Gene Expression Literature Summary

• Symbol: Pfn1
• Name: profilin 1
• ID: MGI:97549

9 matching records from 9 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E17	E18.5	E20	P
Immunohistochemistry (section)						1			1
In situ reporter (knock in)	1	1		1							1				1
Northern blot															1
Western blot			2	1	1	1	3	1		3	1	2	1	2	5
RT-PCR															2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pfn1  profilin 1   (Synonyms: actin binding protein, Pfn)
Results	Reference
2*	J:282177 Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T, Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Front Mol Neurosci. 2019;12:231
7	J:310888 Di Domenico M, Jokwitz M, Witke W, Pilo Boyl P, Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure. Cells. 2021 Sep 3;10(9)
1*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
1	J:233564 Gurniak CB, Chevessier F, Jokwitz M, Jonsson F, Perlas E, Richter H, Matern G, Boyl PP, Chaponnier C, Furst D, Schroder R, Witke W, Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur J Cell Biol. 2014 May-Jun;93(5-6):252-66
6	J:209786 Gurniak CB, Witke W, HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics. Eur J Cell Biol. 2007 Jan;86(1):3-12
3	J:181033 Kullmann JA, Neumeyer A, Gurniak CB, Friauf E, Witke W, Rust MB, Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep. 2011 Jan;13(1):75-82
1	J:309992 Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA, Loss of endogenous thymosin beta4 accelerates glomerular disease. Kidney Int. 2016 Nov;90(5):1056-1070
6*	J:24346 Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ, Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7;81(1):41-51
6*	J:77643 Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ, Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6