Gene Expression Literature Summary

• Symbol: Braf
• Name: Braf transforming gene
• ID: MGI:88190

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2.5	E3.5	E7.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)						2			1			1					1				3
In situ RNA (section)						1			1			1		1		1	1		2
Immunohistochemistry (whole mount)			1
In situ RNA (whole mount)														1
Northern blot				1		1	1							1	1		1				2
Western blot						2	1	1	6	1	1	2				2	1				6
RT-PCR	1	1	1		1	2	1		2		2	1	1	1	1		1	1		1	4
cDNA clones																			1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Braf  Braf transforming gene   (Synonyms: 9930012E13Rik, Braf2, Braf-2, D6Ertd631e)
Results	Reference
5	J:112971 Camarero G, Tyrsin OY, Xiang C, Pfeiffer V, Pleiser S, Wiese S, Gotz R, Rapp UR, Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol. 2006 Oct;26(19):7103-15
1	J:215828 Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS, Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014 Sep 2;124(9):4093-101
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2	J:105998 Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M, Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
1	J:101397 Gotz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M, Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005 Sep;8(9):1169-78
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4	J:241998 Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP, MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Development. 2017 Jun 15;144(12):2141-2152
4	J:216228 Inoue S, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, Ono M, Kure S, Ogura T, Matsubara Y, Aoki Y, New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014 Dec 15;23(24):6553-66
4	J:253459 Inoue SI, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, Aoki Y, Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727
2	J:311572 Kang MC, Park SJ, Kim HJ, Lee J, Yu DH, Bae KB, Ji YR, Park SJ, Jeong J, Jang WY, Kim JH, Choi MS, Lee DS, Lee HS, Lee S, Kim SH, Kim MO, Park G, Choo YS, Cho JY, Ryoo ZY, Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2276-82
3	J:218061 Krishnaswami SR, Kumar S, Ordoukhanian P, Yu BD, Fate and Plasticity of the Epidermis in Response to Congenital Activation of BRAF. J Invest Dermatol. 2015 Feb;135(2):481-9
2	J:207976 Li Q, Zheng S, Han A, Lin CH, Stoilov P, Fu XD, Black DL, The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
1	J:185949 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB, Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
1	J:213126 O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
4	J:199842 Pfeiffer V, Gotz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR, Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. PLoS One. 2013;8(3):e58259
1	J:128917 Provot S, Nachtrab G, Paruch J, Chen AP, Silva A, Kronenberg HM, A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol Cell Biol. 2008 Jan;28(1):344-57
3	J:239455 Shin J, Watanabe S, Hoelper S, Kruger M, Kostin S, Poling J, Kubin T, Braun T, BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 01;5:e18351
2*	J:10369 Storm SM, Cleveland JL, Rapp UR, Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene. 1990 Mar;5(3):345-51
4	J:170095 Urosevic J, Sauzeau V, Soto-Montenegro ML, Reig S, Desco M, Wright EM, Canamero M, Mulero F, Ortega S, Bustelo XR, Barbacid M, Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20
1	J:119299 Voss AK, Krebs DL, Thomas T, C3G regulates the size of the cerebral cortex neural precursor population. EMBO J. 2006 Aug 9;25(15):3652-63
13*	J:61360 Wojnowski L, Stancato LF, Larner AC, Rapp UR, Zimmer A, Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech Dev. 2000 Mar 1;91(1-2):97-104
1*	J:41257 Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, Zimmer A, Endothelial apoptosis in Braf-deficient mice [see comments]. Nat Genet. 1997 Jul;16(3):293-7
5	J:98531 Xie Y, Wang Y, Sun T, Wang F, Trostinskaia A, Puscheck E, Rappolee DA, Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells. Mol Reprod Dev. 2005 May;71(1):1-11
5	J:121660 Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD, Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007 May;10(5):598-607