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Gene Expression Literature Summary
Symbol
Name
ID
Pax8
paired box 8
MGI:97492

81 matching records from 81 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18.5 E A
In situ protein (section) 1 4 1 3 2 1 3 1 3 5 2 2 2 3
In situ RNA (section) 1 8 1 9 2 6 6 5 1 5 1 8 1 10 3 1 2 2 4
In situ RNA (whole mount) 3 10 3 2 5 1 2 1 4 3 2 2 2
Northern blot 1 1 1 1
Western blot 1
RT-PCR 1 1 3 5 1 2 1 2 3
cDNA clones 1 1 1
RNase protection 1 2 1 1 1 1 1 1 2
Nuclease S1 1 1
Primer Extension 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pax8  paired box 8   (Synonyms: Pax-8)
Results  Reference
2J:2251 Adams B, Dorfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer-Fogy I, Busslinger M, Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992 Sep;6(9):1589-607
2*J:129685 Amendola E, De Luca P, Macchia PE, Terracciano D, Rosica A, Chiappetta G, Kimura S, Mansouri A, Affuso A, Arra C, Macchia V, Di Lauro R, De Felice M, A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology. 2005 Dec;146(12):5038-47
2*J:160018 Amendola E, Sanges R, Galvan A, Dathan N, Manenti G, Ferrandino G, Alvino FM, Di Palma T, Scarfo M, Zannini M, Dragani TA, De Felice M, Di Lauro R, A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid. Endocrinology. 2010 Apr;151(4):1948-58
4*J:3679 Asano M, Gruss P, Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech Dev. 1992 Nov;39(1-2):29-39
3J:136177 Barrionuevo F, Naumann A, Bagheri-Fam S, Speth V, Taketo MM, Scherer G, Neubuser A, Sox9 is required for invagination of the otic placode in mice. Dev Biol. 2008 May 1;317(1):213-24
3J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58
1J:126342 Bok J, Brunet LJ, Howard O, Burton Q, Wu DK, Role of hindbrain in inner ear morphogenesis: Analysis of Noggin knockout mice. Dev Biol. 2007 Nov 1;311(1):69-78
1J:174353 Boualia SK, Gaitan Y, Murawski I, Nadon R, Gupta IR, Bouchard M, Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for pax2 and emx2. PLoS One. 2011;6(6):e21529
1J:202352 Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M, A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66
1J:163537 Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B, Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 2010 Aug 20;10(1):89
1*J:63683 Bouchard M, Pfeffer P, Busslinger M, Functional equivalence of the transcription factors pax2 and pax5 in mouse development. Development. 2000 Sep;127(17):3703-13
2J:80208 Bouchard M, Souabni A, Mandler M, Neubuser A, Busslinger M, Nephric lineage specification by Pax2 and Pax8. Genes Dev. 2002 Nov 15;16(22):2958-70
1J:181932 Burnworth B, Pippin J, Karna P, Akakura S, Krofft R, Zhang G, Hudkins K, Alpers CE, Smith K, Shankland SJ, Gelman IH, Nelson PJ, SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus. Lab Invest. 2012 Apr;92(4):499-510
3J:181580 Cali G, Gentile F, Mogavero S, Pallante P, Nitsch R, Ciancia G, Ferraro A, Fusco A, Nitsch L, CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas. Endocrinology. 2012 Jan;153(1):522-34
2J:171072 Carre A, Rachdi L, Tron E, Richard B, Castanet M, Schlumberger M, Bidart JM, Szinnai G, Polak M, Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. PLoS One. 2011;6(2):e16752
5J:100575 Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP, Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92
2J:201586 Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ, Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol. 2013 Sep;15(9):1035-44
2J:91854 De Felice M, Postiglione MP, Di Lauro R, Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases. Endocrinology. 2004 Sep;145(9):4062-7
1*J:143681 Dentice M, Cordeddu V, Rosica A, Ferrara AM, Santarpia L, Salvatore D, Chiovato L, Perri A, Moschini L, Fazzini C, Olivieri A, Costa P, Stoppioni V, Baserga M, De Felice M, Sorcini M, Fenzi G, Di Lauro R, Tartaglia M, Macchia PE, Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab. 2006 Apr;91(4):1428-33
1J:93148 Desai TJ, Malpel S, Flentke GR, Smith SM, Cardoso WV, Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev Biol. 2004 Sep 15;273(2):402-15
9J:144755 Di Palma T, D'Andrea B, Liguori GL, Liguoro A, de Cristofaro T, Del Prete D, Pappalardo A, Mascia A, Zannini M, TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp Cell Res. 2009 Jan 15;315(2):162-75
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:30057 Dudley AT, Lyons KM, Robertson EJ, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 1995 NOV 15;9(22):2795-2807
2J:104223 Fagman H, Andersson L, Nilsson M, The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation. Dev Dyn. 2006 Feb;235(2):444-55
2J:181140 Frezzetti D, Reale C, Cali G, Nitsch L, Fagman H, Nilsson O, Scarfo M, De Vita G, Di Lauro R, The microRNA-processing enzyme Dicer is essential for thyroid function. PLoS One. 2011;6(11):e27648
4J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86
3J:171615 Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH, Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn. 2011 Jun;240(6):1600-12
5J:187047 Gerber SD, Amann R, Wyder S, Trueb B, Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. PLoS One. 2012;7(3):e33457
5J:153202 Gerber SD, Steinberg F, Beyeler M, Villiger PM, Trueb B, The murine Fgfrl1 receptor is essential for the development of the metanephric kidney. Dev Biol. 2009 Nov 1;335(1):106-19
1J:104408 Grote D, Souabni A, Busslinger M, Bouchard M, Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 2006 Jan;133(1):53-61
3*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
5J:176192 Hayashi S, Rocancourt D, Buckingham M, Relaix F, Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
2J:200722 Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE, Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
2J:71074 Hirata H, Tomita K, Bessho Y, Kageyama R, Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001 Aug 15;20(16):4454-66
1J:204470 Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T, Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
2J:137096 Jayasena CS, Ohyama T, Segil N, Groves AK, Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development. 2008 Jul;135(13):2251-61
2J:146225 Kameda Y, Ito M, Nishimaki T, Gotoh N, FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Dev Dyn. 2009 Mar;238(3):503-13
1J:189974 Kiefer SM, Robbins L, Rauchman M, Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function. PLoS One. 2012;7(8):e43098
3J:172983 Kobayashi H, Kawakami K, Asashima M, Nishinakamura R, Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech Dev. 2007 Apr;124(4):290-303
9*J:31258 Kozmik Z, Kurzbauer R, Dorfler P, Busslinger M, Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol. 1993 Oct;13(10):6024-35
2J:96329 Ladher RK, Wright TJ, Moon AM, Mansour SL, Schoenwolf GC, FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005 Mar 1;19(5):603-13
1J:149463 Lania G, Zhang Z, Huynh T, Caprio C, Moon AM, Vitelli F, Baldini A, Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol. 2009 Apr 1;328(1):109-17
1J:157251 Lokmane L, Heliot C, Garcia-Villalba P, Fabre M, Cereghini S, vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development. 2010 Jan;137(2):347-57
2J:173123 Mahoney Rogers AA, Zhang J, Shim K, Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol. 2011 May 1;353(1):94-104
3J:175781 Makki N, Capecchi MR, Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol. 2011 Sep 15;357(2):295-304
3J:169135 Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57
4*J:84449 Meunier D, Aubin J, Jeannotte L, Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice. Dev Dyn. 2003 Jul;227(3):367-78
2J:30339 Millen KJ, Hui CC, Joyner AL, A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development. 1995 Dec;121(12):3935-45
2J:42260 Moser M, Pscherer A, Roth C, Becker J, Mucher G, Zerres K, Dixkens C , Weis J , Guay-Woodford L , Buettner R , Fassler R, Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
2J:120229 Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M, Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007 Apr;18(4):1121-9
5*J:41517 Okladnova O, Poleev A, Fantes J, Lee M, Plachov D, Horst J, The genomic organization of the murine Pax 8 gene and characterization of its basal promoter. Genomics. 1997 Jun 15;42(3):452-61
2J:185279 Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S, Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. Hum Mol Genet. 2012 Jul 15;21(14):3143-55
2*J:95017 Parlato R, Rosica A, Rodriguez-Mallon A, Affuso A, Postiglione MP, Arra C, Mansouri A, Kimura S, Di Lauro R, De Felice M, An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol. 2004 Dec 15;276(2):464-75
4J:65702 Pfeffer PL, Gerster T, Lun K, Brand M, Busslinger M, Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development. 1998 Aug;125(16):3063-74
2J:117030 Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M, Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development. 2007 Jan;134(2):357-66
10*J:72 Plachov D, Chowdhury K, Walther C, Simon D, Guenet JL, Gruss P, Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development. 1990 Oct;110(2):643-51
1J:80538 Postiglione MP, Parlato R, Rodriguez-Mallon A, Rosica A, Mithbaokar P, Maresca M, Marians RC, Davies TF, Zannini MS, De Felice M, Di Lauro R, Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15462-7
1J:195266 Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H, Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet. 2013 Mar;9(3):e1003380
1J:79100 Riccomagno MM, Martinu L, Mulheisen M, Wu DK, Epstein DJ, Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 2002 Sep 15;16(18):2365-78
1J:124257 Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J, {beta}-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development. 2007 Sep;134(17):3177-90
1J:115344 Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
2J:169693 Silberschmidt D, Rodriguez-Mallon A, Mithboakar P, Cali G, Amendola E, Sanges R, Zannini M, Scarfo M, De Luca P, Nitsch L, Di Lauro R, De Felice M, In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol. 2011;11:9
1J:171104 Spina A, Rea S, De Pasquale V, Mastellone V, Avallone L, Pavone LM, Fate map of serotonin transporter-expressing cells in developing mouse thyroid. Anat Rec (Hoboken). 2011 Mar;294(3):384-90
2J:21884 Stark K, Vainio S, Vassileva G, McMahon AP, Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994 Dec 15;372(6507):679-83
2J:17132 Stoykova A, Gruss P, Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci. 1994 Mar;14(3 Pt 2):1395-412
1J:92208 Takasato M, Osafune K, Matsumoto Y, Kataoka Y, Yoshida N, Meguro H, Aburatani H, Asashima M, Nishinakamura R, Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Mech Dev. 2004 Jun;121(6):547-57
1J:197590 Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Rehan V, De Langhe S, Di Cristofano A, Bellusci S, Minoo P, Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr;19(2):111-22
3J:52554 Vainio S, Heikkila M, Kispert A, Chin N, McMahon AP, Female development in mammals is regulated by Wnt-4 signalling. Nature. 1999 Feb 4;397(6718):405-9
2*J:133949 Valerius MT, McMahon AP, Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns. 2008 May;8(5):297-306
1J:142115 Vazquez-Echeverria C, Dominguez-Frutos E, Charnay P, Schimmang T, Pujades C, Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol. 2008 Oct 1;322(1):167-78
2*J:77446 Wendl T, Lun K, Mione M, Favor J, Brand M, Wilson SW, Rohr KB, Pax2.1 is required for the development of thyroid follicles in zebrafish. Development. 2002 Aug;129(15):3751-60
1*J:143212 Westerlund J, Andersson L, Carlsson T, Zoppoli P, Fagman H, Nilsson M, Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia. Dev Dyn. 2008 Dec;237(12):3820-9
2*J:83659 Wright TJ, Mansour SL, Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003 Aug;130(15):3379-90
1J:208647 Xu J, Liu H, Park JS, Lan Y, Jiang R, Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52
1J:57313 Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R, Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
2J:79848 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44
1*J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1J:72984 Ye W, Bouchard M, Stone D, Liu X, Vella F, Lee J, Nakamura H, Ang SL, Busslinger M, Rosenthal A, Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nat Neurosci. 2001 Dec;4(12):1175-81
2*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3J:84974 Zheng W, Huang L, Wei ZB, Silvius D, Tang B, Xu PX, The role of Six1 in mammalian auditory system development. Development. 2003 Sep;130(17):3989-4000
3J:119574 Zou D, Silvius D, Rodrigo-Blomqvist S, Enerback S, Xu PX, Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev Biol. 2006 Oct 15;298(2):430-41

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory