Gene Expression Literature Summary

• Symbol: Apex1
• Name: apurinic/apyrimidinic endonuclease 1
• ID: MGI:88042

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E8.5	E11.5	E13	E13.5	E14.5	E15	E15.5	E18	E18.5	P
Immunohistochemistry (section)													1		1
In situ RNA (section)									1		1	1		1		1
Immunohistochemistry (whole mount)	1			1	1	1
Northern blot														1		1
Western blot																3
RT-PCR	1	1	1	1	2		1			1						3
cDNA clones								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Apex1  apurinic/apyrimidinic endonuclease 1   (Synonyms: HAP1, Ref-1)
Results	Reference
3*	J:170314 Albino D, Brizzolara A, Moretti S, Falugi C, Mirisola V, Scaruffi P, Di Candia M, Truini M, Coco S, Bonassi S, Tonini GP, Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration. Int J Dev Biol. 2011;55(1):65-72
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:269212 Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ, Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294
1	J:161356 Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA, Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science. 2010 Jul 2;329(5987):78-82
1	J:212924 Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ, Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
1	J:286844 Kim J, Kim K, Mo JS, Lee Y, Atm deficiency in the DNA polymerase beta null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation. Nucleic Acids Res. 2020 Apr 17;48(7):3678-3691
4	J:195178 Linke M, May A, Reifenberg K, Haaf T, Zechner U, The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos. Cytogenet Genome Res. 2013;139(2):71-9
1	J:161421 Mann W, Haaf T, Single cell RT-PCR on mouse embryos: a general approach for developmental biology. Methods Mol Biol. 2010;630:3-12
4*	J:145796 May A, Kirchner R, Muller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T, Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres. Biol Reprod. 2009 Jan;80(1):194-202
1*	J:337678 Moreli JB, Santos MRD, Calderon IMP, Hebeda CB, Farsky SHP, Bevilacqua E, Oliani SM, The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus. Int J Mol Sci. 2023 Jun 15;24(12)
6*	J:25961 Ono Y, Watanabe M, Inoue Y, Ohmoto T, Akiyama K, Tsutsui K, Seki S, Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res. 1995 May 26;86(1-2):1-6
1	J:21514 Takiguchi Y, Chen DJ, Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene. Mamm Genome. 1994 Nov;5(11):717-22
1*	J:125220 Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC, Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet. 2007 Aug 31;3(8):e139
1	J:331692 Xin Y, He Q, Liang H, Zhang K, Guo J, Zhong Q, Chen D, Li J, Liu Y, Chen S, m(6)A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina. Elife. 2022 Dec 2;11