Gene Expression Literature Summary

• Symbol: Igfbp3
• Name: insulin-like growth factor binding protein 3
• ID: MGI:96438

54 matching records from 54 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E4	E7.5	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)			1					1	1	2	1	1				2														3
In situ RNA (section)										1		2	1	4	2	5	1	2	1	5	1	5	1	1	2	2			1	7
In situ RNA (whole mount)								2	1	1	1	2		1		1		2
In situ reporter (knock in)																														1
Northern blot												1		1		1		1								1				2
Western blot																1														3
RT-PCR	1	1		1	1	1	1	1		1	1		1	2	1	4	1	1	1	5		6	1	2	1	7	1	1	3	11
cDNA clones												1																		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Igfbp3  insulin-like growth factor binding protein 3   (Synonyms: IGFBP-3)
Results	Reference
1	J:305792 Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U, Lickert H, Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3	J:106102 Carter AM, Nygard K, Mazzuca DM, Han VK, The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. Placenta. 2006 Feb-Mar;27(2-3):278-90
8*	J:98507 Caton J, Bringas P Jr, Zeichner-David M, IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes. Arch Oral Biol. 2005 Feb;50(2):123-9
3	J:238433 Caubit X, Gubellini P, Andrieux J, Roubertoux PL, Metwaly M, Jacq B, Fatmi A, Had-Aissouni L, Kwan KY, Salin P, Carlier M, Lieden A, Rudd E, Shinawi M, Vincent-Delorme C, Cuisset JM, Lemaitre MP, Abderrehamane F, Duban B, Lemaitre JF, Woolf AS, Bockenhauer D, Severac D, Dubois E, Zhu Y, Sestan N, Garratt AN, Kerkerian-Le Goff L, Fasano L, TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Nat Genet. 2016 Nov;48(11):1359-1369
5	J:49984 Damario MA, Liu HC, Mele CA, Horenstein MG, Rosenwaks Z, Immunohistochemical analysis of insulin-like growth factor-binding proteins -1, -2, and -3 in implantation sites of the mouse. J Assist Reprod Genet. 1998 Sep;15(8):513-20
3*	J:86843 Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI, Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol. 2003 Dec 15;264(2):309-22
1	J:198516 Fujita K, Taya Y, Shimazu Y, Aoba T, Soeno Y, Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family. Int J Dev Biol. 2013;57(5):399-406
1*	J:174497 Funatsu N, Inoue T, Nakamura S, Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes. Cereb Cortex. 2004 Sep;14(9):1031-44
1	J:18013 Hahnel A, Schultz GA, Insulin-like growth factor binding proteins are transcribed by preimplantation mouse embryos. Endocrinology. 1994 Apr;134(4):1956-9
1	J:215459 Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T, Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
1	J:244834 Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
2	J:123251 Holm PC, Mader MT, Haubst N, Wizenmann A, Sigvardsson M, Gotz M, Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci. 2007 Jan;34(1):99-119
2*	J:296375 Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, Kriti D, Sebra R, Williams AA, Donovan MJ, Potter SS, Pinto D, Zhang B, van Bakel H, Jabs EW, Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Cell Rep. 2020 Jul 7;32(1):107871
1	J:316922 Holmes G, Gonzalez-Reiche AS, Saturne M, Motch Perrine SM, Zhou X, Borges AC, Shewale B, Richtsmeier JT, Zhang B, van Bakel H, Jabs EW, Single-cell analysis identifies a key role for Hhip in murine coronal suture development. Nat Commun. 2021 Dec 8;12(1):7132
1	J:96096 Iwatsuki K, Tanaka K, Kaneko T, Kazama R, Okamoto S, Nakayama Y, Ito Y, Satake M, Takahashi S, Miyajima A, Watanabe T, Hara T, Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3. Oncogene. 2005 Feb 10;24(7):1129-37
2	J:113301 James MJ, Jarvinen E, Wang XP, Thesleff I, Different roles of Runx2 during early neural crest-derived bone and tooth development. J Bone Miner Res. 2006 Jul;21(7):1034-44
1*	J:98305 Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA, The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr;8(4):611-22
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1	J:175843 Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA, Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16;21(2):315-27
1	J:235014 Legrand JM, Roy E, Ellis JJ, Francois M, Brooks AJ, Khosrotehrani K, STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction. J Invest Dermatol. 2016 Sep;136(9):1781-91
8	J:42775 Lindenbergh-Kortleve DJ, Rosato RR, van Neck JW, Nauta J, van Kleffens M, Groffen C, Zwarthoff EC, Drop SL, Gene expression of the insulin-like growth factor system during mouse kidney development. Mol Cell Endocrinol. 1997 Sep 19;132(1-2):81-91
7*	J:39926 Liu HC, He ZY, Tang YX, Mele CA, Veeck LL, Davis O, Rosenwaks Z, Simultaneous detection of multiple gene expression in mouse and human individual preimplantation embryos. Fertil Steril. 1997 Apr;67(4):733-41
