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Gene Expression Literature Summary
erb-b2 receptor tyrosine kinase 2

66 matching records from 66 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2.5 E3.5 E4.5 E5.5 E6.5 E7.5 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E P
Immunohistochemistry (section) 4 1 1 3 3 3 1 3 1 1 1 1 2 8
In situ RNA (section) 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 3
Immunohistochemistry (whole mount) 1
In situ RNA (whole mount) 1 1 1
Northern blot 2
Western blot 2 5 3 2 2 2 2 1 1 1 1 2 1 9
RT-PCR 1 1 1 1 3 4 2 6 5 1 2 1 5 1 3 1 1 9
cDNA clones 1
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Erbb2  erb-b2 receptor tyrosine kinase 2   (Synonyms: c-erbB2, c-neu, ErbB-2, HER2, HER-2, l11Jus8, mKIAA3023, Neu, Neu oncogene)
Results  Reference
6J:152588 Abe Y, Namba H, Zheng Y, Nawa H, In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons. Neuroscience. 2009 Jun 16;161(1):95-110
1J:194074 Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R, Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
2J:89255 Andrechek ER, Hardy WR, Laing MA, Muller WJ, Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4984-9
2J:146779 Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Muller U, Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4507-12
3J:106953 Bovetti S, De Marchis S, Gambarotta G, Fasolo A, Perroteau I, Puche AC, Bovolin P, Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse. Brain Res. 2006 Mar 10;1077(1):37-47
1J:48515 Britsch S, Li L, Kirchhoff S, Theuring F, Brinkmann V, Birchmeier C, Riethmacher D, The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 1998 Jun 15;12(12):1825-36
5*J:94401 Brown N, Deb K, Paria BC, Das SK, Reese J, Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod. 2004 Dec;71(6):2003-11
4J:70080 Calaora V, Rogister B, Bismuth K, Murray K, Brandt H, Leprince P, Marchionni M, Dubois-Dalcq M, Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J Neurosci. 2001 Jul 1;21(13):4740-51
2*J:94397 Chan R, Hardy WR, Dankort D, Laing MA, Muller WJ, Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004 Nov;131(22):5551-60
2J:74283 Chan R, Hardy WR, Laing MA, Hardy SE, Muller WJ, The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development. Mol Cell Biol. 2002 Feb;22(4):1073-8
6J:179734 Cooley MA, Fresco VM, Dorlon ME, Twal WO, Lee NV, Barth JL, Kern CB, Iruela-Arispe ML, Argraves WS, Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev Dyn. 2012 Feb;241(2):303-14
2J:141339 Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW, Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos. Placenta. 2007 Nov-Dec;28(11-12):1211-8
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:45302 Erickson SL, O'Shea KS, Ghaboosi N, Loverro L, Frantz G, Bauer M, Lu LH, Moore MW, ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997 Dec;124(24):4999-5011
3J:147689 Fisher MC, Clinton GM, Maihle NJ, Dealy CN, Requirement for ErbB2/ErbB signaling in developing cartilage and bone. Dev Growth Differ. 2007 Aug;49(6):503-13
3J:97485 Fox IJ, Kornblum HI, Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res. 2005 Mar 1;79(5):584-97
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1J:102479 Fu AK, Ip FC, Fu WY, Cheung J, Wang JH, Yung WH, Ip NY, Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15224-9
1J:217137 Gallart-Palau X, Tarabal O, Casanovas A, Sabado J, Correa FJ, Hereu M, Piedrafita L, Caldero J, Esquerda JE, Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to alpha-motoneurons and altered during motoneuron diseases. FASEB J. 2014 Aug;28(8):3618-32
3J:23797 Goji J, Nakamura H, Ito H, Mabuchi O, Hashimoto K, Sano K, Expression of c-ErbB2 in human neuroblastoma tissues, adrenal medulla adjacent to tumor, and developing mouse neural crest cells. Am J Pathol. 1995 Mar;146(3):660-72
3J:119151 Grego-Bessa J, Luna-Zurita L, del Monte G, Bolos V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Perez-Pomares JM, de la Pompa JL, Notch signaling is essential for ventricular chamber development. Dev Cell. 2007 Mar;12(3):415-29
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
2J:190992 Harmelink C, Peng Y, DeBenedittis P, Chen H, Shou W, Jiao K, Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013 Jan 1;373(1):53-63
1J:239830 Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM, Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest. 2017 Feb 01;127(2):569-582
2*J:100495 Howard B, Panchal H, McCarthy A, Ashworth A, Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005 Sep 1;19(17):2078-90
1J:185615 Huang Z, Wang Y, Nayak PS, Dammann CE, Sanchez-Esteban J, Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions. J Biol Chem. 2012 May 25;287(22):18091-102
3J:96480 Jiang FX, Harrison LC, Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation. 2005 Feb;73(1):45-9
1J:104361 Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H, Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of pkd1. Am J Pathol. 2006 Jan;168(1):205-20
2J:99502 Jimenez-Farfan D, Guevara J, Zenteno E, Malagon H, Hernandez-Guerrero JC, EGF-R and erbB-2 in murine tooth development after ethanol exposure. Birth Defects Res A Clin Mol Teratol. 2005 Feb;73(2):65-71
1*J:95815 Kang JO, Sucov HM, Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan;122(1):57-65
1J:155405 Katayama K, Zine A, Ota M, Matsumoto Y, Inoue T, Fritzsch B, Aruga J, Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice. PLoS One. 2009;4(11):e7786
1J:239290 Knosp WM, Knox SM, Lombaert IM, Haddox CL, Patel VN, Hoffman MP, Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell. 2015 Mar 23;32(6):667-77
1J:33038 Kramer R, Bucay N, Kane DJ, Martin LE, Tarpley JE, Theill LE, Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8
1J:175663 Laforest B, Andelfinger G, Nemer M, Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011 Jul 1;121(7):2876-87
1J:147414 Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C, Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet. 2008 Oct;4(10):e1000241
2J:29973 Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C, Requirement for neuregulin receptor erbB2 in neural and cardiac development [see comments]. Nature. 1995 Nov 23;378(6555):394-8
1J:82801 Leu M, Bellmunt E, Schwander M, Farinas I, Brenner HR, Muller U, Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development. 2003 Jun;130(11):2291-301
9J:39139 Lim H, Dey SK, Das SK, Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors. Endocrinology. 1997 Mar;138(3):1328-37
6J:102070 Liu J, Nethery D, Kern JA, Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway. Exp Lung Res. 2004 Sep;30(6):465-78
1J:164479 Lozovatsky L, Abayasekara N, Piawah S, Walther Z, CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell. 2009 Nov;20(21):4489-99
4J:236318 Ma H, Yin C, Zhang Y, Qian L, Liu J, ErbB2 is required for cardiomyocyte proliferation in murine neonatal hearts. Gene. 2016 Nov 5;592(2):325-30
1J:199683 McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD, Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
1J:175212 Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF, Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 2010 Sep;17(9):1409-19
1J:212851 Meng Q, Jin C, Chen Y, Chen J, Medvedovic M, Xia Y, Expression of signaling components in embryonic eyelid epithelium. PLoS One. 2014;9(2):e87038
1J:62160 Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T, Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development. 2000 Jun;127(12):2617-27
5*J:91711 Miyazaki Y, Nakanishi Y, Hieda Y, Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland. Dev Dyn. 2004 Aug;230(4):591-6
1J:180400 Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE, The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol. 2012 Jan 1;188(1):29-36
4J:172692 Mysliwiec MR, Bresnick EH, Lee Y, Endothelial jarid2/jumonji is required for normal cardiac development and proper notch1 expression. J Biol Chem. 2011 May 13;286(19):17193-204
5J:64067 Nebigil CG, Choi DS, Dierich A, Hickel P, Le Meur M, Messaddeq N, Launay JM, Maroteaux L, Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9508-13
1J:197299 Ngo ST, Cole RN, Sunn N, Phillips WD, Noakes PG, Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation. J Cell Sci. 2012 Mar 15;125(Pt 6):1531-43
1J:176531 Nowakowski TJ, Mysiak KS, Pratt T, Price DJ, Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon. PLoS One. 2011;6(8):e23013
2J:187102 Ortega MC, Bribian A, Peregrin S, Gil MT, Marin O, de Castro F, Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development. Exp Neurol. 2012 Jun;235(2):610-20
1J:168399 Perala N, Jakobson M, Ola R, Fazzari P, Penachioni JY, Nymark M, Tanninen T, Immonen T, Tamagnone L, Sariola H, Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2011 Feb;81(2):81-91
1J:219260 Rakic S, Kanatani S, Hunt D, Faux C, Cariboni A, Chiara F, Khan S, Wansbury O, Howard B, Nakajima K, Nikolic M, Parnavelas JG, Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons. Cereb Cortex. 2015 Apr;25(4):991-1003
1J:186931 Saito Y, Kojima T, Takahashi N, Mab21l2 is essential for embryonic heart and liver development. PLoS One. 2012;7(3):e32991
1J:100552 Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S, Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005 Sep;25(17):7812-27
4*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1J:132583 Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP, Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008 Feb;14(2):298-311
1J:74258 Stolt CC, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, Bartsch U, Wegner M, Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 2002 Jan 15;16(2):165-70
2J:222460 Tenin G, Clowes C, Wolton K, Krejci E, Wright JA, Lovell SC, Sedmera D, Hentges KE, Erbb2 is required for cardiac atrial electrical activity during development. PLoS One. 2014;9(9):e107041
1J:26833 Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T, Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995 Jul 14;269(5221):230-4
4*J:58414 Toyoda-Ohno H, Obinata M, Matsui Y, Members of the ErbB receptor tyrosine kinases are involved in germ cell development in fetal mouse gonads. Dev Biol. 1999 Nov 15;215(2):399-406
1J:188920 Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, Oettgen P, Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov;139(21):3973-85
1J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Dev Biol. 2000 Aug 15;224(2):152-67
5*J:135516 Wansbury O, Panchal H, James M, Parry S, Ashworth A, Howard B, Dynamic expression of Erbb pathway members during early mammary gland morphogenesis. J Invest Dermatol. 2008 Apr;128(4):1009-21
2J:221937 Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips SE, Miller RJ, Wilson SM, Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290

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