Gene Expression Literature Summary

• Symbol: Gbx1
• Name: gastrulation brain homeobox 1
• ID: MGI:95667

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E18.5	E	P
Immunohistochemistry (section)															1
In situ RNA (section)		1		1	1			2	3	11	5	6	7	1	2		4
In situ RNA (whole mount)	1	1	1	2	1	2	1	2
In situ reporter (knock in)																	1
RT-PCR	1	1	1	1													1
cDNA clones										1						1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gbx1  gastrulation brain homeobox 1   (Synonyms: Gbx-1)
Results	Reference
1*	J:238553 Allaway KC, Machold R, Developmental specification of forebrain cholinergic neurons. Dev Biol. 2017 Jan 01;421(1):1-7
2*	J:286303 Buckley DM, Burroughs-Garcia J, Kriks S, Lewandoski M, Waters ST, Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord. J Dev Biol. 2020 Apr 1;8(2)
1	J:197199 Buckley DM, Burroughs-Garcia J, Lewandoski M, Waters ST, Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. PLoS One. 2013;8(2):e56214
1*	J:13256 Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubenstein JL, Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci. 1993 Jul;13(7):3155-72
2	J:166699 Chen L, Chatterjee M, Li JY, The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci. 2010 Nov 3;30(44):14824-34
3	J:121077 Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V, Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007 Apr 25;27(17):4786-98
1	J:157830 Flandin P, Kimura S, Rubenstein JL, The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24;30(8):2812-23
2	J:163224 Garcia-Lopez M, Abellan A, Legaz I, Rubenstein JL, Puelles L, Medina L, Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 1;506(1):46-74
1	J:224836 Hoch RV, Lindtner S, Price JD, Rubenstein JL, OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:109564 Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF, Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Dev Biol. 2006 Apr 15;292(2):555-64
2*	J:173286 Long JE, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
2*	J:173287 Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL, Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
1	J:310971 Mercurio S, Serra L, Motta A, Gesuita L, Sanchez-Arrones L, Inverardi F, Foglio B, Barone C, Kaimakis P, Martynoga B, Ottolenghi S, Studer M, Guillemot F, Frassoni C, Bovolenta P, Nicolis SK, Sox2 Acts in Thalamic Neurons to Control the Development of Retina-Thalamus-Cortex Connectivity. iScience. 2019 May 31;15:257-273
5	J:201154 Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, Acampora D, Herault Y, Simeone A, Brand M, Dolle P, Rhinn M, The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord. PeerJ. 2013;1:e142
2*	J:135688 Moisan V, Bomgardner D, Tremblay JJ, Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis. BMC Dev Biol. 2008;8:22
1*	J:306191 Monteiro FA, Miranda RM, Samina MC, Dias AF, Raposo AASF, Oliveira P, Reguenga C, Castro DS, Lima D, Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord. Front Cell Dev Biol. 2021;9:642697
12*	J:88939 Rhinn M, Lun K, Werner M, Simeone A, Brand M, Isolation and expression of the homeobox gene Gbx1 during mouse development. Dev Dyn. 2004 Feb;229(2):334-9
1	J:266826 Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR, Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21;91(6):1260-1275
2	J:325356 Su-Feher L, Rubin AN, Silberberg SN, Catta-Preta R, Lim KJ, Ypsilanti AR, Zdilar I, McGinnis CS, McKinsey GL, Rubino TE Jr, Hawrylycz MJ, Thompson C, Gartner ZJ, Puelles L, Zeng H, Rubenstein JLR, Nord AS, Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2108760119
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:196218 Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL, Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 1;521(7):1561-84
11*	J:84239 Waters ST, Wilson CP, Lewandoski M, Cloning and embryonic expression analysis of the mouse Gbx1 gene. Gene Expr Patterns. 2003 Jun;3(3):313-7
1	J:341676 Wen Y, Su Z, Wang Z, Yang L, Liu G, Shang Z, Duan Y, Du H, Li Z, You Y, Li X, Yang Z, Zhang Z, Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2. Mol Neurobiol. 2021 Aug;58(8):3729-3744
1	J:205340 Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, Rubenstein JL, Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014 Jan 1;385(1):94-106
1	J:84641 Zhao Y, Marin O, Hermesz E, Powell A, Flames N, Palkovits M, Rubenstein JL, Westphal H, The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9005-10