Gene Expression Literature Summary

• Symbol: Lgr6
• Name: leucine-rich repeat-containing G protein-coupled receptor 6
• ID: MGI:2441805

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)															1
In situ RNA (section)	3	1	1	1		2	4		1	2				4	6
In situ RNA (whole mount)	1
In situ reporter (knock in)		1		1		2	2		2			1		1	5
RT-PCR		1		2	1	3	3	1	2	3	1		1	1	6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lgr6  leucine-rich repeat-containing G protein-coupled receptor 6   (Synonyms: A530037C04Rik)
Results	Reference
1	J:361602 Bobzin L, Nickle A, Ko S, Ince M, Huang A, Bhojwani A, Roberts R, Merrill AE, FGFR2 directs inhibition of WNT signaling to regulate anterior fontanelle closure during skull development. Development. 2025 Jan 15;152(2):dev204264
1*	J:332853 Castilla-Ibeas A, Zdral S, Galan L, Haro E, Allou L, Campa VM, Icardo JM, Mundlos S, Oberg KC, Ros MA, Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity. Cell Rep. 2023 Jan 13;42(1):111975
2*	J:264603 Da Silva F, Massa F, Motamedi FJ, Vidal V, Rocha AS, Gregoire EP, Cai CL, Wagner KD, Schedl A, Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4. Dev Biol. 2018 Sep 1;441(1):42-51
1	J:340392 Ebeid M, Kishimoto I, Roy P, Zaidi MAA, Cheng AG, Huh SH, beta-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development. PLoS Genet. 2023 Aug;19(8):e1010925
1*	J:361454 Jasmine, Baraiya DH, T T K, Mandal A, Chakraborty S, Sathish N, Francis CMR, Binoy Joseph D, Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns. Dev Biol. 2025 Jan 9;520:155-170
2*	J:290019 Jin YR, Han XH, Nishimori K, Ben-Avraham D, Oh YJ, Shim JW, Yoon JK, Canonical WNT/beta-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice. Front Cell Dev Biol. 2020;8:264
5*	J:210988 Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A, R-spondins/Lgrs expression in tooth development. Dev Dyn. 2014 Jun;243(6):844-51
1	J:268688 Kim YJ, Khoshkhoo S, Frankowski JC, Zhu B, Abbasi S, Lee S, Wu YE, Hunt RF, Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory. Neuron. 2018 Dec 5;100(5):1180-1193.e6
2*	J:212415 Kinzel B, Pikiolek M, Orsini V, Sprunger J, Isken A, Zietzling S, Desplanches M, Dubost V, Breustedt D, Valdez R, Liu D, Theil D, Muller M, Dietrich B, Bouwmeester T, Ruffner H, Tchorz JS, Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
4*	J:203768 Mustata RC, Vasile G, Fernandez-Vallone V, Strollo S, Lefort A, Libert F, Monteyne D, Perez-Morga D, Vassart G, Garcia MI, Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium. Cell Rep. 2013 Oct 31;5(2):421-32
1*	J:202041 Page ME, Lombard P, Ng F, Gottgens B, Jensen KB, The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell. 2013 Oct 3;13(4):471-82
6	J:216158 Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D, Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
1	J:283792 Seishima R, Leung C, Yada S, Murad KBA, Tan LT, Hajamohideen A, Tan SH, Itoh H, Murakami K, Ishida Y, Nakamizo S, Yoshikawa Y, Wong E, Barker N, Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019 Nov 26;10(1):5378
1	J:253067 Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF, Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455
3	J:367352 Silvano S, Napolitano T, Plaisant M, Sousa-De-Veiga A, Fofo H, Ayachi C, Allegrini B, Rekima S, Pichery E, Becam J, Lepage V, Treins C, Etasse L, Tran L, Thevenet J, Pasquetti G, Kerr-Conte J, Pattou F, Botti P, Arduini A, Mizrahi J, Charles B, Collombat P, RSPO1, a potent inducer of pancreatic beta cell neogenesis. Cell Rep Med. 2025 May 20;6(5):102126
8*	J:157895 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
1	J:290878 Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Fullgrabe A, Gerling M, Kasper M, Coordinated hedgehog signaling induces new hair follicles in adult skin. Elife. 2020 Mar 17;9:e46756
4*	J:262420 Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefevre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Basaran S, Yucel EB, Tan TT, Vlaeminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B, RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569
4*	J:312349 van Ineveld RL, Margaritis T, Kooiman BAP, Groenveld F, Ariese HCR, Lijnzaad P, Johnson HR, Korving J, Wehrens EJ, Holstege F, van Rheenen J, Drost J, Rios AC, Bos FL, LGR6 marks nephron progenitor cells. Dev Dyn. 2021 Nov;250(11):1568-1583
1	J:290543 Vidal VP, Jian-Motamedi F, Rekima S, Gregoire EP, Szenker-Ravi E, Leushacke M, Reversade B, Chaboissier MC, Schedl A, R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. Elife. 2020 May 1;9:e53895
4	J:356085 Wang J, Tian GG, Zheng Z, Li B, Xing Q, Wu J, Comprehensive Transcriptomic Analysis of Mouse Gonadal Development Involving Sexual Differentiation, Meiosis and Gametogenesis. Biol Proced Online. 2019;21:20
5*	J:341172 Watanabe K, Horie M, Hayatsu M, Mikami Y, Sato N, Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon. Gene Expr Patterns. 2023 Sep;49:119333
1	J:283063 Wu L, Belyaeva OV, Adams MK, Klyuyeva AV, Lee SA, Goggans KR, Kesterson RA, Popov KM, Kedishvili NY, Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. J Biol Chem. 2019 Nov 8;294(45):17060-17074
1*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
1	J:273440 Zak M, van Oort T, Hendriksen FG, Garcia MI, Vassart G, Grolman W, LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186
5*	J:239360 Zhang Y, Chen Y, Ni W, Guo L, Lu X, Liu L, Li W, Sun S, Wang L, Li H, Dynamic expression of Lgr6 in the developing and mature mouse cochlea. Front Cell Neurosci. 2015;9:165