Gene Expression Literature Summary

• Symbol: Frzb
• Name: frizzled-related protein
• ID: MGI:892032

64 matching records from 64 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E3.5	E5.5	E6.5	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)										1			1		1		2
In situ RNA (section)						1			4		6		10	1	8		8	1	12		6		4	1	6	5		5
In situ RNA (whole mount)					1	4	3	1	4	1	7		3		2		4		1								2
In situ reporter (knock in)																												1
Northern blot									2		1	1		1	1		1		1		2							2
RT-PCR	1	1	1	1	1	1	2		2		4		1	1	5	1		1	6	1		1	2	1		2		9
cDNA clones					1	1													2									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Frzb  frizzled-related protein   (Synonyms: fritz, Frp, frzb-1, Sfrp3)
Results	Reference
3	J:169706 Abdul-Ghani M, Dufort D, Stiles R, De Repentigny Y, Kothary R, Megeney LA, Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals. Mol Cell Biol. 2011 Jan;31(1):163-78
1*	J:176660 Abler LL, Keil KP, Mehta V, Joshi PS, Schmitz CT, Vezina CM, A high-resolution molecular atlas of the fetal mouse lower urogenital tract. Dev Dyn. 2011 Oct;240(10):2364-77
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
2	J:341253 Baxi A, Jourdeuil K, Cox TC, Clouthier DE, Tavares ALP, Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural crest patterning and bone development. Dev Dyn. 2023 Oct;252(10):1303-1315
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5*	J:152099 Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009 Jun 26;108(1):295-303
4	J:52317 Borello U, Coletta M, Tajbakhsh S, Leyns L, De Robertis EM, Buckingham M, Cossu G, Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development. 1999 Oct;126(19):4247-55
3*	J:51411 Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E, Borsani G, Banfi S, Ballabio A, The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function. Hum Mol Genet. 1998 Dec;7(13):1997-2006
4*	J:165759 Chiu HS, Szucsik JC, Georgas KM, Jones JL, Rumballe BA, Tang D, Grimmond SM, Lewis AG, Aronow BJ, Lessard JL, Little MH, Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol. 2010 Aug 15;344(2):1071-87
1	J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
2	J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448
1	J:167834 Dawe CE, Kooistra MK, Fairbridge NA, Pisio AC, McDermid HE, Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev Dyn. 2011 Feb;240(2):372-83
2*	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:90613 Dreyer SD, Naruse T, Morello R, Zabel B, Winterpacht A, Johnson RL, Lee B, Oberg KC, Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004 Jul;4(4):397-405
4*	J:253527 Geng R, Noda T, Mulvaney JF, Lin VY, Edge AS, Dabdoub A, Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. PLoS One. 2016;11(2):e0148339
5	J:187047 Gerber SD, Amann R, Wyder S, Trueb B, Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. PLoS One. 2012;7(3):e33457
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:170579 He F, Xiong W, Wang Y, Li L, Liu C, Yamagami T, Taketo MM, Zhou C, Chen Y, Epithelial Wnt/beta-catenin signaling regulates palatal shelf fusion through regulation of Tgfbeta3 expression. Dev Biol. 2011 Feb 15;350(2):511-9
8	J:80135 Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD, Serup P, Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn. 2002 Nov;225(3):260-70
18*	J:48578 Hoang BH, Thomas JT, Abdul-Karim FW, Correia KM, Conlon RA, Luyten FP, Ballock RT, Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members. Dev Dyn. 1998 Jul;212(3):364-72
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
3	J:184011 John A, Brylka H, Wiegreffe C, Simon R, Liu P, Juttner R, Crenshaw EB 3rd, Luyten FP, Jenkins NA, Copeland NG, Birchmeier C, Britsch S, Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development. Development. 2012 May;139(10):1831-41
1*	J:192625 Keil KP, Mehta V, Branam AM, Abler LL, Buresh-Stiemke RA, Joshi PS, Schmitz CT, Marker PC, Vezina CM, Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development. Endocrinology. 2012 Dec;153(12):6091-103
1	J:190506 Kele J, Andersson ER, Villaescusa JC, Cajanek L, Parish CL, Bonilla S, Toledo EM, Bryja V, Rubin JS, Shimono A, Arenas E, SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells. 2012 May;30(5):865-75
1*	J:94411 Kelly RG, Jerome-Majewska LA, Papaioannou VE, The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet. 2004 Nov 15;13(22):2829-40
5*	J:98792 Kemp C, Willems E, Abdo S, Lambiv L, Leyns L, Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Dev Dyn. 2005 May 5;233(3):1064-1075
2*	J:69787 Kim AS, Lowenstein DH, Pleasure SJ, Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon. Mech Dev. 2001 May;103(1-2):167-72
1	J:209623 Kurosaka H, Iulianella A, Williams T, Trainor PA, Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr 1;124(4):1660-71
4	J:239872 Larsen BM, Hrycaj SM, Newman M, Li Y, Wellik DM, Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation. Development. 2015 Nov 15;142(22):3859-68
1*	J:53153 Lee CS, Buttitta LA, May NR, Kispert A, Fan CM, SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development. 2000 Jan;127(1):109-18
6*	J:40838 Leyns L, Bouwmeester T, Kim SH, Piccolo S, De Robertis EM, Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell. 1997 Mar 21;88(6):747-56
1*	J:98484 Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J, Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun;132(11):2599-609
4	J:84478 Liu H, Mohamed O, Dufort D, Wallace VA, Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev Dyn. 2003 Jul;227(3):323-34
3	J:143184 Liu W, Li L, Li G, Garritano F, Shanske A, Frenz DA, Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth Factors. 2008 Dec;26(6):343-54
2	J:236373 Ludtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A, Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Dev Cell. 2016 Oct 24;39(2):239-253
1	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
8*	J:40600 Mayr T, Deutsch U, Kuhl M, Drexler HC, Lottspeich F, Deutzmann R , Wedlich D , Risau W, Fritz: a secreted frizzled-related protein that inhibits Wnt activity. Mech Dev. 1997 Apr;63(1):109-25
1	J:81152 Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H, Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003 Feb;130(3):495-505
1	J:327818 Murphy P, Armit C, Hill B, Venkataraman S, Frankel P, Baldock RA, Davidson DR, Integrated analysis of Wnt signalling system component gene expression. Development. 2022 Aug 15;149(16):dev200312
1	J:314598 Nik AM, Reyahi A, Ponten F, Carlsson P, Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. Gastroenterology. 2013 May;144(5):1001-11
1	J:180300 Noda T, Oki S, Kitajima K, Harada T, Komune S, Meno C, Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo. Dev Biol. 2012 Feb 1;362(1):83-93
2*	J:332131 Perera SN, Williams RM, Lyne R, Stubbs O, Buehler DP, Sauka-Spengler T, Noda M, Micklem G, Southard-Smith EM, Baker CVH, Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach. Glia. 2020 Dec;68(12):2550-2584
2	J:122585 Qian D, Jones C, Rzadzinska A, Mark S, Zhang X, Steel KP, Dai X, Chen P, Wnt5a functions in planar cell polarity regulation in mice. Dev Biol. 2007 Jun 1;306(1):121-33
1	J:127039 Rash BG, Grove EA, Patterning the dorsal telencephalon: a role for sonic hedgehog?. J Neurosci. 2007 Oct 24;27(43):11595-603
4*	J:268254 Rich CA, Perera SN, Andratschke J, Stolt CC, Buehler DP, Southard-Smith EM, Wegner M, Britsch S, Baker CVH, Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting. Glia. 2018 Dec;66(12):2617-2631
4*	J:56622 Sarkar L, Sharpe PT, Expression of Wnt signalling pathway genes during tooth development. Mech Dev. 1999 Jul;85(1-2):197-200
4*	J:100233 Shou S, Scott V, Reed C, Hitzemann R, Stadler HS, Transcriptome analysis of the murine forelimb and hindlimb autopod. Dev Dyn. 2005 Sep;234(1):74-89
1	J:181526 Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, 't Hoen PA, Kispert A, Christoffels VM, Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2012 Apr;69(8):1377-89
1	J:84052 Stump RJ, Ang S, Chen Y, von Bahr T, Lovicu FJ, Pinson K, de Iongh RU, Yamaguchi TP, Sassoon DA, McAvoy JW, A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev Biol. 2003 Jul 1;259(1):48-61
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1	J:324161 Tang S, Cope DI, Vasquez YM, Monsivais D, BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy. Endocrinology. 2022 May 1;163(5)
1	J:73304 Tebar M, Destree O, de Vree WJ, Ten Have-Opbroek AA, Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung. Mech Dev. 2001 Dec;109(2):437-40
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:95619 Tylzanowski P, Bossuyt W, Thomas JT, Luyten FP, Characterization of Frzb-Cre transgenic mouse. Genesis. 2004 Dec;40(4):200-4
1	J:180902 van de Ven C, Bialecka M, Neijts R, Young T, Rowland JE, Stringer EJ, Van Rooijen C, Meijlink F, Novoa A, Freund JN, Mallo M, Beck F, Deschamps J, Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development. 2011 Aug;138(16):3451-62
1	J:187883 Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK, Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3;150(3):590-605
1*	J:221397 Vanyai HK, Thomas T, Voss AK, Mesodermal expression of Moz is necessary for cardiac septum development. Dev Biol. 2015 Jul 1;403(1):22-9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
8*	J:146657 Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S, Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23
1	J:159315 Xie Z, Ma X, Ji W, Zhou G, Lu Y, Xiang Z, Wang YX, Zhang L, Hu Y, Ding YQ, Zhang WJ, Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6510-5
2	J:343328 Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ, ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
2	J:298597 Yan S, Thienthanasit R, Chen D, Engelen E, Bruhl J, Crossman DK, Kesterson R, Wang Q, Bouazoune K, Jiao K, CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28847-28858
10	J:207050 Zhao X, Huang H, Chen Y, Liu Y, Zhang Z, Ma Q, Qiu M, Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience. 2013 Sep 17;248:594-601