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Gene Expression Literature Summary
Symbol
Name
ID
Igfbp2
insulin-like growth factor binding protein 2
MGI:96437

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E4 E7.5 E8.5 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17.5 E18 E18.5 E19 E A
In situ protein (section) 1 1 1 2 1 1 2 1
In situ RNA (section) 1 2 3 1 5 5 6 1 3 5 1 2 2 1 2 8
In situ RNA (whole mount) 1 1 2 1 2 2 4 2
Northern blot 1 1 1 1 1 2
Western blot 1 1 3
RT-PCR 1 1 1 1 1 1 1 2 2 1 1 1 2 2 2 3 10
cDNA clones 1 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Igfbp2  insulin-like growth factor binding protein 2   (Synonyms: Igfbp-2, IGFBP-2)
Results  Reference
10J:74079 Allan GJ, Flint DJ, Darling SM, Geh J, Patel K, Altered expression of insulin-like growth factor-1 and insulin like growth factor binding proteins-2 and 5 in the mouse mutant Hypodactyly (Hd) correlates with sites of apoptotic activity. Anat Embryol (Berl). 2000 Jul;202(1):1-11
5*J:74084 Arnold PM, Ma JY, Citron BA, Zoubine MN, Festoff BW, Selective developmental regulation of gene expression for insulin-like growth factor-binding proteins in mouse spinal cord. Spine. 2000 Jul 15;25(14):1765-70
2J:180979 Besnard V, Wert SE, Ikegami M, Xu Y, Heffner C, Murray SA, Donahue LR, Whitsett JA, Maternal synchronization of gestational length and lung maturation. PLoS One. 2011;6(11):e26682
3J:106102 Carter AM, Nygard K, Mazzuca DM, Han VK, The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. Placenta. 2006 Feb-Mar;27(2-3):278-90
8*J:98507 Caton J, Bringas P Jr, Zeichner-David M, IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes. Arch Oral Biol. 2005 Feb;50(2):123-9
1*J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
1J:183829 Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH, Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
5J:49984 Damario MA, Liu HC, Mele CA, Horenstein MG, Rosenwaks Z, Immunohistochemical analysis of insulin-like growth factor-binding proteins -1, -2, and -3 in implantation sites of the mouse. J Assist Reprod Genet. 1998 Sep;15(8):513-20
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:18013 Hahnel A, Schultz GA, Insulin-like growth factor binding proteins are transcribed by preimplantation mouse embryos. Endocrinology. 1994 Apr;134(4):1956-9
1*J:84414 Haraguchi S, Tsuda M, Kitajima S, Sasaoka Y, Nomura-Kitabayashid A, Kurokawa K, Saga Y, nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Mech Dev. 2003 Jun;120(6):721-31
3J:42775 Lindenbergh-Kortleve DJ, Rosato RR, van Neck JW, Nauta J, van Kleffens M, Groffen C, Zwarthoff EC, Drop SL, Gene expression of the insulin-like growth factor system during mouse kidney development. Mol Cell Endocrinol. 1997 Sep 19;132(1-2):81-91
7*J:39926 Liu HC, He ZY, Tang YX, Mele CA, Veeck LL, Davis O, Rosenwaks Z, Simultaneous detection of multiple gene expression in mouse and human individual preimplantation embryos. Fertil Steril. 1997 Apr;67(4):733-41
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
3J:46477 Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B, Gearhart J, Identification of elf1, a beta-spectrin, in early mouse liver development. Int J Dev Biol. 1998 Mar;42(2):221-4
2J:122252 Ning Y, Hoang B, Schuller AG, Cominski TP, Hsu MS, Wood TL, Pintar JE, Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene. Endocrinology. 2007 May;148(5):2138-47
7J:201076 Okano T, Kelley MW, Expression of insulin-like growth factor binding proteins during mouse cochlear development. Dev Dyn. 2013 Oct;242(10):1210-21
1J:211117 Pais RS, Moreno-Barriuso N, Hernandez-Porras I, Lopez IP, De Las Rivas J, Pichel JG, Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation. PLoS One. 2013;8(12):e83028
7*J:20162 Schuller AG, Groffen C, van Neck JW, Zwarthoff EC, Drop SL, cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins. Mol Cell Endocrinol. 1994 Aug;104(1):57-66
3J:26909 Schuller AG, van Neck JW, Beukenholdt RW, Zwarthoff EC, Drop SL, IGF, type I IGF receptor and IGF-binding protein mRNA expression in the developing mouse lung. J Mol Endocrinol. 1995 Jun;14(3):349-55
6J:12803 Schuller AG, Zwarthoff EC, Drop SL, Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation. Endocrinology. 1993 Jun;132(6):2544-50
1J:13309 Schultz GA, Hahnel A, Arcellana-Panlilio M, Wang L, Goubau S, Watson A, Harvey M, Expression of IGF ligand and receptor genes during preimplantation mammalian development. Mol Reprod Dev. 1993 Aug;35(4):414-20
2J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
4J:187514 Shibata S, Fukuoka H, Sato R, Abe T, Suzuki Y, An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible. Eur J Histochem. 2012;56(2):e23
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
4J:103255 Suzuki Y, Role of IGFBPs in the morphogenesis of lingual papillae. Anat Rec A Discov Mol Cell Evol Biol. 2005 Sep;286(1):841-7
4*J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
2J:138125 Umekawa T, Sugiyama T, Kihira T, Murabayashi N, Zhang L, Nagao K, Kamimoto Y, Ma N, Yodoi J, Sagawa N, Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism. Endocrinology. 2008 Aug;149(8):3980-8
6J:59625 van Kleffens M, Groffen C, Neck JW, Vermeij-Keers C, Drop SL, mRNA and protein localization of the IGF system during mouse embryonic development in areas with apoptosis. Growth Horm IGF Res. 1999 Jun;9(3):195-204
6J:48168 van Kleffens M, Groffen C, Rosato RR, van den Eijnde SM, van Neck JW, Lindenbergh-Kortleve DJ, Zwarthoff EC, Drop SL, mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization. Mol Cell Endocrinol. 1998 Mar 16;138(1-2):151-61
4J:58580 van Kleffens M, Groffen CA, Dits NF, Lindenbergh-Kortleve DJ, Schuller AG, Bradshaw SL, Pintar JE, Zwarthoff EC, Drop SL, van Neck JW, Generation of antisera to mouse insulin-like growth factor binding proteins (IGFBP)-1 to -6: comparison of IGFBP protein and messenger ribonucleic acid localization in the mouse embryo. Endocrinology. 1999 Dec;140(12):5944-52
2J:25933 Wang E, Wang J, Chin E, Zhou J, Bondy CA, Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. Endocrinology. 1995 Jun;136(6):2741-51
1J:201463 Watson LA, Solomon LA, Li JR, Jiang Y, Edwards M, Shin-ya K, Beier F, Berube NG, Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
2J:64338 Wood TL, Rogler LE, Czick ME, Schuller AG, Pintar JE, Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene. Mol Endocrinol. 2000 Sep;14(9):1472-82

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory