Gene Expression Literature Summary

• Symbol: Tph2
• Name: tryptophan hydroxylase 2
• ID: MGI:2651811

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E2.5	E3.5	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)				1		1	1	2	2			2	1	2		1	1	2		13
In situ RNA (section)				1	1	1	1	6	7		2	3		4	1			4	1	9
In situ reporter (knock in)									1			1		1				1		1
Western blot																				2
RT-PCR	1	1	1	1		1		1	2	3		1	1	3		1	1	2		9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tph2  tryptophan hydroxylase 2
Results	Reference
4*	J:135685 Basu B, Desai R, Balaji J, Chaerkady R, Sriram V, Maiti S, Panicker MM, Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction. 2008 May;135(5):657-69
1*	J:312000 Bell BJ, Liu Q, Kim DW, Lee S, Liu Q, et al., A clock-driven neural network critical for arousal. bioRxiv. 2020;
1	J:86557 Cheng L, Chen CL, Luo P, Tan M, Qiu M, Johnson R, Ma Q, Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003 Nov 5;23(31):9961-7
2	J:265050 Chleilat E, Skatulla L, Rahhal B, Hussein MT, Feuerstein M, Krieglstein K, Roussa E, TGF-beta Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. 2018 Jun 15;381:124-137
6*	J:118743 Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G, Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):329-34
1*	J:279056 Donovan LJ, Spencer WC, Kitt MM, Eastman BA, Lobur KJ, Jiao K, Silver J, Deneris ES, Lmx1b is required at multiple stages to build expansive serotonergic axon architectures. Elife. 2019 Jul 29;8:e48788
2	J:309996 Dumas S, Wallen-Mackenzie A, Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification. Front Cell Dev Biol. 2019;7:307
1	J:269212 Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ, Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294
1	J:316492 Forero A, Ku HP, Malpartida AB, Waldchen S, Alhama-Riba J, Kulka C, Aboagye B, Norton WHJ, Young AMJ, Ding YQ, Blum R, Sauer M, Rivero O, Lesch KP, Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology. 2020 May 15;168:108018
1	J:310851 Grunewald L, Becker N, Camphausen A, O'Leary A, Lesch KP, Freudenberg F, Reif A, Expression of the ADHD candidate gene Diras2 in the brain. J Neural Transm (Vienna). 2018 Jun;125(6):913-923
17*	J:150616 Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch KP, Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol. 2009 Apr;19(4):266-82
3	J:237535 Haugas M, Tikker L, Achim K, Salminen M, Partanen J, Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development. 2016 Dec 01;143(23):4495-4508
1	J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1	J:137064 Jacobsen KX, Vanderluit JL, Slack RS, Albert PR, HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression. Mol Cell Neurosci. 2008 Jul;38(3):349-58
1	J:220591 Kim JY, Kim A, Zhao ZQ, Liu XY, Chen ZF, Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Mol Brain. 2014;7:48
1*	J:316482 Kouwenhoven WM, von Oerthel L, Gruppilo M, Tian J, Wagemans CMRJ, Houwers IGJ, Locker J, Mesman S, Smidt MP, Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate. Int J Mol Sci. 2021 Nov 23;22(23)
1	J:166738 Li Z, Caron MG, Blakely RD, Margolis KG, Gershon MD, Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. J Neurosci. 2010 Dec 8;30(49):16730-40
4	J:165266 Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES, Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010 Oct;13(10):1190-8
1	J:101272 Lossi L, Bottarelli L, Candusso ME, Leiter AB, Rindi G, Merighi A, Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci. 2004 Dec;20(12):3259-69
3*	J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:265733 Maloney SE, Khangura E, Dougherty JD, The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain. Brain Struct Funct. 2016 May;221(4):1809-31
1	J:191676 Manceau V, Kremmer E, Nabel EG, Maucuer A, The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
3	J:284574 Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H, Serotonin Regulates Adult beta-Cell Mass by Stimulating Perinatal beta-Cell Proliferation. Diabetes. 2020 Feb;69(2):205-214
8	J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
7*	J:112970 Ortiz-Alvarado R, Guzman-Quevedo O, Mercado-Camargo R, Haertle T, Vignes C, Bolanos-Jimenez F, Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS Lett. 2006 Oct 2;580(22):5371-6
3	J:218991 Pelosi B, Migliarini S, Pacini G, Pratelli M, Pasqualetti M, Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PLoS One. 2014;9(8):e104318
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
3	J:260927 Rahim RS, St John JA, Crane DI, Meedeniya ACB, Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency. Mol Cell Neurosci. 2018 Apr;88:16-32
1	J:155932 Rose MF, Ahmad KA, Thaller C, Zoghbi HY, Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22462-7
2	J:262201 Teng T, Gaillard A, Muzerelle A, Gaspar P, EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain. eNeuro. 2017 Jan-Feb;4(1):ENEURO.0327-16.2017
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:157942 Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO, The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. J Neurosci. 2010 Jan 27;30(4):1523-38
1	J:323216 Wang YB, Song NN, Zhang L, Ma P, Chen JY, Huang Y, Hu L, Mao B, Ding YQ, Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice. Front Cell Dev Biol. 2022;10:831365
2*	J:237675 Wyler SC, Donovan LJ, Yeager M, Deneris E, Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS Chem Neurosci. 2015 Jul 15;6(7):1198-205
1	J:326661 Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y, Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768
6	J:240993 Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G, A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009 Sep 04;138(5):976-89
3*	J:116706 Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW 4th, Johnson RL, Deneris ES, Chen ZF, Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8