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Gene Expression Literature Summary
Symbol
Name
ID
Epo
erythropoietin
MGI:95407

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E4.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17.5 E18 E18.5 E19.5 A
In situ protein (section) 1 1 1 1 1 1 4 1 2 2 1 3 1 1 1 1 3
In situ RNA (section) 1 1 2 2 1 1
In situ protein (whole mount) 1 1
In situ RNA (whole mount) 1 2 3 2 1 2
Western blot 1 2 1 1 1 1 2
RT-PCR 2 1 3 3 7 1 3 3 8 4 12 2 6 7 1 2 2 2 1 3 1 9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Epo  erythropoietin  
Results  Reference
2J:178222 Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M, Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest. 2011 Oct 3;121(10):3981-90
2J:167039 Brade T, Kumar S, Cunningham TJ, Chatzi C, Zhao X, Cavallero S, Li P, Sucov HM, Ruiz-Lozano P, Duester G, Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development. 2011 Jan;138(1):139-48
1J:123909 Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N, Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
1J:201436 Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M, Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
1J:171578 Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X, Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
2J:141453 Cheng J, Kang X, Zhang S, Yeh ET, SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
2J:182738 Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK, Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13;22(3):651-9
1*J:152211 Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P, Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia. 2009 Oct;57(13):1450-7
5J:132868 Dame C, Kirschner KM, Bartz KV, Wallach T, Hussels CS, Scholz H, Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood. 2006 Jun 1;107(11):4282-90
2*J:149437 Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA, Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science. 2009 Jun 5;324(5932):1289-93
1J:164506 Drogat B, Kalucka J, Gutierrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmuller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ, Vegf regulates embryonic erythroid development through Gata1 modulation. Blood. 2010 Sep 23;116(12):2141-51
1J:64984 Duncan SA, Transcriptional regulation of liver development. Dev Dyn. 2000 Oct;219(2):131-42
1J:55508 Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K, Functions of c-Jun in liver and heart development. J Cell Biol. 1999 May 31;145(5):1049-61
10*J:96497 Ehrenreich H, Hasselblatt M, Knerlich F, von Ahsen N, Jacob S, Sperling S, Woldt H, Vehmeyer K, Nave KA, Siren AL, A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):862-7
3J:170366 England SJ, McGrath KE, Frame JM, Palis J, Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood. 2011 Mar 3;117(9):2708-17
1J:194198 Forand A, Beck L, Leroy C, Rousseau A, Boitez V, Cohen I, Courtois G, Hermine O, Friedlander G, EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro. Blood. 2013 Jan 24;121(4):666-78
3*J:138863 Hayhurst GP, Strick-Marchand H, Mulet C, Richard AF, Morosan S, Kremsdorf D, Weiss MC, Morphogenetic competence of HNF4alpha-deficient mouse hepatic cells. J Hepatol. 2008 Sep;49(3):384-95
1*J:107421 Ito T, Arimitsu N, Takeuchi M, Kawamura N, Nagata M, Saso K, Akimitsu N, Hamamoto H, Natori S, Miyajima A, Sekimizu K, Transcription elongation factor S-II is required for definitive hematopoiesis. Mol Cell Biol. 2006 Apr;26(8):3194-203
7*J:128893 Kertesz N, Wu J, Chen TH, Sucov HM, Wu H, The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 1;276(1):101-10
8J:88407 Knabe W, Knerlich F, Washausen S, Kietzmann T, Siren AL, Brunnett G, Kuhn HJ, Ehrenreich H, Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol (Berl). 2004 Mar;207(6):503-12
5J:102992 Knabe W, Siren AL, Ehrenreich H, Kuhn HJ, Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia. Anat Embryol (Berl). 2005 Oct;210(3):209-19
1J:185536 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW, Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development. 2012 Jul;139(13):2340-50
1J:127228 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML, Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec;11(6):845-57
3J:115610 Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H, Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001 Sep 1;98(5):1408-15
1J:145398 Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG, Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007 Aug 1;110(3):870-6
5J:98265 Makita T, Duncan SA, Sucov HM, Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 1;280(1):59-72
3*J:111472 Makita T, Hernandez-Hoyos G, Chen TH, Wu H, Rothenberg EV, Sucov HM, A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001 Apr 1;15(7):889-901
2*J:50937 Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M, AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93
2J:85043 Otto DM, Henderson CJ, Carrie D, Davey M, Gundersen TE, Blomhoff R, Adams RH, Tickle C, Wolf CR, Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis. Mol Cell Biol. 2003 Sep;23(17):6103-16
1J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503
1J:137609 Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J, Essential role for Nix in autophagic maturation of erythroid cells. Nature. 2008 Jul 10;454(7201):232-5
1J:197686 Shang Y, Doan CN, Arnold TD, Lee S, Tang AA, Reichardt LF, Huang EJ, Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527
2J:174962 Sugiyama D, Kulkeaw K, Mizuochi C, Horio Y, Okayama S, Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun. 2011 Jul 1;410(2):301-6
7J:175070 Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, Yamamoto M, Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages. Mol Cell Biol. 2011 Sep;31(18):3896-905
2J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
6J:104816 Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST, A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006 Jan 25;26(4):1269-74
7*J:89467 Yasuda Y, Matsuo T, Nagao M, Blockade of erythropoietin signal at the early postimplantation period inhibits the development of decidua and embryo in mice. Congenit Anom (Kyoto). 2004 Mar;44(1):9-17
10J:17744 Yasuda Y, Nagao M, Okano M, Masuda S, Sasaki R, Konishi H, Tanimura T, Localization of erythropoietin and Erythropoietin-Receptor in postimplantation mouse embryos. Dev Growth Differ. 1993;35(6):711-722
5J:36212 Yasuda Y, Okano M, Nagao M, Masuda S, Konishi H, Ueda K, Matsuo T, Tsujiguchi K, Tajima S, Sasaki R, Tanimura T, Erythropoietin in mouse avascular yolk sacs is increased by retinoic acid. Dev Dyn. 1996 Oct;207(2):184-94
1J:127025 Yasuda Y, Sasaki T, Takagawa M, Maeda M, Yasuda M, Atsumi T, Fujita Y, Fujita H, Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice. Congenit Anom (Kyoto). 2007 Mar;47(1):22-33
1*J:116886 Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT, Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006 Sep 1;281(35):25703-11
16J:39822 Zimmermann F, Rich IN, Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations. Blood. 1997 Apr 15;89(8):2723-35
1J:196696 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML, The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 Apr 18;121(16):3228-36

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory