Gene Expression Literature Summary

• Symbol: Canx
• Name: calnexin
• ID: MGI:88261

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)							1				1					1			1			3
Immunohistochemistry (whole mount)		1																				1
In situ RNA (whole mount)									1				2
In situ reporter (knock in)										1		1	1		1	1				1
Western blot							1	1	1				1	1	1	1	1		1	1		16
RT-PCR	1	1	1	1	1	1	1		1		1		1	1	1			2			1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Canx  calnexin   (Synonyms: 1110069N15Rik, CNX)
Results	Reference
1	J:245023 Cantu C, Pagella P, Shajiei TD, Zimmerli D, Valenta T, Hausmann G, Basler K, Mitsiadis TA, A cytoplasmic role of Wnt/beta-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Sci Signal. 2017 Feb 07;10(465)
1	J:279421 Carbonell AU, Cho CH, Tindi JO, Counts PA, Bates JC, Erdjument-Bromage H, Cvejic S, Iaboni A, Kvint I, Rosensaft J, Banne E, Anagnostou E, Neubert TA, Scherer SW, Molholm S, Jordan BA, Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome. Nat Commun. 2019 Aug 6;10(1):3529
1	J:308690 Coccia E, Planells-Ferrer L, Badillos-Rodriguez R, Pascual M, Segura MF, Fernandez-Hernandez R, Lopez-Soriano J, Gari E, Soriano E, Barneda-Zahonero B, Moubarak RS, Perez-Garcia MJ, Comella JX, SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell Death Dis. 2020 Feb 3;11(2):82
10*	J:325291 Coe H, Bedard K, Groenendyk J, Jung J, Michalak M, Endoplasmic reticulum stress in the absence of calnexin. Cell Stress Chaperones. 2008 Dec;13(4):497-507
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
1	J:282733 Gerlini R, Amendola E, Conte A, Valente V, Tornincasa M, Credendino SC, Cammarota F, Gentile C, Di Guida L, Paladino S, De Vita G, Fusco A, Pierantoni GM, Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice. Cell Death Dis. 2019 Oct 3;10(10):747
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:343810 Guo CG, Sun R, Wang X, Yuan Y, Xu Y, Li S, Sun X, Wang J, Hu X, Guo T, Chen XW, Xiao RP, Zhang X, Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Mol Metab. 2023 Nov 30;79:101847
1	J:282329 Hildebrandt MR, Wang Y, Li L, Yasmin L, Glubrecht DD, Godbout R, Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Dev Biol. 2019 Nov 15;455(2):420-433
1	J:157011 Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO, The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. J Neurochem. 2010 Feb;112(4):924-39
1*	J:161796 Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, Okawa K, Abe T, Oshima N, Nakahata T, Heike T, Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010 Aug;239(8):2233-45
6	J:134649 Lampton PW, Goldstein CY, Warner CM, The role of tapasin in MHC class I protein trafficking in embryos and T cells. J Reprod Immunol. 2008 Jun;78(1):28-39
1	J:59629 Lehtonen S, Riento K, Olkkonen VM, Lehtonen E, Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Kidney Int. 1999 Sep;56(3):815-26
2	J:208480 Li X, Xu C, Yang P, c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes. 2013 Feb;62(2):599-608
1*	J:111416 Luo S, Mao C, Lee B, Lee AS, GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006 Aug;26(15):5688-97
1*	J:160900 Mao C, Wang M, Luo B, Wey S, Dong D, Wesselschmidt R, Rawlings S, Lee AS, Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One. 2010;5(5):e10852
1*	J:221086 Patra D, DeLassus E, Liang G, Sandell LJ, Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. 2014;9(8):e105674
1	J:117504 Ponten A, Folestad EB, Pietras K, Eriksson U, Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. Circ Res. 2005 Nov 11;97(10):1036-45
1*	J:121082 Prados B, Pena A, Cotarelo RP, Valero MC, Cruces J, Expression of the murine pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of walker-warburg syndrome. Am J Pathol. 2007 May;170(5):1659-68
1	J:111505 Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF, The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res. 2006 May 15;312(9):1566-80
1	J:158701 Silvestre DC, Gil GA, Tomasini N, Bussolino DF, Caputto BL, Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice. PLoS One. 2010;5(3):e9544
2	J:243333 Tian E, Hoffman MP, Ten Hagen KG, O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Nat Commun. 2012 May 29;3:869
1	J:331473 Tran V, Nahle S, Robert A, Desanlis I, Killoran R, Ehresmann S, Thibault MP, Barford D, Ravichandran KS, Sauvageau M, Smith MJ, Kmita M, Cote JF, Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Nat Commun. 2022 Nov 18;13(1):7077
1	J:317051 Tushaus J, Muller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF, The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system. FASEB J. 2021 Nov;35(11):e21962
2*	J:235086 Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni RI, Prestigio C, Giovedi S, Onofri F, Mura E, Guarnieri FC, Marte A, Orlando M, Zara F, Fassio A, Valtorta F, Baldelli P, Corradi A, Benfenati F, PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016 Apr 5;15(1):117-31
1*	J:244948 Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO, Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc. 2014 Oct 20;3(5):e001018
1	J:250342 Wang F, Xu C, Reece EA, Li X, Wu Y, Harman C, Yu J, Dong D, Wang C, Yang P, Zhong J, Yang P, Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. Nat Commun. 2017 May 05;8:15182
1	J:146172 Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK, Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009 Jan 12;184(1):143-58
1	J:178248 Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K, Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608
1	J:270211 Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ, Blackshear PJ, Yang P, Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nat Commun. 2019 Jan 17;10(1):282
2	J:223139 Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T, hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9
1	J:255262 Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY, CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017 Aug 1;20(5):1161-1172
5	J:128422 Zhang X, Szabo E, Michalak M, Opas M, Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci. 2007 Nov;25(7):455-63
3	J:126289 Zhao J, Izumi T, Nunomura K, Satoh S, Watanabe S, MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation. Biochem J. 2007 Nov 15;408(1):51-9
1	J:228307 Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B, Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71
1	J:130727 Zhu H, Cabrera RM, Wlodarczyk BJ, Bozinov D, Wang D, Schwartz RJ, Finnell RH, Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity. BMC Dev Biol. 2007;7:128