3	J:241923 Lopez IP, Pineiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG, Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One. 2016;11(11):e0166388
1	J:187360 McKean DM, Niswander L, Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
2	J:122252 Ning Y, Hoang B, Schuller AG, Cominski TP, Hsu MS, Wood TL, Pintar JE, Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene. Endocrinology. 2007 May;148(5):2138-47
8	J:201076 Okano T, Kelley MW, Expression of insulin-like growth factor binding proteins during mouse cochlear development. Dev Dyn. 2013 Oct;242(10):1210-21
1	J:326026 Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM, Western PS, An essential role for Polycomb Repressive Complex 2 in the mouse ovary. Reproduction. 2022 Feb 17;163(3):167-182
1	J:156743 Qiu Z, Cang Y, Goff SP, c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1136-41
3	J:333399 Rhee S, Paik DT, Yang JY, Nagelberg D, Williams I, Tian L, Roth R, Chandy M, Ban J, Belbachir N, Kim S, Zhang H, Phansalkar R, Wong KM, King DA, Valdez C, Winn VD, Morrison AJ, Wu JC, Red-Horse K, Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction. Eur Heart J. 2021 Nov 1;42(41):4264-4276
1	J:298990 Sah RK, Ma J, Bah FB, Xing Z, Adlat S, Oo ZM, Wang Y, Bahadar N, Bohio AA, Nagi FH, Feng X, Zhang L, Zheng Y, Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
3	J:223633 Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M, Varela-Nieto I, RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. PLoS One. 2010;5(1):e8699
1	J:320731 Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel A, Lopez-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constancia M, The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8
7*	J:20162 Schuller AG, Groffen C, van Neck JW, Zwarthoff EC, Drop SL, cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins. Mol Cell Endocrinol. 1994 Aug;104(1):57-66
5	J:12803 Schuller AG, Zwarthoff EC, Drop SL, Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
1	J:13309 Schultz GA, Hahnel A, Arcellana-Panlilio M, Wang L, Goubau S, Watson A, Harvey M, Expression of IGF ligand and receptor genes during preimplantation mammalian development. Mol Reprod Dev. 1993 Aug;35(4):414-20
1	J:187514 Shibata S, Fukuoka H, Sato R, Abe T, Suzuki Y, An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible. Eur J Histochem. 2012 May 23;56(2):e23
2*	J:129818 Stefan M, Ji H, Simmons RA, Cummings DE, Ahima RS, Friedman MI, Nicholls RD, Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive. Endocrinology. 2005 Oct;146(10):4377-85
4	J:103255 Suzuki Y, Role of IGFBPs in the morphogenesis of lingual papillae. Anat Rec A Discov Mol Cell Evol Biol. 2005 Sep;286(1):841-7
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1	J:168146 Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L, Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011 Feb 1;25(3):238-50
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
6	J:59625 van Kleffens M, Groffen C, Neck JW, Vermeij-Keers C, Drop SL, mRNA and protein localization of the IGF system during mouse embryonic development in areas with apoptosis. Growth Horm IGF Res. 1999 Jun;9(3):195-204
6*	J:48168 van Kleffens M, Groffen C, Rosato RR, van den Eijnde SM, van Neck JW, Lindenbergh-Kortleve DJ, Zwarthoff EC, Drop SL, mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization. Mol Cell Endocrinol. 1998 Mar 16;138(1-2):151-61
5	J:58580 van Kleffens M, Groffen CA, Dits NF, Lindenbergh-Kortleve DJ, Schuller AG, Bradshaw SL, Pintar JE, Zwarthoff EC, Drop SL, van Neck JW, Generation of antisera to mouse insulin-like growth factor binding proteins (IGFBP)-1 to -6: comparison of IGFBP protein and messenger ribonucleic acid localization in the mouse embryo. Endocrinology. 1999 Dec;140(12):5944-52
1	J:302089 Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T, The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget. 2016 Jun 21;7(25):37436-37455
2	J:25933 Wang E, Wang J, Chin E, Zhou J, Bondy CA, Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. Endocrinology. 1995 Jun;136(6):2741-51
3*	J:65653 Wertz K, Herrmann BG, Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
1*	J:307862 Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O, Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. Elife. 2021 May 18;10:e60108
2	J:64338 Wood TL, Rogler LE, Czick ME, Schuller AG, Pintar JE, Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene. Mol Endocrinol. 2000 Sep;14(9):1472-82
3*	J:310487 Xiang C, Frietze KK, Bi Y, Li Y, Dal Pozzo V, Pal S, Alexander N, Baubet V, D'Acunto V, Mason CE, Davuluri RV, Dahmane N, RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Mol Cell Biol. 2021 Jun 23;41(7):e0052620
2	J:167088 Zhao Q, Beck AJ, Vitale JM, Schneider JS, Gao S, Chang C, Elson G, Leibovich SJ, Park JY, Tian B, Nam HS, Fraidenraich D, Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes. Dev Biol. 2011 Jan 1;349(1):53-64