Gene Expression Literature Summary

• Symbol: Mylk
• Name: myosin, light polypeptide kinase
• ID: MGI:894806

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2	E3	E3.5	E7	E8	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)								2				1			1	1		2
In situ RNA (section)						1	1	3		1	2			3	1		1	5
Immunohistochemistry (whole mount)	1	1	1															1
Northern blot																		1
Western blot					1	1			1			2	1	1				4
RT-PCR							1				1		1		1		1	5
cDNA clones				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mylk  myosin, light polypeptide kinase   (Synonyms: 9530072E15Rik, A930019C19Rik, Mlck, MLCK108, MLCK210, nmMlck, telokin)
Results	Reference
1	J:266546 Brown JM, Garcia-Garcia MJ, Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Development. 2018 Oct 5;145(19):dev170019
1*	J:107820 Corbo JC, Cepko CL, A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone Syndrome. PLoS Genet. 2005 Aug 5;1(2):e11
1	J:306256 Dupuis LE, Nelson EL, Hozik B, Porto SC, Rogers-DeCotes A, Fosang A, Kern CB, Adamts5(-/-) Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2067-2081
4*	J:30019 Gallagher PJ, Garcia JG, Herring BP, Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem. 1995 Dec 8;270(49):29090-5
1	J:138249 Goering W, Adham IM, Pasche B, Manner J, Ochs M, Engel W, Zoll B, Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice. Cytogenet Genome Res. 2008;121(2):88-95
1	J:239161 Guo C, Balsara ZR, Hill WG, Li X, Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration. Development. 2017 Feb 01;144(3):400-408
11	J:68051 Herring BP, Lyons GE, Hoggatt AM, Gallagher PJ, Telokin expression is restricted to smooth muscle tissues during mouse development. Am J Physiol Cell Physiol. 2001 Jan;280(1):C12-21
1	J:203847 Hoggatt AM, Kim JR, Ustiyan V, Ren X, Kalin TV, Kalinichenko VV, Herring BP, The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013 Oct 4;288(40):28477-87
1	J:65015 Hoggatt AM, Kriegel AM, Smith AF, Herring BP, Hepatocyte nuclear factor-3 homologue 1 (HFH-1) represses transcription of smooth muscle-specific genes. J Biol Chem. 2000 Oct 6;275(40):31162-70
2	J:283803 Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE, Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2;129(12):5374-5380
2	J:179089 Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz DB, Davis EC, Dichek DA, Transforming Growth Factor-beta Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):e1-e11
3	J:40991 Kabir N, Yamamura H, Niki I, Iida Y, Uzzaman M, Sarkar D, Hayasaka S , Takagishi Y , Inouye M , Hidaka H, Immunocytochemical detection and spatial distribution of myosin light-chain kinase in preimplantation mouse embryos. J Exp Zool. 1997 Jun 15;278(3):147-55
1	J:341375 Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon RJ, Somlyo A, p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Front Physiol. 2023;14:1228488
1	J:226425 Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmuller U, Palis J, Zheng Y, Kalfa TA, Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood. 2015 Sep 17;126(12):1473-82
5	J:222090 Liang QX, Zhang QH, Qi ST, Wang ZW, Hu MW, Ma XS, Zhu MS, Schatten H, Wang ZB, Sun QY, Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod. 2015 Apr;92(4):97
1	J:246153 Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS, N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 Aug 01;428(1):118-134
2	J:245570 Ma X, Adelstein RS, A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65
1	J:127463 Ma X, Bao J, Adelstein RS, Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice. Mol Biol Cell. 2007 Jun;18(6):2305-12
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:202129 Martin E, Caubit X, Airik R, Vola C, Fatmi A, Kispert A, Fasano L, TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity. PLoS One. 2013;8(5):e63721
1	J:320380 Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, van Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP, Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Matrix Biol. 2021 Sep;103-104:37-57
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:221298 Wang Y, Hu G, Liu F, Wang X, Wu M, Schwarz JJ, Zhou J, Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ Res. 2014 Mar 14;114(6):957-65
1	J:341147 Young RE, Jones MK, Hines EA, Li R, Luo Y, Shi W, Verheyden JM, Sun X, Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching. Dev Cell. 2020 Apr 6;53(1):73-85.e5