Gene Expression Literature Summary

• Symbol: Il7
• Name: interleukin 7
• ID: MGI:96561

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E4	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18.5	E19.5	E20	E	P
Immunohistochemistry (section)										1											1
In situ RNA (section)					1	2	2		1		1	1		1							1
In situ RNA (whole mount)					1
In situ reporter (knock in)														1							1
RT-PCR	1	1	1	1	4	1	4	1	4		5	4		5	1	3	5	3	3	1	6
cDNA clones					1
Nuclease S1													1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Il7  interleukin 7   (Synonyms: A630026I06Rik, hlb368, Il-7)
Results	Reference
5*	J:120667 Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG, The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. J Immunol. 2003 Aug 1;171(3):1297-303
1	J:217502 Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR, Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
4	J:31226 Gerwin N, Jia GQ, Kulbacki R, Gutierrez-Ramos JC, Interleukin gene expression in mouse preimplantation development. Dev Immunol. 1995;4(3):169-79
1*	J:145693 Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER, Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev Biol. 2009 Mar 1;327(1):216-27
2*	J:189751 Hara T, Shitara S, Imai K, Miyachi H, Kitano S, Yao H, Tani-ichi S, Ikuta K, Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol. 2012 Aug 15;189(4):1577-84
3	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:124645 Itoi M, Tsukamoto N, Yoshida H, Amagai T, Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol. 2007 Aug;19(8):953-64
1	J:190615 Liang B, Hara T, Wagatsuma K, Zhang J, Maki K, Miyachi H, Kitano S, Yabe-Nishimura C, Tani-Ichi S, Ikuta K, Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. J Immunol. 2012 Nov 1;189(9):4444-50
3	J:291487 Liu D, Kousa AI, O'Neill KE, Rouse P, Popis M, Farley AM, Tomlinson SR, Ulyanchenko S, Guillemot F, Seymour PA, Jorgensen MC, Serup P, Koch U, Radtke F, Blackburn CC, Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development. Development. 2020 Jun 22;147(12):dev178582
1	J:123554 Meier D, Bornmann C, Chappaz S, Schmutz S, Otten LA, Ceredig R, Acha-Orbea H, Finke D, Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 2007 May;26(5):643-54
5*	J:36693 Michaelson MD, Mehler MF, Xu H, Gross RE, Kessler JA, Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain. Dev Biol. 1996 Oct 10;179(1):251-63
7*	J:44503 Montgomery RA, Dallman MJ, Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. Cytokine. 1997 Oct;9(10):717-26
7*	J:55762 Montgomery RA, Dallman MJ, Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol. 1991 Jul 15;147(2):554-60
11*	J:49918 Murray AM, Simm B, Beagley KW, Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development. Cytokine. 1998 May;10(5):337-45
1	J:327225 Nagakubo D, Hirakawa M, Iwanami N, Boehm T, Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Sci Rep. 2022 Aug 8;12(1):13554
1*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
1	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
1	J:149246 Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, Richie ER, IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis. 2009 Apr;47(4):281-7
2*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
2	J:32519 Tsuda S, Rieke S, Hashimoto Y, Nakauchi H, Takahama Y, Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells. J Immunol. 1996 May 1;156(9):3233-42
1	J:81255 Yilmaz ZB, Weih DS, Sivakumar V, Weih F, RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J. 2003 Jan 2;22(1):121-30
9	J:95866 Zamisch M, Moore-Scott B, Su DM, Lucas PJ, Manley N, Richie ER, Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol. 2005 Jan 1;174(1):60-7
2	J:146244 Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT, Hafen K, Tsukamoto N, Amagai T, Taketo MM, Krenger W, Hollander GA, Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol. 2009 Mar 1;182(5):2997-3007