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Gene Expression Literature Summary
Symbol
Name
ID
Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2 E2.5 E3 E3.5 E4 E4.5 E5.5 E6.5 E7.5 E8 E8.5 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E14.5 E15 E15.5 E16.5 E17 E18 E18.5 E19 A
In situ protein (section) 1 1 1 2 1 4 1 2 1 1 1 1 1 1 1 1 1 11
In situ RNA (section) 3 1 3 1 1 1 1 1 8
In situ protein (whole mount) 1 1 1 1 1
Northern blot 1 1 1 3
Western blot 2 1 1 1 1 5
RT-PCR 1 1 1 1 1 2 1 1 1 2 1 2 2 1 9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ptgs2  prostaglandin-endoperoxide synthase 2   (Synonyms: Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, Pghs2, PGHS-2, PHS-2, prostaglandin G/H synthase, Tis10)
Results  Reference
1J:201804 Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ, Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol. 2013 Sep;11(9):e1001666
9J:33787 Chakraborty I, Das SK, Wang J, Dey SK, Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J Mol Endocrinol. 1996 Apr;16(2):107-22
3J:168442 Chang HY, Locker J, Lu R, Schuster VL, Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation. 2010 Feb 2;121(4):529-36
2J:178944 Daikoku T, Cha J, Sun X, Tranguch S, Xie H, Fujita T, Hirota Y, Lydon J, Demayo F, Maxson R, Dey SK, Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Dev Cell. 2011 Dec 13;21(6):1014-25
1J:101604 Li Q, Ishikawa TO, Oshima M, Taketo MM, The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res. 2005 Oct 1;65(19):8622-7
1J:56144 Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM, Dey SK, Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 1999 Jun 15;13(12):1561-74
1*J:122356 Lovgren AK, Kovarova M, Koller BH, cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol. 2007 Jun;27(12):4416-30
3J:68785 Mandal AK, Zhang Z, Chou JY, Zimonjic D, Keck CL, Popescu N, Mukherjee AB, Molecular characterization of murine pancreatic phospholipase A(2). DNA Cell Biol. 2001 Mar;20(3):149-57
5J:80198 Marshburn PB, Shabanowitz RB, Clark MR, Immunohistochemical localization of prostaglandin H synthase in the embryo and uterus of the mouse from ovulation through implantation. Mol Reprod Dev. 1990 Apr;25(4):309-16
4J:171849 Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T, Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011 Jan 4;121(1):318-27
10J:85979 Muller-Decker K, Leder C, Neumann M, Neufang G, Bayerl C, Schweizer J, Marks F, Furstenberger G, Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression. J Invest Dermatol. 2003 Oct;121(4):661-8
6J:201437 Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM, BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun 3;123(6):2539-50
5J:121988 Pakrasi PL, Jain AK, Evaluation of cyclooxygenase 2 derived endogenous prostacyclin in mouse preimplantation embryo development in vitro. Life Sci. 2007 Mar 27;80(16):1503-7
2J:185829 Park CB, DeMayo FJ, Lydon JP, Dufort D, NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod. 2012 Jun;86(6):194
5*J:79717 Park JM, Yang T, Arend LJ, Smart AM, Schnermann JB, Briggs JP, Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction. Am J Physiol. 1997 Oct;273(4 Pt 2):F538-44
5*J:77471 Parman T, Wells PG, Embryonic prostaglandin H synthase-2 (PHS-2) expression and benzo[a]pyrene teratogenicity in PHS-2 knockout mice. FASEB J. 2002 Jul;16(9):1001-9
1J:61911 Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA, Dey SK, Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 2000 May;141(5):1872-81
4J:55394 Reese J, Brown N, Paria BC, Morrow J, Dey SK, COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period [published erratum appears in Mol Cell Endocrinol 1999 Aug 20;154(1-2):195]. Mol Cell Endocrinol. 1999 Apr 25;150(1-2):23-31
2J:64073 Reese J, Paria BC, Brown N, Zhao X, Morrow JD, Dey SK, Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9759-64
4J:55108 Rocca B, Spain LM, Pure E, Langenbach R, Patrono C, FitzGerald GA, Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development. J Clin Invest. 1999 May 15;103(10):1469-77
2J:163898 Shim M, Foley J, Anna C, Mishina Y, Eling T, Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem. 2010 May 21;285(21):16206-17
4J:77681 Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow J, Bonventre JV, Dey SK, Cytosolic phospholipase A2alpha deficiency is crucial for 'on-time' embryo implantation that directs subsequent development. Development. 2002 Jun;129(12):2879-89
4J:164572 Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK, Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16887-92
6J:126290 Tong GQ, Heng BC, Ng SC, Cumulus-specific genes are transcriptionally silent following somatic cell nuclear transfer in a mouse model. J Zhejiang Univ Sci B. 2007 Aug;8(8):533-9
1J:142315 Tsai CY, Chou CK, Yang CW, Lai YC, Liang CC, Chen CM, Tsai TF, Hurp deficiency in mice leads to female infertility caused by an implantation defect. J Biol Chem. 2008 Sep 26;283(39):26302-6
5J:37534 van der Weiden RM, Wisse LJ, Helmerhorst FM, Keirse MJ, Poelmann RE, Immunohistochemical and ultrastructural localization of prostaglandin H synthase in the preimplantation mouse embryo. J Reprod Fertil. 1996 Jul;107(2):161-6
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3J:128959 Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK, Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor {delta} Signaling Is Critical to Pregnancy Success. J Biol Chem. 2007 Dec 28;282(52):37770-37782
1J:195917 Yajima I, Colombo S, Puig I, Champeval D, Kumasaka M, Belloir E, Bonaventure J, Mark M, Yamamoto H, Taketo MM, Choquet P, Etchevers HC, Beermann F, Delmas V, Monassier L, Larue L, A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus. PLoS One. 2013;8(1):e53183
1J:85229 Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P, Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003 Sep;35(1):49-56

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory