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Gene Expression Literature Summary
platelet/endothelial cell adhesion molecule 1

1231 matching records from 1231 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E3.5 E4.5 E5.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E A
In situ protein (section) 1 1 1 10 15 52 39 149 28 146 18 113 18 150 9 126 10 118 14 85 10 73 6 53 13 105 3 3 3 59 257
In situ RNA (section) 1 1 2 2 1 2 2 3 2 2 1 2
In situ protein (whole mount) 2 6 14 67 33 171 16 138 13 58 5 59 2 48 2 29 1 18 2 11 1 14 1 13 2 22 46
In situ RNA (whole mount) 2 1 6 1 6 2 1 2 1 1 2
Northern blot 1 1 1 1 1 1 1 2
Western blot 1 1 1 1 1 2 1 1 1 1 5
RT-PCR 1 1 1 1 2 2 2 11 3 14 5 2 7 2 9 1 3 4 1 2 2 1 2 1 4 10 18
cDNA clones 1 3
RNase protection 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pecam1  platelet/endothelial cell adhesion molecule 1   (Synonyms: Cd31, PECAM-1)
Results  Reference
3J:123910 Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, Birot O, Ming Y, Kvanta A, Edholm D, Aspenstrom P, Kissil J, Claesson-Welsh L, Shimono A, Holmgren L, Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev. 2007 Aug 15;21(16):2055-68
2J:65909 Abbott BD, Buckalew AR, Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, ang-1, and tie-2. Dev Dyn. 2000 Dec;219(4):526-38
1J:148987 Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL, Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol. 2009 May;29(10):2748-61
2J:185552 Acharya A, Baek ST, Huang G, Eskiocak B, Goetsch S, Sung CY, Banfi S, Sauer MF, Olsen GS, Duffield JS, Olson EN, Tallquist MD, The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development. 2012 Jun;139(12):2139-49
2*J:98394 Adameyko II, Mudry RE, Houston-Cummings NR, Veselov AP, Gregorio CC, Tevosian SG, Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein. Dev Dyn. 2005 Jun;233(2):540-52
3J:117821 Adams D, Larman B, Oxburgh L, Developmental expression of mouse Follistatin-like 1 (Fstl1): Dynamic regulation during organogenesis of the kidney and lung. Gene Expr Patterns. 2007 Feb;7(4):491-500
1J:67296 Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R, The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 2001 Jan 12;104(1):57-69
1J:63877 Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR, Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell. 2000 Jul;6(1):109-16
2J:53085 Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R, Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999 Feb 1;13(3):295-306
4J:151060 Ahlbrecht K, Schmitz J, Seay U, Schwarz C, Mittnacht-Kraus R, Gaumann A, Haberberger RV, Herold S, Breier G, Grimminger F, Seeger W, Voswinckel R, Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development. Am J Respir Cell Mol Biol. 2008 Aug;39(2):163-70
2J:126886 Ahnfelt-Ronne J, Jorgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sorensen J, An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem. 2007 Sep;55(9):925-30
2J:93811 Ain R, Trinh ML, Soares MJ, Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface. Dev Dyn. 2004 Dec;231(4):700-8
1*J:68216 Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H, Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97
3J:211339 Al-Zahrani KN, Sekhon P, Tessier DR, Yockell-Lelievre J, Pryce BR, Baron KD, Howe GA, Sriram RK, Daniel K, Mckay M, Lo V, Quizi J, Addison CL, Gruslin A, Sabourin LA, Essential role for the SLK protein kinase in embryogenesis and placental tissue development. Dev Dyn. 2014 May;243(5):640-51
3J:69637 Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M, The wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev Biol. 2001 Jun 1;234(1):244-60
6J:33592 Alexander CM, Hansell EJ, Behrendtsen O, Flannery ML, Kishnani NS, Hawkes SP, Werb Z, Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development. 1996 Jun;122(6):1723-36
2J:134891 Alkemade FE, Gittenberger-de Groot AC, Schiel AE, VanMunsteren JC, Hogers B, van Vliet LS, Poelmann RE, Havekes LM, Willems van Dijk K, DeRuiter MC, Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life. Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2228-35
1J:139369 Allen JM, Brachvogel B, Farlie PG, Fitzgerald J, Bateman JF, The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes. Matrix Biol. 2008 May;27(4):295-305
1J:121898 Allinson KR, Carvalho RL, van den Brink S, Mummery CL, Arthur HM, Generation of a floxed allele of the mouse endoglin gene. Genesis. 2007 Jun;45(6):391-5
2J:178985 Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A, The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science. 2011 Dec 23;334(6063):1727-31
1J:144483 Alves NL, Goff OR, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP, Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1512-7
1J:126336 Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E, HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007 Nov;134(21):3917-28
1J:204445 Andersen DC, Laborda J, Baladron V, Kassem M, Sheikh SP, Jensen CH, Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013 Sep;140(18):3743-53
3*J:169064 Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12
2J:116978 Aoki M, Mieda M, Ikeda T, Hamada Y, Nakamura H, Okamoto H, R-spondin3 is required for mouse placental development. Dev Biol. 2007 Jan 1;301(1):218-26
5J:98453 Ara T, Tokoyoda K, Okamoto R, Koni PA, Nagasawa T, The role of CXCL12 in the organ-specific process of artery formation. Blood. 2005 Apr 15;105(8):3155-61
1J:137057 Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, Itohara S, Terasaki T, Oohira A, Mishina Y, Yamada M, BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 2008 Jul;38(3):417-30
1J:201332 Arnold TD, Zang K, Vallejo-Illarramendi A, Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality. Dis Model Mech. 2013 Sep-Oct;6(5):1205-12
1J:187154 Arora R, Metzger RJ, Papaioannou VE, Multiple roles and interactions of tbx4 and tbx5 in development of the respiratory system. PLoS Genet. 2012 Aug;8(8):e1002866
1J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1J:166932 Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H, Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development. 2010 Nov;137(22):3823-33
2J:128367 Astorga J, Carlsson P, Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development. 2007 Oct;134(20):3753-61
3J:126737 Astrof S, Crowley D, Hynes RO, Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol. 2007 Nov 1;311(1):11-24
2*J:83663 Atchison FW, Capel B, Means AR, Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003 Aug;130(15):3579-86
2J:98307 Azcoitia V, Aracil M, Martinez-A C, Torres M, The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 2005 Apr 15;280(2):307-20
2J:213517 Azzoni E, Conti V, Campana L, Dellavalle A, Adams RH, Cossu G, Brunelli S, Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo. Development. 2014 May;141(9):1821-34
5J:50951 Bader BL, Rayburn H, Crowley D, Hynes RO, Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 1998 Nov 13;95(4):507-19
1J:100029 Bader BL, Smyth N, Nedbal S, Miosge N, Baranowsky A, Mokkapati S, Murshed M, Nischt R, Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice. Mol Cell Biol. 2005 Aug;25(15):6846-56
2*J:177483 Baker JR, Jeffery R, May RD, Mathies M, Spencer-Dene B, Poulsom R, Hogg N, Distinct roles for S100a8 in early embryo development and in the maternal deciduum. Dev Dyn. 2011 Sep;240(9):2194-203
1J:188551 Balamotis MA, Pennella MA, Stevens JL, Wasylyk B, Belmont AS, Berk AJ, Complexity in transcription control at the activation domain-mediator interface. Sci Signal. 2009;2(69):ra20
13*J:29332 Baldwin HS, Shen HM, Yan HC, DeLisser HM, Chung A, Mickanin C, Trask T, Kirschbaum NE, Newman PJ, Albelda SM, Buck CA, Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development. 1994 Sep;120(9):2539-53
2J:76864 Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF, Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7734-9
3J:213328 Banerjee I, Moore Morris T, Evans SM, Chen J, Thymosin beta4 is not required for embryonic viability or vascular development. Circ Res. 2013 Feb 1;112(3):e25-8
3J:185264 Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J, Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3;110(3):456-64
2J:179687 Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D, Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97
1J:111623 Barbosky L, Lawrence DK, Karunamuni G, Wikenheiser JC, Doughman YQ, Visconti RP, Burch JB, Watanabe M, Apoptosis in the developing mouse heart. Dev Dyn. 2006 Jul 31;235(9):2592-2602
2*J:165398 Barnes RM, Firulli BA, Conway SJ, Vincentz JW, Firulli AB, Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn. 2010 Nov;239(11):3086-97
1J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9
3J:212526 Bartelle BB, Berrios-Otero CA, Rodriguez JJ, Friedland AE, Aristizabal O, Turnbull DH, Novel genetic approach for in vivo vascular imaging in mice. Circ Res. 2012 Mar 30;110(7):938-47
2J:79427 Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL, c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002 Oct 1;16(19):2530-43
1J:92637 Baumann CI, Bailey AS, Li W, Ferkowicz MJ, Yoder MC, Fleming WH, PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood. 2004 Aug 15;104(4):1010-6
3J:125783 Baumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, Wolburg H, Wolburg-Buchholz K, Deutsch U, Vestweber D, Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. 2006 Jun 15;107(12):4754-62
1J:152968 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T, Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug;17(2):175-86
1J:157997 Beck L, Leroy C, Beck-Cormier S, Forand A, Salaun C, Paris N, Bernier A, Urena-Torres P, Prie D, Ollero M, Coulombel L, Friedlander G, The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One. 2010;5(2):e9148
1J:180971 Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S, Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449
2*J:49955 Belaoussoff M, Farrington SM, Baron MH, Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
2J:128915 Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z, The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol Cell Biol. 2008 Jan;28(1):282-92
2J:113396 Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, Burton GJ, Murphy JJ, Norton JD, Clark AR, Turner M, The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn. 2006 Nov;235(11):3144-55
1J:131960 Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA, R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 2008 Mar;135(6):1049-58
2J:60503 Bellomo D, Headrick JP, Silins GU, Paterson CA, Thomas PS, Gartside M, Mould A, Cahill MM, Tonks ID, Grimmond SM, Townson S, Wells C, Little M, Cummings MC, Hayward NK, Kay GF, Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res. 2000 Feb 4;86(2):E29-35
1J:160610 Bellon A, Luchino J, Haigh K, Rougon G, Haigh J, Chauvet S, Mann F, VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain. Neuron. 2010 Apr 29;66(2):205-19
3J:210589 Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C, Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014 May 22;509(7501):507-11
3*J:99531 Benedito R, Duarte A, Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns. 2005 Aug;5(6):750-5
6J:145172 Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A, Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol. 2008;8:117
1J:188330 Benezech C, Mader E, Desanti G, Khan M, Nakamura K, White A, Ware CF, Anderson G, Caamano JH, Lymphotoxin-beta Receptor Signaling through NF-kappaB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells. Immunity. 2012 Oct 19;37(4):721-34
2*J:56426 Bi W, Drake CJ, Schwarz JJ, The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol. 1999 Jul 15;211(2):255-67
3J:171712 Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, Hooper SB, Cole TJ, cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
2J:112223 Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J, Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development. 2006 Sep;133(17):3429-40
5J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
3J:159112 Bohmer R, Neuhaus B, Buhren S, Zhang D, Stehling M, Bock B, Kiefer F, Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010 Mar 16;18(3):437-49
1J:201077 Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C, Integrin alphaIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 May 15;2(5):525-32
1J:175788 Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV, Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 2011;6(7):e22217
1J:186872 Bonegio RG, Beck LH, Kahlon RK, Lu W, Salant DJ, The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int. 2011 May;79(10):1099-112
2J:111643 Boras-Granic K, Grosschedl R, Hamel PA, Genetic interaction between Lef1 and Alx4 is required for early embryonic development. Int J Dev Biol. 2006;50(7):601-10
1J:52317 Borello U, Coletta M, Tajbakhsh S, Leyns L, De Robertis EM, Buckingham M, Cossu G, Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development. 1999 Oct;126(19):4247-55
6J:186594 Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S, CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res. 2011 Aug 19;109(5):486-91
1J:166085 Bott RC, Clopton DT, Fuller AM, McFee RM, Lu N, McFee RM, Cupp AS, KDR-LacZ-expressing cells are involved in ovarian and testis-specific vascular development, suggesting a role for VEGFA in the regulation of this vasculature. Cell Tissue Res. 2010 Oct;342(1):117-30
1J:202792 Boucherat O, Montaron S, Berube-Simard FA, Aubin J, Philippidou P, Wellik DM, Dasen JS, Jeannotte L, Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L817-30
2J:214083 Boucherat O, Nadeau V, Berube-Simard FA, Charron J, Jeannotte L, Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
3J:146210 Boulday G, Blecon A, Petit N, Chareyre F, Garcia LA, Niwa-Kawakita M, Giovannini M, Tournier-Lasserve E, Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech. 2009 Mar;2(3-4):168-77
2J:98922 Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development. 2005 Jul;132(13):3045-54
1J:125196 Bouma GJ, Washburn LL, Albrecht KH, Eicher EM, Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14994-9
1J:212891 Bouvree K, Brunet I, Del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A, Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation. Circ Res. 2012 Aug 3;111(4):437-45
2J:206581 Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, Francois M, Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
1J:206586 Boyle SC, Liu Z, Kopan R, Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development. 2014 Jan;141(2):346-54
1J:72548 Brachtendorf G, Kuhn A, Samulowitz U, Knorr R, Gustafsson E, Potocnik AJ, Fassler R, Vestweber D, Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoietic clusters in the dorsal aorta. Dev Dyn. 2001 Nov;222(3):410-9
2J:98505 Brachvogel B, Moch H, Pausch F, Schlotzer-Schrehardt U, Hofmann C, Hallmann R, von der Mark K, Winkler T, Poschl E, Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages. Development. 2005 Jun;132(11):2657-68
3*J:73299 Brachvogel B, Welzel H, Moch H, von der Mark K, Hofmann C, Poschl E, Sequential expression of annexin A5 in the vasculature and skeletal elements during mouse development. Mech Dev. 2001 Dec;109(2):389-93
1*J:137460 Bradford ST, Wilhelm D, Koopman P, Comparative analysis of anti-mouse SRY antibodies. Sex Dev. 2007;1(5):305-10
1J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
3J:104401 Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R, Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 2006 Jan 2;172(1):151-62
2J:30623 Breier G, Breviario F, Caveda L, Berthier R, Schnurch H, Gotsch U, Vestweber D, Risau W, Dejana E, Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
1J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
6J:76133 Brennan J, Karl J, Capel B, Divergent Vascular Mechanisms Downstream of Sry Establish the Arterial System in the XY Gonad. Dev Biol. 2002 Apr 15;244(2):418-28
3J:116552 Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC, Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov;55(11):2974-85
1J:188916 Brohl D, Vasyutina E, Czajkowski MT, Griger J, Rassek C, Rahn HP, Purfurst B, Wende H, Birchmeier C, Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
2J:111066 Brown D, Yu BD, Joza N, Benit P, Meneses J, Firpo M, Rustin P, Penninger JM, Martin GR, Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9918-23
6J:203143 Bryson JL, Griffith AV, Hughes B 3rd, Saito F, Takahama Y, Richie ER, Manley NR, Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus. PLoS One. 2013;8(6):e65196
1J:189958 Buaas FW, Gardiner JR, Clayton S, Val P, Swain A, In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development. 2012 Dec;139(24):4561-70
9J:36690 Buck CA, Edelman JM, Buck CE, Kennedy G, Baldwin HS, Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes Commun. 1996 Aug;4(2):69-87
3J:113303 Burgu B, McCarthy LS, Shah V, Long DA, Wilcox DT, Woolf AS, Vascular endothelial growth factor stimulates embryonic urinary bladder development in organ culture. BJU Int. 2006 Jul;98(1):217-25
2J:198769 Burstyn-Cohen T, Heeb MJ, Lemke G, Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest. 2009 Oct;119(10):2942-53
2J:185482 Burtscher I, Barkey W, Schwarzfischer M, Theis FJ, Lickert H, The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development. Genesis. 2012 Jun;50(6):496-505
2J:200762 Buttler K, Becker J, Pukrop T, Wilting J, Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice. Dev Biol. 2013 Sep 15;381(2):365-76
1J:136688 Buttler K, Ezaki T, Wilting J, Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev Biol. 2008;8:43
4*J:108556 Buttler K, Kreysing A, von Kaisenberg CS, Schweigerer L, Gale N, Papoutsi M, Wilting J, Mesenchymal cells with leukocyte and lymphendothelial characteristics in murine embryos. Dev Dyn. 2006 Jun;235(6):1554-1562
5*J:73775 Byrd N, Becker S, Maye P, Narasimhaiah R, St-Jacques B, Zhang X, McMahon J, McMahon A, Grabel L, Hedgehog is required for murine yolk sac angiogenesis. Development. 2002 Jan;129(2):361-72
1J:100584 Byrd NA, Meyers EN, Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005 Aug 1;284(1):233-45
1J:137459 Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM, A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 3;454(7200):104-8
2J:198628 Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL, Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
1J:110536 Cai Z, de Bruijn M, Ma X, Dortland B, Luteijn T, Downing RJ, Dzierzak E, Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity. 2000 Oct;13(4):423-31
4J:49374 Calabrese G, Fernandez de Recondo M, Recondo E, Wainstok de Calmanovici R, Platelet endothelial cell adhesion molecule-1 expression during mouse postimplantation development. Cell Mol Biol (Noisy-le-grand). 1998 May;44(3):537-41
1J:172050 Calderon L, Boehm T, Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7517-22
2J:186083 Calderon L, Boehm T, Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell. 2012 Mar 30;149(1):159-72
1J:152319 Calmont A, Ivins S, Van Bueren KL, Papangeli I, Kyriakopoulou V, Andrews WD, Martin JF, Moon AM, Illingworth EA, Basson MA, Scambler PJ, Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development. 2009 Sep;136(18):3173-83
2J:214093 Cambier L, Plate M, Sucov HM, Pashmforoush M, Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
1J:166217 Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO, The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLoS One. 2010;5(10):e13433
4J:28379 Canete Soler R, Gui YH, Linask KK, Muschel RJ, MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis and may be associated with vascularization. Brain Res Dev Brain Res. 1995 Aug 28;88(1):37-52
6J:205073 Cano E, Carmona R, Munoz-Chapuli R, Wt1-expressing progenitors contribute to multiple tissues in the developing lung. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L322-32
5J:196361 Cappellari O, Benedetti S, Innocenzi A, Tedesco FS, Moreno-Fortuny A, Ugarte G, Lampugnani MG, Messina G, Cossu G, Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013 Mar 25;24(6):586-99
7J:137137 Carlson TR, Hu H, Braren R, Kim YH, Wang RA, Cell-autonomous requirement for {beta}1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice. Development. 2008 Jun;135(12):2193-202
4J:32219 Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A, Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996 Apr 4;380(6573):435-9
4J:56509 Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oostuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, HerbertJM, Collen D, Dejana E, Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57
1J:171033 Carramolino L, Fuentes J, Garcia-Andres C, Azcoitia V, Riethmacher D, Torres M, Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis. Circ Res. 2010 Apr 16;106(7):1197-201
1J:98373 Carvalho RL, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karlsson S, Dijke PT, Arthur HM, Mummery CL, Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development. 2004 Dec;131(24):6237-47
2J:192176 Casanova JC, Travisano S, de la Pompa JL, Epithelial-to-mesenchymal transition in epicardium is independent of snail1. Genesis. 2013 Jan;51(1):32-40
1J:199615 Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R, Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem. 2013 Jun 7;288(23):16655-70
1J:196959 Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, Sitia G, Harrelson Z, Evans SM, Guidotti LG, Harvey RP, Brendolan A, Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18;38(4):782-91
3J:161794 Catela C, Kratsios P, Hede M, Lang F, Rosenthal N, Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis. Dev Dyn. 2010 Jun 21;
4J:85505 Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, Corsi A, Bianco P, Wolburg H, Moore R, Oreda B, Kemler R, Dejana E, The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol. 2003 Sep 15;162(6):1111-22
3J:92203 Chae SS, Paik JH, Allende ML, Proia RL, Hla T, Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol. 2004 Apr 15;268(2):441-7
3J:173947 Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY, Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest. 2011 May 2;121(5):1871-81
2J:163845 Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M, Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol. 2010;10:84
1J:192829 Chandler RL, Brennan J, Schisler JC, Serber D, Patterson C, Magnuson T, ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013 Jan;33(2):265-80
2J:210983 Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A, A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 2014 Jul;243(7):894-905
2J:116008 Chang S, Young BD, Li S, Qi X, Richardson JA, Olson EN, Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006 Jul 28;126(2):321-34
1J:189064 Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC, WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012 Dec;139(23):4461-72
1J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
1J:190484 Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML, Blood flow reprograms lymphatic vessels to blood vessels. J Clin Invest. 2012 Jun 1;122(6):2006-17
2J:183485 Chen D, Jarrell A, Guo C, Lang R, Atit R, Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012 Apr;139(8):1522-33
3J:164907 Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F, Impaired pancreatic development in Hif2-alpha deficient mice. Biochem Biophys Res Commun. 2010 Aug 27;399(3):440-5
1J:151951 Chen H, Ko G, Zatti A, Di Giacomo G, Liu L, Raiteri E, Perucco E, Collesi C, Min W, Zeiss C, De Camilli P, Cremona O, Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43
1J:195489 Chen H, Zhang W, Sun X, Yoshimoto M, Chen Z, Zhu W, Liu J, Shen Y, Yong W, Li D, Zhang J, Lin Y, Li B, Vandusen NJ, Snider P, Schwartz RJ, Conway SJ, Field LJ, Yoder MC, Firulli AB, Carlesso N, Towbin JA, Shou W, Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development. 2013 May;140(9):1946-57
2J:112200 Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis L, Decaestecker M, Takahashi T, Breyer MD, Hao CM, Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol. 2006 May;17(5):1283-91
1J:208766 Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Ruegg MA, Hall MN, Ma L, Long F, WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014 Jan;10(1):e1004145
2J:185237 Chen L, Ma Y, Kim EY, Yu W, Schwartz RJ, Qian L, Wang J, Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival. PLoS One. 2012;7(2):e31005
1J:159824 Chen L, Mupo A, Huynh T, Cioffi S, Woods M, Jin C, McKeehan W, Thompson-Snipes L, Baldini A, Illingworth E, Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol. 2010 May 3;189(3):417-24
2J:97450 Chen Q, Yuan Y, Lin S, Chang Y, Zhuo X, Wei W, Tao P, Ruan L, Li Q, Li Z, Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis. Biochem Biophys Res Commun. 2005 May 20;330(4):1230-6
1J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
4J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
1J:139006 Chen Y, Doughman YQ, Gu S, Jarrell A, Aota S, Cvekl A, Watanabe M, Dunwoodie SL, Johnson RS, van Heyningen V, Kleinjan DA, Beebe DC, Yang YC, Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development. 2008 Sep;135(17):2939-48
2*J:211539 Chen Y, Gridley T, Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res. 2013 Jun;28(6):1412-21
1J:191848 Cheng Z, Sundberg-Smith LJ, Mangiante LE, Sayers RL, Hakim ZS, Musunuri S, Maguire CT, Majesky MW, Zhou Z, Mack CP, Taylor JM, Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2193-202
1J:183874 Cherrier M, Sawa S, Eberl G, Notch, Id2, and RORgammat sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J Exp Med. 2012 Apr 9;209(4):729-40
6J:182738 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK, Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13;22(3):651-9
2J:129651 Chi L, Itaranta P, Zhang S, Vainio S, Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology. 2006 Aug;147(8):3777-88
1J:194202 Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E, The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest. 2012 Dec 3;122(12):4569-79
1J:206313 Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA, The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13:40
2J:198786 Chislock EM, Ring C, Pendergast AM, Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12432-7
1J:106177 Cho CH, Lee SY, Shin HS, Philipson KD, Lee CO, Partial rescue of the Na+-Ca2+ exchanger (NCX1) knock-out mouse by transgenic expression of NCX1. Exp Mol Med. 2003 Apr 30;35(2):125-35
2J:193165 Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ Jr, Grapin-Botton A, Magnuson MA, Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
1J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
1J:198502 Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G, The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol. 2013 May;15(5):502-10
1J:184511 Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE, Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012 Jun;139(11):1931-40
2J:135052 Cohen TV, Kosti O, Stewart CL, The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac. Development. 2007 Apr;134(7):1385-95
3J:31111 Collo G, Domanico SZ, Klier G, Quaranta V, Gradient of integrin alpha 6A distribution in the myocardium during early heart development. Cell Adhes Commun. 1995 May;3(2):101-13
2J:97179 Colnot C, de la Fuente L, Huang S, Hu D, Lu C, St-Jacques B, Helms JA, Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development. 2005 Mar;132(5):1057-67
3J:90362 Colnot C, Lu C, Hu D, Helms JA, Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Dev Biol. 2004 May 1;269(1):55-69
2*J:67305 Colnot CI, Helms JA, A molecular analysis of matrix remodeling and angiogenesis during long bone development. Mech Dev. 2001 Feb;100(2):245-50
1J:177793 Combes AN, Bowles J, Feng CW, Chiu HS, Khoo PL, Jackson A, Little MH, Tam PP, Koopman P, Expression and functional analysis of Dkk1 during early gonadal development. Sex Dev. 2011;5(3):124-30
2J:158334 Combes AN, Spiller CM, Harley VR, Sinclair AH, Dunwoodie SL, Wilhelm D, Koopman P, Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol. 2010;54(4):683-9
3J:145183 Combes AN, Wilhelm D, Davidson T, Dejana E, Harley V, Sinclair A, Koopman P, Endothelial cell migration directs testis cord formation. Dev Biol. 2009 Feb 1;326(1):112-20
1J:77480 Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P, Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002 Jul;8(7):702-10
1J:102537 Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, Carmeliet P, Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res. 2003 Dec 1;60(3):569-79
1J:141344 Compton LA, Potash DA, Brown CB, Barnett JV, Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res. 2007 Oct 12;101(8):784-91
1J:169003 Cool J, DeFalco TJ, Capel B, Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):167-72
2J:169692 Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL, Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011;11:12
5J:163848 Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E, The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell. 2010 Jun 15;18(6):938-49
2J:206194 Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E, Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609
1J:183829 Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH, Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
2J:157804 Corsi JM, Houbron C, Billuart P, Brunet I, Bouvree K, Eichmann A, Girault JA, Enslen H, Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76
1J:174772 Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A, Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 8;146(1):67-79
3*J:177134 Cossette S, Misra R, The identification of different endothelial cell populations within the mouse proepicardium. Dev Dyn. 2011 Oct;240(10):2344-53
3J:126065 Costa MR, Kessaris N, Richardson WD, Gotz M, Hedin-Pereira C, The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J Neurosci. 2007 Oct 17;27(42):11376-88
1J:166893 Cote M, Provost PR, Gerard-Hudon MC, Tremblay Y, Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth. BMC Dev Biol. 2010;10:111
1J:162821 Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC, Rossant J, Hedgehog regulates distinct vascular patterning events through VEGF-dependent and -independent mechanisms. Blood. 2010 Jul 29;116(4):653-60
1J:91492 Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M, Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol. 2004 Jul 15;271(2):263-71
2J:108646 Cowden KD, Simon MC, The bHLH/PAS factor MOP3 does not participate in hypoxia responses. Biochem Biophys Res Commun. 2002 Feb 1;290(4):1228-36
1J:145696 Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M, Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol Endocrinol. 2009 Mar;23(3):324-36
6J:80863 Crawley JT, Gu JM, Ferrell G, Esmon CT, Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. Thromb Haemost. 2002 Aug;88(2):259-66
2J:174203 Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M, miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol. 2011 Jun 27;193(7):1197-212
2J:98446 Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E, Drake CJ, VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood. 2005 Apr 1;105(7):2771-6
2J:92051 Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE, Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development. 2004 Aug;131(16):4095-105
1J:82211 Cui S, Schwartz L, Quaggin SE, Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn. 2003 Mar;226(3):512-22
1J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
4J:174085 Cunningham K, Uchida Y, O'Donnell E, Claudio E, Li W, Soneji K, Wang H, Mukouyama YS, Siebenlist U, Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet. 2011 Aug 15;20(16):3198-206
1J:183690 Curtis CD, Griffin CT, The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol. 2012 Apr;32(7):1312-20
2*J:86230 Cusella De Angelis MG, Balconi G, Bernasconi S, Zanetta L, Boratto R, Galli D, Dejana E, Cossu G, Skeletal myogenic progenitors in the endothelium of lung and yolk sac. Exp Cell Res. 2003 Nov 1;290(2):207-16
1J:154975 D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM, Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development. 2009 Dec;136(23):4043-53
1J:159507 D'Amico G, Korhonen EA, Waltari M, Saharinen P, Laakkonen P, Alitalo K, Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):207-9
7J:177484 Daane JM, Downs KM, Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis. Dev Dyn. 2011 Sep;240(9):2175-93
1J:106927 Dackor RT, Fritz-Six K, Dunworth WP, Gibbons CL, Smithies O, Caron KM, Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol Cell Biol. 2006 Apr;26(7):2511-8
4J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
1J:139168 Dakubo GD, Mazerolle C, Furimsky M, Yu C, St-Jacques B, McMahon AP, Wallace VA, Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol. 2008 Aug 1;320(1):242-55
1*J:75937 Damert A, Miquerol L, Gertsenstein M, Risau W, Nagy A, Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development. 2002 Apr;129(8):1881-92
3J:143865 Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA, Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):641-6
1J:166533 Daneman R, Zhou L, Kebede AA, Barres BA, Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010 Nov 25;468(7323):562-6
3J:206101 Danussi C, Del Bel Belluz L, Pivetta E, Modica TM, Muro A, Wassermann B, Doliana R, Sabatelli P, Colombatti A, Spessotto P, EMILIN1/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance. Mol Cell Biol. 2013 Nov;33(22):4381-94
1J:176605 Darland DC, Cain JT, Berosik MA, Saint-Geniez M, Odens PW, Schaubhut GJ, Frisch S, Stemmer-Rachamimov A, Darland T, D'Amore PA, Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Dev Biol. 2011 Oct 1;358(1):9-22
6J:213676 Dartsch N, Schulte D, Hagerling R, Kiefer F, Vestweber D, Fusing VE-cadherin to alpha-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation. Mol Cell Biol. 2014 May;34(9):1634-48
1*J:68158 Dauvillier S, Ott M, Renard J, Legouy E, BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development. Mech Dev. 2001 Mar;101(1-2):221-5
1*J:82458 Davenport TG, Jerome-Majewska LA, Papaioannou VE, Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development. 2003 May;130(10):2263-73
3J:194470 Davis RB, Curtis CD, Griffin CT, BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013 Mar;140(6):1272-81
2J:46399 de la Pompa JL, Timmerman LA, Takimoto H, Yoshida H, Elia AJ, Samper E, Potter J, Wakeham A, Marengere L, Langille BL, Crabtree GR, Mak TW, Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum [see comments]. Nature. 1998 Mar 12;392(6672):182-6
1J:131535 De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S, Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE. 2008;3(1):e1516
3J:211622 DeFalco T, Bhattacharya I, Williams AV, Sams DM, Capel B, Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
1J:202074 Defalco T, Saraswathula A, Briot A, Iruela-Arispe ML, Capel B, Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biol Reprod. 2013 Apr;88(4):91
5J:171480 DeFalco T, Takahashi S, Capel B, Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol. 2011 Apr 1;352(1):14-26
1*J:85424 DeFelice M, Silberschmidt D, DiLauro R, Xu Y, Wert SE, Weaver TE, Bachurski CJ, Clark JC, Whitsett JA, TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem. 2003 Sep 12;278(37):35574-83
3J:198676 Degenhardt K, Singh MK, Aghajanian H, Massera D, Wang Q, Li J, Li L, Choi C, Yzaguirre AD, Francey LJ, Gallant E, Krantz ID, Gruber PJ, Epstein JA, Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nat Med. 2013 Jun;19(6):760-5
4J:178290 del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Perez-Pomares JM, de la Pompa JL, Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis. Circ Res. 2011 Apr 1;108(7):824-36
2J:124179 Del Monte G, Grego-Bessa J, Gonzalez-Rajal A, Bolos V, De La Pompa JL, Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop. Dev Dyn. 2007 Sep;236(9):2594-614
1J:87374 Delacour A, Nepote V, Trumpp A, Herrera PL, Nestin expression in pancreatic exocrine cell lineages. Mech Dev. 2004 Jan;121(1):3-14
1J:181488 Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG, Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44(3):343-7
1J:137723 Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M, Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol. 2008 Jul 15;319(2):309-20
2J:207561 Dellinger MT, Meadows SM, Wynne K, Cleaver O, Brekken RA, Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One. 2013;8(9):e74686
4J:43111 Delorme B, Dahl E, Jarry-Guichard T, Briand JP, Willecke K, Gros D , Theveniau-Ruissy M, Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system. Circ Res. 1997 Sep;81(3):423-37
3J:198221 Deng Y, Larrivee B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M, Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood. 2013 May 9;121(19):3988-96, S1-9
2J:128702 Deng Y, Yang J, McCarty M, Su B, MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis. Am J Physiol Cell Physiol. 2007 Oct;293(4):C1404-11
1J:169713 Diao H, Aplin JD, Xiao S, Chun J, Li Z, Chen S, Ye X, Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biol Reprod. 2011 Feb;84(2):255-65
1J:114885 Dietz ML, Bernaciak TM, Vendetti F, Kielec JM, Hildebrand JD, Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. J Biol Chem. 2006 Jul 21;281(29):20542-54
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:196028 Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR, Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 2012 May 31;1(5):401-7
1J:107426 Dinapoli L, Batchvarov J, Capel B, FGF9 promotes survival of germ cells in the fetal testis. Development. 2006 Apr;133(8):1519-27
3J:125903 Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, Thurston G, Yancopoulos GD, Gale NW, Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8
2J:190411 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY, Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem. 2012 Sep 14;287(38):32172-9
2J:64681 Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafii S, Hempstead BL, Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000 Nov;127(21):4531-40
4J:100174 Dorner AA, Wegmann F, Butz S, Wolburg-Buchholz K, Wolburg H, Mack A, Nasdala I, August B, Westermann J, Rathjen FG, Vestweber D, Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development. J Cell Sci. 2005 Aug 1;118(Pt 15):3509-21
1J:209469 Douglas NC, Arora R, Chen CY, Sauer MV, Papaioannou VE, Investigating the role of tbx4 in the female germline in mice. Biol Reprod. 2013 Dec;89(6):148
1*J:179731 Douglas NC, Heng K, Sauer MV, Papaioannou VE, Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system. Dev Dyn. 2012 Feb;241(2):365-75
2J:150211 Downes M, Francois M, Ferguson C, Parton RG, Koopman P, Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet. 2009 Aug 1;18(15):2839-50
2J:70294 Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T, McNagny KM, Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. J Exp Med. 2001 Jul 2;194(1):13-27
1J:98982 Doyonnas R, Nielsen JS, Chelliah S, Drew E, Hara T, Miyajima A, McNagny KM, Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood. 2005 Jun 1;105(11):4170-8
3J:60758 Drake CJ, Fleming PA, Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood. 2000 Mar 1;95(5):1671-9
5J:207219 Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM, Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013 Dec 12;504(7479):277-81
2J:164506 Drogat B, Kalucka J, Gutierrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmuller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ, Vegf regulates embryonic erythroid development through Gata1 modulation. Blood. 2010 Sep 23;116(12):2141-51
1*J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
5J:214531 Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K, Tao W, Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS One. 2014;9(3):e90701
2J:86673 Duan LJ, Nagy A, Fong GH, Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol Reprod. 2003 Dec;69(6):1852-8
5J:93157 Duarte A, Hirashima M, Benedito R, Trindade A, Diniz P, Bekman E, Costa L, Henrique D, Rossant J, Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004 Oct 15;18(20):2474-8
3J:137630 Dubois NC, Adolphe C, Ehninger A, Wang RA, Robertson EJ, Trumpp A, Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development. 2008 Jul;135(14):2455-65
2J:50761 Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K, Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science. 1998 Oct 30;282(5390):946-9
1J:53225 Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, Luis de la Pompa J, Elia A, Wakeham A, Karan-Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW, Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol. 1999 Mar 1;162(5):3022-30
2J:208714 Duong T, Koltowska K, Pichol-Thievend C, Le Guen L, Fontaine F, Smith KA, Truong V, Skoczylas R, Stacker SA, Achen MG, Koopman P, Hogan BM, Francois M, VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 2014 Feb 13;123(7):1102-12
1J:100441 Dupays L, Jarry-Guichard T, Mazurais D, Calmels T, Izumo S, Gros D, Theveniau-Ruissy M, Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants. J Mol Cell Cardiol. 2005 May;38(5):787-98
1J:106827 Duvillie B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ, Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology. 2002 Apr;143(4):1530-7
2J:206881 Dyer L, Wu Y, Moser M, Patterson C, BMPER-induced BMP signaling promotes coronary artery remodeling. Dev Biol. 2014 Feb 15;386(2):385-94
1J:106392 Eblaghie MC, Reedy M, Oliver T, Mishina Y, Hogan BL, Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol. 2006 Mar 1;291(1):67-82
2J:189829 Edqvist PH, Niklasson M, Vidal-Sanz M, Hallbook F, Forsberg-Nilsson K, Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation. PLoS One. 2012;7(8):e42488
1*J:97177 Edsbagge J, Johansson JK, Esni F, Luo Y, Radice GL, Semb H, Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 2005 Mar;132(5):1085-92
1J:96118 Eguchi M, Eguchi-Ishimae M, Green A, Enver T, Greaves M, Directing oncogenic fusion genes into stem cells via an SCL enhancer. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1133-8
2J:139945 El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M, SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development. 2008 Sep;135(17):2981-91
1J:170236 El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D, Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1;350(1):112-26
1J:173840 El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D, Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15;353(2):242-58
5*J:58825 Elefanty AG, Begley CG, Hartley L, Papaevangeliou B, Robb L, SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues. Blood. 1999 Dec 1;94(11):3754-63
1J:159593 Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MV, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, Condorelli G, The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ. 2009 Dec;16(12):1590-8
1J:109435 Ema M, Takahashi S, Rossant J, Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood. 2006 Jan 1;107(1):111-7
8J:140543 Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S, Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood. 2006 Dec 15;108(13):4018-24
1*J:164221 Enciso JM, Konecny CM, Karpen HE, Hirschi KK, Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a rac1 and FAK activation pathway in vivo. Dev Dyn. 2010 Aug 24;
2J:198627 Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H, Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013 Aug;140(15):3128-38
1*J:87377 Enkhmandakh B, Bitchevaia N, Ruddle F, Bayarsaihan D, The early embryonic expression of TFII-I during mouse preimplantation development. Gene Expr Patterns. 2004 Jan;4(1):25-8
1J:195593 Epaud R, Aubey F, Xu J, Chaker Z, Clemessy M, Dautin A, Ahamed K, Bonora M, Hoyeau N, Flejou JF, Mailleux A, Clement A, Henrion-Caude A, Holzenberger M, Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. PLoS One. 2012;7(11):e48071
1J:147266 Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ, Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell. 2004 Mar;6(3):437-43
2J:84753 Escalante-Alcalde D, Hernandez L, Le Stunff H, Maeda R, Lee HS, Jr-Gang-Cheng, Sciorra VA, Daar I, Spiegel S, Morris AJ, Stewart CL, The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development. 2003 Oct;130(19):4623-37
6J:147285 Eshkar-Oren I, Viukov SV, Salameh S, Krief S, Oh CD, Akiyama H, Gerber HP, Ferrara N, Zelzer E, The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development. 2009 Apr;136(8):1263-72
1J:202337 Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM, Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15;382(2):375-84
1J:62744 Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, Alber Kuivenhoven J, Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000 Mar 13;2(2):67-75
10J:104223 Fagman H, Andersson L, Nilsson M, The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation. Dev Dyn. 2006 Feb;235(2):444-55
4J:117856 Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, Nilsson M, The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum Mol Genet. 2007 Feb 1;16(3):276-85
2J:200563 Fan P, Chen Z, Tian P, Liu W, Jiao Y, Xue Y, Bhattacharya A, Wu J, Lu M, Guo Y, Cui Y, Gu W, Gu W, Yue J, miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival. PLoS One. 2013;8(4):e60888
2J:196018 Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W, Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012 Jul 26;2(1):52-61
1J:193938 Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL, Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol. 2012 Oct;14(10):1046-56
1J:208348 Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, Ruhrberg C, Zachary I, Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development. 2014 Feb;141(3):556-62
1J:176047 Fantin A, Schwarz Q, Davidson K, Normando EM, Denti L, Ruhrberg C, The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development. 2011 Oct;138(19):4185-91
2J:163512 Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S, Peri F, Wilson SW, Ruhrberg C, Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. 2010 Aug 5;116(5):829-40
1J:195430 Fantin A, Vieira JM, Plein A, Denti L, Fruttiger M, Pollard JW, Ruhrberg C, NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood. 2013 Mar 21;121(12):2352-62
1J:201629 Faurobert E, Rome C, Lisowska J, Manet-Dupe S, Boulday G, Malbouyres M, Balland M, Bouin AP, Keramidas M, Bouvard D, Coll JL, Ruggiero F, Tournier-Lasserve E, Albiges-Rizo C, CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol. 2013 Aug 5;202(3):545-61
2J:162664 Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z, PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development. Mol Cell Biol. 2010 Jul;30(14):3711-21
2J:166769 Feng X, Krebs LT, Gridley T, Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development. 2010 Dec;137(24):4191-9
3J:118252 Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA, Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
1J:166627 Feng Y, Yang Y, Ortega MM, Copeland JN, Zhang M, Jacob JB, Fields TA, Vivian JL, Fields PE, Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood. 2010 Nov 25;116(22):4483-91
1J:177142 Ferdous A, Morris J, Abedin MJ, Collins S, Richardson JA, Hill JA, Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16307-12
4*J:171432 Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H, Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011 May;138(10):1925-34
1J:111418 Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G, Blasi F, Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol. 2006 Aug;26(15):5650-62
1J:162692 Finzsch M, Schreiner S, Kichko T, Reeh P, Tamm ER, Bosl MR, Meijer D, Wegner M, Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010 May 17;189(4):701-12
2J:97663 Fiore R, Rahim B, Christoffels VM, Moorman AF, Puschel AW, Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system. Mol Cell Biol. 2005 Mar;25(6):2310-9
2J:89444 Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M, The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
4*J:90268 Fitch MJ, Campagnolo L, Kuhnert F, Stuhlmann H, Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn. 2004 Jun;230(2):316-24
1J:186497 Flaht A, Jankowska-Steifer E, Radomska DM, Madej M, Gula G, Kujawa M, Ratajska A, Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts. Dev Dyn. 2012 Sep;241(9):1473-86
4J:211183 Flaht-Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska-Steifer E, Madej M, Niderla-Bielinska J, Radomska-Lesniewska D, Ratajska A, Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec (Hoboken). 2014 Jun;297(6):1115-30
2J:187965 Fleming A, Ghahramani N, Zhu MX, Delot EC, Vilain E, Membrane beta-catenin and adherens junctions in early gonadal patterning. Dev Dyn. 2012 Nov;241(11):1782-98
1J:100236 Flintoff-Dye NL, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W, Burkin DJ, Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn. 2005 Sep;234(1):11-21
1J:142875 Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ, The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec;4(12):e1000315
1J:26845 Fong GH, Rossant J, Gertsenstein M, Breitman ML, Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 6;376(6535):66-70
1*J:54830 Fong GH, Zhang L, Bryce DM, Peng J, Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development. 1999 Jul;126(13):3015-25
3J:115909 Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH, Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell. 2006 Jan 13;124(1):161-73
2J:131558 Foster K, Sheridan J, Veiga-Fernandes H, Roderick K, Pachnis V, Adams R, Blackburn C, Kioussis D, Coles M, Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol. 2008 Mar 1;180(5):3183-9
1J:159895 Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D, The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26;285(9):6770-80
1J:93083 Fraidenraich D, Stillwell E, Romero E, Wilkes D, Manova K, Basson CT, Benezra R, Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science. 2004 Oct 8;306(5694):247-52
4J:140104 Franco CA, Mericskay M, Parlakian A, Gary-Bobo G, Gao-Li J, Paulin D, Gustafsson E, Li Z, Serum response factor is required for sprouting angiogenesis and vascular integrity. Dev Cell. 2008 Sep;15(3):448-61
5J:143564 Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P, Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008 Dec 4;456(7222):643-7
1J:183953 Francois M, Short K, Secker GA, Combes A, Schwarz Q, Davidson TL, Smyth I, Hong YK, Harvey NL, Koopman P, Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol. 2012 Apr 15;364(2):89-98
1J:78685 Frank DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM, An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development. 2002 Oct;129(19):4591-603
3J:140245 French WJ, Creemers EE, Tallquist MD, Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep;28(18):5646-57
2J:130930 Fritz-Six KL, Dunworth WP, Li M, Caron KM, Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest. 2008 Jan;118(1):40-50
1J:181550 Frob F, Bremer M, Finzsch M, Kichko T, Reeh P, Tamm ER, Charnay P, Wegner M, Establishment of myelinating schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Glia. 2012 May;60(5):806-19
2J:144581 Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L, Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov;118(11):3725-37
1J:152272 Fu Y, Chang A, Chang L, Niessen K, Eapen S, Setiadi A, Karsan A, Differential regulation of transforming growth factor {beta} signaling pathways by notch in human endothelial cells. J Biol Chem. 2009 Jul 17;284(29):19452-62
1J:170886 Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM, The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011 Feb 18;144(4):577-89
1*J:129634 Fukuda T, Yamagata K, Fujiyama S, Matsumoto T, Koshida I, Yoshimura K, Mihara M, Naitou M, Endoh H, Nakamura T, Akimoto C, Yamamoto Y, Katagiri T, Foulds C, Takezawa S, Kitagawa H, Takeyama K, O'Malley BW, Kato S, DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nat Cell Biol. 2007 May;9(5):604-11
1J:135553 Furman C, Sieminski AL, Kwiatkowski AV, Rubinson DA, Vasile E, Bronson RT, Fassler R, Gertler FB, Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol. 2007 Nov 19;179(4):761-75
2J:92247 Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N, Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004 Aug 13;279(33):34741-9
2J:189007 Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG, Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov;139(21):4007-19
3J:189010 Gaengel K, Niaudet C, Hagikura K, Siemsen BL, Muhl L, Hofmann JJ, Ebarasi L, Nystrom S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellstrom M, Fuxe J, Uhlen P, Adams R, Jakobsson L, Majumdar A, VestweberD, Uv A, Betsholtz C, The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell. 2012 Sep 11;23(3):587-99
3J:67371 Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, Yancopoulos GD, Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 2001 Feb 15;230(2):151-60
4J:94740 Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD, Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54
1J:104351 Gao X, Chen X, Taglienti M, Rumballe B, Little MH, Kreidberg JA, Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development. 2005 Dec;132(24):5437-49
1J:173953 Gara SK, Grumati P, Squarzoni S, Sabatelli P, Urciuolo A, Bonaldo P, Paulsson M, Wagener R, Differential and restricted expression of novel collagen VI chains in mouse. Matrix Biol. 2011 May;30(4):248-57
2J:165114 Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T, Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9)
1*J:155152 Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R, Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. Circ Res. 2008 Sep 26;103(7):710-6
1J:208880 Gauvrit S, Philippe J, Lesage M, Tjwa M, Godin I, Germain S, The role of RNA interference in the developmental separation of blood and lymphatic vasculature. Vasc Cell. 2014;6(1):9
2J:160476 Ge C, Stanley P, Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes. BMC Dev Biol. 2010;10:36
1J:154510 Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R, Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol. 2009 Oct;28(8):456-62
1J:69576 Gendron RL, Adams LC, Paradis H, Tubedown-1, a novel acetyltransferase associated with blood vessel development. Dev Dyn. 2000 Jun;218(2):300-15
3J:43434 George EL, Baldwin HS, Hynes RO, Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood. 1997 Oct 15;90(8):3073-81
3*J:74909 Gerety SS, Anderson DJ, Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development. 2002 Mar;129(6):1397-410
5J:57908 Gerety SS, Wang HU, Chen ZF, Anderson DJ, Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999 Sep;4(3):403-14
1J:139005 Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS, Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008 Sep;135(17):2959-68
2J:209773 Gewies A, Castineiras-Vilarino M, Ferch U, Jahrling N, Heinrich K, Hoeckendorf U, Przemeck GK, Munding M, Gross O, Schroeder T, Horsch M, Karran EL, Majid A, Antonowicz S, Beckers J, Hrabe de Angelis M, Dodt HU, Peschel C, Forster I, Dyer MJ, Ruland J, Prdm6 is essential for cardiovascular development in vivo. PLoS One. 2013;8(11):e81833
1J:77384 Gill J, Malin M, Hollander GA, Boyd R, Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol. 2002 Jul;3(7):635-42
3J:91658 Gitler AD, Lu MM, Epstein JA, PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
1J:174860 Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP, Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. Blood. 2011 Jul 28;118(4):1163-74
2J:134643 Goddeeris MM, Rho S, Petiet A, Davenport CL, Johnson GA, Meyers EN, Klingensmith J, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. Development. 2008 May;135(10):1887-95
1J:135134 Goddeeris MM, Schwartz R, Klingensmith J, Meyers EN, Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development. 2007 Apr;134(8):1593-604
2J:145756 Goldman DC, Donley N, Christian JL, Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis. Mech Dev. 2009 Mar-Apr;126(3-4):117-27
2J:108516 Goldman DC, Hackenmiller R, Nakayama T, Sopory S, Wong C, Kulessa H, Christian JL, Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development. 2006 May;133(10):1933-42
2J:187355 Goldshmit Y, Galea MP, Bartlett PF, Turnley AM, EphA4 regulates central nervous system vascular formation. J Comp Neurol. 2006 Aug 20;497(6):864-75
1J:199943 Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K, Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation. Bone. 2013 Jul;55(1):102-12
1J:107987 Gonzalez-Iriarte M, Carmona R, Perez-Pomares JM, Macias D, Costell M, Munoz-Chapuli R, Development of the coronary arteries in a murine model of transposition of great arteries. J Mol Cell Cardiol. 2003 Jul;35(7):795-802
8J:173280 Goossens S, Janzen V, Bartunkova S, Yokomizo T, Drogat B, Crisan M, Haigh K, Seuntjens E, Umans L, Riedt T, Bogaert P, Haenebalcke L, Berx G, Dzierzak E, Huylebroeck D, Haigh JJ, The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization. Blood. 2011 May 26;117(21):5620-30
7*J:137168 Gordon EJ, Gale NW, Harvey NL, Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn. 2008 Jul;237(7):1901-9
3J:167063 Gordon EJ, Rao S, Pollard JW, Nutt SL, Lang RA, Harvey NL, Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development. 2010 Nov;137(22):3899-910
1J:168516 Gordon FE, Nutt CL, Cheunsuchon P, Nakayama Y, Provencher KA, Rice KA, Zhou Y, Zhang X, Klibanski A, Increased expression of angiogenic genes in the brains of mouse meg3-null embryos. Endocrinology. 2010 Jun;151(6):2443-52
1J:176247 Gordon J, Manley NR, Mechanisms of thymus organogenesis and morphogenesis. Development. 2011 Sep;138(18):3865-78
1J:110623 Gori F, Friedman LG, Demay MB, Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol. 2006 Jul 15;295(2):498-506
4*J:54177 Gory-Faure S, Prandini MH, Pointu H, Roullot V, Pignot-Paintrand I, Vernet M, Huber P, Role of vascular endothelial-cadherin in vascular morphogenesis. Development. 1999 May;126(10):2093-102
1J:175454 Goss AM, Tian Y, Cheng L, Yang J, Zhou D, Cohen ED, Morrisey EE, Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol. 2011 Aug 15;356(2):541-52
3J:138334 Goupille O, Saint Cloment C, Lopes M, Montarras D, Robert B, Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells. Dev Dyn. 2008 Aug;237(8):2187-94
4J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
1J:136236 Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B, Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008 May 29;453(7195):662-6
5J:108464 Grazioli A, Alves CS, Konstantopoulos K, Yang JT, Defective blood vessel development and pericyte/pvSMC distribution in alpha4 integrin-deficient mouse embryos. Dev Biol. 2006 May 1;293(1):165-77
1J:119151 Grego-Bessa J, Luna-Zurita L, del Monte G, Bolos V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Perez-Pomares JM, de la Pompa JL, Notch signaling is essential for ventricular chamber development. Dev Cell. 2007 Mar;12(3):415-29
10J:189012 Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA, Radial construction of an arterial wall. Dev Cell. 2012 Sep 11;23(3):482-93
1J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57
1J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
2J:130852 Griffin CT, Brennan J, Magnuson T, The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb;135(3):493-500
3J:169096 Griffin CT, Curtis CD, Davis RB, Muthukumar V, Magnuson T, The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2282-7
3J:71309 Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR, A role for thrombin receptor signaling in endothelial cells during embryonic development. Science. 2001 Aug 31;293(5535):1666-70
1J:196480 Grisanti L, Clavel C, Cai X, Rezza A, Tsai SY, Sennett R, Mumau M, Cai CL, Rendl M, Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. J Invest Dermatol. 2013 Feb;133(2):344-53
1J:93314 Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W, Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 2004 Nov 11;167(1):149-60
1J:93799 Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD, Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul;5(1):45-57
3J:95697 Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD, Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8
2J:77728 Gu JL, Muller S, Mancino V, Offermanns S, Simon MI, Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9352-7
1J:170840 Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Munoz-Chapuli R, Hastie ND, Perez-Pomares JM, Martinez-Estrada OM, Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2. Development. 2011 Mar;138(6):1093-7
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:137592 Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71
1J:176445 Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M, Connective tissue growth factor acts within both endothelial cells and {beta} cells to promote proliferation of developing {beta} cells. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15242-7
1J:128936 Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK, The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol. 2008 Jan;28(1):397-409
5J:195888 Gustafsson E, Almonte-Becerril M, Bloch W, Costell M, Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. PLoS One. 2013;8(1):e53715
2J:122656 Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K, Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
8J:194396 Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F, A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013 Feb 12;32(5):629-44
1J:196827 Hahn N, Dietz CT, Kuhl S, Vossmerbaeumer U, Kroll J, KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Invest Ophthalmol Vis Sci. 2012 May;53(6):3260-8
3J:137909 Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K, Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol. 2008 Aug;28(15):4843-50
3J:185218 Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM, CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 2012;7(2):e30562
1*J:93580 Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW, A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Development. 2004 Oct;131(20):5197-209
1J:66259 Hamada K, Oike Y, Takakura N, Ito Y, Jussila L, Dumont DJ, Alitalo K, Suda T, VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis. Blood. 2000 Dec 1;96(12):3793-800
3J:100493 Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A, The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005 Sep 1;19(17):2054-65
1J:120082 Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman JR, Tanaka S, Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta. Differentiation. 2007 Mar;75(3):268-78
2*J:83560 Hamilton TG, Klinghoffer RA, Corrin PD, Soriano P, Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol. 2003 Jun;23(11):4013-25
2J:131988 Han D, Jeon S, Sohn DH, Lee C, Ahn S, Kim WK, Chung H, Seong RH, SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development. Dev Biol. 2008 Mar 1;315(1):136-46
3J:98913 Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ, Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?. Circ Res. 2004 Apr 30;94(8):1115-23
1J:162637 Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP, Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature. 2010 Jul 1;466(7302):62-7
1J:189751 Hara T, Shitara S, Imai K, Miyachi H, Kitano S, Yao H, Tani-ichi S, Ikuta K, Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol. 2012 Aug 15;189(4):1577-84
1J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
2J:159025 Hattori T, Muller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bosl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K, SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development. 2010 Mar;137(6):901-11
1J:203163 Hayashi M, Pluchinotta M, Momiyama A, Tanaka Y, Nishikawa S, Kataoka H, Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp Hematol. 2012 Sep;40(9):738-750.e11
5J:137645 He C, Hu H, Braren R, Fong SY, Trumpp A, Carlson TR, Wang RA, c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development. 2008 Jul;135(14):2467-77
6J:171969 He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W, Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal. 2010;3(116):ra26
3*J:65677 Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV, VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev Dyn. 2000 Nov;219(3):341-52
1J:203907 Herrnberger L, Seitz R, Kuespert S, Bosl MR, Fuchshofer R, Tamm ER, Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem Cell Biol. 2012 Nov;138(5):709-24
7J:200722 Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE, Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
2J:134127 Hidai C, Kawana M, Habu K, Kazama H, Kawase Y, Iwata T, Suzuki H, Quertermous T, Kokubun S, Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery. Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec;287(2):1165-75
1J:152574 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA, Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96
3J:143962 High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA, Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1955-9
3J:77905 Hildebrand JD, Soriano P, Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
2J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21
1J:177843 Hillman RT, Feng BY, Ni J, Woo WM, Milenkovic L, Hayden Gephart MG, Teruel MN, Oro AE, Chen JK, Scott MP, Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev. 2011 Nov 15;25(22):2333-46
2J:192195 Himes KP, Koppes E, Chaillet JR, Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
5*J:135686 Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T, Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 1;316(1):149-59
1J:146415 Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T, PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006 Apr;133(7):1389-98
1J:87890 Hisa T, Spence SE, Rachel RA, Fujita M, Nakamura T, Ward JM, Devor-Henneman DE, Saiki Y, Kutsuna H, Tessarollo L, Jenkins NA, Copeland NG, Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J. 2004 Jan 28;23(2):450-9
2J:189213 Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y, Iruela-Arispe ML, Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 2012 Dec;139(23):4449-60
1J:170943 Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A, Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
1J:120302 Holster T, Pakkanen O, Soininen R, Sormunen R, Nokelainen M, Kivirikko KI, Myllyharju J, Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. J Biol Chem. 2007 Jan 26;282(4):2512-9
5J:139204 Holtz ML, Misra RP, Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality. BMC Dev Biol. 2008;8:65
1J:171452 Holtz ML, Misra RP, Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev Biol. 2011;11:18
1J:122868 Hong KH, Seki T, Oh SP, Activin receptor-like kinase 1 is essential for placental vascular development in mice. Lab Invest. 2007 Jul;87(7):670-9
2J:84800 Horiuchi K, Weskamp G, Lum L, Hammes HP, Cai H, Brodie TA, Ludwig T, Chiusaroli R, Baron R, Preissner KT, Manova K, Blobel CP, Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol. 2003 Aug;23(16):5614-24
1J:88638 Hosaka T, Biggs WH 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC, Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004 Apr 2;101(9):2975-80
1J:150354 Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T, Tutt D, Davidson T, Browne C, Dejana E, Koopman P, Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development. 2009 Jul;136(14):2385-91
2J:152840 Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, Shen CK, Yan YT, Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 2009 Sep 3;583(17):2765-71
2J:139642 Hou Y, Li F, Karin M, Ostrowski MC, Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Sep 24;237(10):2926-2935
1J:176596 Hu D, Cross JC, Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta. Dev Biol. 2011 Oct 1;358(1):231-9
1J:183412 Hu GD, Chen YH, Zhang L, Tong WC, Cheng YX, Luo YL, Cai SX, Zhang L, The generation of the endothelial specific cdc42-deficient mice and the effect of cdc42 deletion on the angiogenesis and embryonic development. Chin Med J (Engl). 2011 Dec;124(24):4155-9
2J:157570 Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z, Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
2*J:87043 Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J, Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development. 2003 Dec;130(24):6111-9
1*J:171497 Huang HP, Hong CL, Kao CY, Lin SW, Lin SR, Wu HL, Shi GY, You LR, Wu CL, Yu IS, Gene targeting and expression analysis of mouse Tem1/endosialin using a lacZ reporter. Gene Expr Patterns. 2011 Mar 22;
2J:198192 Huang J, Arsenault M, Kann M, Lopez-Mendez C, Saleh M, Wadowska D, Taglienti M, Ho J, Miao Y, Sims D, Spears J, Lopez A, Wright G, Hartwig S, The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013 Jun;242(6):790-9
9J:137692 Huang X, Gao X, Diaz-Trelles R, Ruiz-Lozano P, Wang Z, Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180. Dev Biol. 2008 Jul 15;319(2):258-66
1J:182094 Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ, Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2575-86
1J:170679 Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB, Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011 Feb;9(2):e1001020
3J:162581 Huillard E, Ziercher L, Blond O, Wong M, Deloulme JC, Souchelnytskyi S, Baudier J, Cochet C, Buchou T, Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol. 2010 Jun;30(11):2737-49
4J:181120 Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S, Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15;21(6):1374-83
1J:122952 Hung IH, Yu K, Lavine KJ, Ornitz DM, FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol. 2007 Jul 15;307(2):300-13
1J:68468 Huss WJ, Hanrahan CF, Barrios RJ, Simons JW, Greenberg NM, Angiogenesis and prostate cancer: identification of a molecular progression switch. Cancer Res. 2001 Mar 15;61(6):2736-43
1J:147972 Hutcheson DA, Zhao J, Merrell A, Haldar M, Kardon G, Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin. Genes Dev. 2009 Apr 15;23(8):997-1013
1J:95106 Iavarone A, King ER, Dai XM, Leone G, Stanley ER, Lasorella A, Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature. 2004 Dec 23;432(7020):1040-5
1J:130931 Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T, The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest. 2008 Jan;118(1):29-39
2J:143529 Ichise H, Ichise T, Ohtani O, Yoshida N, Phospholipase C{gamma}2 is necessary for separation of blood and lymphatic vasculature in mice. Development. 2009 Jan;136(2):191-5
2J:159024 Ichise T, Yoshida N, Ichise H, H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development. 2010 Mar;137(6):1003-13
1J:146619 Ieda M , Tsuchihashi T , Ivey KN , Ross RS , Hong TT , Shaw RM , Srivastava D, Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb;16(2):233-44
1*J:70060 Ikeda A, Ikeda S, Gridley T, Nishina PM, Naggert JK, Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum Mol Genet. 2001 Jun 1;10(12):1325-34
1J:115338 Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y, Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development. 2006 Nov;133(22):4463-73
2J:82150 Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH, Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21;92(3):300-7
2J:199909 Im SK, Jeong H, Jeong HW, Kim KT, Hwang D, Ikegami M, Kong YY, Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
1J:94723 Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, Krane SM, Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7
3J:207517 Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, Griffin CT, The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013 Dec;9(12):e1004031
2J:119027 Inman KE, Downs KM, Brachyury is required for elongation and vasculogenesis in the murine allantois. Development. 2006 Aug;133(15):2947-59
2J:188305 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y, Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 May;31(4):234-45
1J:52605 Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM, Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development. 2001 Jan;128(1):25-33
2J:119566 Ishimura A, Ng JK, Taira M, Young SG, Osada S, Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct;133(19):3919-28
1J:108713 Itaranta P, Chi L, Seppanen T, Niku M, Tuukkanen J, Peltoketo H, Vainio S, Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney. Dev Biol. 2006 May 15;293(2):473-83
2J:185149 Itoh F, Itoh S, Adachi T, Ichikawa K, Matsumura Y, Takagi T, Festing M, Watanabe T, Weinstein M, Karlsson S, Kato M, Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. Blood. 2012 May 31;119(22):5320-8
4J:149886 Itoh F, Itoh S, Carvalho RL, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S, Mummery CL, Dijke PT, Kato M, Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation. Lab Invest. 2009 Jul;89(7):800-10
1*J:97633 Ivanova M, Dobrzycka KM, Jiang S, Michaelis K, Meyer R, Kang K, Adkins B, Barski OA, Zubairy S, Divisova J, Lee AV, Oesterreich S, Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol. 2005 Apr;25(8):2995-3006
1J:83260 Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM, Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun;130(12):2779-91
4J:45554 Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL, Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998 Jan 15;12(2):149-62
1J:135241 Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV, Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan;46(1):8-18
1J:101033 Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB, GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005 Oct;234(2):355-62
