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Gene Expression Literature Summary
growth differentiation factor 5

107 matching records from 107 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E10.5 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17.5 E18 E18.5 E19.5 E P
Immunohistochemistry (section) 1 2 3 1 1 1 1 3
In situ RNA (section) 2 8 3 20 2 33 1 37 3 20 12 3 5 1 6
In situ RNA (whole mount) 7 1 19 3 18 2 12 3 1 1
Northern blot 1
Western blot 1 1
RT-PCR 1 3 2 7 1 1 2 2 1 1 3 5
cDNA clones 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Gdf5  growth differentiation factor 5   (Synonyms: bp, brp, cartilage-derived morphogenetic protein-1, CDMP-1)
Results  Reference
1J:79879 Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B, The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
5*J:75699 Albrecht AN, Schwabe GC, Stricker S, Boddrich A, Wanker EE, Mundlos S, The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67
5J:126336 Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E, HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007 Nov;134(21):3917-28
1J:132300 Amin S, Matalova E, Simpson C, Yoshida H, Tucker AS, Incudomalleal joint formation: the roles of apoptosis, migration and downregulation. BMC Dev Biol. 2007;7:134
1J:175541 Bangs F, Antonio N, Thongnuek P, Welten M, Davey MG, Briscoe J, Tickle C, Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development. 2011 Aug;138(15):3261-72
2J:99990 Barna M, Pandolfi PP, Niswander L, Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005 Jul 14;436(7048):277-81
1*J:59288 Baur ST, Mai JJ, Dymecki SM, Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development. 2000 Feb;127(3):605-19
2J:223863 Bhattaram P, Penzo-Mendez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V, SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 Dec 8;207(5):657-71
5J:48000 Brunet LJ, McMahon JA, McMahon AP, Harland RM, Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton [see comments]. Science. 1998 May 29;280(5368):1455-7
2J:223752 Cai T, Yang L, Cai W, Guo S, Yu P, Li J, Hu X, Yan M, Shao Q, Jin Y, Sun ZS, Luo ZJ, Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8064-9
3J:149242 Cameron TL, Belluoccio D, Farlie PG, Brachvogel B, Bateman JF, Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20
1J:98432 Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S, Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh. Development. 2004 May;131(10):2339-47
1*J:71186 Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF, Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol. 2001 Aug 15;236(2):421-35
1J:182705 Choe Y, Siegenthaler JA, Pleasure SJ, A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23;73(4):698-712
3J:87281 Coleman CM, Loredo GA, Lo CW, Tuan RS, Correlation of GDF5 and connexin 43 mRNA expression during embryonic development. Anat Rec A Discov Mol Cell Evol Biol. 2003 Dec;275(2):1117-21
1J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
4J:150879 Dathe K, Kjaer KW, Brehm A, Meinecke P, Nurnberg P, Neto JC, Brunoni D, Tommerup N, Ott CE, Klopocki E, Seemann P, Mundlos S, Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2. Am J Hum Genet. 2009 Apr;84(4):483-92
2J:243210 Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M, Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017 Jun 01;426(1):56-68
3*J:202818 Degenkolbe E, Konig J, Zimmer J, Walther M, Reissner C, Nickel J, Ploger F, Raspopovic J, Sharpe J, Dathe K, Hecht JT, Mundlos S, Doelken SC, Seemann P, A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PLoS Genet. 2013 Oct;9(10):e1003846
1J:203785 Delpretti S, Montavon T, Leleu M, Joye E, Tzika A, Milinkovitch M, Duboule D, Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding. Cell Rep. 2013 Oct 17;5(1):137-50
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
5J:131874 Di-Poi N, Zakany J, Duboule D, Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development. PLoS Genet. 2007 Dec 21;3(12):e232
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:90613 Dreyer SD, Naruse T, Morello R, Zabel B, Winterpacht A, Johnson RL, Lee B, Oberg KC, Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004 Jul;4(4):397-405
6J:160493 Dy P, Smits P, Silvester A, Penzo-Mendez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V, Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol. 2010 May 15;341(2):346-59
1J:221660 Eyal S, Blitz E, Shwartz Y, Akiyama H, Schweitzer R, Zelzer E, On the development of the patella. Development. 2015 May 15;142(10):1831-9
4J:204883 Feenstra JM, Kanaya K, Pira CU, Hoffman SE, Eppey RJ, Oberg KC, Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ. 2012 May;54(4):451-62
7J:147878 Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D, A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200
1J:169766 Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y, Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell. 2011 Feb 15;20(2):163-76
5J:171478 Gao Y, Lan Y, Liu H, Jiang R, The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr 1;352(1):83-91
1J:79899 Grotewold L, Ruther U, The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol. 2002 Nov 1;251(1):129-41
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
6*J:93028 Guo X, Day TF, Jiang X, Garrett-Beal L, Topol L, Yang Y, Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004 Oct 1;18(19):2404-17
2J:146802 Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A, Shirouzu M, Yokoyama S, Taiji M, Iseki S, Ornitz DM, Koseki H, FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat Genet. 2009 Mar;41(3):289-98
1J:100475 Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ, The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10898-903
1J:144140 Hill TP, Taketo MM, Birchmeier W, Hartmann C, Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development. 2006 Apr;133(7):1219-29
1*J:71423 Houweling AC, Dildrop R, Peters T, Mummenhoff J, Moorman AF, Ruther U, Christoffels VM, Gene and cluster-specific expression of the Iroquois family members during mouse development. Mech Dev. 2001 Sep;107(1-2):169-74
3J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
3J:132023 Hwang CH, Wu DK, Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hum Mol Genet. 2008 Mar 15;17(6):844-53
2J:122506 Hyde G, Dover S, Aszodi A, Wallis GA, Boot-Handford RP, Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. Dev Biol. 2007 Apr 15;304(2):825-33
2*J:138805 Ikegawa M, Han H, Okamoto A, Matsui R, Tanaka M, Omi N, Miyamae M, Toguchida J, Tashiro K, Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice. Dev Dyn. 2008 Sep;237(9):2506-17
1J:141606 Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, Morimoto Y, Nishioka K, Hatamura I, Yoshida M, Muragaki Y, Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells. 2008 Apr;13(4):355-63
3J:121337 Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams JA, Nakamura T, Enomoto-Iwamoto M, Pacifici M, Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol. 2007 May 1;305(1):40-51
1J:224585 Jenner F, IJpma A, Cleary M, Heijsman D, Narcisi R, van der Spek PJ, Kremer A, van Weeren R, Brama P, van Osch GJ, Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos. Stem Cells Dev. 2014 Aug 15;23(16):1883-98
6J:148688 Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM, Zelzer E, Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell. 2009 May;16(5):734-43
1J:193467 Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung UI, Kawaguchi H, Tabin CJ, SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol. 2013 Jan 29;13(1):4
3J:194035 Kan A, Tabin CJ, c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
2J:121700 Kolanczyk M, Kossler N, Kuhnisch J, Lavitas L, Stricker S, Wilkening U, Manjubala I, Fratzl P, Sporle R, Herrmann BG, Parada LF, Kornak U, Mundlos S, Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet. 2007 Apr 15;16(8):874-86
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
2J:133905 Koyama E, Ochiai T, Rountree RB, Kingsley DM, Enomoto-Iwamoto M, Iwamoto M, Pacifici M, Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling. Ann N Y Acad Sci. 2007 Nov;1116:100-12
1*J:167066 Koyama E, Yasuda T, Minugh-Purvis N, Kinumatsu T, Yallowitz AR, Wellik DM, Pacifici M, Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements. Development. 2010 Nov;137(22):3795-800
1J:102448 Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI, Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem. 2005 Oct 21;280(42):35704-12
3J:231594 Kumar M, Syed SM, Taketo MM, Tanwar PS, Epithelial Wnt/betacatenin signalling is essential for epididymal coiling. Dev Biol. 2016 Apr 15;412(2):234-49
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1J:50972 Lee KJ, Mendelsohn M, Jessell TM, Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev. 1998 Nov 1;12(21):3394-407
1J:203783 Li L, Liu B, Wapinski OL, Tsai MC, Qu K, Zhang J, Carlson JC, Lin M, Fang F, Gupta RA, Helms JA, Chang HY, Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep. 2013 Oct 17;5(1):3-12
4J:194283 Liu J, Li Q, Kuehn MR, Litingtung Y, Vokes SA, Chiang C, Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning. Dev Biol. 2013 Mar 15;375(2):160-71
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2*J:98500 Meech R, Edelman DB, Jones FS, Makarenkova HP, The homeobox transcription factor Barx2 regulates chondrogenesis during limb development. Development. 2005 May;132(9):2135-46
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1J:170582 Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011 Mar 1;351(1):70-81
3J:97323 Niedermaier M, Schwabe GC, Fees S, Helmrich A, Brieske N, Seemann P, Hecht J, Seitz V, Stricker S, Leschik G, Schrock E, Selby PB, Mundlos S, An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. J Clin Invest. 2005 Apr 1;115(4):900-909
1J:237505 Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA, PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 Dec 15;143(24):4608-4619
5J:205042 Osorio C, Chacon PJ, Kisiswa L, White M, Wyatt S, Rodriguez-Tebar A, Davies AM, Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development. 2013 Dec;140(23):4751-62
2*J:108109 Oxburgh L, Chu GC, Michael SK, Robertson EJ, TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
1J:187969 Pazin DE, Gamer LW, Cox KA, Rosen V, Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
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4J:134727 Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson RS, Longaker MT, Giaccia AJ, Schipani E, Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol. 2007 May 7;177(3):451-64
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3J:238878 Ray A, Singh PN, Sohaskey ML, Harland RM, Bandyopadhyay A, Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation. Development. 2015 Mar 15;142(6):1169-79
4J:134490 Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN, The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May;135(9):1713-23
4J:96756 Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML, Carpten JD, The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005 Mar;115(3):622-31
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2J:100917 Seemann P, Schwappacher R, Kjaer KW, Krakow D, Lehmann K, Dawson K, Stricker S, Pohl J, Ploger F, Staub E, Nickel J, Sebald W, Knaus P, Mundlos S, Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. J Clin Invest. 2005 Sep;115(9):2373-81
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6J:234264 Shwartz Y, Viukov S, Krief S, Zelzer E, Joint Development Involves a Continuous Influx of Gdf5-Positive Cells. Cell Rep. 2016 Jun 21;15(12):2577-87
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1J:99926 Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M, Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 2005 May 13;280(19):19185-95
5J:241783 Tang L, Wu X, Zhang H, Lu S, Wu M, Shen C, Chen X, Wang Y, Wang W, Shen Y, Gu M, Ding X, Jin X, Fei J, Wang Z, A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome. Hum Mol Genet. 2017 Apr 01;26(7):1280-1293
1J:113431 Tavella S, Biticchi R, Morello R, Castagnola P, Musante V, Costa D, Cancedda R, Garofalo S, Forced chondrocyte expression of sonic hedgehog impairs joint formation affecting proliferation and apoptosis. Matrix Biol. 2006 Sep;25(7):389-97
2J:116943 Thomas JT, Prakash D, Weih K, Moos M Jr, CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces. J Biol Chem. 2006 Sep 8;281(36):26725-33
6J:52419 Tsumaki N, Tanaka K, Arikawa-Hirasawa E, Nakase T, Kimura T, Thomas JT, Ochi T, Luyten FP, Yamada Y, Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation. J Cell Biol. 1999 Jan 11;144(1):161-73
2J:88584 Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE, Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Development. 2004 Mar;131(6):1235-45
3J:108573 Tylzanowski P, Mebis L, Luyten FP, The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects. Dev Dyn. 2006 Jun;235(6):1599-607
4J:68793 Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto-Iwamoto M, Ohmori T, Enomoto H, Nakata K, Takada K, Kurisu K, Komori T, Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol. 2001 Apr 2;153(1):87-100
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