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Gene Expression Literature Summary
Symbol
Name
ID
Mcph1
microcephaly, primary autosomal recessive 1
MGI:2443308

4 matching records from 4 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E12 E12.5 E13.5 E14 E14.5 E15.5 E16 P
In situ RNA (section) 1 1 1 1
Western blot 1 2
RT-PCR 1 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Mcph1  microcephaly, primary autosomal recessive 1   (Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik)
Results  Reference
5*J:180706 Gruber R, Zhou Z, Sukchev M, Joerss T, Frappart PO, Wang ZQ, MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol. 2011 Nov;13(11):1325-34
1J:262823 Kasowitz SD, Ma J, Anderson SJ, Leu NA, Xu Y, Gregory BD, Schultz RM, Wang PJ, Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412
6J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1J:261356 Zhou ZW, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang ZQ, DNA damage response in microcephaly development of MCPH1 mouse model. DNA Repair (Amst). 2013 Aug;12(8):645-55

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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory