huylebroeck D, Haigh J, van den Oord J, Larue L, Davidson I, Marine JC, Berx G, Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 2014 Aug;21(8):1250-61
1*	J:105843 Hakami RM, Hou L, Baxter LL, Loftus SK, Southard-Smith EM, Incao A, Cheng J, Pavan WJ, Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage. Mech Dev. 2006 Feb;123(2):124-34
1*	J:222440 Huang J, Liu Y, Oltean A, Beebe DC, Bmp4 from the optic vesicle specifies murine retina formation. Dev Biol. 2015 Jun 1;402(1):119-26
2	J:341969 Jacob T, Annusver K, Czarnewski P, Dalessandri T, Kalk C, Levra Levron C, Campama Sanz N, Kastriti ME, Mikkola ML, Rendl M, Lichtenberger BM, Donati G, Bjorklund AK, Kasper M, Molecular and spatial landmarks of early mouse skin development. Dev Cell. 2023 Oct 23;58(20):2140-2162.e5
1	J:101313 Lanning JL, Wallace JS, Zhang D, Diwakar G, Jiao Z, Hornyak TJ, Altered melanocyte differentiation and retinal pigmented epithelium transdifferentiation induced by Mash1 expression in pigment cell precursors. J Invest Dermatol. 2005 Oct;125(4):805-17
1*	J:157352 Loftus SK, Baxter LL, Buac K, Watkins-Chow DE, Larson DM, Pavan WJ, Comparison of melanoblast expression patterns identifies distinct classes of genes. Pigment Cell Melanoma Res. 2009 Oct;22(5):611-22
1*	J:242244 Ma X, Li H, Wang Y, Wang J, Zheng Q, Hua J, Yang J, Pan L, Lu F, Qu J, Hou L, DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium. Hum Mol Genet. 2017 May 01;26(9):1612-1621
1*	J:136642 Matera I, Watkins-Chow DE, Loftus SK, Hou L, Incao A, Silver DL, Rivas C, Elliott EC, Baxter LL, Pavan WJ, A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum Mol Genet. 2008 Jul 15;17(14):2118-31
2	J:226887 Raviv S, Bharti K, Rencus-Lazar S, Cohen-Tayar Y, Schyr R, Evantal N, Meshorer E, Zilberberg A, Idelson M, Reubinoff B, Grebe R, Rosin-Arbesfeld R, Lauderdale J, Lutty G, Arnheiter H, Ashery-Padan R, PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet. 2014;10(5):e1004360
3	J:242073 Seberg HE, Van Otterloo E, Loftus SK, Liu H, Bonde G, Sompallae R, Gildea DE, Santana JF, Manak JR, Pavan WJ, Williams T, Cornell RA, TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017 Mar;13(3):e1006636
1	J:133403 Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ, The secreted metalloprotease AMAMTS20 is required for melanoblast survival. PLoS Genet. 2008;4(2):e1000003
2*	J:194281 Silver DL, Leeds KE, Hwang HW, Miller EE, Pavan WJ, The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. Dev Biol. 2013 Mar 15;375(2):172-81
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:195156 Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Phan Dinh Tuy F, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA, Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet. 2013 Jan;9(1):e1003094
1*	J:279788 Wen B, Li S, Li H, Chen Y, Ma X, Wang J, Lu F, Qu J, Hou L, Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium. Sci Rep. 2016 Feb 15;6:21208