About   Help   FAQ
Gene Expression Literature Summary
integrin alpha 2b

55 matching records from 55 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3.5 E4 E5.5 E6.5 E7 E7.5 E8 E8.5 E9.5 E10 E10.5 E11 E11.5 E12.5 E13 E13.5 E14.5 E15.5 E17.5 E18.5 E P
Immunohistochemistry (section) 1 1 1 2 3 8 1 6 3 4 1 3 5 2 1 1 3 9
In situ RNA (section) 2
Immunohistochemistry (whole mount) 1 2 2 3 4 2 2 1 2
Northern blot 1
RT-PCR 1 1 1 1 1 2 2 1 1 1 3 1 1 3 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Itga2b  integrin alpha 2b   (Synonyms: alphaIIb, CD41, GpIIb, GP IIb, platelet glycoprotein IIb)
Results  Reference
2J:98307 Azcoitia V, Aracil M, Martinez-A C, Torres M, The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 2005 Apr 15;280(2):307-20
1J:201077 Boisset JC, Clapes T, Van Der Linden R, Dzierzak E, Robin C, Integrin alphaIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013 May 15;2(5):525-32
1J:82868 Braun A, Bordoy R, Stanchi F, Moser M, Kostka G G, Ehler E, Brandau O, Fassler R, PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp Cell Res. 2003 Apr 1;284(2):239-50
1J:171033 Carramolino L, Fuentes J, Garcia-Andres C, Azcoitia V, Riethmacher D, Torres M, Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis. Circ Res. 2010 Apr 16;106(7):1197-201
2J:195350 Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, Hirota Y, Sakurai T, Imakawa K, Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7(11):e48933
1J:171873 Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R, Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J Clin Invest. 2010 Dec 1;120(12):4353-65
2J:182738 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK, Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13;22(3):651-9
1J:198786 Chislock EM, Ring C, Pendergast AM, Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12432-7
3J:227188 Choe Y, Huynh T, Pleasure SJ, Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets. Elife. 2015;4
1J:193165 Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ Jr, Grapin-Botton A, Magnuson MA, Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
4*J:75349 Corbel C, Salaun J, alphaIIb Integrin Expression during Development of the Murine Hemopoietic System. Dev Biol. 2002 Mar 15;243(2):301-11
1J:237076 Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT, CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 01;126(6):2254-66
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1J:84564 Emambokus NR, Frampton J, The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity. 2003 Jul;19(1):33-45
4*J:84599 Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC, CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep;130(18):4393-403
1J:217097 Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa IA, Domingues RG, Bento T, Almeida AR, Ribeiro H, Potocnik AJ, Enomoto H, Veiga-Fernandes H, The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature. 2014 Oct 2;514(7520):98-101
3J:140201 Goldie LC, Lucitti JL, Dickinson ME, Hirschi KK, Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis. Blood. 2008 Oct 15;112(8):3194-204
1*J:64178 Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, Favier R, Bernstein A, Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug;13(2):167-77
2J:170815 Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES, RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 2011 Mar 17;471(7338):368-72
1J:241239 Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HK, LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage. Cell Rep. 2016 Nov 22;17(9):2286-2298
3J:99494 Li W, Ferkowicz MJ, Johnson SA, Shelley WC, Yoder MC, Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev. 2005 Feb;14(1):44-54
3J:214813 Liakhovitskaia A, Rybtsov S, Smith T, Batsivari A, Rybtsova N, Rode C, de Bruijn M, Buchholz F, Gordon-Keylock S, Zhao S, Medvinsky A, Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Development. 2014 Sep;141(17):3319-23
1J:224446 Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC, Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015;6:7739
4J:81386 Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH, Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003 Jan 15;101(2):508-16
1J:181273 Monks DC, Morrow BE, Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. Dev Dyn. 2012 Mar;241(3):563-73
5J:44398 Ohyama K, Kawano H, Kawamura K, Localization of extracellular matrix molecules, integrins and their regulators, TGF betas, is correlated with axon pathfinding in the spinal cord of normal and Danforth's short tail mice. Brain Res Dev Brain Res. 1997 Nov 12;103(2):143-54
1J:237500 Osipovich AB, Gangula R, Vianna PG, Magnuson MA, Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016 Dec 15;143(24):4595-4607
1J:218711 Padron-Barthe L, Temino S, Villa del Campo C, Carramolino L, Isern J, Torres M, Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo. Blood. 2014 Oct 16;124(16):2523-32
1J:139476 Pang L, Xue HH, Szalai G, Wang X, Wang Y, Watson DK, Leonard WJ, Blobel GA, Poncz M, Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood. 2006 Oct 1;108(7):2198-206
5*J:225923 Potts KS, Sargeant TJ, Dawson CA, Josefsson EC, Hilton DJ, Alexander WS, Taoudi S, Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015 Aug 6;126(6):807-16
4*J:106178 Rampon C, Huber P, Multilineage hematopoietic progenitor activity generated autonomously in the mouse yolk sac: analysis using angiogenesis-defective embryos. Int J Dev Biol. 2003 May;47(4):273-80
1J:203162 Ray A, Treloar HB, IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci. 2012 Jul;50(3-4):238-49
1J:138069 Rolny C, Nilsson I, Magnusson P, Armulik A, Jakobsson L, Wentzel P, Lindblom P, Norlin J, Betsholtz C, Heuchel R, Welsh M, Claesson-Welsh L, Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation. Blood. 2006 Sep 15;108(6):1877-86
8J:92219 Rout UK, Wang J, Paria BC, Armant DR, Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. Dev Biol. 2004 Apr 1;268(1):135-51
2J:171472 Sand FW, Hornblad A, Johansson JK, Loren C, Edsbagge J, Stahlberg A, Magenheim J, Ilovich O, Mishani E, Dor Y, Ahlgren U, Semb H, Growth-limiting role of endothelial cells in endoderm development. Dev Biol. 2011 Apr 15;352(2):267-77
2J:166908 Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D, Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010 Dec;137(23):3941-52
3*J:42727 Schultz JF, Mayernik L, Rout UK, Armant DR, Integrin trafficking regulates adhesion to fibronectin during differentiation of mouse peri-implantation blastocysts. Dev Genet. 1997;21(1):31-43
1*J:78982 Shavit JA, Motohashi H, Onodera K, Akasaka J, Yamamoto M, Engel JD, Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev. 1998 Jul 15;12(14):2164-74
1J:158252 Shimizu R, Kobayashi E, Engel JD, Yamamoto M, Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. Genes Cells. 2009 Sep;14(9):1119-31
1J:190893 Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL, ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med. 2012 Nov 19;209(12):2291-305
1J:228184 Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Lavina B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Makinen T, cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Rep. 2015 Mar 10;
1J:152911 Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ, Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009 Sep 17;114(12):2401-10
1J:226222 Swiers G, Baumann C, O'Rourke J, Giannoulatou E, Taylor S, Joshi A, Moignard V, Pina C, Bee T, Kokkaliaris KD, Yoshimoto M, Yoder MC, Frampton J, Schroeder T, Enver T, Gottgens B, de Bruijn MF, Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level. Nat Commun. 2013;4:2924
1J:185562 Tanaka Y, Joshi A, Wilson NK, Kinston S, Nishikawa S, Gottgens B, The transcriptional programme controlled by Runx1 during early embryonic blood development. Dev Biol. 2012 Jun 15;366(2):404-19
1J:161922 Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ, A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
3J:163605 Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, Koyanagi M, Yoshida Y, Okamura T, Kuroki M, Sasazuki T, Shirasawa S, Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14199-204
2J:160267 Uhrin P, Zaujec J, Breuss JM, Olcaydu D, Chrenek P, Stockinger H, Fuertbauer E, Moser M, Haiko P, Fassler R, Alitalo K, Binder BR, Kerjaschki D, Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010 May 13;115(19):3997-4005
1J:187883 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK, Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3;150(3):590-605
1*J:93502 Watanabe D, Suetake I, Tajima S, Hanaoka K, Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages. Gene Expr Patterns. 2004 Nov;5(1):43-9
1J:165653 Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Gottgens B, Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010 Oct 8;7(4):532-44
2J:167832 Yamaguchi YL, Tanaka SS, Oshima N, Kiyonari H, Asashima M, Nishinakamura R, Translocon-associated protein subunit Trap-gamma/Ssr3 is required for vascular network formation in the mouse placenta. Dev Dyn. 2011 Feb;240(2):394-403
1J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374
1J:165571 Yokomizo T, Dzierzak E, Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development. 2010 Nov;137(21):3651-61
1J:241286 Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS, SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One. 2017;12(5):e0178095
1J:166646 Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson JC, Iruela-Arispe ML, Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood. 2010 Nov 4;116(18):3435-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.10
The Jackson Laboratory