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Gene Expression Literature Summary
Symbol
Name
ID
Rara
retinoic acid receptor, alpha
MGI:97856

78 matching records from 78 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4.5 E6 E6.5 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19.5 E A
In situ protein (section) 1 1 1 2 2 1 3 4 2 1 1 2 2 3
In situ RNA (section) 2 2 1 5 2 1 1 4 2 11 9 2 6 2 7 4 1 4 3 1 4 12
In situ protein (whole mount) 1
In situ RNA (whole mount) 1 2 1 2 1 3 5 1 2 1 1 1 1
Northern blot 1 1 2 2 3 1 1 1 4
Western blot 1 1 2 1 1 1 2 1 2 1 3 2 2
RT-PCR 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 4 1 3 4 1 2 1 4 1 1 5 7
cDNA clones 1 1 1
RNase protection 1 1 3 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Rara  retinoic acid receptor, alpha   (Synonyms: RARalpha1, RAR alpha 1)
Results  Reference
1J:38786 Anchan RM, Drake DP, Haines CF, Gerwe EA, LaMantia AS, Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway [published erratum appears in J Comp Neurol 1997 Jul 28;384(2):321]. J Comp Neurol. 1997 Mar 10;379(2):171-84
6J:39333 Ang HL, Duester G, Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis. Dev Dyn. 1997 Apr;208(4):536-43
1J:85293 Bhasin N, Maynard TM, Gallagher PA, LaMantia AS, Mesenchymal/epithelial regulation of retinoic acid signaling in the olfactory placode. Dev Biol. 2003 Sep 1;261(1):82-98
1J:74102 Bitoh Y, Shimotake T, Kubota Y, Kimura O, Iwai N, Impaired distribution of retinoic acid receptors in the hindgut-tailgut region of murine embryos with anorectal malformations. J Pediatr Surg. 2001 Feb;36(2):377-80
4J:20940 Bloch-Zupan A, Decimo D, Loriot M, Mark MP, Ruch JV, Expression of nuclear retinoic acid receptors during mouse odontogenesis. Differentiation. 1994 Sep;57(3):195-203
3*J:90291 Bohnsack BL, Lai L, Dolle P, Hirschi KK, Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev. 2004 Jun 1;18(11):1345-58
1J:108333 Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, Yashiro K, Chawengsaksophak K, Wilson MJ, Rossant J, Hamada H, Koopman P, Retinoid signaling determines germ cell fate in mice. Science. 2006 Apr 28;312(5773):596-600
3J:101677 Butts SC, Liu W, Li G, Frenz DA, Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid. Birth Defects Res A Clin Mol Teratol. 2005 Apr;73(4):218-28
2J:165076 Cammas L, Trensz F, Jellali A, Ghyselinck NB, Roux MJ, Dolle P, Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3281-90
3*J:94934 Challen GA, Martinez G, Davis MJ, Taylor DF, Crowe M, Teasdale RD, Grimmond SM, Little MH, Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol. 2004 Sep;15(9):2344-57
1J:147160 Chambers D, Wilson LJ, Alfonsi F, Hunter E, Saxena U, Blanc E, Lumsden A, Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6
1J:179634 Chassot AA, Gregoire EP, Lavery R, Taketo MM, de Rooij DG, Adams IR, Chaboissier MC, RSPO1/beta-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One. 2011;6(10):e25641
1J:173924 Chatzi C, Brade T, Duester G, Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia. PLoS Biol. 2011 Apr;9(4):e1000609
1*J:84416 Chazaud C, Dolle P, Rossant J, Mollard R, Retinoic acid signaling regulates murine bronchial tubule formation. Mech Dev. 2003 Jun;120(6):691-700
2*J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1J:171491 Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ, Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol Biol. 2010 Mar;42(3):276-85
3J:45003 Colbert MC, Rubin WW, Linney E, LaMantia AS, Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. Dev Dyn. 1995 Sep;204(1):1-12
1J:197449 Coles GL, Ackerman KG, Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
5J:23958 Cook M, Gould A, Brand N, Davies J, Strutt P, Shaknovich R, Licht J, Waxman S, Chen Z, Gluecksohn-Waelsch S, Krumlauf R, Zelent A, Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2249-53
4J:106409 Desai TJ, Chen F, Lu J, Qian J, Niederreither K, Dolle P, Chambon P, Cardoso WV, Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol. 2006 Mar 1;291(1):12-24
3*J:45214 Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P, Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature. 1989 Dec 7;342(6250):702-5
3*J:29564 Dolle P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P, Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development. 1990 Dec;110(4):1133-51
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
5J:44591 Garel S, Marin F, Grosschedl R, Charnay P, Ebf1 controls early cell differentiation in the embryonic striatum. Development. 1999 Dec;126(23):5285-94
2*J:92497 Gaub MP, Rochette-Egly C, Lutz Y, Ali S, Matthes H, Scheuer I, Chambon P, Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation. Exp Cell Res. 1992 Aug;201(2):335-46
7J:43344 Ghyselinck NB, Dupe V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C , Chambon P , Mark M, Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997 Jun;41(3):425-47
2J:48522 Ghyselinck NB, Wendling O, Messaddeq N, Dierich A, Lampron C, Decimo D, Viville S, Chambon P, Mark M, Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart. Dev Biol. 1998 Jun 15;198(2):303-18
1J:140201 Goldie LC, Lucitti JL, Dickinson ME, Hirschi KK, Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis. Blood. 2008 Oct 15;112(8):3194-204
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3J:34183 Grondona JM, Kastner P, Gansmuller A, Decimo D, Chambon P, Mark M, Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Development. 1996 Jul;122(7):2173-88
3*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
7*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*J:3323 Harnish DC, Jiang H, Soprano KJ, Kochhar DM, Soprano DR, Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos. Dev Dyn. 1992 Jul;194(3):239-46
1J:152814 Hornberg M, Gussing F, Berghard A, Bohm S, Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation. J Neurochem. 2009 Aug;110(4):1263-75
1J:138257 Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD, Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb;13(2):159-70
1J:121381 Hu P, Zhang M, Napoli JL, Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Biochim Biophys Acta. 2007 Apr;1770(4):694-705
5J:159513 Huang J, Bi Y, Zhu GH, He Y, Su Y, He BC, Wang Y, Kang Q, Chen L, Zuo GW, Luo Q, Shi Q, Zhang BQ, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells. Liver Int. 2009 Nov;29(10):1569-81
7J:126275 Imanishi S, Sugimoto M, Morita M, Kume S, Manabe N, Changes in Expression and Localization of GPRC5B and RARalpha in the Placenta and Yolk Sac During Middle to Late Gestation in Mice. J Reprod Dev. 2007 Oct;53(5):1131-6
6J:81047 Kobayashi H, Spilde TL, Bhatia AM, Buckingham RB, Hembree MJ, Prasadan K, Preuett BL, Imamura M, Gittes GK, Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions. Gastroenterology. 2002 Oct;123(4):1331-40
3*J:12691 Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P, Function of retinoic acid receptor gamma in the mouse. Cell. 1993 May 21;73(4):643-58
2*J:13574 Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P, High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9
1*J:29061 Luo J, Pasceri P, Conlon RA, Rossant J, Giguere V, Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep;53(1):61-71
9J:98265 Makita T, Duncan SA, Sucov HM, Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 1;280(1):59-72
3J:170256 Marino D, Dabouras V, Brandli AW, Detmar M, A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development. J Vasc Res. 2010 Nov 23;48(3):236-251
1J:191130 Maynard TM, Gopalakrishna D, Meechan DW, Paronett EM, Newbern JM, Lamantia AS, 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
4*J:72759 McCaffery P, Wagner E, O'Neil J, Petkovich M, Drager UC, Dorsal and ventral rentinoic territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Mech Dev. 1999 Jul;85(1-2):203-14
1*J:52599 Mendelsohn C, Batourina E, Fung S, Gilbert T, Dodd J, Stromal cells mediate retinoid-dependent functions essential for renal development. Development. 1999 Mar;126(6):1139-48
5*J:63187 Mollard R, Viville S, Ward SJ, Decimo D, Chambon P, Dolle P, Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo. Mech Dev. 2000 Jun;94(1-2):223-32
5J:69008 Mori M, Ghyselinck NB, Chambon P, Mark M, Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. Invest Ophthalmol Vis Sci. 2001 May;42(6):1312-8
5*J:54162 Naitoh H, Mori C, Nishimura Y, Shiota K, Altered expression of retinoic acid (RA) receptor mRNAs in the fetal mouse secondary palate by all-trans and 13-cis RAs: implications for RA-induced teratogenesis. J Craniofac Genet Dev Biol. 1998 Oct-Dec;18(4):202-10
1J:68926 Nervi C, Borello U, Fazi F, Buffa V, Pelicci PG, Cossu G, Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. Cancer Res. 2001 Feb 15;61(4):1247-9
4*J:88404 Nishizawa H, Manabe N, Morita M, Sugimoto M, Imanishi S, Miyamoto H, Effects of in utero exposure to bisphenol A on expression of RARalpha and RXRalpha mRNAs in murine embryos. J Reprod Dev. 2003 Dec;49(6):539-45
2J:100386 Nishizawa H, Morita M, Sugimoto M, Imanishi S, Manabe N, Effects of in utero exposure to bisphenol a on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos. J Reprod Dev. 2005 Jun;51(3):315-24
2J:74219 Ogino Y, Suzuki K, Haraguchi R, Satoh Y, Dolle P, Yamada G, External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. Ann N Y Acad Sci. 2001 Dec;948:13-31
4J:57264 Raz Y, Kelley MW, Retinoic acid signaling is necessary for the development of the organ of Corti. Dev Biol. 1999 Sep 1;213(1):180-93
6*J:92496 Rochette-Egly C, Gaub MP, Lutz Y, Ali S, Scheuer I, Chambon P, Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues. Mol Endocrinol. 1992 Dec;6(12):2197-209
6*J:80765 Romand R, Hashino E, Dolle P, Vonesch JL, Chambon P, Ghyselinck NB, The retinoic acid receptors RARalpha and RARgamma are required for inner ear development. Mech Dev. 2002 Dec;119(2):213-23
1J:46635 Romand R, Sapin V, Dolle P, Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear. J Comp Neurol. 1998 Apr 13;393(3):298-308
4*J:32072 Ruberte E, Dolle P, Chambon P, Morriss-Kay G, Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development. 1991 Jan;111(1):45-60
1J:12881 Ruberte E, Friederich V, Chambon P, Morriss-Kay G, Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Development. 1993 May;118(1):267-82
1J:57145 Rubin WW, LaMantia AS, Age-dependent retinoic acid regulation of gene expression distinguishes the cervical, thoracic, lumbar, and sacral spinal cord regions during development. Dev Neurosci. 1999;21(2):113-25
8J:38200 Sapin V, Ward SJ, Bronner S, Chambon P, Dolle P, Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Dev Dyn. 1997 Feb;208(2):199-210
2*J:139174 Sato Y, Heuckeroth RO, Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Dev Biol. 2008 Aug 1;320(1):185-98
1J:173650 Sgantzis N, Yiakouvaki A, Remboutsika E, Kontoyiannis DL, HuR controls lung branching morphogenesis and mesenchymal FGF networks. Dev Biol. 2011 Jun 15;354(2):267-79
1J:28346 Taylor LE, Bennett GD, Finnell RH, Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar;15(1):13-25
2J:52596 Toresson H, Mata de Urquiza A, Fagerstrom C, Perlmann T, Campbell K, Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development. 1999 Mar;126(6):1317-26
2J:150707 Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H, Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009 Jul 15;23(14):1689-98
4*J:61711 Ulven SM, Gundersen TE, Weedon MS, Landaas VO, Sakhi AK, Fromm SH, Geronimo BA, Moskaug JO, Blomhoff R, Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Dev Biol. 2000 Apr 15;220(2):379-91
1*J:100030 Urano A, Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, Taki T, Akazawa H, Nakajima H, Komuro I, Yoshida N, Hayashi Y, Handa H, Kitamura T, Nosaka T, Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol. 2005 Aug;25(15):6834-45
2*J:134349 Vezina CM, Allgeier SH, Fritz WA, Moore RW, Strerath M, Bushman W, Peterson RE, Retinoic acid induces prostatic bud formation. Dev Dyn. 2008 May;237(5):1321-33
5J:19315 Viallet JP, Dhouailly D, Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development. J Invest Dermatol. 1994 Jul;103(1):116-21
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2J:47808 Whitesides J, Hall M, Anchan R, LaMantia AS, Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse. J Comp Neurol. 1998 May 18;394(4):445-61
2J:149466 Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M, Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009 Apr 15;328(2):315-27
12J:16894 Yamagata T, Momoi MY, Yanagisawa M, Kumagai H, Yamakado M, Momoi T, Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos. Brain Res Dev Brain Res. 1994 Feb 18;77(2):163-76
1*J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
3*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3*J:9855 Zelent A, Krust A, Petkovich M, Kastner P, Chambon P, Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature. 1989 Jun 29;339(6227):714-7

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last database update
07/15/2014
MGI 5.18
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