4J:107401 Jadrich JL, O'connor MB, Coucouvanis E, The TGF{beta} activated kinase TAK1 regulates vascular development in vivo. Development. 2006 Apr;133(8):1529-41
1J:213127 Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML, Lymphatic function is required prenatally for lung inflation at birth. J Exp Med. 2014 May 5;211(5):815-26
1J:212472 James AC, Szot JO, Iyer K, Major JA, Pursglove SE, Chapman G, Dunwoodie SL, Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochim Biophys Acta. 2014 Jul;1843(7):1272-84
5J:204444 James JM, Nalbandian A, Mukouyama YS, TGFbeta signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin. Development. 2013 Sep;140(18):3903-14
3J:188056 Jameson SA, Lin YT, Capel B, Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol. 2012 Oct 1;370(1):24-32
1J:101320 Jeanes A, Wilhelm D, Wilson MJ, Bowles J, McClive PJ, Sinclair AH, Koopman P, Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction. 2005 Oct;130(4):509-16
3J:174022 Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, Quaggin SE, Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011 Jun 1;121(6):2278-89
1J:106304 Jeays-Ward K, Dandonneau M, Swain A, Wnt4 is required for proper male as well as female sexual development. Dev Biol. 2004 Dec 15;276(2):431-40
3*J:84602 Jeays-Ward K, Hoyle C, Brennan J, Dandonneau M, Alldus G, Capel B, Swain A, Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development. 2003 Aug;130(16):3663-70
1J:114852 Jiang F, Herman GE, Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet. 2006 Nov 15;15(22):3293-305
3J:199291 Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J, Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep;140(17):3589-94
1*J:153715 Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ, Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56
2J:205426 Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X, Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Mol Cell Biol. 2013 Nov;33(21):4181-97
1J:154905 Joeng KS, Long F, The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009 Dec;136(24):4177-85
3J:163480 Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H, N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010 Jun;48(6):374-81
1J:194049 Johansson PA, Irmler M, Acampora D, Beckers J, Simeone A, Gotz M, The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
2J:199917 Johnen H, Gonzalez-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM, Gadd45g is essential for primary sex determination, male fertility and testis development. PLoS One. 2013;8(3):e58751
1J:191756 Johnson KD, Hsu AP, Ryu MJ, Wang J, Gao X, Boyer ME, Liu Y, Lee Y, Calvo KR, Keles S, Zhang J, Holland SM, Bresnick EH, Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity. J Clin Invest. 2012 Oct 1;122(10):3692-704
1J:160004 Jokela H, Rantakari P, Lamminen T, Strauss L, Ola R, Mutka AL, Gylling H, Miettinen T, Pakarinen P, Sainio K, Poutanen M, Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. Endocrinology. 2010 Apr;151(4):1884-92
6J:133680 Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY, Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med. 2008 Apr;14(4):448-53
2J:137628 Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A, Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development. 2008 Jul;135(14):2479-88
7J:190719 Joza S, Wang J, Fox E, Hillman V, Ackerley C, Post M, Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
1J:180262 Jubb AM, Strickland LA, Liu SD, Mak J, Schmidt M, Koeppen H, Neuropilin-1 expression in cancer and development. J Pathol. 2012 Jan;226(1):50-60
1J:167708 Jung Y, Kissil JL, McCarty JH, beta8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart. Dev Dyn. 2011 Jan;240(1):271-7
1J:154863 Junge HJ, Yang S, Burton JB, Paes K, Shu X, French DM, Costa M, Rice DS, Ye W, TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009 Oct 16;139(2):299-311
3J:170815 Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES, RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 2011 Mar 17;471(7338):368-72
1J:95006 Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, Sapozhnikov AM, Whitsett JA, Costa RH, Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L521-30
4J:70364 Kalinichenko VV, Lim L, Stolz DB, Shin B, Rausa FM, Clark J, Whitsett JA, Watkins SC, Costa RH, Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol. 2001 Jul 15;235(2):489-506
3J:173649 Kanady JD, Dellinger MT, Munger SJ, Witte MH, Simon AM, Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol. 2011 Jun 15;354(2):253-66
1J:130822 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R, Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15;313(2):584-93
1J:103761 Kaneko-Oshikawa C, Nakagawa T, Yamada M, Yoshikawa H, Matsumoto M, Yada M, Hatakeyama S, Nakayama K, Nakayama KI, Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol Cell Biol. 2005 Dec;25(24):10953-64
2J:152727 Kanemura H, Satoh T, Bilasy SE, Ueda S, Hirashima M, Kataoka T, Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2009 Oct 2;387(4):754-9
1J:131554 Kang J, Gu Y, Li P, Johnson BL, Sucov HM, Thomas PS, PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008 Mar;237(3):692-701
4J:213291 Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ, Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013 Jun 21;113(1):22-31
5J:87394 Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, Betsholtz C, Alitalo K, Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004 Jan;5(1):74-80
2J:161985 Karunamuni G, Yang K, Doughman YQ, Wikenheiser J, Bader D, Barnett J, Austin A, Parsons-Wingerter P, Watanabe M, Expression of lymphatic markers during avian and mouse cardiogenesis. Anat Rec (Hoboken). 2010 Feb;293(2):259-70
2J:48268 Kasarskis A, Manova K, Anderson KV, A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
2J:173620 Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B, p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth. Development. 2011 Jun;138(11):2235-47
2J:214903 Kataoka H, Hayashi M, Kobayashi K, Ding G, Tanaka Y, Nishikawa S, Region-specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6-positive caudal-lateral primitive mesoderm. Exp Hematol. 2013 Jun;41(6):567-581.e9
5J:183083 Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, Tabin CJ, Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13;22(3):639-50
1*J:162757 Kawamura N, Tabata H, Sun-Wada GH, Wada Y, Optic Nerve Compression and Retinal Degeneration in Tcirg1 Mutant Mice Lacking the Vacuolar-Type H-ATPase a3 Subunit. PLoS One. 2010;5(8):e12086
1*J:58077 Kawasaki T, Kitsukawa T, Bekku Y, Matsuda Y, Sanbo M, Yagi T, Fujisawa H, A requirement for neuropilin-1 in embryonic vessel formation. Development. 1999 Nov;126(21):4895-902
1J:75836 Kearney JB, Ambler CA, Monaco KA, Johnson N, Rapoport RG, Bautch VL, Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood. 2002 Apr 1;99(7):2397-407
1J:90967 Kearney JB, Kappas NC, Ellerstrom C, DiPaola FW, Bautch VL, The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood. 2004 Jun 15;103(12):4527-35
1J:69874 Keith B, Adelman DM, Simon MC, Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6692-7
3J:193320 Keller LV, Kuchler-Bopp S, Lesot H, Restoring physiological cell heterogeneity in the mesenchyme during tooth engineering. Int J Dev Biol. 2012;56(9):737-46
5*J:128893 Kertesz N, Wu J, Chen TH, Sucov HM, Wu H, The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 1;276(1):101-10
1J:130907 Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O'Connor CL, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ, A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol. 2008 Jan 1;180(1):601-8
1J:209515 Khalaj M, Abbasi A, Yamanishi H, Akiyama K, Wakitani S, Kikuchi S, Hirose M, Yuzuriha M, Magari M, Degheidy HA, Abe K, Ogura A, Hashimoto H, Kunieda T, A missense mutation in Rev7 disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem. 2014 Feb 7;289(6):3811-24
1J:121242 Khandekar M, Brandt W, Zhou Y, Dagenais S, Glover TW, Suzuki N, Shimizu R, Yamamoto M, Lim KC, Engel JD, A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Development. 2007 May;134(9):1703-12
4J:131824 Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R, Takakura N, Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J. 2008 Feb 6;27(3):522-34
1J:72108 Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabe de Angelis M, The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8
2J:119297 Kikkawa Y, Miner JH, Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function. Dev Biol. 2006 Aug 1;296(1):265-77
1*J:168037 Kim B, Kim Y, Sakuma R, Hui CC, Ruther U, Jorgensen JS, Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol. 2011 Jan 15;349(2):417-26
3J:100263 Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV, The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005 Jun 10;280(23):22278-86
10*J:122404 Kim KE, Sung HK, Koh GY, Lymphatic development in mouse small intestine. Dev Dyn. 2007 Jul;236(7):2020-5
4J:204461 Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H, Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms. Mech Dev. 2013 Nov-Dec;130(11-12):553-66
2J:189883 Kim ST, Adair-Kirk TL, Senior RM, Miner JH, Functional consequences of cell type-restricted expression of laminin alpha5 in mouse placental labyrinth and kidney glomerular capillaries. PLoS One. 2012;7(7):e41348
4J:110252 Kim Y, Kobayashi A, Sekido R, DiNapoli L, Brennan J, Chaboissier MC, Poulat F, Behringer RR, Lovell-Badge R, Capel B, Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 2006 Jun;4(6):e187
5J:144857 Kim YH, Hu H, Guevara-Gallardo S, Lam MT, Fong SY, Wang RA, Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development. 2008 Nov;135(22):3755-64
2J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
2J:199297 Kitagawa M, Hojo M, Imayoshi I, Goto M, Ando M, Ohtsuka T, Kageyama R, Miyamoto S, Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech Dev. 2013 Sep-Oct;130(9-10):458-66
1J:184822 Kitagawa M, Takebe A, Ono Y, Imai T, Nakao K, Nishikawa SI, Era T, Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-alpha. J Biol Chem. 2012 Jun 23;
2*J:175301 Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H, Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Expr Patterns. 2011 Oct;11(7):371-7
1J:146528 Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML, Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
2J:153248 Kogata N, Tribe RM, Fassler R, Way M, Adams RH, Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction. Genes Dev. 2009 Oct 1;23(19):2278-83
4J:164800 Koike S, Keino-Masu K, Masu M, Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun. 2010 Sep 10;400(1):66-71
4J:164765 Kokai E, Voss F, Fleischer F, Kempe S, Marinkovic D, Wolburg H, Leithauser F, Schmidt V, Deutsch U, Wirth T, Myc regulates embryonic vascular permeability and remodeling. Circ Res. 2009 May 22;104(10):1151-9
5J:206877 Kolander KD, Holtz ML, Cossette SM, Duncan SA, Misra RP, Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol. 2014 Feb 1;386(1):204-15
4*J:71479 Kolatsi-Joannou M, Li XZ, Suda T, Yuan HT, Woolf AS, Expression and potential role of angiopoietins and Tie-2 in early development of the mouse metanephros. Dev Dyn. 2001 Sep;222(1):120-6
1J:215101 Kondo S, Bottos A, Allegood JC, Masson R, Maurer FG, Genoud C, Kaeser P, Huwiler A, Murakami M, Spiegel S, Hynes NE, Memo has a novel role in S1P signaling and crucial for vascular development. PLoS One. 2014;9(4):e94114
1J:106055 Kono M, Mi Y, Liu Y, Sasaki T, Allende ML, Wu YP, Yamashita T, Proia RL, The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem. 2004 Jul 9;279(28):29367-73
2J:156090 Koo BH, Coe DM, Dixon LJ, Somerville RP, Nelson CM, Wang LW, Young ME, Lindner DJ, Apte SS, ADAMTS9 Is a Cell-Autonomously Acting,Anti-Angiogenic Metalloprotease Expressed by Microvascular Endothelial Cells. Am J Pathol. 2010 Mar;176(3):1494-504
1J:101173 Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, Kong YY, Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development. 2005 Aug;132(15):3459-70
2J:130369 Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN, Kong YY, An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS ONE. 2007;2(11):e1221
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
3J:71581 Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, Chu ML, Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
2*J:44365 Kozak KR, Abbott B, Hankinson O, ARNT-deficient mice and placental differentiation. Dev Biol. 1997 Nov 15;191(2):297-305
1J:209780 Krcmery J, Gupta R, Sadleir RW, Ahrens MJ, Misener S, Kamide C, Fitchev P, Losordo DW, Crawford SE, Simon HG, Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. PLoS One. 2013;8(11):e80809
1J:93125 Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T, Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 2004 Oct 15;18(20):2469-73
2J:163061 Krebs LT, Starling C, Chervonsky AV, Gridley T, Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis. 2010 Mar;48(3):146-50
2J:62571 Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP, Gallahan D, Closson V, Kitajewski J, Callahan R, Smith GH, Stark KL, Gridley T, Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 2000 Jun 1;14(11):1343-52
1J:142212 Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, Robbins J, Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18930-5
2J:169855 Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM, Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90
1J:123073 Kruger I, Vollmer M, Simmons DG, Elsasser HP, Philipsen S, Suske G, Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects. Dev Dyn. 2007 Aug;236(8):2235-44
1J:80175 Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J, Deletion of the Cancer-amplified Coactivator AIB3 Results in Defective Placentation and Embryonic Lethality. J Biol Chem. 2002 Nov 22;277(47):45356-60
3J:63252 Kubo H, Fujiwara T, Jussila L, Hashi H, Ogawa M, Shimizu K, Awane M, Sakai Y, Takabayashi A, Alitalo K, Yamaoka Y, Nishikawa SI, Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood. 2000 Jul 15;96(2):546-53
4J:137720 Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T, Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008 Jul;118(7):2393-403
2J:177298 Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T, Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011 May 9;208(5):949-60
1J:170405 Kueh AJ, Dixon MP, Voss AK, Thomas T, HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011 Feb;31(4):845-60
7*J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
1J:143206 Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ, Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008 Dec;135(24):3989-93
5J:166127 Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ, Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9
2J:71693 Kume T, Jiang H, Topczewska JM, Hogan BL, The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82
1J:44352 Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM, The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997 Nov 15;11(22):2996-3006
4J:160163 Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H, von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May;137(9):1563-71
3J:106261 Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y, Sehara-Fujisawa A, Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28
1*J:23137 Kwee L, Baldwin HS, Shen HM, Stewart CL, Buck C, Buck CA, Labow MA, Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development. 1995 Feb;121(2):489-503
3*J:77750 Kwon YT, Kashina AS, Davydov IV, Hu RG, An JY, Seo JW, Du F, Varshavsky A, An essential role of N-terminal arginylation in cardiovascular development. Science. 2002 Jul 5;297(5578):96-9
3J:62182 Lai KM, Pawson T, The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 2000 May 1;14(9):1132-45
1*J:86515 Lai L, Bohnsack BL, Niederreither K, Hirschi KK, Retinoic acid regulates endothelial cell proliferation during vasculogenesis. Development. 2003 Dec;130(26):6465-6474
1*J:50306 Lakkis MM, Epstein JA, Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart. Development. 1998 Nov;125(22):4359-67
2J:72169 Lammert E, Cleaver O, Melton D, Induction of pancreatic differentiation by signals from blood vessels. Science. 2001 Oct 19;294(5542):564-7
1J:170050 Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E, CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80
3J:207611 Lange AW, Haitchi HM, LeCras TD, Sridharan A, Xu Y, Wert SE, James J, Udell N, Thurner PJ, Whitsett JA, Sox17 is required for normal pulmonary vascular morphogenesis. Dev Biol. 2014 Mar 1;387(1):109-20
1J:162807 Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY, Netrin-4 induces lymphangiogenesis in vivo. Blood. 2010 Jul 1;115(26):5418-26
6J:138814 Lavine KJ, Long F, Choi K, Smith C, Ornitz DM, Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development. 2008 Sep;135(18):3161-71
1J:131577 Lavine KJ, Schmid GJ, Smith CS, Ornitz DM, Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs. Dev Dyn. 2008 Mar;237(3):713-24
7J:109722 Lavine KJ, White AC, Park C, Smith CS, Choi K, Long F, Hui CC, Ornitz DM, Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 2006 Jun 15;20(12):1651-66
1J:138574 Laws MJ, Taylor RN, Sidell N, DeMayo FJ, Lydon JP, Gutstein DE, Bagchi MK, Bagchi IC, Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival. Development. 2008 Aug;135(15):2659-68
2J:123725 Lax S, Hou TZ, Jenkinson E, Salmon M, MacFadyen JR, Isacke CM, Anderson G, Cunningham AF, Buckley CD, CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett. 2007 Jul 24;581(18):3550-6
2J:107096 Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL, VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci. 2006 Mar;9(3):340-8
2J:155850 Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K, ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 8;2(5):497-507
1J:175843 Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA, Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16;21(2):315-27
4J:170768 Lee HW, Qin YX, Kim YM, Park EY, Hwang JS, Huo GH, Yang CW, Kim WY, Kim J, Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney. Cell Tissue Res. 2011 Feb;343(2):429-44
1J:134270 Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS, A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42
1J:127228 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML, Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec;11(6):845-57
1J:184934 Lee SH, Che X, Jeong JH, Choi JY, Lee YJ, Lee YH, Bae SC, Lee YM, Runx2 protein stabilizes hypoxia-inducible factor-1alpha through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem. 2012 Apr 27;287(18):14760-71
4J:130230 Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross RS, Giordano FJ, Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol. 2008 Jan;28(2):794-802
1J:178364 Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT, Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96
1J:85643 Levchenko T, Aase K, Troyanovsky B, Bratt A, Holmgren L, Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin. J Cell Sci. 2003 Sep 15;116(Pt 18):3803-10
1J:201783 Levet S, Ciais D, Merdzhanova G, Mallet C, Zimmers TA, Lee SJ, Navarro FP, Texier I, Feige JJ, Bailly S, Vittet D, Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation. Blood. 2013 Jul 25;122(4):598-607
3J:95358 Levinson RS, Batourina E, Choi C, Vorontchikhina M, Kitajewski J, Mendelsohn CL, Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development. 2005 Feb;132(3):529-39
3J:200617 Li A, Hardy R, Stoner S, Tuckermann J, Seibel M, Zhou H, Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS One. 2013;8(5):e63578
1J:78384 Li C, Xiao J, Hormi K, Borok Z, Minoo P, Wnt5a participates in distal lung morphogenesis. Dev Biol. 2002 Aug 1;248(1):68-81
1J:143910 Li M, Li C, Liu YH, Xing Y, Hu L, Borok Z, Kwong KY, Minoo P, Mesodermal Deletion of Transforming Growth Factor-{beta} Receptor II Disrupts Lung Epithelial Morphogenesis: cross-talk between TGF-{beta} and Sonic hedgehog pathways. J Biol Chem. 2008 Dec 26;283(52):36257-64
1J:171220 Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Bruning JC, Pashmforoush M, Sucov HM, IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May;138(9):1795-805
3J:179213 Li P, Pashmforoush M, Sucov HM, Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012 Jan 1;361(1):116-24
2J:63443 Li Q, Estepa G, Memet S, Israel A, Verma IM, Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 2000 Jul 15;14(14):1729-33
2J:201731 Li S, Haigh K, Haigh JJ, Vasudevan A, Endothelial VEGF sculpts cortical cytoarchitecture. J Neurosci. 2013 Sep 11;33(37):14809-15
2J:84789 Li S, Wang DZ, Wang Z, Richardson JA, Olson EN, The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9366-70
1J:99494 Li W, Ferkowicz MJ, Johnson SA, Shelley WC, Yoder MC, Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev. 2005 Feb;14(1):44-54
2J:195048 Li W, Kohara H, Uchida Y, James JM, Soneji K, Cronshaw DG, Zou YR, Nagasawa T, Mukouyama YS, Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell. 2013 Feb 25;24(4):359-71
7J:198558 Li W, Mukouyama YS, Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature. Dev Dyn. 2013 Aug;242(8):976-88
1J:193698 Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP, Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1738-43
1*J:92194 Li Y, Zhang H, Choi SC, Litingtung Y, Chiang C, Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol. 2004 Jun 1;270(1):214-31
1J:196758 Li YN, Pinzon-Duarte G, Dattilo M, Claudepierre T, Koch M, Brunken WJ, The expression and function of netrin-4 in murine ocular tissues. Exp Eye Res. 2012 Mar;96(1):24-35
2J:184380 Li YN, Radner S, French MM, Pinzon-Duarte G, Daly GH, Burgeson RE, Koch M, Brunken WJ, The gamma3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies. Matrix Biol. 2012 Mar;31(2):120-34
1J:193721 Li Z, Lan Y, He W, Chen D, Wang J, Zhou F, Wang Y, Sun H, Chen X, Xu C, Li S, Pang Y, Zhang G, Yang L, Zhu L, Fan M, Shang A, Ju Z, Luo L, Ding Y, Guo W, Yuan W, Yang X, Liu B, Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell. 2012 Nov 2;11(5):663-75
2J:88215 Li Z, Takakura N, Oike Y, Imanaka T, Araki K, Suda T, Kaname T, Kondo T, Abe K, Yamamura K, Defective smooth muscle development in qkI-deficient mice. Dev Growth Differ. 2003 Oct-Dec;45(5-6):449-62
1J:214813 Liakhovitskaia A, Rybtsov S, Smith T, Batsivari A, Rybtsova N, Rode C, de Bruijn M, Buchholz F, Gordon-Keylock S, Zhao S, Medvinsky A, Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Development. 2014 Sep;141(17):3319-23
2J:204126 Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM, HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013 Aug 2;113(4):399-407
1J:75316 Liao HJ, Kume T, McKay C, Xu MJ, Ihle JN, Carpenter G, Absence of Erythrogenesis and Vasculogenesis in Plcg1-deficient Mice. J Biol Chem. 2002 Mar 15;277(11):9335-41
4J:126627 Licht AH, Muller-Holtkamp F, Flamme I, Breier G, Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development. Blood. 2006 Jan 15;107(2):584-90
2J:94180 Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG, Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004 Nov 4;432(7013):107-12
1J:91830 Liebner S, Cattelino A, Gallini R, Rudini N, Iurlaro M, Piccolo S, Dejana E, Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol. 2004 Aug 2;166(3):359-67
3J:173635 Lieven O, Ruther U, The Dkk1 dose is critical for eye development. Dev Biol. 2011 Jul 1;355(1):124-37
2J:165360 Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD, Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 9;285(28):21526-36
1J:185347 Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD, Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012 Jun 25;197(7):907-19
1*J:50309 Lin Q, Lu J, Yanagisawa H, Webb R, Lyons GE, Richardson JA, Olson EN, Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 1998 Nov;125(22):4565-74
4J:208418 Lindskog H, Kim YH, Jelin EB, Kong Y, Guevara-Gallardo S, Kim TN, Wang RA, Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. Development. 2014 Mar;141(5):1120-8
2J:194053 Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL, Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
3J:139461 Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love P, Lipp M, Kondo S, Manley N, Takahama Y, Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. 2006 Oct 15;108(8):2531-9
3J:143769 Liu CF, Bingham N, Parker K, Yao HH, Sex-specific roles of beta-catenin in mouse gonadal development. Hum Mol Genet. 2009 Feb 1;18(3):405-17
2J:213585 Liu J, Deutsch U, Jeong J, Lobe CG, Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development. Genesis. 2014 Sep;52(9):809-16
2J:87224 Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M, Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec;130(25):6221-31
2J:183122 Liu Y, Antonyak M, Peng X, Visualization of mouse embryo angiogenesis by fluorescence-based staining. Methods Mol Biol. 2012;843:79-85
2J:71961 Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL, Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000 Oct;106(8):951-61
1J:198632 Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R, The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development. Dev Cell. 2013 Jun 24;25(6):585-98
1J:119882 Liu Z, Lavine KJ, Hung IH, Ornitz DM, FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol. 2007 Feb 1;302(1):80-91
2J:148514 Lomeli H, Starling C, Gridley T, Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes. 2009;2:22
2J:137351 Londesborough A, Vaahtomeri K, Tiainen M, Katajisto P, Ekman N, Vallenius T, Makela TP, LKB1 in endothelial cells is required for angiogenesis and TGF{beta}-mediated vascular smooth muscle cell recruitment. Development. 2008 Jul;135(13):2331-8
3J:58809 Loomes KM, Underkoffler LA, Morabito J, Gottlieb S, Piccoli DA, Spinner NB, Baldwin HS, Oakey RJ, The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome. Hum Mol Genet. 1999 Dec;8(13):2443-9
2J:184582 Lopes M, Gooupille O, Saint Cloment C, Robert B, Msx1 is expressed in retina endothelial cells at artery branching sites. Biol Open. 2012;1(4):376-384
4J:173525 Lopes M, Goupille O, Cloment CS, Lallemand Y, Cumano A, Robert B, Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development. 2011 Jul;138(14):3055-66
3J:67322 Loughna S, Sato TN, A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Mol Cell. 2001 Jan;7(1):233-9
1J:137835 Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, Willson TA, Henley KJ, Ellis S, Voss AK, Metcalf D, Hilton DJ, Alexander WS, Kile BT, The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol. 2008 Jul;9(7):810-9
1J:202226 Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH, Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1;382(1):110-23
1J:171535 Lu Q, Xin Y, Ye F, Foulks G, Li Q, 14-3-3{sigma} Controls Corneal Epithelium Homeostasis and Wound Healing. Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2389-96
1J:126240 Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Breant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A, The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86
1J:165329 Luna-Zurita L, Prados B, Grego-Bessa J, Luxan G, del Monte G, Benguria A, Adams RH, Perez-Pomares JM, de la Pompa JL, Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 2010 Oct 1;120(10):3493-507
1J:176019 Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X, G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12925-30
3J:98422 Luo Y, Radice GL, N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol. 2005 Apr 11;169(1):29-34
2J:185190 Lutter S, Xie S, Tatin F, Makinen T, Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012 Jun 11;197(6):837-49
3J:178362 Luxey M, Laussu J, Jungas T, Davy A, Generation of transgenic mice overexpressing EfnB2 in endothelial cells. Genesis. 2011 Oct;49(10):811-20
4J:208733 Ma A, Wang L, Gao Y, Chang Z, Peng H, Zeng N, Gui YS, Tian X, Li X, Cai B, Zhang H, Xu KF, Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality. Hum Mol Genet. 2014 Feb 1;23(3):693-705
1J:38829 Ma GT, Roth ME, Groskopf JC, Tsai FY, Orkin SH, Grosveld F, Engel JD , Linzer DI, GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development. 1997 Feb;124(4):907-14
2J:141152 Ma Q, Zhou B, Pu WT, Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol. 2008 Nov 1;323(1):98-104
1J:194480 Ma S, Kwon HJ, Johng H, Zang K, Huang Z, Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469
2J:205113 Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM, Fascin 1 is dispensable for developmental and tumour angiogenesis. Biol Open. 2013;2(11):1187-91
4J:138861 Maatouk DM, DiNapoli L, Alvers A, Parker KL, Taketo MM, Capel B, Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. Hum Mol Genet. 2008 Oct 1;17(19):2949-55
3J:203797 Maatouk DM, Mork L, Chassot AA, Chaboissier MC, Capel B, Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. Dev Biol. 2013 Nov 15;383(2):295-306
2J:192186 Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B, Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012;7(10):e47238
1*J:116141 Macfadyen J, Savage K, Wienke D, Isacke CM, Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development. Gene Expr Patterns. 2007 Jan;7(3):363-9
2*J:74493 Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G, Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188). Mech Dev. 2002 Feb;111(1-2):61-73
3J:156474 Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ, Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J. 2010 Jan 20;29(2):424-41
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4J:181009 Magenheim J, Ilovich O, Lazarus A, Klochendler A, Ziv O, Werman R, Hija A, Cleaver O, Mishani E, Keshet E, Dor Y, Blood vessels restrain pancreas branching, differentiation and growth. Development. 2011 Nov;138(21):4743-52
1*J:69847 Mahlapuu M, Enerback S, Carlsson P, Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development. 2001 Jun;128(12):2397-406
1*J:66591 Mahlapuu M, Ormestad M, Enerback S, Carlsson P, The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development. 2001 Jan;128(2):155-66
3J:73841 Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D, Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation. 2001 Dec;69(2-3):135-44
4*J:46939 Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD, Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [see comments]. Science. 1997 Jul 4;277(5322):55-60
2J:204322 Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H, An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. PLoS One. 2013;8(6):e68134
1J:95885 Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA, PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005 Feb 1;19(3):397-410
2J:132020 Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H, Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53
1J:152700 Mancini ML, Terzic A, Conley BA, Oxburgh LH, Nicola T, Vary CP, Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis. Dev Dyn. 2009 Aug 24;238(10):2479-2493
1J:124260 Mancini ML, Verdi JM, Conley BA, Nicola T, Spicer DB, Oxburgh LH, Vary CP, Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol. 2007 Aug 15;308(2):520-33
4J:194288 Manosalva I, Gonzalez A, Kageyama R, Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Dev Biol. 2013 Mar 15;375(2):140-51
2J:195652 Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS, Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem. 2013 Feb 8;288(6):4252-64
2J:122944 Manuylov NL, Fujiwara Y, Adameyko II, Poulat F, Tevosian SG, The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev Biol. 2007 Jul 15;307(2):356-67
6J:143586 Manuylov NL, Smagulova FO, Leach L, Tevosian SG, Ovarian development in mice requires the GATA4-FOG2 transcription complex. Development. 2008 Nov;135(22):3731-43
5J:173838 Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG, Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15;353(2):229-41
1J:160363 Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP, Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May;137(10):1721-9
2J:171425 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM 3rd, Hofmann I, Mostov KE, Reichardt LF, p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May;138(10):2099-109
1J:82727 Maretto S, Cordenonsi M, Dupont S, Braghetta P, Broccoli V, Hassan AB, Volpin D, Bressan GM, Piccolo S, Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3299-304
1J:127540 Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG, Lemaigre FP, The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol. 2007 Nov 15;311(2):579-89
1J:145856 Marlier A, Schmidt-Ott KM, Gallagher AR, Barasch J, Karihaloo A, Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric bud. Mech Dev. 2009 Mar-Apr;126(3-4):91-8
2J:102398 Marneros AG, Fan J, Yokoyama Y, Gerber HP, Ferrara N, Crouch RK, Olsen BR, Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol. 2005 Nov;167(5):1451-9
1J:185336 Marteau L, Pacary E, Valable S, Bernaudin M, Guillemot F, Petit E, Angiopoietin-2 regulates cortical neurogenesis in the developing telencephalon. Cereb Cortex. 2011 Jul;21(7):1695-702
1J:183610 Martinez-Corral I, Olmeda D, Dieguez-Hurtado R, Tammela T, Alitalo K, Ortega S, In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6223-8
1J:166573 Martinez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P, Hosen N, Hill RE, Munoz-Chapuli R, Hastie ND, Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet. 2010 Jan;42(1):89-93
1J:113127 Matsui T, Kanai-Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, Kurohmaru M, Koopman P, Kanai Y, Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006 Sep 1;119(Pt 17):3513-26
1J:152912 Matsumoto K, Li Y, Jakuba C, Sugiyama Y, Sayo T, Okuno M, Dealy CN, Toole BP, Takeda J, Yamaguchi Y, Kosher RA, Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development. 2009 Aug;136(16):2825-35
4J:72168 Matsumoto K, Yoshitomi H, Rossant J, Zaret KS, Liver organogenesis promoted by endothelial cells prior to vascular function. Science. 2001 Oct 19;294(5542):559-63
2J:122926 Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL, Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood. 2006 Feb 15;107(4):1357-65
1J:105944 Mattiske D, Kume T, Hogan BL, The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol. 2006 Feb 15;290(2):447-58
4J:92178 May SR, Stewart NJ, Chang W, Peterson AS, A Titin mutation defines roles for circulation in endothelial morphogenesis. Dev Biol. 2004 Jun 1;270(1):31-46
5J:212088 Mayeuf-Louchart A, Lagha M, Danckaert A, Rocancourt D, Relaix F, Vincent SD, Buckingham M, Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8844-9
2J:94376 McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO, Selective ablation of {alpha}v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan;132(1):165-176
4J:79611 McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO, Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol. 2002 Nov;22(21):7667-77
1*J:67157 McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T, Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development. 2001 Feb;128(4):491-502
1J:116273 McGannon P, Miyazaki Y, Gupta PC, Traboulsi EI, Colmenares C, Ocular abnormalities in mice lacking the Ski proto-oncogene. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4231-7
1J:79922 McGiffert C, Contos JJ, Friedman B, Chun J, Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 2002 Oct 30;531(1):103-8
2J:158087 McPherson JP, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak-Zablocki E, Hakem A, Azami SA, Cardoso R, Fish J, Sanchez O, Post M, Hakem R, Essential role for Bclaf1 in lung development and immune system function. Cell Death Differ. 2009 Feb;16(2):331-9
2J:192712 Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O, Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
6J:194961 Meadows SM, Ratliff LA, Singh MK, Epstein JA, Cleaver O, Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling. Dev Dyn. 2013 May;242(5):570-80
1*J:190997 Medio M, Yeh E, Popelut A, Babajko S, Berdal A, Helms JA, Wnt/beta-catenin signaling and Msx1 promote outgrowth of the maxillary prominences. Front Physiol. 2012;3:375
1*J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
3J:155272 Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD, Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 5;103(12):1393-401
1J:104700 Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Belmonte JC, Chien KR, Ruiz-Lozano P, Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18455-60
1J:182340 Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M, Kruppel-like factor 4 regulates membranous and endochondral ossification. Exp Cell Res. 2012 Feb 15;318(4):311-25
2J:198274 Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS, PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26;288(17):12232-43
1J:205235 Miki T, Shamma A, Kitajima S, Takegami Y, Noda M, Nakashima Y, Watanabe K, Takahashi C, The ss1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res. 2010 May;8(5):665-76
1J:81386 Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH, Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15;101(2):508-16
7J:181007 Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans SM, Tzahor E, The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov;138(21):4777-87
2J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1J:190156 Miller MF, Cohen ED, Baggs JE, Lu MM, Hogenesch JB, Morrisey EE, Wnt ligands signal in a cooperative manner to promote foregut organogenesis. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15348-53
1*J:59925 Miner JH, Li C, Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol. 2000 Jan 15;217(2):278-89
1*J:64090 Miquerol L, Langille BL, Nagy A, Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development. 2000 Sep;127(18):3941-6
1*J:100943 Mirza M, Raschperger E, Philipson L, Pettersson RF, Sollerbrant K, The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2). Exp Cell Res. 2005 Sep 10;309(1):110-20
1J:152236 Misfeldt AM, Boyle SC, Tompkins KL, Bautch VL, Labosky PA, Baldwin HS, Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors. Dev Biol. 2009 Sep 1;333(1):78-89
1J:199453 Mithal DS, Ren D, Miller RJ, CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development. Glia. 2013 Aug;61(8):1288-305
6*J:130526 Mitiku N, Baker JC, Genomic analysis of gastrulation and organogenesis in the mouse. Dev Cell. 2007 Dec;13(6):897-907
1J:92631 Miyawaki T, Uemura A, Dezawa M, Yu RT, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T, Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci. 2004 Sep 15;24(37):8124-34
1J:103755 Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL, Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
2J:187282 Mizuochi C, Fraser ST, Biasch K, Horio Y, Kikushige Y, Tani K, Akashi K, Tavian M, Sugiyama D, Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis. PLoS One. 2012;7(4):e35763
3J:80618 Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF, CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity. Mol Cell Biol. 2002 Dec;22(24):8709-20
1J:179059 Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A, Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood. 2011 Dec 15;118(25):6553-61
1J:167831 Moffatt P, Lee ER, St-Jacques B, Matsumoto K, Yamaguchi Y, Roughley PJ, Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Dev Dyn. 2011 Feb;240(2):404-12
1J:175241 Mohseni P, Sung HK, Murphy AJ, Laliberte CL, Pallari HM, Henkelman M, Georgiou J, Xie G, Quaggin SE, Thorner PS, Eriksson JE, Nagy A, Nestin Is Not Essential for Development of the CNS But Required for Dispersion of Acetylcholine Receptor Clusters at the Area of Neuromuscular Junctions. J Neurosci. 2011 Aug 10;31(32):11547-11552
1J:199658 Moik D, Bottcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fassler R, Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J Biol Chem. 2013 Jun 28;288(26):18863-71
1J:182886 Moik DV, Janbandhu VC, Fassler R, Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
1J:141609 Mokkapati S, Baranowsky A, Mirancea N, Smyth N, Breitkreutz D, Nischt R, Basement membranes in skin are differently affected by lack of nidogen 1 and 2. J Invest Dermatol. 2008 Sep;128(9):2259-67
2J:149544 Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F, The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development. 2009 Jun;136(11):1813-21
2J:168021 Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR, Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 2011 Jan 15;349(2):494-502
3J:154437 Montanez E, Wickstrom SA, Altstatter J, Chu H, Fassler R, Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 2009 Oct 21;28(20):3132-44
3J:141643 Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N, Zhou Q, Ward NL, Watanabe M, Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
2J:214760 Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, Dunwoodie SL, Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014 Aug 1;392(1):62-79
1*J:110719 Moreno-Barriuso N, Lopez-Malpartida AV, de Pablo F, Pichel JG, Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006 Aug;235(8):2040-50
1*J:83431 Morgan EA, Nguyen SB, Scott V, Stadler HS, Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003 Jul;130(14):3095-109
3J:155348 Mori K, Itoi M, Tsukamoto N, Amagai T, Foxn1 is essential for vascularization of the murine thymus anlage. Cell Immunol. 2010;260(2):66-9
4J:89474 Morikawa Y, Cserjesi P, Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204
3J:156690 Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R, Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci. 2010 Jan 15;123(Pt 2):213-24
3J:191285 Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya-Tsuji J, TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012 Nov 1;120(18):3846-57
1J:107439 Morisada T, Oike Y, Yamada Y, Urano T, Akao M, Kubota Y, Maekawa H, Kimura Y, Ohmura M, Miyamoto T, Nozawa S, Koh GY, Alitalo K, Suda T, Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood. 2005 Jun 15;105(12):4649-56
1J:94757 Morita K, Sasaki H, Furuse M, Tsukita S, Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol. 1999 Oct 4;147(1):185-94
1J:105797 Mototani Y, Miyoshi I, Okamura T, Moriya T, Meng Y, Yuan Pei X, Kameo S, Kasai N, Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease. Genomics. 2006 Feb;87(2):191-9
1J:152699 Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP, Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009 Aug 24;238(10):2670-2679
1J:182740 Moya IM, Umans L, Maas E, Pereira PN, Beets K, Francis A, Sents W, Robertson EJ, Mummery CL, Huylebroeck D, Zwijsen A, Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell. 2012 Mar 13;22(3):501-14
2J:140559 Mu W, Wang W, Schimenti JC, An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol. 2008 Oct;28(20):6439-51
1J:85946 Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, Birchmeier W, Morrisey EE, Whitsett JA, beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem. 2003 Oct 10;278(41):40231-8
2J:73417 Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM, Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10454-9
1J:152419 Mugford JW, Yu J, Kobayashi A, McMahon AP, High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15;333(2):312-23
1J:183123 Mukouyama YS, James J, Nam J, Uchida Y, Whole-mount confocal microscopy for vascular branching morphogenesis. Methods Mol Biol. 2012;843:69-78
1J:171515 Muller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E, The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
1J:141347 Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L, Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circ Res. 2007 Sep 28;101(7):682-91
2J:77927 Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S, Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet. 2002 Jul 15;11(15):1731-42
2J:147279 Nadeau V, Guillemette S, Belanger LF, Jacob O, Roy S, Charron J, Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development. 2009 Apr;136(8):1363-74
1J:201437 Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM, BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun 3;123(6):2539-50
2J:177135 Naiche LA, Arora R, Kania A, Lewandoski M, Papaioannou VE, Identity and fate of Tbx4-expressing cells reveal developmental cell fate decisions in the allantois, limb, and external genitalia. Dev Dyn. 2011 Oct;240(10):2290-300
3*J:83256 Naiche LA, Papaioannou VE, Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93
1*J:91716 Nakajima M, Moriizumi E, Koseki H, Shirasawa T, Presenilin 1 is essential for cardiac morphogenesis. Dev Dyn. 2004 Aug;230(4):795-9
3*J:84418 Nakajima M, Yuasa S, Ueno M, Takakura N, Koseki H, Shirasawa T, Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev. 2003 Jun;120(6):657-67
1J:103759 Nakamura Y, Hamada Y, Fujiwara T, Enomoto H, Hiroe T, Tanaka S, Nose M, Nakahara M, Yoshida N, Takenawa T, Fukami K, Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development. Mol Cell Biol. 2005 Dec;25(24):10979-88
9J:194919 Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, Li W, Zang H, Ruiz-Lozano P, Mukouyama YS, Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85
2J:131817 Navankasattusas S, Whitehead KJ, Suli A, Sorensen LK, Lim AH, Zhao J, Park KW, Wythe JD, Thomas KR, Chien CB, Li DY, The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development. 2008 Feb;135(4):659-67
1J:64067 Nebigil CG, Choi DS, Dierich A, Hickel P, Le Meur M, Messaddeq N, Launay JM, Maroteaux L, Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9508-13
2J:196288 Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V, Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84
1J:167976 Nelms BL, Pfaltzgraff ER, Labosky PA, Functional interaction between Foxd3 and Pax3 in cardiac neural crest development. Genesis. 2011 Jan;49(1):10-23
1J:209137 Newton K, Dugger DL, Wickliffe KE, Kapoor N, de Almagro MC, Vucic D, Komuves L, Ferrando RE, French DM, Webster J, Roose-Girma M, Warming S, Dixit VM, Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
2J:154375 Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S, Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009 Nov 1;335(1):208-15
1J:67327 Ng YS, Rohan R, Sunday ME, Demello DE, D'Amore PA, Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn. 2001 Feb;220(2):112-21
2J:177397 Nguyen HL, Lee YJ, Shin J, Lee E, Park SO, McCarty JH, Oh SP, TGF-beta signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest. 2011 Nov;91(11):1554-63
1J:77264 Nguyen NM, Miner JH, Pierce RA, Senior RM, Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. Dev Biol. 2002 Jun 15;246(2):231-44
4J:163740 Ni A, Lashnits E, Yao LC, Baluk P, McDonald DM, Rapid remodeling of airway vascular architecture at birth. Dev Dyn. 2010 Sep;239(9):2354-66
6J:167379 Nichol D, Shawber C, Fitch MJ, Bambino K, Sharma A, Kitajewski J, Stuhlmann H, Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood. 2010 Dec 23;116(26):6133-43
2J:160263 Nielsen CM, Dymecki SM, Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol. 2010 Apr 15;340(2):430-7
1J:139512 Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A, Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol. 2008 Jul 28;182(2):315-25
1J:165035 Niklasson M, Bergstrom T, Zhang XQ, Gustafsdottir SM, Sjogren M, Edqvist PH, Vennstrom B, Forsberg M, Forsberg-Nilsson K, Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells. Exp Cell Res. 2010 Oct 15;316(17):2779-89
1J:191589 Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T, Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem. 2012 Sep 28;287(40):33179-90
3J:83341 Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S, Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003 May 12;161(3):653-60
1J:149138 Norrmen C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Yla-Herttuala S, Alitalo K, Petrova TV, FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol. 2009 May 4;185(3):439-57
1J:75828 Noveroske JK, Lai L, Gaussin V, Northrop JL, Nakamura H, Hirschi KK, Justice MJ, Quaking is essential for blood vessel development. Genesis. 2002 Mar;32(3):218-30
1J:192805 Nyren R, Chang CL, Lindstrom P, Barmina A, Vorrsjo E, Ali Y, Juntti-Berggren L, Bensadoun A, Young SG, Olivecrona T, Olivecrona G, Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency. BMC Physiol. 2012;12:14
4J:170867 Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP, p120-Catenin is required for mouse vascular development. Circ Res. 2010 Mar 19;106(5):941-51
2J:50566 Offermanns S, Mancino V, Revel JP, Simon MI, Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science. 1997 Jan 24;275(5299):533-6
1*J:136004 Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H, MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol. 2008 May;28(10):3424-36
1J:91198 Oh J, Takahashi R, Adachi E, Kondo S, Kuratomi S, Noma A, Alexander DB, Motoda H, Okada A, Seiki M, Itoh T, Itohara S, Takahashi C, Noda M, Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene. 2004 Jun 24;23(29):5041-8
3J:107674 Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M, The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001 Dec 14;107(6):789-800
3J:181485 Oh JH, Park SY, de Crombrugghe B, Kim JE, Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun. 2012 Feb 24;418(4):634-40
1J:155001 Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS, Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20
7J:207212 Oh WJ, Gu C, Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013 Oct 16;80(2):458-69
1J:182534 Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, Higashiyama S, BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis. Blood. 2012 Mar 15;119(11):2688-98
2J:78347 Oike Y, Ito Y, Hamada K, Zhang XQ, Miyata K, Arai F, Inada T, Araki K, Nakagata N, Takeya M, Kisanuki YY, Yanagisawa M, Gale NW, Suda T, Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood. 2002 Aug 15;100(4):1326-33
1J:195536 Ojala JR, Pikkarainen T, Elmberger G, Tryggvason K, Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor a5-deficient mice. Am J Pathol. 2013 May;182(5):1681-95
4J:188751 Okada A, Tomooka Y, Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex. Neurosci Lett. 2012 May 16;516(2):259-64
1*J:138735 Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC, A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood. 2008 Sep 15;112(6):2336-9
1J:139209 Okamura Y, Saga Y, Pofut1 is required for the proper localization of the Notch receptor during mouse development. Mech Dev. 2008 Aug;125(8):663-73
1J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
2J:161574 Onitsuka I, Tanaka M, Miyajima A, Characterization and functional analyses of hepatic mesothelial cells in mouse liver development. Gastroenterology. 2010 Apr;138(4):1525-35, 1535.e1-6
1J:213582 Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM, Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Dev Cell. 2014 May 12;29(3):330-9
1J:100747 Ortega N, Behonick DJ, Colnot C, Cooper DN, Werb Z, Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell. 2005 Jun;16(6):3028-39
1J:171374 Osorio KM, Lilja KC, Tumbar T, Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol. 2011 Apr 4;193(1):235-50
2J:85043 Otto DM, Henderson CJ, Carrie D, Davey M, Gundersen TE, Blomhoff R, Adams RH, Tickle C, Wolf CR, Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis. Mol Cell Biol. 2003 Sep;23(17):6103-16
1J:178680 Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M, Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development. 2011 Dec;138(23):5235-46
4J:71947 Ozerdem U, Grako KA, Dahlin-Huppe K, Monosov E, Stallcup WB, NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev Dyn. 2001 Oct;222(2):218-27
2J:190949 Ozkan A, Bicer A, Avsar T, Seker A, Toktas ZO, Bozkurt SU, Basak AN, Kilic T, Temporal expression analysis of angiogenesis-related genes in brain development. Vasc Cell. 2012;4(1):16
1J:93030 Paik JH, Skoura A, Chae SS, Cowan AE, Han DK, Proia RL, Hla T, Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004 Oct 1;18(19):2392-403
1J:211117 Pais RS, Moreno-Barriuso N, Hernandez-Porras I, Lopez IP, De Las Rivas J, Pichel JG, Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation. PLoS One. 2013;8(12):e83028
4J:123628 Papadaki C, Alexiou M, Cecena G, Verykokakis M, Bilitou A, Cross JC, Oshima RG, Mavrothalassitis G, Transcriptional repressor erf determines extraembryonic ectoderm differentiation. Mol Cell Biol. 2007 Jul;27(14):5201-13
1J:92266 Parekh V, McEwen A, Barbour V, Takahashi Y, Rehg JE, Jane SM, Cunningham JM, Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Mol Cell Biol. 2004 Aug;24(16):7113-29
4J:112269 Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K, Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development. 2006 Sep;133(17):3473-84
1J:85367 Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY, Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol. 2003 Sep 1;261(1):251-67
1J:90570 Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier DY, De Sauvage FJ, Ye W, The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 2004 Apr 15;428(6984):754-8
1J:99570 Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP, JAM-A expression during embryonic development. Dev Dyn. 2005 Aug;233(4):1517-24
3J:79305 Patan S, TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res. 1998 Jul;56(1):1-21
1J:135374 Patra D, Xing X, Davies S, Bryan J, Franz C, Hunziker EB, Sandell LJ, Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol. 2007 Nov 19;179(4):687-700
1J:179464 Paul A, Laufer E, Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):133-40
1J:178114 Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM, Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011;17(11):1466-72
3J:63415 Peng J, Zhang L, Drysdale L, Fong GH, The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8386-91
4J:204743 Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE, Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29;500(7464):589-92
1J:66010 Pennisi D, Bowles J, Nagy A, Muscat G, Koopman P, Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol. 2000 Dec;20(24):9331-6
2J:185875 Pennisi DJ, Kinna G, Chiu HS, Simmons DG, Wilkinson L, Little MH, Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta. Placenta. 2012 Mar;33(3):175-82
2J:54469 Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY, The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 1999 Apr 15;13(8):1037-49
2J:76609 Peters EM, Botchkarev VA, Muller-Rover S, Moll I, Rice FL, Paus R, Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol. 2002 Jun 17;448(1):28-52
1J:111937 Petros TJ, Williams SE, Mason CA, Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development. Mol Cell Neurosci. 2006 May-Jun;32(1-2):49-66
2J:137010 Petrou P, Pavlakis E, Dalezios Y, Galanopoulos VK, Chalepakis G, Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome. J Biol Chem. 2005 Mar 18;280(11):10350-6
2J:92818 Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, Miura N, Alitalo K, Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med. 2004 Sep;10(9):974-981
1J:183103 Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, Girard JP, Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol. 2012 Apr 1;188(7):3488-95
3J:165713 Pierreux CE, Cordi S, Hick AC, Achouri Y, Ruiz de Almodovar C, Prevot PP, Courtoy PJ, Carmeliet P, Lemaigre FP, Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. Dev Biol. 2010 Nov 1;347(1):216-27
5J:40135 Pinter E, Barreuther M, Lu T, Imhof BA, Madri JA, Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus. Am J Pathol. 1997 May;150(5):1523-30
2J:54566 Pinter E, Mahooti S, Wang Y, Imhof BA, Madri JA, Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. Am J Pathol. 1999 May;154(5):1367-79
1J:94974 Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT, Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. Am J Pathol. 2004 Dec;165(6):1895-906
1J:198710 Plaks V, Rinkenberger J, Dai J, Flannery M, Sund M, Kanasaki K, Ni W, Kalluri R, Werb Z, Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11109-14
3J:181761 Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E, Mechanoinduction of lymph vessel expansion. EMBO J. 2012 Feb 15;31(4):788-804
2J:117504 Ponten A, Folestad EB, Pietras K, Eriksson U, Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. Circ Res. 2005 Nov 11;97(10):1036-45
2J:94637 Pu WT, Ishiwata T, Juraszek AL, Ma Q, Izumo S, GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004 Nov 1;275(1):235-44
1J:54983 Puri MC, Partanen J, Rossant J, Bernstein A, Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development. Development. 1999 Oct;126(20):4569-80
1J:99275 Qin Y, Bishop CE, Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry. Hum Mol Genet. 2005 May 1;14(9):1221-9
1J:140378 Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC, Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31;26(21):4445-56
5J:158668 Qu X, Tompkins K, Batts LE, Puri M, Baldwin S, Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice. Development. 2010 Apr;137(8):1285-95
3J:134483 Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA, Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May;135(9):1625-34
3J:119481 Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Ackerson T, Qin Y, Malik AB, Costa RH, Kalinichenko VV, Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box m1 transcription factor. Dev Dyn. 2007 Mar 15;236(4):1000-1013
1J:122951 Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, Veltmaat JM, Del Moral PM, De Langhe S, Parsa S, Kelly LK, Kelly R, Shia W, Keshet E, Minoo P, Warburton D, Bellusci S, Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15;307(2):237-47
4J:73723 Ramirez MI, Pollack L, Millien G, Cao YX, Hinds A, Williams MC, The alpha-isoform of caveolin-1 is a marker of vasculogenesis in early lung development. J Histochem Cytochem. 2002 Jan;50(1):33-42
1J:110805 Ramirez-Bergeron DL, Runge A, Adelman DM, Gohil M, Simon MC, HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell. 2006 Jul;11(1):81-92
3J:138143 Rampon C, Bouillot S, Climescu-Haulica A, Prandini MH, Cand F, Vandenbrouck Y, Huber P, Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta. Physiol Genomics. 2008 Jul 15;34(2):193-204
3J:94272 Rampon C, Prandini MH, Bouillot S, Pointu H, Tillet E, Frank R, Vernet M, Huber P, Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells. Exp Cell Res. 2005 Jan 1;302(1):48-60
4J:212179 Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A, Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52
1*J:119474 Rangel R, Sun Y, Guzman-Rojas L, Ozawa MG, Sun J, Giordano RJ, Van Pelt CS, Tinkey PT, Behringer RR, Sidman RL, Arap W, Pasqualini R, Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4588-93
1J:46398 Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH, The transcription factor NF-ATc is essential for cardiac valve formation [see comments]. Nature. 1998 Mar 12;392(6672):186-90
2J:111505 Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF, The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res. 2006 May 15;312(9):1566-80
3J:201133 Rattner A, Yu H, Williams J, Smallwood PM, Nathans J, Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
10J:158886 Red-Horse K, Ueno H, Weissman IL, Krasnow MA, Coronary arteries form by developmental reprogramming of venous cells. Nature. 2010 Mar 25;464(7288):549-53
5J:54766 Redick SD, Bautch VL, Developmental platelet endothelial cell adhesion molecule expression suggests multiple roles for a vascular adhesion molecule. Am J Pathol. 1999 Apr;154(4):1137-47
4*J:138799 Redies C, Heyder J, Kohoutek T, Staes K, Van Roy F, Expression of protocadherin-1 (Pcdh1) during mouse development. Dev Dyn. 2008 Sep;237(9):2496-505
2J:77725 Regan CP, Li W, Boucher DM, Spatz S, Su MS, Kuida K, Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9248-53
3J:208938 Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC, Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013 Dec;62(12):4154-64
4J:208409 Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC, Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development. 2014 Apr;141(7):1480-91
2J:111998 Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC, The mouse gcd2 mutation causes primordial germ cell depletion. Mech Dev. 2006 Jul;123(7):559-69
1J:185828 Ren Y, Cowan RG, Migone FF, Quirk SM, Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice. Biol Reprod. 2012 Jun;86(6):174
1J:152318 Rhee DY, Zhao XQ, Francis RJ, Huang GY, Mably JD, Lo CW, Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development. 2009 Sep;136(18):3185-93
1J:199892 Rhee S, Guerrero-Zayas MI, Wallingford MC, Ortiz-Pineda P, Mager J, Tremblay KD, Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS One. 2013;8(3):e58828
1J:118803 Ribes V, Otto DM, Dickmann L, Schmidt K, Schuhbaur B, Henderson C, Blomhoff R, Wolf CR, Tickle C, Dolle P, Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis. Dev Biol. 2007 Mar 1;303(1):66-81
1J:213067 Riccomagno MM, Sun LO, Brady CM, Alexandropoulos K, Seo S, Kurokawa M, Kolodkin AL, Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
1*J:95790 Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J, Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R652-60
1J:175402 Ripen AM, Nitta T, Murata S, Tanaka K, Takahama Y, Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t. Eur J Immunol. 2011 May;41(5):1278-87
1J:144217 Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR, Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb;136(3):495-505
2J:145552 Risley M, Garrod D, Henkemeyer M, McLean W, EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009 Mar-Apr;126(3-4):230-9
1J:161417 Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE, The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development. Dev Biol. 2010 Jun 15;342(2):146-56
2J:204684 Rivas V, Carmona R, Munoz-Chapuli R, Mendiola M, Nogues L, Reglero C, Miguel-Martin M, Garcia-Escudero R, Dorn GW 2nd, Hardisson D, Mayor F Jr, Penela P, Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest. 2013 Nov 1;123(11):4714-30
3J:197674 Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP, The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013 Jun 20;498(7454):318-24
2J:97176 Robert-Moreno A, Espinosa L, de la Pompa JL, Bigas A, RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development. 2005 Mar;132(5):1117-26
1J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
2J:137647 Robert-Moreno A, Guiu J, Ruiz-Herguido C, Lopez ME, Ingles-Esteve J, Riera L, Tipping A, Enver T, Dzierzak E, Gridley T, Espinosa L, Bigas A, Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J. 2008 Jul 9;27(13):1886-95
1J:75491 Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ, Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
1J:95118 Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL, A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. Mol Cell Biol. 2004 Dec;24(24):10515-28
1J:165694 Roselli S, Wallez Y, Wang L, Vervoort V, Pasquale EB, The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal. 2010 Nov;22(11):1745-52
4J:137277 Ross A, Munger S, Capel B, Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev. 2007;1(2):127-37
2J:195902 Rossdeutsch A, Smart N, Dube KN, Turner M, Riley PR, Essential role for thymosin beta4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res. 2012 Aug 3;111(4):e89-102
1J:200244 Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM, Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79
2J:170315 Rothova M, Feng J, Sharpe PT, Peterkova R, Tucker AS, Contribution of mesoderm to the developing dental papilla. Int J Dev Biol. 2011;55(1):59-64
4J:84689 Rousseau B, Larrieu-Lahargue F, Bikfalvi A, Javerzat S, Involvement of fibroblast growth factors in choroidal angiogenesis and retinal vascularization. Exp Eye Res. 2003 Aug;77(2):147-56
2J:184021 Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T, Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012 Apr 17;22(4):887-901
8J:79490 Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, Fujisawa H, Betsholtz C, Shima DT, Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 2002 Oct 15;16(20):2684-98
1J:126927 Ruiz-Ederra J, Verkman AS, Aquaporin-1 independent microvessel proliferation in a neonatal mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4802-10
3J:189158 Ruiz-Herguido C, Guiu J, D'Altri T, Ingles-Esteve J, Dzierzak E, Espinosa L, Bigas A, Hematopoietic stem cell development requires transient Wnt/beta-catenin activity. J Exp Med. 2012 Jul 30;209(8):1457-68
2J:213073 Runck LA, Method A, Bischoff A, Levitt M, Pena A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G, Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93
2J:113221 Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P, Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. Cancer Immun. 2006;6:10
1J:48084 Ryan HE, Lo J, Johnson RS, HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998 Jun 1;17(11):3005-15
1J:189950 Sabbir MG, Wigle N, Loewen S, Gu Y, Buse C, Hicks GG, Mowat MR, Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform. BMC Biol. 2010;8:17
5J:181330 Sabine A, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hagerling R, Pollmann C, Bebber D, Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Makinen T, Kiefer F, Kwak BR, Petrova TV, Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation. Dev Cell. 2012 Feb 14;22(2):430-45
1J:159519 Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K, Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev. 2010 May;24(9):875-80
3J:112241 Saint-Geniez M, Maldonado AE, D'Amore PA, VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3135-42
2J:148533 Saito K, Dubreuil V, Arai Y, Wilsch-Brauninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB, Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8350-5
1J:205755 Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R, The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth. Nat Commun. 2013;4:1398
3J:103506 Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S, Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ. 2002 Nov;9(11):1196-206
4J:123026 Sakamoto Y, Hara K, Kanai-Azuma M, Matsui T, Miura Y, Tsunekawa N, Kurohmaru M, Saijoh Y, Koopman P, Kanai Y, Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 2007 Aug 31;360(3):539-44
2J:96124 Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M, Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
1J:207377 Sanalkumar R, Johnson KD, Gao X, Boyer ME, Chang YI, Hewitt KJ, Zhang J, Bresnick EH, Mechanism governing a stem cell-generating cis-regulatory element. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1091-100
1*J:72727 Sanchez MJ, Bockamp EO, Miller J, Gambardella L, Green AR, Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer. Development. 2001 Dec;128(23):4815-27
4J:171472 Sand FW, Hornblad A, Johansson JK, Loren C, Edsbagge J, Stahlberg A, Magenheim J, Ilovich O, Mishani E, Dor Y, Ahlgren U, Semb H, Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011 Apr 15;352(2):267-77
5J:171522 Sandell LL, Iulianella A, Melton KR, Lynn M, Walker M, Inman KE, Bhatt S, Leroux-Berger M, Crawford M, Jones NC, Dennis JF, Trainor PA, A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
2J:178190 Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y, DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res. 2010 Oct 29;107(9):1102-5
3J:166908 Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D, Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010 Dec;137(23):3941-52
1J:138911 Sato Y, Baba T, Zubair M, Miyabayashi K, Toyama Y, Maekawa M, Owaki A, Mizusaki H, Sawamura T, Toshimori K, Morohashi K, Katoh-Fukui Y, Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature. Mol Reprod Dev. 2008 Sep;75(9):1361-71
3J:165879 Satyanarayana A, Gudmundsson KO, Chen X, Coppola V, Tessarollo L, Keller JR, Hou SX, RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010 Oct 21;116(16):2921-31
1J:92269 Saunders DN, Hird SL, Withington SL, Dunwoodie SL, Henderson MJ, Biben C, Sutherland RL, Ormandy CJ, Watts CK, Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol. 2004 Aug;24(16):7225-34
1J:131426 Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H, Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
1J:198319 Sayin VI, Nilton A, Ibrahim MX, Agren P, Larsson E, Petit MM, Hulten LM, Stahlman M, Johansson BR, Bergo MO, Lindahl P, Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS One. 2013;8(2):e55720
1J:145434 Scehnet JS, Jiang W, Kumar SR, Krasnoperov V, Trindade A, Benedito R, Djokovic D, Borges C, Ley EJ, Duarte A, Gill PS, Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood. 2007 Jun 1;109(11):4753-60
1J:94978 Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M, T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003 Jul 15;22(14):3546-56
5*J:24331 Schlaeger TM, Qin Y, Fujiwara Y, Magram J, Sato TN, Vascular endothelial cell lineage-specific promoter in transgenic mice. Development. 1995 Apr;121(4):1089-98
5*J:53835 Schmahl J, Eicher EM, Washburn LL, Capel B, Sry induces cell proliferation in the mouse gonad. Development. 2000 Jan;127(1):65-73
1J:92065 Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B, Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627-36
6J:124110 Schmidt M, Paes K, De Maziere A, Smyczek T, Yang S, Gray A, French D, Kasman I, Klumperman J, Rice DS, Ye W, EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007 Aug;134(16):2913-23
1J:53304 Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF, JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48
1J:145608 Schuster-Gossler K, Harris B, Johnson KR, Serth J, Gossler A, Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. BMC Dev Biol. 2009;9:6
10J:181230 Scotti M, Kmita M, Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development. 2012 Feb;139(4):731-9
1J:138768 Screen M, Dean W, Cross JC, Hemberger M, Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development. 2008 Oct;135(19):3311-20
1J:85877 Seki T, Yun J, Oh SP, Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. 2003 Oct 3;93(7):682-9
2J:132647 Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M, Wakisaka N, Hino T, Suzuki-Migishima R, Kohda T, Ogura A, Ogata T, Yokoyama M, Kaneko-Ishino T, Ishino F, Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
1J:181602 Sengupta A, Chakraborty S, Paik J, Yutzey KE, Evans-Anderson HJ, FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev Dyn. 2012 Apr;241(4):803-13
2J:119144 Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T, The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006 Jun 15;294(2):458-70
1J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
5J:181974 Seo S, Singh HP, Lacal PM, Sasman A, Fatima A, Liu T, Schultz KM, Losordo DW, Lehmann OJ, Kume T, Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
1J:178647 Serafimidis I, Heximer S, Beis D, Gavalas A, G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. Mol Cell Biol. 2011 Nov;31(22):4442-53
2J:89594 Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F, Zammataro L, Primo L, Tamagnone L, Logan M, Tessier-Lavigne M, Taniguchi M, Puschel AW, Bussolino F, Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature. 2003 Jul 24;424(6947):391-7
1J:163753 Sessa A, Mao CA, Colasante G, Nini A, Klein WH, Broccoli V, Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes Dev. 2010 Aug 15;24(16):1816-26
4J:168028 Shah SR, Esni F, Jakub A, Paredes J, Lath N, Malek M, Potoka DA, Prasadan K, Mastroberardino PG, Shiota C, Guo P, Miller KA, Hackam DJ, Burns RC, Tulachan SS, Gittes GK, Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation. Dev Biol. 2011 Jan 15;349(2):342-9
3J:197686 Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ, Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527
1*J:179032 Sharlin DS, Visser TJ, Forrest D, Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology. 2011 Dec;152(12):5053-64
6J:136953 Shaut CA, Keene DR, Sorensen LK, Li DY, Stadler HS, HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet. 2008 May;4(5):e1000073
1*J:119722 Shaut CA, Saneyoshi C, Morgan EA, Knosp WM, Sexton DR, Stadler HS, HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia. Dev Dyn. 2007 Feb 15;236(4):951-960
1J:119477 Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T, Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev. 2007 Mar 15;21(6):694-707
2J:127386 Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J, Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest. 2007 Nov;117(11):3369-82
5*J:51965 Sheibani N, Sorenson CM, Frazier WA, Tissue specific expression of alternatively spliced murine PECAM-1 isoforms. Dev Dyn. 1999 Jan;214(1):44-54
1J:99637 Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL, Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol. 2005 Jun 20;169(6):941-52
1J:83299 Shi S, Stanley P, Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5234-9
1J:195140 Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK, Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013 Feb;9(2):e1003298
1J:92328 Shi W, van den Hurk JA, Alamo-Bethencourt V, Mayer W, Winkens HJ, Ropers HH, Cremers FP, Fundele R, Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues. Dev Biol. 2004 Aug 1;272(1):53-65
1J:178936 Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ, TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43
1J:168015 Shibata M, Garcia-Garcia MJ, The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol. 2011 Jan 15;349(2):331-41
1J:85949 Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, Marino S, Wittwer J, Scheidweiler A, Eckner R, Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 2003 Oct 1;22(19):5175-85
3J:145448 Shimoda H, Immunohistochemical demonstration of Angiopoietin-2 in lymphatic vascular development. Histochem Cell Biol. 2009 Feb;131(2):231-8
4J:144155 Shin D, Anderson DJ, Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. Dev Dyn. 2005 Aug;233(4):1589-604
1J:89608 Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju KH, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata Y, Kurihara H, Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation. 2001 Oct 16;104(16):1964-71
2J:110936 Shiojiri N, Niwa T, Sugiyama Y, Koike T, Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development. Cell Tissue Res. 2006 Jun;324(3):547-52
2J:94926 Shiojiri N, Sugiyama Y, Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology. 2004 Aug;40(2):346-55
2J:183596 Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I, Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling. Circ Res. 2011 Mar 18;108(6):664-75
9J:187683 Shoham AB, Malkinson G, Krief S, Shwartz Y, Ely Y, Ferrara N, Yaniv K, Zelzer E, S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct;139(20):3859-69
1J:79395 Shu W, Jiang YQ, Lu MM, Morrisey EE, Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development. 2002 Oct;129(20):4831-42
1J:135068 Shukunami C, Takimoto A, Miura S, Nishizaki Y, Hiraki Y, Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development. Cell Tissue Res. 2008 Apr;332(1):111-22
2J:187998 Shung CY, Ota S, Zhou ZQ, Keene DR, Hurlin PJ, Disruption of a Sox9-beta-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. Hum Mol Genet. 2012 Nov 1;21(21):4628-44
1J:199438 Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ, Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15;2(7):647-59
2J:124878 Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martinez-A C, Mackay CR, Mackay F, Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
1J:80178 Simon AM, McWhorter AR, Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40. Dev Biol. 2002 Nov 15;251(2):206-20
2J:83788 Simon AM, McWhorter AR, Decreased intercellular dye-transfer and downregulation of non-ablated connexins in aortic endothelium deficient in connexin37 or connexin40. J Cell Sci. 2003 Jun 1;116(Pt 11):2223-36
2J:103077 Simon AM, McWhorter AR, Role of connexin37 and connexin40 in vascular development. Cell Commun Adhes. 2003 Jul-Dec;10(4-6):379-85
1J:87369 Simon AM, McWhorter AR, Dones JA, Jackson CL, Chen H, Heart and head defects in mice lacking pairs of connexins. Dev Biol. 2004 Jan 15;265(2):369-83
1J:187013 Simon R, Brylka H, Schwegler H, Venkataramanappa S, Andratschke J, Wiegreffe C, Liu P, Fuchs E, Jenkins NA, Copeland NG, Birchmeier C, Britsch S, A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis. EMBO J. 2012 Jun 29;31(13):2922-36
3J:203464 Sims-Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, Gittes G, Bates CM, Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme. PLoS One. 2013;8(6):e65993
2J:98806 Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A, Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development. 2005 Jun;132(12):2697-707
3J:178150 Singh MK, Lu MM, Massera D, Epstein JA, MicroRNA-processing Enzyme Dicer Is Required in Epicardium for Coronary Vasculature Development. J Biol Chem. 2011 Nov 25;286(47):41036-45
1J:119668 Sirois J, Cote JF, Charest A, Uetani N, Bourdeau A, Duncan SA, Daniels E, Tremblay ML, Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev. 2006 Dec;123(12):869-80
1J:191486 Sivina M, Yamada T, Park CS, Puppi M, Coskun S, Hirschi K, Lacorazza HD, The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1185-91
4J:186037 Smart N, Dube KN, Riley PR, Identification of Thymosin beta4 as an effector of Hand1-mediated vascular development. Nat Commun. 2010;1:46
3J:119685 Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS, Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006;6:30
1*J:97474 Smith CA, McClive PJ, Sinclair AH, Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Dev Dyn. 2005 May;233(1):188-93
1J:144349 Smith L, Willan J, Warr N, Brook FA, Cheeseman M, Sharpe R, Siggers P, Greenfield A, The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice. PLoS ONE. 2008;3(12):e4091
1J:147647 Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ, Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008 Apr 11;102(7):752-60
4J:80044 Sohn SJ, Sarvis BK, Cado D, Winoto A, ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002 Nov 8;277(45):43344-51
2J:186473 Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y, Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
3J:85366 Sorensen LK, Brooke BS, Li DY, Urness LD, Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol. 2003 Sep 1;261(1):235-50
2J:193767 Souza CM, Davidson D, Rhee I, Gratton JP, Davis EC, Veillette A, The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability. J Biol Chem. 2012 Dec 14;287(51):43180-90
1J:63242 Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK, Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol. 2000 Aug;20(15):5643-52
3J:142286 Sridurongrit S, Larsson J, Schwartz R, Ruiz-Lozano P, Kaartinen V, Signaling via the Tgf-beta type I receptor Alk5 in heart development. Dev Biol. 2008 Oct 1;322(1):208-18
2J:155959 Srinivasan R, Zabuawala T, Huang H, Zhang J, Gulati P, Fernandez S, Karlo JC, Landreth GE, Leone G, Ostrowski MC, Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One. 2009;4(12):e8283
5J:158959 Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G, The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010 Apr 1;24(7):696-707
5J:177488 Srinivasan RS, Oliver G, Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97
1J:81698 Stalmans I, Lambrechts D, De Smet F, Jansen S, Wang J, Maity S, Kneer P, Von Der Ohe M, Swillen A, Maes C, Gewillig M, Molin DG, Hellings P, Boetel T, Haardt M, Compernolle V, Dewerchin M, Plaisance S, Vlietinck R, Emanuel B, Gittenberger-De Groot AC, Scambler P, Morrow B, Driscol DA, Moons L, Esguerra CV, Carmeliet G, Behn-Krappa A, Devriendt K, Collen D, Conway SJ, Carmeliet P, VEGF: A modifier of the del22q11 (DiGeorge) syndrome?. Nat Med. 2003 Feb;9(2):173-82
4J:132583 Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP, Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008 Feb;14(2):298-311
1J:50513 Steingrimsson E, Tessarollo L, Reid SW, Jenkins NA, Copeland NG, The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998 Dec;125(23):4607-16
1J:142352 Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP, Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21;322(5905):1247-50
1J:98489 Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP, Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May;132(10):2451-62
2J:84301 Stolt CC, Lommes P, Sock E, Chaboissier MC, Schedl A, Wegner M, The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003 Jul 1;17(13):1677-89
7J:154782 Strilic B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E, The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell. 2009 Oct;17(4):505-15
2J:125893 Suchting S, Freitas C, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A, The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3225-30
1J:191584 Sueyoshi T, Yamamoto K, Akiyama H, Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation. Matrix Biol. 2012 Jul;31(6):352-9
1J:190873 Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K, Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep. 2012 Nov 29;2(5):1363-74
2J:194131 Sugiyama D, Kulkeaw K, Mizuochi C, TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
1J:167033 Sugiyama Y, Koike T, Shiojiri N, Developmental changes of cell adhesion molecule expression in the fetal mouse liver. Anat Rec (Hoboken). 2010 Oct;293(10):1698-710
5J:156959 Sugiyama Y, Takabe Y, Nakakura T, Tanaka S, Koike T, Shiojiri N, Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development. Dev Dyn. 2010 Feb;239(2):386-97
1J:208725 Sui Z, Nowak RB, Bacconi A, Kim NE, Liu H, Li J, Wickrema A, An XL, Fowler VM, Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014 Jan 30;123(5):758-67
2J:167262 Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S, LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood. 2010 Dec 2;116(23):5060-70
1J:56519 Sun X, Meyers EN, Lewandoski M, Martin GR, Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999 Jul 15;13(14):1834-46
2J:156167 Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans SM, Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007 Apr 1;304(1):286-96
2J:74151 Sund M, Vaisanen T, Kaukinen S, Ilves M, Tu H, Autio-Harmainen H, Rauvala H, Pihlajaniemi T, Distinct expression of type XIII collagen in neuronal structures and other tissues during mouse development. Matrix Biol. 2001 Jul;20(4):215-31
8J:37459 Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD, Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [see comments]. Cell. 1996 Dec 27;87(7):1171-80
1J:171839 Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P, Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan 4;121(1):328-41
3J:165898 Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y, Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem. 2010 Aug 6;285(32):24494-507
1J:147764 Svensson P, Bergqvist I, Norlin S, Edlund H, MFng is dispensable for mouse pancreas development and function. Mol Cell Biol. 2009 Apr;29(8):2129-38
1J:205050 Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM, Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Development. 2013 Nov;140(22):4574-82
1J:152846 Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH, Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development. 2009 Aug;136(15):2653-63
2J:99096 Tachibana K, Jones N, Dumont DJ, Puri MC, Bernstein A, Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Mol Cell Biol. 2005 Jun;25(11):4693-702
12J:79222 Taichman DB, Loomes KM, Schachtner SK, Guttentag S, Vu C, Williams P, Oakey RJ, Baldwin HS, Notch1 and Jagged1 expression by the developing pulmonary vasculature. Dev Dyn. 2002 Oct;225(2):166-75
6J:164624 Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y, The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol. 2009 Aug;20(8):1714-23
1J:119194 Takahashi M, Kojima M, Nakajima K, Suzuki-Migishima R, Takeuchi T, Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol. 2007 Mar 15;303(2):549-60
2J:86844 Takahashi T, Takahashi K, Gerety S, Wang H, Anderson DJ, Daniel TO, Temporally compartmentalized expression of ephrin-B2 during renal glomerular development. J Am Soc Nephrol. 2001 Dec;12(12):2673-82
6J:82356 Takahashi T, Takahashi K, St John PL, Fleming PA, Tomemori T, Watanabe T, Abrahamson DR, Drake CJ, Shirasawa T, Daniel TO, A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol. 2003 Mar;23(5):1817-31
4J:63424 Takakura N, Watanabe T, Suenobu S, Yamada Y, Noda T, Ito Y, Satake M, Suda T, A role for hematopoietic stem cells in promoting angiogenesis. Cell. 2000 Jul 21;102(2):199-209
2J:175868 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC, Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct;31(19):4097-106
3J:188649 Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M, Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood. 2012 Jul 26;120(4):914-23
1J:75477 Takashima S, Kitakaze M, Asakura M, Asanuma H, Sanada S, Tashiro F, Niwa H, Miyazaki Ji J, Hirota S, Kitamura Y, Kitsukawa T, Fujisawa H, Klagsbrun M, Hori M, Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3657-62
1J:132871 Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H, Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood. 2006 Jun 1;107(11):4317-25
1J:108390 Takebe A, Era T, Okada M, Martin Jakt L, Kuroda Y, Nishikawa S, Microarray analysis of PDGFRalpha+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. Dev Biol. 2006 May 1;293(1):25-37
2J:114669 Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH, Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor {alpha} Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2. Mol Cell Biol. 2006 Nov;26(22):8336-46
1*J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
2J:152868 Takimoto A, Nishizaki Y, Hiraki Y, Shukunami C, Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation. Dev Biol. 2009 Aug 15;332(2):196-211
2J:181470 Tam SJ, Richmond DL, Kaminker JS, Modrusan Z, Martin-McNulty B, Cao TC, Weimer RM, Carano RA, van Bruggen N, Watts RJ, Death Receptors DR6 and TROY Regulate Brain Vascular Development. Dev Cell. 2012 Feb 14;22(2):403-17
1J:99926 Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M, Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005 May 13;280(19):19185-95
2J:138577 Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K, Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature. 2008 Jul 31;454(7204):656-60
1J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
3J:178926 Tan M, Zhao Y, Kim SJ, Liu M, Jia L, Saunders TL, Zhu Y, Sun Y, SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation. Dev Cell. 2011 Dec 13;21(6):1062-76
1*J:52597 Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S, The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999 Mar;126(6):1269-80
1*J:56673 Tanaka M, Lyons GE, Izumo S, Expression of the Nkx3.1 homobox gene during pre and postnatal development. Mech Dev. 1999 Jul;85(1-2):179-82
2J:116891 Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H, Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem. 2006 Sep 1;281(35):25822-30
1J:63763 Tanaka Y, Naruse I, Hongo T, Xu M, Nakahata T, Maekawa T, Ishii S, Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein. Mech Dev. 2000 Jul;95(1-2):133-45
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5J:143587 Tang H, Brennan J, Karl J, Hamada Y, Raetzman L, Capel B, Notch signaling maintains Leydig progenitor cells in the mouse testis. Development. 2008 Nov;135(22):3745-53
2J:136802 Tang H, Ross A, Capel B, Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. Dev Biol. 2008 Jun 1;318(1):73-81
1J:149534 Tang M, Miyamoto Y, Huang EJ, Multiple roles of {beta}-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development. 2009 Jun;136(12):2027-38
1J:106926 Tang N, Mack F, Haase VH, Simon MC, Johnson RS, pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol. 2006 Apr;26(7):2519-30
2J:122355 Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, Oike Y, Yonemitsu Y, Maehara Y, Yoshimura A, Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007 Jun;27(12):4541-50
2J:125052 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H, Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63
2J:130422 Tanjore H, Zeisberg EM, Gerami-Naini B, Kalluri R, Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn. 2008 Jan;237(1):75-82
2J:122300 Taoudi S, Medvinsky A, Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9399-403
4J:196073 Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, Kim BY, Kwon YT, UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5
1J:108342 Terszowski G, Muller SM, Bleul CC, Blum C, Schirmbeck R, Reimann J, Pasquier LD, Amagai T, Boehm T, Rodewald HR, Evidence for a functional second thymus in mice. Science. 2006 Apr 14;312(5771):284-7
1J:88903 Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ, Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3338-45
1J:78688 Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH, Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct;129(19):4627-34
1J:62879 Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH, FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39
1J:151368 Theveniau-Ruissy M, Dandonneau M, Mesbah K, Ghez O, Mattei MG, Miquerol L, Kelly RG, The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning. Circ Res. 2008 Jul 18;103(2):142-8
1J:185988 Thiele F, Cohrs CM, Flor A, Lisse TS, Przemeck GK, Horsch M, Schrewe A, Gailus-Durner V, Ivandic B, Katus HA, Wurst W, Reisenberg C, Chaney H, Fuchs H, Hans W, Beckers J, Marini JC, Hrabe de Angelis M, Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Hum Mol Genet. 2012 Aug 15;21(16):3535-45
1J:84386 Thumkeo D, Keel J, Ishizaki T, Hirose M, Nonomura K, Oshima H, Oshima M, Taketo MM, Narumiya S, Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol. 2003 Jul;23(14):5043-55
3J:152821 Tian Y, Lei L, Cammarano M, Nekrasova T, Minden A, Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev. 2009 Aug-Sep;126(8-9):710-20
1J:101189 Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L, Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11746-50
5J:87765 Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, Aranda S, Palomo S, McCormick F, Izpisua-Belmonte JC, de la Pompa JL, Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004 Jan 1;18(1):99-115
3J:192736 Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P, Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1;122(11):3862-72
1J:167709 Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB, Long form of latent TGF-beta binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn. 2011 Jan;240(1):176-87
1J:128204 Tolosano E, Cutufia MA, Hirsch E, Stefanuto G, Voyron S, Fasolo A, Silengo L, Altruda F, Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis. Eur J Neurosci. 1996 Mar;8(3):521-9
1J:133934 Tomizuka K, Horikoshi K, Kitada R, Sugawara Y, Iba Y, Kojima A, Yoshitome A, Yamawaki K, Amagai M, Inoue A, Oshima T, Kakitani M, R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling. Hum Mol Genet. 2008 May 1;17(9):1278-91
3J:204328 Tondeleir D, Drogat B, Slowicka K, Bakkali K, Bartunkova S, Goossens S, Haigh JJ, Ampe C, Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS One. 2013;8(6):e67855
1J:154033 Torres R, Ramirez JC, A chemokine targets the nucleus: Cxcl12-gamma isoform localizes to the nucleolus in adult mouse heart. PLoS One. 2009;4(10):e7570
2J:122753 Tozer S, Bonnin MA, Relaix F, Di Savino S, Garcia-Villalba P, Coumailleau P, Duprez D, Involvement of vessels and PDGFB in muscle splitting during chick limb development. Development. 2007 Jul;134(14):2579-91
1*J:119977 Tremblay LO, Nagy Kovacs E, Daniels E, Wong NK, Sutton-Smith M, Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C, Herscovics A, Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. J Biol Chem. 2007 Jan 26;282(4):2558-66
4J:138721 Trindade A, Ram Kumar S, Scehnet JS, Lopes-da-Costa L, Becker J, Jiang W, Liu R, Gill PS, Duarte A, Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood. 2008 Sep 1;112(5):1720-9
1J:162840 Trompouki E, Tsagaratou A, Kosmidis SK, Dolle P, Qian J, Kontoyiannis DL, Cardoso WV, Mosialos G, Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May;11(5):469-76
1J:184206 Tron AE, Arai T, Duda DM, Kuwabara H, Olszewski JL, Fujiwara Y, Bahamon BN, Signoretti S, Schulman BA, DeCaprio JA, The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78
1J:175540 Tsau C, Ito M, Gromova A, Hoffman MP, Meech R, Makarenkova HP, Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling. Development. 2011 Aug;138(15):3307-17
2J:71477 Tsuda T, Wang H, Timpl R, Chu ML, Fibulin-2 expression marks transformed mesenchymal cells in developing cardiac valves, aortic arch vessels, and coronary vessels. Dev Dyn. 2001 Sep;222(1):89-100
2J:88517 Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI, Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
3J:111403 Tsunematsu R, Nishiyama M, Kotoshiba S, Saiga T, Kamura T, Nakayama KI, Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol Cell Biol. 2006 Aug;26(16):6157-69
2J:121629 Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK, TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol. 2007 May 15;305(2):508-521
1J:149923 Ueda H, Miyazaki Y, Matsusaka T, Utsunomiya Y, Kawamura T, Hosoya T, Ichikawa I, Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol. 2008 Apr;19(4):685-94
2J:184923 Ugarte G, Cappellari O, Perani L, Pistocchi A, Cossu G, Noggin recruits mesoderm progenitors from the dorsal aorta to a skeletal myogenic fate. Dev Biol. 2012 May 1;365(1):91-100
2J:132526 Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S, Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007 Jun;12(6):773-85
6J:65521 Urness LD, Sorensen LK, Li DY, Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000 Nov;26(3):328-31
1J:154909 Ustiyan V, Wang IC, Ren X, Zhang Y, Snyder J, Xu Y, Wert SE, Lessard JL, Kalin TV, Kalinichenko VV, Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus. Dev Biol. 2009 Dec 15;336(2):266-79
1*J:210584 van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marban E, Molkentin JD, c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
5J:161850 van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO, Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010 Jul;137(14):2439-49
3*J:80128 van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H, PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis. Dev Dyn. 2002 Nov;225(3):336-43
1J:187883 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK, Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3;150(3):590-605
1J:110324 van Meeteren LA, Ruurs P, Stortelers C, Bouwman P, van Rooijen MA, Pradere JP, Pettit TR, Wakelam MJ, Saulnier-Blache JS, Mummery CL, Moolenaar WH, Jonkers J, Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol. 2006 Jul;26(13):5015-22
6J:104372 van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J, The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006 Feb;133(3):419-28
1J:96850 van Tuyl M, Groenman F, Kuliszewski M, Ridsdale R, Wang J, Tibboel D, Post M, Overexpression of lunatic fringe does not affect epithelial cell differentiation in the developing mouse lung. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L672-82
3J:119174 van Tuyl M, Groenman F, Wang J, Kuliszewski M, Liu J, Tibboel D, Post M, Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol. 2007 Mar 15;303(2):514-526
3J:210365 Varadkar P, Despres D, Kraman M, Lozier J, Phadke A, Nagaraju K, Mccright B, The protein phosphatase 2A B56gamma regulatory subunit is required for heart development. Dev Dyn. 2014 Jun;243(6):778-90
1*J:132939 Varadkar P, Kraman M, Despres D, Ma G, Lozier J, McCright B, Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn. 2008 Apr;237(4):1144-52
1J:175538 Vega-Hernandez M, Kovacs A, De Langhe S, Ornitz DM, FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development. 2011 Aug;138(15):3331-40
2J:152652 Venkatesh DA, Park KS, Harrington A, Miceli-Libby L, Yoon JK, Liaw L, Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res. 2008 Aug 15;103(4):423-31
3J:121420 Vieira JM, Schwarz Q, Ruhrberg C, Selective requirements for NRP1 ligands during neurovascular patterning. Development. 2007 May;134(10):1833-43
2J:188920 Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, Oettgen P, Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
1*J:71910 Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G, Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev. 2001 Oct;108(1-2):161-4
1J:101718 Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ, The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development. 2005 Mar;132(6):1315-25
1J:213584 Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M, Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014 Oct 1;23(19):5087-101
1J:46127 Visvader JE, Fujiwara Y, Orkin SH, Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 1998 Feb 15;12(4):473-9
2J:137357 Vivatbutsiri P, Ichinose S, Hytonen M, Sainio K, Eto K, Iseki S, Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J Anat. 2008 May;212(5):603-11
1J:204465 Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S, Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep;140(18):3731-42
1J:81587 Volpert OV, Pili R, Sikder HA, Nelius T, Zaichuk T, Morris C, Shiflett CB, Devlin MK, Conant K, Alani RM, Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell. 2002 Dec;2(6):473-83
2J:175466 von Gise A, Zhou B, Honor LB, Ma Q, Petryk A, Pu WT, WT1 regulates epicardial epithelial to mesenchymal transition through beta-catenin and retinoic acid signaling pathways. Dev Biol. 2011 Aug 15;356(2):421-31
1*J:80219 Voss AK, Gruss P, Thomas T, The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation. Development. 2003 Jan;130(2):355-67
2J:171496 Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD, The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet. 2011 Jun 1;20(11):2182-94
3J:102417 Wagner N, Wagner KD, Theres H, Englert C, Schedl A, Scholz H, Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 2005 Nov 1;19(21):2631-42
2J:153835 Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H, The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009 Sep 21;186(6):805-16
4J:84143 Wakayama T, Hamada K, Yamamoto M, Suda T, Iseki S, The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation. Histochem Cell Biol. 2003 May;119(5):355-62
1J:100588 Walker DL, Vacha SJ, Kirby ML, Lo CW, Connexin43 deficiency causes dysregulation of coronary vasculogenesis. Dev Biol. 2005 Aug 15;284(2):479-98
3J:167309 Waller-Evans H, Promel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Davies B, Aparicio SA, Grosse J, Russ AP, The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010;5(11):e14047
2J:181634 Wallgard E, Nitzsche A, Larsson J, Guo X, Dieterich LC, Dimberg A, Olofsson T, Ponten FC, Makinen T, Kalen M, Hellstrom M, Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Dev Dyn. 2012 Apr;241(4):770-86
4J:140124 Walls JR, Coultas L, Rossant J, Henkelman RM, Three-dimensional analysis of vascular development in the mouse embryo. PLoS ONE. 2008;3(8):e2853
1J:94468 Wandzioch E, Kolterud A, Jacobsson M, Friedman SL, Carlsson L, Lhx2-/- mice develop liver fibrosis. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16549-54
1J:163702 Wang A, Ma X, Conti MA, Liu C, Kawamoto S, Adelstein RS, Nonmuscle myosin II isoform and domain specificity during early mouse development. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50
1J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
1J:122563 Wang G, Woods A, Agoston H, Ulici V, Glogauer M, Beier F, Genetic ablation of Rac1 in cartilage results in chondrodysplasia. Dev Biol. 2007 Jun 15;306(2):612-23
6J:75288 Wang HU, Chen ZF, Anderson DJ, Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998 May 29;93(5):741-53
1J:42409 Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH, Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 1997 Jul 16;16(14):4374-83
1J:139708 Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN, The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261-71
2J:161965 Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Luthi U, Barberis A, Benjamin LE, Makinen T, Nobes CD, Adams RH, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010 May 27;465(7297):483-6
2J:199879 Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K, Klein D, Taylor V, Zhou B, Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One. 2013;8(4):e60244
1J:56404 Wani MA, Wert SE, Lingrel JB, Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development. J Biol Chem. 1999 Jul 23;274(30):21180-5
1J:158680 Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E, Meijlink F, Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 2010 Apr;137(7):1067-73
2J:167034 Wansleeben C, Feitsma H, Tertoolen L, Kroon C, Guryev V, Cuppen E, Meijlink F, A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction. Int J Dev Biol. 2010;
3J:108961 Ward RD, Stone BM, Raetzman LT, Camper SA, Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol. 2006 Jun;20(6):1378-90
1J:147206 Warr N, Siggers P, Bogani D, Brixey R, Pastorelli L, Yates L, Dean CH, Wells S, Satoh W, Shimono A, Greenfield A, Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol. 2009 Feb 15;326(2):273-84
1J:134681 Wasteson P, Johansson BR, Jukkola T, Breuer S, Akyurek LM, Partanen J, Lindahl P, Developmental origin of smooth muscle cells in the descending aorta in mice. Development. 2008 May;135(10):1823-32
1J:205519 Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S, Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013 Nov 27;5(4):926-32
5J:165754 Watanabe T, Koibuchi N, Chin MT, Transcription factor CHF1/Hey2 regulates coronary vascular maturation. Mech Dev. 2010 Sep-Dec;127(9-12):418-27
1J:108444 Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki KI, Kanno J, Saga Y, Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006 May;133(9):1625-34
1J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1*J:83697 Weaver M, Batts L, Hogan BL, Tissue interactions pattern the mesenchyme of the embryonic mouse lung. Dev Biol. 2003 Jun 1;258(1):169-84
1J:55441 Weaver M, Yingling JM, Dunn NR, Bellusci S, Hogan BL, Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development. 1999 Sep;126(18):4005-15
1J:169178 Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW, The ARID Family Transcription Factor Bright Is Required for both Hematopoietic Stem Cell and B Lineage Development. Mol Cell Biol. 2011 Mar;31(5):1041-53
4J:151187 Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC, Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood. 2009 Jul 30;114(5):1123-30
3*J:125199 Wei P, Satoh T, Edamatsu H, Aiba A, Setsu T, Terashima T, Kitazawa S, Nakao K, Yoshikawa Y, Tamada M, Kataoka T, Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Biochem Biophys Res Commun. 2007 Nov 9;363(1):106-12
1J:199205 Wei W, Hou J, Alder O, Ye X, Lee S, Cullum R, Chu A, Zhao Y, Warner SM, Knight DA, Yang D, Jones SJ, Marra MA, Hoodless PA, Genome-wide microRNA and messenger RNA profiling in rodent liver development implicates mir302b and mir20a in repressing transforming growth factor-beta signaling. Hepatology. 2013 Jun;57(6):2491-501
1J:189923 Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone G, Schulte-Merker S, de Bruin A, E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J. 2012 Oct 3;31(19):3871-84
1J:126506 Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M, Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29;99(7):749-57
1J:206319 Welcker JE, Hernandez-Miranda LR, Paul FE, Jia S, Ivanov A, Selbach M, Birchmeier C, Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
1*J:143212 Westerlund J, Andersson L, Carlsson T, Zoppoli P, Fagman H, Nilsson M, Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia. Dev Dyn. 2008 Dec;237(12):3820-9
3J:128368 White AC, Lavine KJ, Ornitz DM, FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development. 2007 Oct;134(20):3743-52
1J:107406 White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM, FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development. 2006 Apr;133(8):1507-17
4J:146527 Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY, The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009 Feb;15(2):177-84
2J:75859 Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G, An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 2002 Apr 2;21(7):1505-13
4J:57646 Wigle JT, Oliver G, Prox1 function is required for the development of the murine lymphatic system. Cell. 1999 Sep 17;98(6):769-78
4J:103443 Wilhelm D, Martinson F, Bradford S, Wilson MJ, Combes AN, Beverdam A, Bowles J, Mizusaki H, Koopman P, Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol. 2005 Nov 1;287(1):111-24
3J:139011 Wilkinson GA, Schittny JC, Reinhardt DP, Klein R, Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008 Aug;237(8):2220-34
2J:147543 Wilkinson L, Gilbert T, Kinna G, Ruta LA, Pennisi D, Kett M, Little MH, Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development. J Am Soc Nephrol. 2007 Jun;18(6):1697-708
3J:102947 Wilm B, Ipenberg A, Hastie ND, Burch JB, Bader DM, The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. Development. 2005 Dec;132(23):5317-28
5J:203698 Wilson CW, Parker LH, Hall CJ, Smyczek T, Mak J, Crow A, Posthuma G, De Maziere A, Sagolla M, Chalouni C, Vitorino P, Roose-Girma M, Warming S, Klumperman J, Crosier PS, Ye W, Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood. 2013 Nov 21;122(22):3678-90
2J:99574 Wilson MJ, Liaw L, Koopman P, Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005 Aug;233(4):1488-95
2J:121518 Wilting J, Buttler K, Schulte I, Papoutsi M, Schweigerer L, Manner J, The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart. Dev Biol. 2007 May 15;305(2):451-459
2J:39636 Winnier GE, Hargett L, Hogan BL, The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 1997 Apr 1;11(7):926-40
2J:211804 Woik N, Dietz CT, Schaker K, Kroll J, Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2alpha in mice. Dis Model Mech. 2014 Jun;7(6):683-92
1J:136573 Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA, Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008 Apr 25;283(17):11850-9
2J:206656 Worzfeld T, Swiercz JM, Senturk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S, Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
6J:193198 Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain AA, Moreno-Rodriguez RA, Markwald RR, O'Rourke BP, Sharp DJ, Zheng D, Lenz J, Baldwin HS, Chang CP, Zhou B, Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012 Nov 21;151(5):1083-96
1*J:53885 Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML, Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development. 1999 Aug;126(16):3597-605
3J:203805 Wu SP, Dong XR, Regan JN, Su C, Majesky MW, Tbx18 regulates development of the epicardium and coronary vessels. Dev Biol. 2013 Nov 15;383(2):307-20
3J:214991 Wu ZQ, Rowe RG, Lim KC, Lin Y, Willis A, Tang Y, Li XY, Nor JE, Maillard I, Weiss SJ, A Snail1/Notch1 signalling axis controls embryonic vascular development. Nat Commun. 2014;5:3998
2J:107211 Wynne F, Ball M, McLellan AS, Dockery P, Zimmermann W, Moore T, Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Reproduction. 2006 Apr;131(4):721-32
1J:96775 Xia L, Ju T, Westmuckett A, An G, Ivanciu L, McDaniel JM, Lupu F, Cummings RD, McEver RP, Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J Cell Biol. 2004 Feb 2;164(3):451-9
1J:117792 Xia L, McEver RP, Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice. Methods Enzymol. 2006;416:314-31
5J:202407 Xiao Y, Woo WM, Nagao K, Li W, Terunuma A, Mukouyama YS, Oro AE, Vogel JC, Brownell I, Perivascular hair follicle stem cells associate with a venule annulus. J Invest Dermatol. 2013 Oct;133(10):2324-31
3J:152906 Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL, Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol. 2009 Sep;175(3):1315-27
1J:197855 Xie J, Yoon J, Yang SS, Lin SH, Huang CL, WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem. 2013 Mar 22;288(12):8566-74
1J:111824 Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN, A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11189-94
1J:136063 Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC, Cited2 is required for fetal lung maturation. Dev Biol. 2008 May 1;317(1):95-105
1*J:51595 Xu C, Liguori G, Persico MG, Adamson ED, Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94
2J:214676 Xu J, Nie X, Cai X, Cai CL, Xu PX, Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney. Dev Biol. 2014 Jul 1;391(1):17-31
4J:148361 Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O, Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Dev Biol. 2009 May 15;329(2):269-79
2J:155893 Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE, Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56
3J:156869 Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A, Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol. 2010 Jan 11;188(1):115-30
1J:54907 Xue Y, Gao X, Lindsell CE, Norton CR, Chang B, Hicks C, Gendron-Maguire M , Rand EB , Weinmaster G , Gridley T, Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet. 1999 May;8(5):723-30
2J:146829 Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K, Craniofacial malformation in R-spondin2 knockout mice. Biochem Biophys Res Commun. 2009 Apr 10;381(3):453-8
3J:123757 Yamada Y, Takakura N, Physiological pathway of differentiation of hematopoietic stem cell population into mural cells. J Exp Med. 2006 Apr 17;203(4):1055-65
1J:68082 Yamada Y, Takakura N, Yasue H, Ogawa H, Fujisawa H, Suda T, Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis. Blood. 2001 Mar 15;97(6):1671-8
2J:60342 Yamagishi H, Olson EN, Srivastava D, The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000 Feb;105(3):261-70
2J:167832 Yamaguchi YL, Tanaka SS, Oshima N, Kiyonari H, Asashima M, Nishinakamura R, Translocon-associated protein subunit Trap-gamma/Ssr3 is required for vascular network formation in the mouse placenta. Dev Dyn. 2011 Feb;240(2):394-403
4J:174909 Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M, Yamashita JK, The {kappa} opioid system regulates endothelial cell differentiation and pathfinding in vascular development. Blood. 2011 Jul 21;118(3):775-85
2J:124125 Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH, Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007 Aug 1;308(1):44-53
5J:126692 Yamamoto Y, Shiraishi I, Dai P, Hamaoka K, Takamatsu T, Regulation of embryonic lung vascular development by vascular endothelial growth factor receptors, Flk-1 and Flt-1. Anat Rec (Hoboken). 2007 Aug;290(8):958-73
1J:132655 Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M, Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol Cell Biol. 2008 Feb;28(4):1285-97
4*J:84651 Yamazaki D, Suetsugu S, Miki H, Kataoka Y, Nishikawa S, Fujiwara T, Yoshida N, Takenawa T, WAVE2 is required for directed cell migration and cardiovascular development. Nature. 2003 Jul 24;424(6947):452-6
3J:29184 Yan HC, Baldwin HS, Sun J, Buck CA, Albelda SM, DeLisser HM, Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem. 1995 Oct 6;270(40):23672-80
2J:107620 Yan L, Carr J, Ashby PR, Murry-Tait V, Thompson C, Arthur JS, Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol. 2003 Dec 16;3:11
1J:48566 Yanagisawa H, Hammer RE, Richardson JA, Williams SC, Clouthier DE, Yanagisawa M, Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice [see comments]. J Clin Invest. 1998 Jul 1;102(1):22-33
1*J:163441 Yang DH, Yoon JY, Lee SH, Bryja V, Andersson ER, Arenas E, Kwon YG, Choi KY, Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha. Circ Res. 2009 Feb 13;104(3):372-9
1J:127356 Yang E, Shim JS, Woo HJ, Kim KW, Kwon HJ, Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. Biochem Biophys Res Commun. 2007 Nov 16;363(2):336-41
3*J:60748 Yang J, Boerm M, McCarty M, Bucana C, Fidler IJ, Zhuang Y, Su B, Mekk3 is essential for early embryonic cardiovascular development. Nat Genet. 2000 Mar;24(3):309-13
2J:35566 Yang K, Cepko CL, Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci. 1996 Oct 1;16(19):6089-99
2*J:97770 Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G, Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330-5
2J:53289 Yang X, Castilla LH, Xu X, Li C, Gotay J, Weinstein M, Liu PP, Deng CX, Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
2J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374
6J:191306 Yang Y, Garcia-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G, Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 2012 Sep 13;120(11):2340-8
3*J:119856 Yang ZZ, Tschopp O, Di-Poi N, Bruder E, Baudry A, Dummler B, Wahli W, Hemmings BA, Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol. 2005 Dec;25(23):10407-18
1J:107812 Yao HH, Aardema J, Holthusen K, Sexually dimorphic regulation of inhibin Beta B in establishing gonadal vasculature in mice. Biol Reprod. 2006 May;74(5):978-83
3*J:87040 Yao HH, DiNapoli L, Capel B, Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. Development. 2003 Dec;130(24):5895-902
3*J:90277 Yao HH, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B, Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004 Jun;230(2):210-5
1J:82007 Yao HH, Whoriskey W, Capel B, Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev. 2002 Jun 1;16(11):1433-40
1J:152576 Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR, HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci. 2009 Jul;12(7):829-38
5J:155882 Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E, Benson DW, Ivy D, Perryman MB, Garrett-Sinha LA, Grossfeld P, Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects and abnormal ventricular morphology in mice. Hum Mol Genet. 2009 Dec 15;
1J:111701 Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM, Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84
1J:107205 Yevtodiyenko A, Schmidt JV, Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta. Dev Dyn. 2006 Apr;235(4):1115-23
1J:161211 Yi J, Chen M, Wu X, Yang X, Xu T, Zhuang Y, Han M, Xu R, Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn. 2010 Jul;239(7):2005-13
1J:142646 Yi L, Domyan ET, Lewandoski M, Sun X, Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn. 2008 Dec 18;238(1):123-137
2J:70892 Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP, Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
1J:116228 Yoder M, Hildebrand JD, Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization. Cell Motil Cytoskeleton. 2007 Jan;64(1):49-63
5J:165571 Yokomizo T, Dzierzak E, Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development. 2010 Nov;137(21):3651-61
4J:174699 Yokomizo T, Ng CE, Osato M, Dzierzak E, Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters. Blood. 2011 Jun 9;117(23):6132-4
3J:117242 Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M, Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 2007 Jan 10;26(1):184-96
1J:119669 Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM, BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006 Dec;133(23):4667-78
1J:137915 Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG, Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol. 2008 Aug;28(15):4794-804
1J:138865 Yoshida T, Vivatbutsiri P, Morriss-Kay G, Saga Y, Iseki S, Cell lineage in mammalian craniofacial mesenchyme. Mech Dev. 2008 Sep-Oct;125(9-10):797-808
4J:87724 Yoshitomi H, Zaret KS, Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development. 2004 Feb;131(4):807-17
1J:93296 Yu H, Wessels A, Chen J, Phelps AL, Oatis J, Tint GS, Patel SB, Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev Biol. 2004 Mar 2;4(1):1
2J:189062 Yu H, Ye X, Guo N, Nathans J, Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development. 2012 Dec;139(23):4383-94
1J:184004 Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP, Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May;139(10):1863-73
4J:165724 Yu S, Poe B, Schwarz M, Elliot SA, Albertine KH, Fenton S, Garg V, Moon AM, Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development. Dev Biol. 2010 Nov 1;347(1):92-108
2J:79393 Yuan L, Moyon D, Pardanaud L, Breant C, Karkkainen MJ, Alitalo K, Eichmann A, Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development. 2002 Oct;129(20):4797-806
1J:99332 Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, Mucenski ML, Suda T, Morishita K, Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005 Jun 1;24(11):1976-87
3J:127444 Zamora M, Manner J, Ruiz-Lozano P, Epicardium-derived progenitor cells require beta-catenin for coronary artery formation. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18109-14
5J:153636 Zeini M, Hang CT, Lehrer-Graiwer J, Dao T, Zhou B, Chang CP, Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development. 2009 Oct;136(19):3335-45
1*J:70830 Zelzer E, Glotzer DJ, Hartmann C, Thomas D, Fukai N, Soker S, Olsen BR, Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech Dev. 2001 Aug;106(1-2):97-106
3*J:75934 Zelzer E, McLean W, Ng YS, Fukai N, Reginato AM, Lovejoy S, D'Amore PA, Olsen BR, Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development. 2002 Apr;129(8):1893-904
1J:70281 Zeng X, Gray M, Stahlman MT, Whitsett JA, TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo. Dev Dyn. 2001 Jul;221(3):289-301
2J:154181 Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, Wang L, Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 5;114(19):4300-9
7J:208012 Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko JD, Wang L, Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan 2;124(1):209-21
5J:164023 Zhang C, Tian L, Chi C, Wu X, Yang X, Han M, Xu T, Zhuang Y, Deng K, Adam10 is essential for early embryonic cardiovascular development. Dev Dyn. 2010 Aug 27;
4J:144734 Zhang H, He Y, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W, AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest. 2008 Dec;118(12):3904-16
3J:171387 Zhang H, Tse J, Hu X, Witte M, Bernas M, Kang J, Tilahun F, Hong YK, Qiu M, Chen L, Novel discovery of LYVE-1 expression in the hyaloid vascular system. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6157-61
1J:143443 Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F, Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development. 2008 Nov;135(21):3611-22
1J:196860 Zhang J, Wang Y, Gao Z, Yun Z, Ye J, Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality. Clin Exp Pharmacol Physiol. 2012 Feb;39(2):145-50
1*J:187393 Zhang L, Yuan G, Liu H, Lin H, Wan C, Chen Z, Expression pattern of Sox2 during mouse tooth development. Gene Expr Patterns. 2012 Aug;12(7-8):273-81
5J:177405 Zhang L, Zhou F, Han W, Shen B, Luo J, Shibuya M, He Y, VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010 Dec;20(12):1319-31
2J:198224 Zhang S, Loch AJ, Radtke F, Egan SE, Xu K, Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dyn. 2013 Jun;242(6):678-86
1J:175992 Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguin P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, HuiCC, Bruneau BG, Backx PH, Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13576-81
1J:199412 Zhang T, Liu J, Zhang J, Thekkethottiyil EB, Macatee TL, Ismat FA, Wang F, Stoller JZ, Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS One. 2013;8(2):e57032
2J:143763 Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, Epstein JA, Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol. 2009 Jan 1;325(1):82-93
5J:204703 Zhang Z, Zhou B, Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. PLoS One. 2013;8(7):e70570
4J:206589 Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M, Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
1*J:68672 Zhao J, Chen H, Peschon JJ, Shi W, Zhang Y, Frank SJ, Warburton D, Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. Dev Biol. 2001 Apr 1;232(1):204-18
3J:167088 Zhao Q, Beck AJ, Vitale JM, Schneider JS, Gao S, Chang C, Elson G, Leibovich SJ, Park JY, Tian B, Nam HS, Fraidenraich D, Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. Dev Biol. 2011 Jan 1;349(1):53-64
1J:135185 Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA, Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9
1J:97579 Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA, GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31
1J:162690 Zhao X, Peng X, Sun S, Park AY, Guan JL, Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol. 2010 Jun 14;189(6):955-65
1*J:117102 Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E, Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81
5J:187714 Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, Kahn ML, Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell. 2012 Aug 14;23(2):342-55
6J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76
2J:137426 Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT, Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13
3J:186857 Zhou J, Pashmforoush M, Sucov HM, Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One. 2012;7(3):e32429
1J:125640 Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM, Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct;39(10):1225-34
3J:120066 Zhou X, Tian F, Sandzen J, Cao R, Flaberg E, Szekely L, Cao Y, Ohlsson C, Bergo MO, Boren J, Akyurek LM, Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3919-24
1J:172282 Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ, Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One. 2011;6(4):e18795
3*J:77682 Zhu J, Motejlek K, Wang D, Zang K, Schmidt A, Reichardt LF, beta8 integrins are required for vascular morphogenesis in mouse embryos. Development. 2002 Jun;129(12):2891-903
5J:201739 Zhu Q, Kim YH, Wang D, Oh SP, Luo K, SnoN facilitates ALK1-Smad1/5 signaling during embryonic angiogenesis. J Cell Biol. 2013 Sep 16;202(6):937-50
1J:168607 Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T, A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system. Exp Cell Res. 2010 Sep 10;316(15):2477-86
1J:68652 Zilian O, Saner C, Hagedorn L, Lee H, Sauberli E, Suter U, Sommer L, Aguet M, Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol. 2001 Apr 3;11(7):494-501
1J:209508 Zimmerman MW, McQueeney KE, Isenberg JS, Pitt BR, Wasserloos KA, Homanics GE, Lazo JS, Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J Biol Chem. 2014 Feb 28;289(9):5904-13
1J:196696 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML, The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 Apr 18;121(16):3228-36
6J:157920 Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML, Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19;18(1):39-51
2J:145436 Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM, Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood. 2007 Jun 1;109(11):4742-52
1J:63719 Zwijsen A, van Rooijen MA, Goumans MJ, Dewulf N, Bosman EA, ten Dijke P, Mummery CL, Huylebroeck D, Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis. Dev Dyn. 2000 Aug;218(4):663-70

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