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Gene Expression Literature Summary
Symbol
Name
ID
Tph2
tryptophan hydroxylase 2
MGI:2651811

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1 E2.5 E3.5 E9.5 E10 E10.5 E11 E11.5 E12.5 E13 E14.5 E15 E15.5 E17 E18.5 E A
In situ protein (section) 1 1 1 1 1 1 2 6
In situ RNA (section) 1 1 1 4 4 1 2 2 1 3
Western blot 2
RT-PCR 1 1 1 1 1 1 3 1 1 2 1 2 7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tph2  tryptophan hydroxylase 2  
Results  Reference
4*J:135685 Basu B, Desai R, Balaji J, Chaerkady R, Sriram V, Maiti S, Panicker MM, Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction. 2008 May;135(5):657-69
1J:86557 Cheng L, Chen CL, Luo P, Tan M, Qiu M, Johnson R, Ma Q, Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003 Nov 5;23(31):9961-7
6*J:118743 Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G, Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):329-34
15J:150616 Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch KP, Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. Eur Neuropsychopharmacol. 2009 Apr;19(4):266-82
1J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1J:137064 Jacobsen KX, Vanderluit JL, Slack RS, Albert PR, HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression. Mol Cell Neurosci. 2008 Jul;38(3):349-58
1J:166738 Li Z, Caron MG, Blakely RD, Margolis KG, Gershon MD, Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. J Neurosci. 2010 Dec 8;30(49):16730-40
4J:165266 Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES, Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010 Oct;13(10):1190-8
1J:101272 Lossi L, Bottarelli L, Candusso ME, Leiter AB, Rindi G, Merighi A, Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci. 2004 Dec;20(12):3259-69
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:191676 Manceau V, Kremmer E, Nabel EG, Maucuer A, The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
8J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
7J:112970 Ortiz-Alvarado R, Guzman-Quevedo O, Mercado-Camargo R, Haertle T, Vignes C, Bolanos-Jimenez F, Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS Lett. 2006 Oct 2;580(22):5371-6
1J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
1J:155932 Rose MF, Ahmad KA, Thaller C, Zoghbi HY, Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22462-7
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:157942 Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO, The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. J Neurosci. 2010 Jan 27;30(4):1523-38
2J:116706 Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW 4th, Johnson RL, Deneris ES, Chen ZF, Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory