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Gene Expression Literature Summary
Symbol
Name
ID
Disc1
disrupted in schizophrenia 1
MGI:2447658

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E10.5 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E A
In situ protein (section) 2 2 2 3 1 1 1 2 1 1 5
In situ RNA (section) 1 1 1 1 1 2
Western blot 1 1 3 1 1 1 3 1 1 1 3
RT-PCR 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Disc1  disrupted in schizophrenia 1  
Results  Reference
5*J:89963 Austin CP, Ky B, Ma L, Morris JA, Shughrue PJ, Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience. 2004;124(1):3-10
1*J:167582 Fukuda T, Sugita S, Inatome R, Yanagi S, CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem. 2010 Dec 24;285(52):40554-61
4J:171976 Ishizuka K, Kamiya A, Oh EC, Kanki H, Seshadri S, Robinson JF, Murdoch H, Dunlop AJ, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, Houslay MD, Katsanis N, Sawa A, DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 2011 May 5;473(7345):92-6
5J:147568 Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH, Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31
3*J:138305 Meyer KD, Morris JA, Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008 Sep;8(7-8):494-501
1J:151421 Meyer KD, Morris JA, Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet. 2009 Sep 1;18(17):3286-97
1J:179756 Muhlhans J, Brandstatter JH, Giessl A, The centrosomal protein pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS One. 2011;6(10):e26496
4*J:175873 Osbun N, Li J, O'Driscoll MC, Strominger Z, Wakahiro M, Rider E, Bukshpun P, Boland E, Spurrell CH, Schackwitz W, Pennacchio LA, Dobyns WB, Black GC, Sherr EH, Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. Am J Med Genet A. 2011 Aug;155A(8):1865-76
13J:94923 Schurov IL, Handford EJ, Brandon NJ, Whiting PJ, Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment. Mol Psychiatry. 2004 Dec;9(12):1100-10
3J:158688 Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A, Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5622-7
3J:143557 Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, Chatzi C, He S, Mackie I, Brandon NJ, Marquis KL, Day M, Hurko O, McCaig CD, Riedel G, St Clair D, Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci. 2008 Oct 22;28(43):10893-904
2J:163156 Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH, Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010 Jul 15;67(1):33-48
4J:179900 Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J, Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons. J Neurosci. 2012 Jan 11;32(2):738-45

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory