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Gene Expression Literature Summary
Symbol
Name
ID
Ckm
creatine kinase, muscle
MGI:88413

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E8.5 E9.5 E10.5 E11 E11.5 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E18.5 E19.5 P
Immunohistochemistry (section) 1 1
In situ RNA (section) 1 1 1 1 1 1 1 2 1 1 1 1
Northern blot 1 1 1 3
Western blot 1 1
RT-PCR 2 1 2 1 2 2 2 2 1 2 2 3 7 1 8
RNase protection 2 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ckm  creatine kinase, muscle   (Synonyms: Ckmm, MCK, M-CK)
Results  Reference
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4J:257501 Dykes IM, van Bueren KL, Scambler PJ, HIC2 regulates isoform switching during maturation of the cardiovascular system. J Mol Cell Cardiol. 2018 Jan;114:29-37
2*J:38042 Ferrari S, Molinari S, Melchionna R, Cusella-De Angelis MG, Battini R , De Angelis L , Kelly R , Cossu G, Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. Cell Growth Differ. 1997 Jan;8(1):23-34
1*J:14208 Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH, Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene [see comments]. Nature. 1993 Aug 5;364(6437):501-6
1J:238480 He K, Hu J, Yu H, Wang L, Tang F, Gu J, Ge L, Wang H, Li S, Hu P, Jin Y, Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation. J Biol Chem. 2017 Jan 06;292(1):351-360
1J:274465 Lee HJ, Kao CY, Lin SC, Xu M, Xie X, Tsai SY, Tsai MJ, Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. Sci Rep. 2017 Jun 9;7(1):3136
1J:242127 Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, Tessarollo L, Gaetano C, Mukouyama YS, Thiele CJ, Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem. 2014 Oct 24;289(43):29801-16
1J:52277 Lu J, Webb R, Richardson JA, Olson EN, MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):552-7
6*J:706 Lyons GE, Muhlebach S, Moser A, Masood R, Paterson BM, Buckingham ME, Perriard JC, Developmental regulation of creatine kinase gene expression by myogenic factors in embryonic mouse and chick skeletal muscle. Development. 1991 Nov;113(3):1017-29
1J:203690 Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R, Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
2J:160383 Messina G, Biressi S, Monteverde S, Magli A, Cassano M, Perani L, Roncaglia E, Tagliafico E, Starnes L, Campbell CE, Grossi M, Goldhamer DJ, Gronostajski RM, Cossu G, Nfix regulates fetal-specific transcription in developing skeletal muscle. Cell. 2010 Feb 19;140(4):554-66
1J:31724 Miner JH, Miller JB, Wold BJ, Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart. Development. 1992 Apr;114(4):853-60
1*J:40478 Myer A, Wagner DS, Vivian JL, Olson EN, Klein WH, Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo. Dev Biol. 1997 May 15;185(2):127-38
2J:229482 Nagandla H, Lopez S, Yu W, Rasmussen TL, Tucker HO, Schwartz RJ, Stewart MD, Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1. Dev Biol. 2016 Feb 1;410(1):86-97
2J:178574 Nitzki F, Zibat A, Frommhold A, Schneider A, Schulz-Schaeffer W, Braun T, Hahn H, Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice. Oncogene. 2011 Oct 27;30(43):4428-36
4J:105941 Ohkawa Y, Marfella CG, Imbalzano AN, Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006 Feb 8;25(3):490-501
2*J:29279 Patapoutian A, Yoon JK, Miner JH, Wang S, Stark K, Wold B, Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 1995 Oct;121(10):3347-58
1J:187969 Pazin DE, Gamer LW, Cox KA, Rosen V, Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
1J:29672 Rawls A, Morris JH, Rudnicki M, Braun T, Arnold HH, Klein WH, Olson EN, Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis. Dev Biol. 1995 Nov;172(1):37-50
1*J:48809 Rawls A, Valdez MR, Zhang W, Richardson J, Klein WH, Olson EN, Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development. 1998 Jul;125(13):2349-58
1J:178379 Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P, Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
1J:138823 Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM, PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21;454(7207):961-7
1*J:84571 Takahashi C, Bronson RT, Socolovsky M, Contreras B, Lee KY, Jacks T, Noda M, Kucherlapati R, Ewen ME, Rb and N-ras function together to control differentiation in the mouse. Mol Cell Biol. 2003 Aug;23(15):5256-68
1J:94087 Takahashi C, Contreras B, Bronson RT, Loda M, Ewen ME, Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression. Mol Cell Biol. 2004 Dec;24(23):10406-15
1*J:61155 Valdez MR, Richardson JA, Klein WH, Olson EN, Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol. 2000 Mar 15;219(2):287-98
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:54065 Vivian JL, Gan L, Olson EN, Klein WH, A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 1;208(1):44-55
8*J:56670 Washabaugh CH, Ontell MP, Kant JA, Ontell M, Creatine kinase transcript accumulation: effect of nerve during muscle development. Dev Dyn. 1999 Aug;215(4):285-96
5*J:63331 Yamane A, Mayo M, Shuler C, Crowe D, Ohnuki Y, Dalrymple K, Saeki Y, Expression of myogenic regulatory factors during the development of mouse tongue striated muscle. Arch Oral Biol. 2000 Jan;45(1):71-8
5*J:74099 Yamane A, Ohnuki Y, Saeki Y, Delayed embryonic development of mouse masseter muscle correlates with delayed MyoD family expression. J Dent Res. 2000 Dec;79(12):1933-6
1*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
2J:26105 Zhang W, Behringer RR, Olson EN, Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory